NLRP3 is Required for Complement-Mediated Caspase-1 and IL-1beta Activation in ICH

Complement-mediated ‘bystander’ damage initiates host NLRP3 inflammasome activation

(2016) Rahul Suresh et al.   JOURNAL OF CELL SCIENCE

Post-Injury Administration of Tert-butylhydroquinone Attenuates Acute Neurological Injury After Intracerebral Hemorrhage in Mice

(2016) Sangeetha Sukumari-Ramesh et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Effect of apolipoprotein C3 genetic polymorphisms on serum lipid levels and the risk of intracerebral hemorrhage

(2015) Yan Jiang et al.   Lipids in Health and Disease

Mechanism of NLRP3 inflammasome activation

(2014) Fayyaz S. Sutterwala et al.   Annals of the New York Academy of Sciences

NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Ischemic Stroke

(2014) Fan Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cholesterol Crystals Induce Complement-Dependent Inflammasome Activation and Cytokine Release

(2014) E. O. Samstad et al.   JOURNAL OF IMMUNOLOGY

Correlation between serum IL-1beta levels and cerebral edema extent in a hypertensive intracerebral hemorrhage rat model

(2014) Pingbo Wei et al.   NEUROLOGICAL RESEARCH

Love and death: microglia, NLRP3 and the Alzheimer's brain

(2013) Tobias Goldmann et al.   CELL RESEARCH

Neuroprotective effects of argatroban and C5a receptor antagonist (PMX53) following intracerebral haemorrhage

(2013) G. Li et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Cutting Edge: The NLRP3 Inflammasome Links Complement-Mediated Inflammation and IL-1  Release

(2013) F. Laudisi et al.   JOURNAL OF IMMUNOLOGY

Dysregulation of Complement System and CD4+ T Cell Activation Pathways Implicated in Allergic Response

(2013) Alexessander Couto Alves et al.   PLoS One

Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

(2013) D Yang-Wei Fann et al.   Cell Death & Disease

Kidney Diseases Caused by Complement Dysregulation: Acquired, Inherited, and Still More to Come

(2012) Saskia F. Heeringa et al.   Clinical & Developmental Immunology

Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage

(2012) Sen Lin et al.   Journal of Neuroinflammation

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Regulation of inflammasome signaling

(2012) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

(2012) Sarah L Doyle et al.   NATURE MEDICINE

Toll-like receptor (TLR) and inflammasome actions in the central nervous system

(2012) Richa Hanamsagar et al.   TRENDS IN IMMUNOLOGY

Neuregulin-1 Effects on Endothelial and Blood–Brain Barrier Permeability After Experimental Injury

(2012) Josephine Lok et al.   Translational Stroke Research

NLRP3-Inflammasome Activating DAMPs Stimulate an Inflammatory Response in Glia in the Absence of Priming Which Contributes to Brain Inflammation after Injury

(2012) Catherine Diane Savage et al.   Frontiers in Immunology

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

Critical Care Management of Acute Intracerebral Hemorrhage

(2011) Joshua N. Goldstein et al.   Current Treatment Options in Neurology

The NLRP3 Inflammasome Contributes to Brain Injury in Pneumococcal Meningitis and Is Activated through ATP-Dependent Lysosomal Cathepsin B Release

(2011) Tobias Hoegen et al.   JOURNAL OF IMMUNOLOGY

Advances in Neuroprotective Strategies: Potential Therapies for Intracerebral Hemorrhage

(2010) Brian Y. Hwang et al.   CEREBROVASCULAR DISEASES

The acute management of intracerebral hemorrhage

(2010) Oliver Flower et al.   Current Opinion in Critical Care

Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis

(2010) Charlotte JJ van Asch et al.   LANCET NEUROLOGY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production

(2009) C. Fang et al.   BLOOD

Synergistic neuroprotective effects of C3a and C5a receptor blockade following intracerebral hemorrhage

(2009) Matthew C. Garrett et al.   BRAIN RESEARCH

Inflammasomes: too big to miss

(2009) Andrea Stutz et al.   JOURNAL OF CLINICAL INVESTIGATION

Intracerebral haemorrhage

(2009) Adnan I Qureshi et al.   LANCET

Ac-YVAD-CMK Decreases Blood–Brain Barrier Degradation by Inhibiting Caspase-1 Activation of Interleukin-1β in Intracerebral Hemorrhage Mouse Model

(2009) Bihua Wu et al.   Translational Stroke Research

C3a Receptor Antagonist Attenuates Brain Injury after Intracerebral Hemorrhage

(2008) Michal A Rynkowski et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE