Complement: Bridging the innate and adaptive immune systems in sterile inflammation

Systemic activation of NLRP3 inflammasome and plasma α-synuclein levels are correlated with motor severity and progression in Parkinson’s disease

(2020) Zheng Fan et al.   Journal of Neuroinflammation

Global Environmental Change and Noncommunicable Disease Risks

(2019) Howard Frumkin et al.   Annual Review of Public Health

Outcomes in Solid-Organ Transplantation: Success and Stagnation

(2019) Abbas Rana et al.   TEXAS HEART INSTITUTE JOURNAL

NLRP3 inflammasome couples purinergic signaling with activation of the complement cascade for the optimal release of cells from bone marrow

(2019) Mariusz Z. Ratajczak et al.   LEUKEMIA

Drug Development for Alzheimer’s Disease: Microglia Induced Neuroinflammation as a Target?

(2019) Yuan Dong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of Complement-Related Inflammation and Vascular Dysfunction in Hypertension

(2019) Cheng-Chao Ruan et al.   HYPERTENSION

Role of T-cell activation in salt-sensitive hypertension

(2019) Jiafa Ren et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inflammation and Cancer: Triggers, Mechanisms, and Consequences

(2019) Florian R. Greten et al.   IMMUNITY

The Complement Receptor C5aR2: A Powerful Modulator of Innate and Adaptive Immunity

(2019) Xaria X. Li et al.   JOURNAL OF IMMUNOLOGY

Neuroinflammation and functional connectivity in Alzheimer's disease: interactive influences on cognitive performance

(2019) L. Passamonti et al.   JOURNAL OF NEUROSCIENCE

ACC/AHA Versus ESC/ESH on Hypertension Guidelines

(2019) George Bakris et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Clinical promise of next-generation complement therapeutics

(2019) Dimitrios C. Mastellos et al.   NATURE REVIEWS DRUG DISCOVERY

Complement Nomenclature—Deconvoluted

(2019) Suzanne S. Bohlson et al.   Frontiers in Immunology

Novel Molecular Leads for the Prevention of Damage and the Promotion of Repair in Neuroimmunological Disease

(2019) Mahshad Kolahdouzan et al.   Frontiers in Immunology

Complement-independent bystander injury in AQP4-IgG seropositive neuromyelitis optica produced by antibody-dependent cellular cytotoxicity

(2019) Tianjiao Duan et al.   Acta Neuropathologica Communications

Phenotypic variability and its pathological basis in amyotrophic lateral sclerosis

(2019) Takahiro Takeda et al.   NEUROPATHOLOGY

Complement and the Regulation of T Cell Responses

(2018) Erin E. West et al.   Annual Review of Immunology

Deficiency of Complement C3a and C5a Receptors Prevents Angiotensin II–Induced Hypertension via Regulatory T CellsNovelty and Significance

(2018) Xiao-Hui Chen et al.   CIRCULATION RESEARCH

The role of the alternative pathway of complement activation in glomerular diseases

(2018) Emilia Łukawska et al.   CLINICAL AND EXPERIMENTAL MEDICINE

T Cell Expression of C5a Receptor 2 Augments Murine Regulatory T Cell (TREG) Generation and TREG-Dependent Cardiac Allograft Survival

(2018) Divya A. Verghese et al.   JOURNAL OF IMMUNOLOGY

Identifying the role of complement in triggering neuroinflammation after traumatic brain injury

(2018) Ali Alawieh et al.   JOURNAL OF NEUROSCIENCE

Aliskiren inhibits renin-mediated complement activation

(2018) Zivile D. Békássy et al.   KIDNEY INTERNATIONAL

Mobilization of hematopoietic stem cells as a result of innate immunity-mediated sterile inflammation in the bone marrow microenvironment—the involvement of extracellular nucleotides and purinergic signaling

(2018) Mariusz Z Ratajczak et al.   LEUKEMIA

Myeloid-derived suppressor cells coming of age

(2018) Filippo Veglia et al.   NATURE IMMUNOLOGY

Neuroinflammation: Microglia and T Cells Get Ready to Tango

(2018) Sjoerd T. T. Schetters et al.   Frontiers in Immunology

Hypertension

(2018) Suzanne Oparil et al.   Nature Reviews Disease Primers

Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis

(2018) Iliana Michailidou et al.   Acta Neuropathologica Communications

C5aR1 regulates migration of suppressive myeloid cells required for costimulatory blockade-induced murine allograft survival

