Mobilization of hematopoietic stem cells as a result of innate immunity-mediated sterile inflammation in the bone marrow microenvironment—the involvement of extracellular nucleotides and purinergic signaling

Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell

(2018) Jonathan Hoggatt et al.   CELL

Evidence of a Pivotal Role for the Distal Part of the Complement Cascade in the Diurnal Release of Hematopoietic Stem Cells into Peripheral Blood

(2016) Sylwia Borkowska et al.   CELL TRANSPLANTATION

Downregulation of Heme Oxygenase 1 (HO-1) Activity in Hematopoietic Cells Enhances Their Engraftment after Transplantation

(2016) Mateusz Adamiak et al.   CELL TRANSPLANTATION

Activation of the complement cascade enhances motility of leukemic cells by downregulating expression of HO-1

(2016) A Abdelbaset-Ismail et al.   LEUKEMIA

Toll-like receptor signaling-deficient mice are easy mobilizers: evidence that TLR signaling prevents mobilization of hematopoietic stem/progenitor cells in HO-1-dependent manner

(2016) M Adamiak et al.   LEUKEMIA

Novel evidence that the mannan-binding lectin pathway of complement activation plays a pivotal role in triggering mobilization of hematopoietic stem/progenitor cells by activation of both the complement and coagulation cascades

(2016) M Adamiak et al.   LEUKEMIA

An introduction to the roles of purinergic signalling in neurodegeneration, neuroprotection and neuroregeneration

(2016) Geoffrey Burnstock   NEUROPHARMACOLOGY

DAMPs activating innate immune responses in sepsis

(2015) Jung-Woo Kang et al.   AGEING RESEARCH REVIEWS

Adenosine signaling promotes hematopoietic stem and progenitor cell emergence

(2015) Lili Jing et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Evidence that a lipolytic enzyme—hematopoietic-specific phospholipase C-β2—promotes mobilization of hematopoietic stem cells by decreasing their lipid raft-mediated bone marrow retention and increasing the promobilizing effects of granulocytes

(2015) M Adamiak et al.   LEUKEMIA

Membrane lipid rafts, master regulators of hematopoietic stem cell retention in bone marrow and their trafficking

(2015) M Z Ratajczak et al.   LEUKEMIA

PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells

(2015) Shiri Gur-Cohen et al.   NATURE MEDICINE

Big opportunities for small molecules in immuno-oncology

(2015) Jerry L. Adams et al.   NATURE REVIEWS DRUG DISCOVERY

Novel evidence that crosstalk between the complement, coagulation and fibrinolysis proteolytic cascades is involved in mobilization of hematopoietic stem/progenitor cells (HSPCs)

(2014) S Borkowska et al.   LEUKEMIA

A novel view of the adult bone marrow stem cell hierarchy and stem cell trafficking

(2014) M Z Ratajczak   LEUKEMIA

Hematopoietic stem cell niche maintenance during homeostasis and regeneration

(2014) Avital Mendelson et al.   NATURE MEDICINE

Identification of Heme Oxygenase 1 (HO-1) as a Novel Negative Regulator of Mobilization of Hematopoietic Stem/Progenitor Cells

(2014) Marcin Wysoczynski et al.   Stem Cell Reviews and Reports

Oxidative Stress Sensitizes Retinal Pigmented Epithelial (RPE) Cells to Complement-mediated Injury in a Natural Antibody-, Lectin Pathway-, and Phospholipid Epitope-dependent Manner

(2013) Kusumam Joseph et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The nucleotide sugar UDP-glucose mobilizes long-term repopulating primitive hematopoietic cells

(2013) Sungho Kook et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential stem- and progenitor-cell trafficking by prostaglandin E2

(2013) Jonathan Hoggatt et al.   NATURE

Humoral Pattern Recognition and the Complement System

(2013) S. E. Degn et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors

(2012) D. Gonzalez-Nieto et al.   BLOOD

S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release

(2012) K. Golan et al.   BLOOD

Hematopoietic stem cell mobilizing agents G-CSF, cyclophosphamide or AMD3100 have distinct mechanisms of action on bone marrow HSC niches and bone formation

(2012) I G Winkler et al.   LEUKEMIA

Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2

(2012) D. Heja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice

(2011) J. G. Juarez et al.   BLOOD

Sleep and circadian rhythm regulate circulating complement factors and immunoregulatory properties of C5a

(2011) Edimara S. Reis et al.   BRAIN BEHAVIOR AND IMMUNITY

Many mechanisms mediating mobilization: an alliterative review

(2011) Jonathan Hoggatt et al.   CURRENT OPINION IN HEMATOLOGY

Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice

(2011) Matthew J. Christopher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential

(2010) Ananta Paine et al.   BIOCHEMICAL PHARMACOLOGY

Fifth complement cascade protein (C5) cleavage fragments disrupt the SDF-1/CXCR4 axis: Further evidence that innate immunity orchestrates the mobilization of hematopoietic stem/progenitor cells

(2010) Ali Jalili et al.   EXPERIMENTAL HEMATOLOGY

Innate immunity as orchestrator of stem cell mobilization

(2010) M Z Ratajczak et al.   LEUKEMIA

Novel insight into stem cell mobilization-Plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/membrane attack complex

(2010) M Z Ratajczak et al.   LEUKEMIA

The endosteal ‘osteoblastic’ niche and its role in hematopoietic stem cell homing and mobilization

(2010) J-P Lévesque et al.   LEUKEMIA

The Ins and Outs of Hematopoietic Stem Cells: Studies to Improve Transplantation Outcomes

(2010) Leah A. Marquez-Curtis et al.   Stem Cell Reviews and Reports

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

Circadian rhythms influence hematopoietic stem cells

(2009) Simón Méndez-Ferrer et al.   CURRENT OPINION IN HEMATOLOGY

Mannose-binding lectin and innate immunity

(2009) W. K. Eddie Ip et al.   IMMUNOLOGICAL REVIEWS

Mobilization studies in complement-deficient mice reveal that optimal AMD3100 mobilization of hematopoietic stem cells depends on complement cascade activation by AMD3100-stimulated granulocytes

(2009) H M Lee et al.   LEUKEMIA

Impaired mobilization of hematopoietic stem/progenitor cells in C5-deficient mice supports the pivotal involvement of innate immunity in this process and reveals novel promobilization effects of granulocytes

(2009) H M Lee et al.   LEUKEMIA

Heme oxygenase-1 deficiency leads to disrupted response to acute stress in stem cells and progenitors

(2008) Y.-A. Cao et al.   BLOOD