T Cell Expression of C5a Receptor 2 Augments Murine Regulatory T Cell (TREG) Generation and TREG-Dependent Cardiac Allograft Survival

Critical role for complement receptor C5aR2 in the pathogenesis of renal ischemia-reperfusion injury

(2017) Felix Poppelaars et al.   FASEB JOURNAL

Monitoring C5aR2 Expression Using a Floxed tdTomato-C5aR2 Knock-In Mouse

(2017) Christian M. Karsten et al.   JOURNAL OF IMMUNOLOGY

TLR-Induced Murine Dendritic Cell (DC) Activation Requires DC-Intrinsic Complement

(2017) Joong-Hyuk Sheen et al.   JOURNAL OF IMMUNOLOGY

Erythropoietin Receptor-Mediated Molecular Crosstalk Promotes T Cell Immunoregulation and Transplant Survival

(2017) Carolina Purroy et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling

(2016) Daniel E Croker et al.   IMMUNOLOGY AND CELL BIOLOGY

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells

(2016) G. Arbore et al.   SCIENCE

The Novel Receptor C5aR2 Is Required for C5a-Mediated Human Mast Cell Adhesion, Migration, and Proinflammatory Mediator Production

(2015) Priyanka Pundir et al.   JOURNAL OF IMMUNOLOGY

Atheroprotective role of C5ar2 deficiency in apolipoprotein E-deficient mice

(2015) Jaco Selle et al.   THROMBOSIS AND HAEMOSTASIS

C5L2 is required for C5a-triggered receptor internalization and ERK signaling

(2014) Wei-Chan Hsu et al.   CELLULAR SIGNALLING

C5a2 can modulate ERK1/2 signaling in macrophages via heteromer formation with C5a1 and β-arrestin recruitment

(2014) Daniel E Croker et al.   IMMUNOLOGY AND CELL BIOLOGY

IFN-γ and IL-17 Production in Experimental Autoimmune Encephalomyelitis Depends on Local APC–T Cell Complement Production

(2014) Jinbo Liu et al.   JOURNAL OF IMMUNOLOGY

The interaction between C5a and both C5aR and C5L2 receptors is required for production of G-CSF during acute inflammation

(2013) Markus Bosmann et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulatory T cells and transplantation tolerance

(2013) Robert Hilbrands et al.   Immunotherapy

Functional Roles for C5a and C5aR but Not C5L2 in the Pathogenesis of Human and Experimental Cerebral Malaria

(2013) Hani Kim et al.   INFECTION AND IMMUNITY

Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells

(2013) Wing-hong Kwan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Receptors for C3a and C5a Modulate Stability of Alloantigen-Reactive Induced Regulatory T Cells

(2013) W. van der Touw et al.   JOURNAL OF IMMUNOLOGY

Disruption of the Complement Anaphylatoxin Receptor C5L2 Exacerbates Inflammation in Allergic Contact Dermatitis

(2013) R. Wang et al.   JOURNAL OF IMMUNOLOGY

Extrathymic Generation of Regulatory T Cells in Placental Mammals Mitigates Maternal-Fetal Conflict

(2012) Robert M. Samstein et al.   CELL

C5L2: a controversial receptor of complement anaphylatoxin, C5a

(2012) Rui Li et al.   FASEB JOURNAL

Transcription Factor Foxo1 Represses T-bet-Mediated Effector Functions and Promotes Memory CD8+ T Cell Differentiation

(2012) Rajesh R. Rao et al.   IMMUNITY

Absence of signaling into CD4+ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3+ regulatory T cells

(2012) Michael G Strainic et al.   NATURE IMMUNOLOGY

Sphingosine Kinase 1 Mediation of Expression of the Anaphylatoxin Receptor C5L2 Dampens the Inflammatory Response to Endotoxin

(2012) Kurt Bachmaier et al.   PLoS One

B Cell Receptor Signal Transduction in the GC Is Short-Circuited by High Phosphatase Activity

(2012) A. M. Khalil et al.   SCIENCE

Complement Regulates CD4 T-Cell Help to CD8 T Cells Required for Murine Allograft Rejection

(2011) Mark Vieyra et al.   AMERICAN JOURNAL OF PATHOLOGY

Fates of CD4+ T Cells in a Tolerant Environment Depend on Timing and Place of Antigen Exposure

(2011) B. E. Burrell et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs

(2011) Miguel Fribourg et al.   CELL

TGF-β in transplantation tolerance

(2011) Frederico S Regateiro et al.   CURRENT OPINION IN IMMUNOLOGY

Sustained suppression by Foxp3+regulatory T cells is vital for infectious transplantation tolerance

(2011) Adrian R. Kendal et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD4+ regulatory T cells in solid organ transplantation

(2010) Fadi Issa et al.   Current Opinion in Organ Transplantation

Immune Cell-Derived C3 Is Required for Autoimmune Diabetes Induced by Multiple Low Doses of Streptozotocin

(2010) M. Lin et al.   DIABETES

The C5a Receptor (C5aR) C5L2 Is a Modulator of C5aR-mediated Signal Transduction

(2010) Claire E. Bamberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Critical Role for C5L2 in the Pathogenesis of Experimental Allergic Asthma

(2010) X. Zhang et al.   JOURNAL OF IMMUNOLOGY

The Harmful Role of C5a on Innate Immunity in Sepsis

(2010) Peter A. Ward   Journal of Innate Immunity

Contrasting roles for all-trans retinoic acid in TGF-β–mediated induction ofFoxp3andIl10genes in developing regulatory T cells

(2009) Craig L. Maynard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis

(2008) P. N. Lalli et al.   BLOOD

Locally Produced Complement Fragments C5a and C3a Provide Both Costimulatory and Survival Signals to Naive CD4+ T Cells

(2008) Michael G. Strainic et al.   IMMUNITY

Functional roles for C5a receptors in sepsis

(2008) Daniel Rittirsch et al.   NATURE MEDICINE