(2018) Ines Llaudo et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Kidney donation and transplantation in Australia: more than a supply and demand equation

(2018) Jeremy R Chapman et al.   MEDICAL JOURNAL OF AUSTRALIA

The complement system in glioblastoma multiforme

(2018) T. A. M. Bouwens van der Vlis et al.   Acta Neuropathologica Communications

Absence of recipient C3aR1 signaling limits expansion and differentiation of alloreactive CD8+ T cell immunity and prolongs murine cardiac allograft survival

(2018) Douglas R. Mathern et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Multiple sclerosis - a review

(2018) R. Dobson et al.   EUROPEAN JOURNAL OF NEUROLOGY

Traumatic Brain Injury in Aged Mice Induces Chronic Microglia Activation, Synapse Loss, and Complement-Dependent Memory Deficits

(2018) Karen Krukowski et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Contribution of Neurons and Glial Cells to Complement-Mediated Synapse Removal during Development, Aging and in Alzheimer’s Disease

(2018) Celia Luchena et al.   MEDIATORS OF INFLAMMATION

The role of the complement system in cancer

(2017) Vahid Afshar-Kharghan   JOURNAL OF CLINICAL INVESTIGATION

The immunology of hypertension

(2017) Allison E. Norlander et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Kallikrein Cleaves C3 and Activates Complement

(2017) Sarah Irmscher et al.   Journal of Innate Immunity

Structure and activation of C1, the complex initiating the classical pathway of the complement cascade

(2017) Simon A. Mortensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TCR-stimulated changes in cell surface CD46 expression generate type 1 regulatory T cells

(2017) Siobhan Ni Choileain et al.   Science Signaling

A Combined PD-1/C5a Blockade Synergistically Protects against Lung Cancer Growth and Metastasis

(2017) Daniel Ajona et al.   Cancer Discovery

Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes

(2017) Weihua Zhao et al.   JAMA Neurology

TCR-stimulated changes in cell surface CD46 expression generate type 1 regulatory T cells

(2017) Siobhan Ni Choileain et al.   Science Signaling

Myeloid-Derived Suppressor Cells

(2017) Dmitry I. Gabrilovich   Cancer Immunology Research

Immune Modulation in the Treatment of Amyotrophic Lateral Sclerosis: A Review of Clinical Trials

(2017) Syed I. Khalid et al.   Frontiers in Neurology

Cell death and inflammation: the case for IL-1 family cytokines as the canonical DAMPs of the immune system

(2016) Seamus J. Martin   FEBS Journal

The TNF Receptor Superfamily in Co-stimulating and Co-inhibitory Responses

(2016) Lindsay K. Ward-Kavanagh et al.   IMMUNITY

Complement C5a activates microglial NLRP3 inflammasomes and drives neurodegeneration in Parkinson's disease through C5aR1

(2016) Richard Gordon et al.   IMMUNOBIOLOGY

A journey through the lectin pathway of complement-MBL and beyond

(2016) Peter Garred et al.   IMMUNOLOGICAL REVIEWS

Complement component C3 - The “Swiss Army Knife” of innate immunity and host defense

(2016) Daniel Ricklin et al.   IMMUNOLOGICAL REVIEWS

Complementing the inflammasome

(2016) Martha Triantafilou et al.   IMMUNOLOGY

Collectin-11 detects stress-induced L-fucose pattern to trigger renal epithelial injury

(2016) Conrad A. Farrar et al.   JOURNAL OF CLINICAL INVESTIGATION

The Complement C3a Receptor Contributes to Melanoma Tumorigenesis by Inhibiting Neutrophil and CD4+T Cell Responses

(2016) Jamileh A. Nabizadeh et al.   JOURNAL OF IMMUNOLOGY

NLRP3 is Required for Complement-Mediated Caspase-1 and IL-1beta Activation in ICH

(2016) Sheng-Tao Yao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Neuroinflammation: the devil is in the details

(2016) Damon J. DiSabato et al.   JOURNAL OF NEUROCHEMISTRY

Inflammatory Response in the CNS: Friend or Foe?

