Article
Chemistry, Inorganic & Nuclear
Miguel A. Camacho-Fernandez, Joseph W. Ziller, Zhibin Guan
Summary: Three arene tethered ruthenium(II) complexes were compared for olefin polymerization, with nitrogen-containing complex 2 showing 1.5 times higher activity than sulfur-containing complex 1. Theoretical calculations on migratory insertion barriers were in agreement with experimental results.
Article
Chemistry, Inorganic & Nuclear
Aswathi N. E. Ravindran, Dharmalingam Sindhuja, Nattamai Bhuvanesh, Ramasamy Karvembu
Summary: The catalytic activity of Ru(II)-arene complexes containing ferrocene thiosemicarbazone (Fc-TSC) ligands towards the selective synthesis of 1,2-disubstituted benzimidazoles via acceptorless dehydrogenative coupling of diamines with primary alcohols was investigated. The electronic effect of ligands on the catalytic activity of their complexes was studied, leading to the conclusion of achieving good to moderate yields in the synthesis of 1,2-disubstituted benzimidazoles.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Stephen Mensah, Joseph D. Rosenthal, Mamta Dagar, Tyson Brown, Jonathan J. Mills, Christopher G. Hamaker, Gregory M. Ferrence, Michael I. Webb
Summary: The evolution of high virulence bacterial strains has led to the development of novel therapeutic agents. Metal-based therapeutics, with their structural variability and unique modes of action, show great promise. This study focused on the preparation and evaluation of ruthenium(ii)-arene complexes containing Schiff base ligands with an attached ferrocene, and identified a complex with prominent activity against clinically relevant bacterial strains.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Physical
Songwei Zhang, Jerry Pui Ho Li, Jingpeng Zhao, Dan Wu, Biao Yuan, Willinton Yesid Hernandez, Wen-Juan Zhou, Tao He, Yi Yu, Yong Yang, Vitaly Ordomsky, Tao Li
Summary: The study presents a Ru@metal-organic framework (MOF) tandem catalyst that can directly convert monoalcohols and diols into acetals without the formation of carboxylic acids. The presence of Lewis acid sites in the MOF works together with Ru active sites to efficiently suppress the formation of over-oxidation byproducts.
Review
Chemistry, Multidisciplinary
Nataliia Vereshchuk, Marcos Gil-Sepulcre, Abolfazl Ghaderian, Jan Holub, Carolina Gimbert-Surinach, Antoni Llobet
Summary: Today, sustainable and clean energy conversion strategies rely on sunlight and water as sources of protons and electrons, similar to Photosystem II. However, the thermodynamics and complexity of the water oxidation reaction make it difficult to find efficient and stable molecules capable of achieving this task. Ru coordination complexes have been identified as some of the best understood water oxidation catalysts, and their catalytic performance and key factors influencing their performance have been extensively studied.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Applied
Ramya Prabaharan, Ramesh Rengan, Devan Umapathy, Antony Joseph Velanganni Arockiam, Jan Grzegorz Malecki
Summary: The study synthesized six new arene ruthenium (II) complexes and evaluated their anticancer activity through MTT assay and staining techniques, demonstrating good cytotoxicity against cancer cell lines, particularly with complex 6 showing potential anticancer activity.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Bhaskarjyoti Sarma, Rishi Ranjan, Nimesh R. Chauhan, Suman Mukhopadhyay, Angshuman Roy Choudhury, Komal M. Vyas
Summary: Efficient Ru(II) catalysts with substituted aniline based ligands were synthesized and their catalytic performance for the conversion of primary amine to secondary amine was investigated. Among them, [Ru-1] showed 100% selectivity and > 99% conversion without formation of any imine derivatives, suggesting its higher effectiveness compared to other catalysts. The catalytic performance of [Ru-1] demonstrated that it is one of the most active Ru(II) based catalytic systems for N-alkylation of anilines under milder and solvent-free conditions.
MOLECULAR CATALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Elena de la Torre-Rubio, Laura Munoz-Moreno, Ana M. Bajo, Maria-Selma Arias-Perez, Tomas Cuenca, Lourdes Gude, Eva Royo
Summary: Water-soluble half-sandwich ruthenium(II) polypyridyl-glycoconjugates have been synthesized and their behavior in water and interactions with DNA have been studied. These compounds bind DNA through minor groove binding, external electrostatic interactions, and a non-classical intercalation mechanism. They also exhibit cytotoxicity against prostate cancer cells and have anti-migratory and MMP-9 inhibitory activities.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Applied
Imtiyaz Yousuf, Masrat Bashir
Summary: A new organoruthenium(II) complex was designed, synthesized, and evaluated for cytotoxicity. The complex exhibited significant intermolecular interactions in the crystal structure, and showed preferential affinity toward minor groove in DNA photocleavage activity. Cytotoxic studies revealed moderate but selective activity against pancreatic and cervical cancer cell lines.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Tamilthendral Veerappan, Ramesh Rengan
Summary: A sustainable synthesis of substituted pyrazoles is achieved via an eco-friendly dehydrogenative annulation reaction using newly synthesized binuclear Ru-(II) p-cymene complexes. The reaction proceeds under mild conditions, producing H(2)O/H-2 as the only byproduct, and yields a range of polysubstituted pyrazoles and a therapeutic gout medicine analogue successfully.
Article
Chemistry, Applied
Saranya Sundar, Ramesh Rengan, Anandaraj Pennamuthiriyan, David Semeril
Summary: A facile catalytic one-pot synthesis of N-acylhydrazones has been described using arene ruthenium (II) complexes. The method provides a wide range of N-acylhydrazones in good yields with high selectivity and functional group tolerance, without any alkylated products.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Sankar Monika, Rengan Ramesh
Summary: This study reports the synthesis of a new series of organometallic dinuclear ruthenium(ii) arene complexes and investigates their in vitro antiproliferative activity and cancer cell death mechanism. The formation of complexes was confirmed by various spectroscopic techniques. The synthesized complexes showed higher inhibition of cancer cells compared to the standard cisplatin drug, and apoptosis was confirmed through morphological changes and phosphatidylserine externalization.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Tianyu Han, Yuying Wu, Weinan Han, Kaiwen Yan, Jian Zhao, Yanyan Sun
Summary: The facile modification of ligands in organometallic Ru(II)-arene complexes provides more opportunities for optimizing their pharmacological profiles. This study designed and synthesized three Ru(II)-arene complexes containing a GST inhibitor (NBDHEX), with in vitro results showing increased activities against tumor cells, especially in complex 3 which demonstrated the highest activity. Complex 3, with more alkyl groups in the arene ligand, exhibited increased electron density at the Ru(II) center leading to improved hydrolysis rate and higher anticancer activity.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Pragti, Sreshtha Nayek, Satyam Singh, Avinash Sonawane, Ivo Grabchev, Rakesh Ganguly, Suman Mukhopadhyay
Summary: In this study, three Ru(II) arene complexes with a bidentate benzimidazole-based ligand were synthesized and their antitumor activity was studied by varying the co-ligand X. The synthesized compounds showed good interactions with serum albumin proteins, had good drug stability and lipophilic character. They were found to bind with DNA and could induce apoptosis in cancer cells, as well as upregulate cleaved caspase-3 expression and downregulate BCLXL expression. These findings provide a new direction for the investigation of antitumor ruthenium-based metallodrugs using benzimidazole-based ligands.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Oksana Desiatkina, Martin Moesching, Nicoleta Anghel, Ghalia Boubaker, Yosra Amdouni, Andrew Hemphill, Julien Furrer, Emilia Paunescu
Summary: A library of nucleobase-tethered trithiolato-bridged dinuclear ruthenium(II)-arene conjugates was synthesized and evaluated for their anti-Toxoplasma activity. Two promising compounds were identified, which exhibited low toxicity against host cells and have potential as treatment options.
Article
Chemistry, Organic
Jonathan Barrios-Rivera, Yingjian Xu, Guy J. Clarkson, Martin Wills
Summary: The application of enantiomerically-pure ruthenium(II) catalysts containing N - functionalised TsDPEN ligand to the asymmetric transfer hydrogenation of 15 examples of alpha-heterocyclic acetophenone derivatives is reported, with products of up to 99% ee formed. (C) 2021 Elsevier Ltd. All rights reserved.
Article
Chemistry, Organic
Rina Soni, Shubhangi S. Soman
Summary: Coumarin containing hetero[n]helicene like molecules were synthesized through specific reactions, and their photophysical properties were found to be affected by substitution. Some synthesized compounds exhibited bright emission in solution, thin film, and solid state. The structures of intermediate compounds were confirmed by experiments and compared with computational results.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Adedibu C. Tella, Adetola C. Oladipo, Victoria T. Olayemi, Allen Gordon, Adeniyi S. Ogunlaja, Lukman O. Alimi, Stephen P. Argent, Robert Mokaya, Guy J. Clarkson, Richard I. Walton
Summary: Two calcium coordination compounds were grown at room temperature and characterized. The structures of the compounds are stabilized by a network of hydrogen bonds. Compound 1 exhibits high excitation energies and chemical hardness, making it a better electron acceptor. Compound 2 is softer with better polarizability and reactivity.
STRUCTURAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Kanubhai D. Katariya, Rina Soni, Kiran J. Nakum, Shubhangi S. Soman, Mohamed Hagaar
Summary: New coumarin esters with Schiff base linkage and different alkyl chains have been synthesized and studied for their mesomorphic behavior. The compounds were characterized using various analytical techniques and their phase transitions and mesophase behavior were investigated. The results showed that most of the synthesized compounds exhibited enantiotropic nematic phase, and some also displayed enantiotropic smectic C phase. The relationship between the structural parameters and the mesomorphic behavior was explained using DFT theoretical calculations and compared with experimental results.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Inorganic & Nuclear
Satarupa Das, Jinfang Zhang, Thomas W. Chamberlain, Guy J. Clarkson, Richard I. Walton
Summary: CO2 epoxidation to cyclic carbonates under mild, solvent-free conditions is a promising pathway for sustainable CO2 utilization. However, previous metal-organic frameworks (MOFs) used for this purpose are not suitable for commercial utilization due to the nonrenewable ligands used. This study presents new yttrium MOFs based on renewable 2,5-furandicarboxylate (FDC) ligands, which exhibit high catalytic activity and conversion efficiency for CO2 epoxidation reactions.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Guy J. Clarkson, Stefan Roesner
Summary: An efficient methodology for the synthesis of benzofuropyridines and dibenzofurans from fluoropyridines or fluoroarenes and 2-bromophenyl acetates is presented. The streamlined one-pot procedure involves four-step directed ortho-lithiation, zincation, Negishi cross-coupling, and intramolecular nucleophilic aromatic substitution, enabling the easy assembly of a diverse set of fused benzofuro heterocycles.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Rina Soni, Kiran J. Nakum, Kanubhai D. Katariya, Shubhangi S. Soman, Shady Nada, Mohamed Hagar
Summary: In this study, two series of Coumarin-based Schiff base-ester mesogenic compounds were synthesized and characterized. By varying the alkyl chain length at both ends of the molecules, different liquid crystal behaviors and phase transitions were observed. The theoretical study was also discussed in terms of dipole moment, molecular electrostatic potentials, frontier molecular orbitals, and geometrical structure.
Article
Chemistry, Multidisciplinary
Jiangping Liu, Andrew W. Prentice, Guy J. Clarkson, Jack M. Woolley, Vasilios G. Stavros, Martin J. Paterson, Peter J. Sadler
Summary: This study reports a Ru(II) polypyridyl prodrug, RuAzNM, functionalized with azo and nitrogen mustard, which exhibits multimodal theranostic properties towards hypoxic cancer cells. Reduction of the azo group in hypoxic cell microenvironments leads to the generation of reactive oxygen species and mtDNA crosslinking, while the resulting phosphorescent RuNH2 serves as a diagnostic signal and activates phototherapy. This unique strategy allows controlled multimodal theranostics to be realized in hypoxic cells, making RuAzNM a highly selective and effective cancer-cell-selective theranostic agent.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Inorganic & Nuclear
Noha Khamis, Guy J. Clarkson, Martin Wills
Summary: The synthesis of a variety of N-(heterocyclesulfonyl)-functionalized Noyori-Ikariya catalysts was described in this study. These complexes were prepared from C2-symmetric 1,2-diphenylethylene-1,2-diamine (DPEN) and characterized using multiple methods including X-ray crystallography. The complexes exhibited catalytic activity in the asymmetric transfer hydrogenation (ATH) of various acetophenone derivatives, yielding products with high enantioselectivity in most cases, especially for ortho-substituted acetophenones.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Physical
Kanubhai D. Katariya, Kiran J. Nakum, Rina Soni, Shubhangi S. Soman, Mohamed Hagar
Summary: Here, two series of Coumarin Schiff base-esters liquid crystals were prepared and characterized. The compounds were studied for their mesomorphic behavior using DSC and POM, and the relationship between structural parameters and mesomorphic behavior was explored. The results showed that compounds with different chain lengths and symmetrical structures exhibited different phase transitions.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Organic
Ye Zheng, Martin Wills
Summary: In this study, the reduction of Bpin-containing ketones by asymmetric transfer hydrogenation (ATH) was investigated. It was found that the reaction products exhibited high ee when the Bpin group was in the para- or meta-position.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Feng Chen, Isolda Romero-Canelon, Abraha Habtemariam, Ji-Inn Song, Samya Banerjee, Guy J. Clarkson, Lijiang Song, Ivan Prokes, Peter J. Sadler
Summary: We synthesized a series of novel substituted sulfonyl ethylenediamine (en) Ru-II arene complexes, which showed antiproliferative activity against cancer cells and exhibited catalytic activity in transfer hydrogenation reactions and reactions with thiols.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Gianluca Accorsi, Agostina-Lina Capodilupo, Rosa Maria Claramunt, Guy J. Clarkson, A. Farran, Francesco G. Gatti, Salvador Leon, Silvia Venturi
Summary: A series of three new 3-(-aryl)-1,1,1-trifluoro-3-(2-phenylhydrazono)propan-2-ones were synthesized and characterized by NMR spectroscopy and X-ray diffraction analysis. The introduction of different substituents on the molecules caused significant changes in the photoisomerization dynamics, with the N-H•••F-C(sp(3)) interaction playing a key role in stabilizing the Z isomer. DFT calculations supported the experimental findings and provided a basis for future design of new photoswitching materials.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Sara Pischedda, Sergio Stoccoro, Antonio Zucca, Giuseppe Sciortino, Fabrizio Ortu, Guy J. Clarkson
Summary: Various palladium (II) and platinum (II) complexes have been synthesized using different ligands and characterized through detailed spectroscopic analysis, X-ray structural analysis, and elemental analysis. The study revealed the inertness of these synthesized compounds towards metalation, attributed to higher angle steric strain compared to analogous bipyridine complexes.
DALTON TRANSACTIONS
(2021)
