4.7 Article

Asymmetric Transfer Hydrogenation of Functionalized Acetylenic Ketones

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 78, Issue 17, Pages 8594-8605

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo401284c

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Funding

  1. Warwick University

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A systematic study of the asymmetric transfer hydrogenations of functionalized acetylenic ketones and diketones has been completed, together with a total synthesis of (S,S)-(-)-yashabushidiol B. In several cases, excellent enantioselectivities and yields were achieved.

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