(2016) Marta Sochocka et al.   MOLECULAR NEUROBIOLOGY

Autocrine Complement Inhibits IL10-Dependent T-cell-Mediated Antitumor Immunity to Promote Tumor Progression

(2016) Y. Wang et al.   Cancer Discovery

Complement C1q-C3-associated synaptic changes in multiple sclerosis hippocampus

(2015) Iliana Michailidou et al.   ANNALS OF NEUROLOGY

Targeting Pathogenic Postischemic Self-Recognition by Natural IgM to Protect Against Posttransplantation Cardiac Reperfusion InjuryCLINICAL PERSPECTIVE

(2015) Carl Atkinson et al.   CIRCULATION

Complement activation, regulation, and molecular basis for complement-related diseases

(2015) G. Bajic et al.   EMBO JOURNAL

The role of complement activation in atherogenesis: the first 40 years

(2015) Sonia I. Vlaicu et al.   IMMUNOLOGIC RESEARCH

IL-27 Induces Th17 Differentiation in the Absence of STAT1 Signaling

(2015) Anneli Peters et al.   JOURNAL OF IMMUNOLOGY

Is the Complement Activation Product C3a a Proinflammatory Molecule? Re-evaluating the Evidence and the Myth

(2015) Liam G. Coulthard et al.   JOURNAL OF IMMUNOLOGY

The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury

(2015) F. H. Brennan et al.   JOURNAL OF NEUROSCIENCE

Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling

(2015) Tomokazu Sumida et al.   Nature Communications

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Complement 5a Receptor Mediates Angiotensin II–Induced Cardiac Inflammation and Remodeling

(2014) Congcong Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Complement C5a Receptor Facilitates Cancer Metastasis by Altering T-Cell Responses in the Metastatic Niche

(2014) S. K. Vadrevu et al.   CANCER RESEARCH

Complement and spinal cord injury: Traditional and non-traditional aspects of complement cascade function in the injured spinal cord microenvironment

(2014) Sheri L. Peterson et al.   EXPERIMENTAL NEUROLOGY

Donor Deficiency of Decay-Accelerating Factor Accelerates Murine T Cell-Mediated Cardiac Allograft Rejection

(2014) V. Pavlov et al.   JOURNAL OF IMMUNOLOGY

Complement protein C1q bound to apoptotic cells suppresses human macrophage and dendritic cell-mediated Th17 and Th1 T cell subset proliferation

(2014) Elizabeth V. Clarke et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neurodegeneration by Activation of the Microglial Complement-Phagosome Pathway

(2014) L.-G. Bodea et al.   JOURNAL OF NEUROSCIENCE

‘Neuroinflammation’ differs categorically from inflammation: transcriptomes of Alzheimer's disease, Parkinson's disease, schizophrenia and inflammatory diseases compared

(2014) Michaela D. Filiou et al.   NEUROGENETICS

Role for terminal complement activation in amyotrophic lateral sclerosis disease progression

(2014) T. M. Woodruff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C1-Esterase-Inhibitor for Primary Graft Dysfunction in Lung Transplantation

(2014) Wiebke Sommer et al.   TRANSPLANTATION

Versatility of the complement system in neuroinflammation, neurodegeneration and brain homeostasis

(2014) Franca Orsini et al.   Frontiers in Cellular Neuroscience

Autocrine Effects of Tumor-Derived Complement

(2014) Min Soon Cho et al.   Cell Reports

Complement, C1q, and C1q-Related Molecules Regulate Macrophage Polarization

(2014) Suzanne S. Bohlson et al.   Frontiers in Immunology

High Blood Pressure: The Leading Global Burden of Disease Risk Factor and the Need for Worldwide Prevention Programs

(2013) Samantha Bromfield et al.   CURRENT HYPERTENSION REPORTS

The resolution of neuroinflammation in neurodegeneration: leukocyte recruitment via the choroid plexus

(2013) Michal Schwartz et al.   EMBO JOURNAL

Structural genomic variation in childhood epilepsies with complex phenotypes

(2013) Ingo Helbig et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation

(2013) K. Triantafilou et al.   JOURNAL OF CELL SCIENCE

Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells

(2013) Wing-hong Kwan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD4+CD25+Foxp3 regulatory T cells and vascular dysfunction in hypertension

