Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis

The Alternative Receptor for Complement Component 5a, C5aR2, Conveys Neuroprotection in Traumatic Spinal Cord Injury

(2017) Patrick J.C. Biggins et al.   JOURNAL OF NEUROTRAUMA

The Controversial C5a Receptor C5aR2: Its Role in Health and Disease

(2017) Ting Zhang et al.   Journal of Immunology Research

Multiple sclerosis: experimental models and reality

(2016) Hans Lassmann et al.   ACTA NEUROPATHOLOGICA

Complement peptide C3a stimulates neural plasticity after experimental brain ischaemia

(2016) Anna Stokowska et al.   BRAIN

Complement C3 on microglial clusters in multiple sclerosis occur in chronic but not acute disease: Implication for disease pathogenesis

(2016) Iliana Michailidou et al.   GLIA

Complementing the inflammasome

(2016) Martha Triantafilou et al.   IMMUNOLOGY

Complement is activated in progressive multiple sclerosis cortical grey matter lesions

(2016) Lewis M. Watkins et al.   Journal of Neuroinflammation

Expression of IL-1β in rhesus EAE and MS lesions is mainly induced in the CNS itself

(2016) Saskia Maria Burm et al.   Journal of Neuroinflammation

Complement activation at the motor end-plates in amyotrophic lateral sclerosis

(2016) Nawal Bahia El Idrissi et al.   Journal of Neuroinflammation

Sex matters: Systemic complement activity of female C57BL/6J and BALB/cJ mice is limited by serum terminal pathway components

(2016) Juha Kotimaa et al.   MOLECULAR IMMUNOLOGY

An interferon-β-resistant and NLRP3 inflammasome–independent subtype of EAE with neuronal damage

(2016) Makoto Inoue et al.   NATURE NEUROSCIENCE

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells

(2016) G. Arbore et al.   SCIENCE

Experimental priming of encephalitogenic Th1/Th17 cells requires pertussis toxin-driven IL-1β production by myeloid cells

(2016) Francesca Ronchi et al.   Nature Communications

M. leprae components induce nerve damage by complement activation: identification of lipoarabinomannan as the dominant complement activator

(2015) Nawal Bahia El Idrissi et al.   ACTA NEUROPATHOLOGICA

Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides

(2015) Richard S. Geary et al.   ADVANCED DRUG DELIVERY REVIEWS

Complement C1q-C3-associated synaptic changes in multiple sclerosis hippocampus

(2015) Iliana Michailidou et al.   ANNALS OF NEUROLOGY

Complement activation and expression during chronic relapsing experimental autoimmune encephalomyelitis in the Biozzi ABH mouse

(2015) V. Ramaglia et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury

(2015) F. H. Brennan et al.   JOURNAL OF NEUROSCIENCE

Increased inflammasome related gene expression profile in PBMC may facilitate T helper 17 cell induction in multiple sclerosis

(2015) E. Peelen et al.   MOLECULAR IMMUNOLOGY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Complement, a target for therapy in inflammatory and degenerative diseases

(2015) B. Paul Morgan et al.   NATURE REVIEWS DRUG DISCOVERY

An anticomplement agent that homes to the damaged brain and promotes recovery after traumatic brain injury in mice

(2015) Marieta M. Ruseva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anticomplement C5 therapy with eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

(2015) Edwin K.S. Wong et al.   Translational Research

Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury

(2015) Minako Ito et al.   Nature Communications

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Inhibition of the Membrane Attack Complex of the Complement System Reduces Secondary Neuroaxonal Loss and Promotes Neurologic Recovery after Traumatic Brain Injury in Mice

(2014) K. Fluiter et al.   JOURNAL OF IMMUNOLOGY

Cerebrospinal fluid IL-1β correlates with cortical pathology load in multiple sclerosis at clinical onset

(2014) Dario Seppi et al.   JOURNAL OF NEUROIMMUNOLOGY

Cerebrospinal fluid detection of interleukin-1β in phase of remission predicts disease progression in multiple sclerosis

(2014) Silvia Rossi et al.   Journal of Neuroinflammation

Complement activation in multiple sclerosis plaques: an immunohistochemical analysis

(2014) Gillian Ingram et al.   Acta Neuropathologica Communications

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

Spinal cord injury induced changes of nuclear receptors PPARα and LXRβ and modulation with oleic acid/albumin treatment

(2013) Daniel Fandel et al.   BRAIN RESEARCH

The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation

(2013) K. Triantafilou et al.   JOURNAL OF CELL SCIENCE

Cutting Edge: The NLRP3 Inflammasome Links Complement-Mediated Inflammation and IL-1  Release

(2013) F. Laudisi et al.   JOURNAL OF IMMUNOLOGY

Association between Change in Normal Appearing White Matter Metabolites and Intrathecal Inflammation in Natalizumab-Treated Multiple Sclerosis

(2012) Johan Mellergård et al.   PLoS One

NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis

(2012) M. Inoue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-  Therapy Against EAE Is Effective Only When Development of the Disease Depends on the NLRP3 Inflammasome

(2012) M. Inoue et al.   Science Signaling

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

Identification of a central role for complement in osteoarthritis

(2011) Qian Wang et al.   NATURE MEDICINE

Functionally active complement proteins C6 and C7 detected in C6- and C7-deficient individuals

(2010) R. WÜRZNER et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Cutting Edge: Critical Role for PYCARD/ASC in the Development of Experimental Autoimmune Encephalomyelitis

(2010) P. J. Shaw et al.   JOURNAL OF IMMUNOLOGY

NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses

(2010) D. Gris et al.   JOURNAL OF IMMUNOLOGY

The Inflammasome Sensor, NLRP3, Regulates CNS Inflammation and Demyelination via Caspase-1 and Interleukin-18

(2010) S. Jha et al.   JOURNAL OF NEUROSCIENCE

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Immunoglobulins and complement in postmortem multiple sclerosis tissue

(2009) Michael H. Barnett et al.   ANNALS OF NEUROLOGY

Functions of C5a receptors

(2009) Peter A. Ward   JOURNAL OF MOLECULAR MEDICINE-JMM

Quantification of Myelin and Axon Pathology During Relapsing Progressive Experimental Autoimmune Encephalomyelitis in the Biozzi ABH Mouse

(2009) Samuel J. Jackson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Deficiency of the complement regulator CD59a exacerbates Wallerian degeneration

(2009) Valeria Ramaglia et al.   MOLECULAR IMMUNOLOGY

Natalizumab treatment in multiple sclerosis: marked decline of chemokines and cytokines in cerebrospinal fluid

(2009) J. Mellergård et al.   Multiple Sclerosis Journal

Glatiramer acetate increases IL-1 receptor antagonist but decreases T cell-induced IL-1  in human monocytes and multiple sclerosis

(2009) D. Burger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Receptors for complement C5a. The importance of C5aR and the enigmatic role of C5L2

(2008) Hyun Lee et al.   IMMUNOLOGY AND CELL BIOLOGY

Complement and humoral immunity

(2008) Michael C. Carroll   VACCINE