(2013) Modar Kassan et al.   JOURNAL OF HYPERTENSION

Cutting Edge: Receptors for C3a and C5a Modulate Stability of Alloantigen-Reactive Induced Regulatory T Cells

(2013) W. van der Touw et al.   JOURNAL OF IMMUNOLOGY

Soluble complement complex C5b-9 promotes microglia activation

(2013) Chao Yang et al.   JOURNAL OF NEUROIMMUNOLOGY

The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization

(2013) Mike C. L. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overview of Complement Activation and Regulation

(2013) Marina Noris et al.   SEMINARS IN NEPHROLOGY

Effector Mechanisms of Rejection

(2013) A. Moreau et al.   Cold Spring Harbor Perspectives in Medicine

Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors

(2012) Sarah Schwitalla et al.   CANCER CELL

The Role of Type 1 Angiotensin Receptors on T Lymphocytes in Cardiovascular and Renal Diseases

(2012) Jiandong Zhang et al.   CURRENT HYPERTENSION REPORTS

Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival

(2012) Jenny S. Henkel et al.   EMBO Molecular Medicine

Generation of complement component C5a by ischemic neurons promotes neuronal apoptosis

(2012) Dale Pavlovski et al.   FASEB JOURNAL

Mutant huntingtin fragmentation in immune cells tracks Huntington’s disease progression

(2012) Andreas Weiss et al.   JOURNAL OF CLINICAL INVESTIGATION

Complement Protein C1q Directs Macrophage Polarization and Limits Inflammasome Activity during the Uptake of Apoptotic Cells

(2012) M. E. Benoit et al.   JOURNAL OF IMMUNOLOGY

Anaphylatoxin C5a Creates a Favorable Microenvironment for Lung Cancer Progression

(2012) Leticia Corrales et al.   JOURNAL OF IMMUNOLOGY

Absence of signaling into CD4+ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3+ regulatory T cells

(2012) Michael G Strainic et al.   NATURE IMMUNOLOGY

Anti-Complement Component C5 mAb Synergizes with CTLA4Ig to Inhibit Alloreactive T cells and Prolong Cardiac Allograft Survival in Mice

(2011) H. Raedler et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Enhancing CNS Repair in Neurological Disease

(2011) Xiaohua Xu et al.   CNS DRUGS

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Complement regulation of T-cell alloimmunity

(2010) Hugo Raedler et al.   Current Opinion in Organ Transplantation

Molecular Intercommunication between the Complement and Coagulation Systems

(2010) U. Amara et al.   JOURNAL OF IMMUNOLOGY

Cancer and the Complement Cascade

(2010) M. J. Rutkowski et al.   MOLECULAR CANCER RESEARCH

CNS-specific expression of C3a and C5a exacerbate demyelination severity in the cuprizone model

(2010) Sarah A. Ingersoll et al.   MOLECULAR IMMUNOLOGY

Properdin: Emerging Roles of a Pattern-Recognition Molecule

(2009) Claudia Kemper et al.   Annual Review of Immunology

Metformin Attenuated the Autoimmune Disease of the Central Nervous System in Animal Models of Multiple Sclerosis

(2009) N. Nath et al.   JOURNAL OF IMMUNOLOGY

C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production

(2009) Deborah A. Fraser et al.   JOURNAL OF NEUROCHEMISTRY

The alternative complement pathway revisited

(2008) Morten Harboe et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The complement cascade: Yin-Yang in neuroinflammation - neuro-protection and -degeneration

(2008) Jessy John Alexander et al.   JOURNAL OF NEUROCHEMISTRY

The role of complement and complement regulators in mediating motor nerve terminal injury in murine models of Guillain–Barré syndrome

(2008) Hugh J. Willison et al.   JOURNAL OF NEUROIMMUNOLOGY

Complement anaphylatoxin C5a neuroprotects through regulation of glutamate receptor subunit 2 in vitro and in vivo

(2008) Piali Mukherjee et al.   Journal of Neuroinflammation

Complement 5a Receptor Inhibition Improves Renal Allograft Survival

(2008) F. Gueler et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Modulation of the antitumor immune response by complement

(2008) Maciej M Markiewski et al.   NATURE IMMUNOLOGY

Mechanism of cellular rejection in transplantation

(2008) Elizabeth Ingulli   PEDIATRIC NEPHROLOGY