Article
Food Science & Technology
Janaina Trindade Piagette, Jose Eudes Gomes Pinheiro Junior, Samia Hassan Husein Kanaan, Camila Teixeira Herrera, Leandro Ortiz Bastilhos, Franck Maciel Pecanha, Dalton Valentim Vassallo, Marta Miguel-Castro, Giulia Alessandra Wiggers
Summary: In this study, we investigated the protective effects of pretreatment with egg white hydrolysate (EWH) on the cardiovascular system, especially resistance vessels, against damage caused by high levels of Cd exposure. The results showed that EWH pretreatment reduced the increased vascular contractile response and protected mesenteric resistance arteries (MRA) from vascular damage induced by Cd exposure. EWH pretreatment also maintained normal blood pressure, reduced oxidative stress through the NOX1 pathway, prevented inflammatory cascades (COX-2, TNF alpha, NF-kappa B), and protected MRA from Caspase-3 activation induced by Cd.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Food Science & Technology
Paola Zambelli Moraes, Jose Eudes Gomes Pinheiro Junior, Caroline Silveira Martinez, Camila Rodrigues Moro, Grazielly Caroline da Silva, Marina Diaz Rodriguez, Maylla Ronacher Simoes, Fernando Barbosa Junior, Franck Maciel Pecanha, Dalton Valentim Vassallo, Marta Miguel, Giulia Alessandra Wiggers
Summary: This study found that EWH can prevent cardiovascular damage caused by high levels of Cd exposure by reducing blood pressure, vascular dysfunction, inflammation, and oxidative stress through multiple mechanisms.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Food Science & Technology
Hen-Yo Ho, Jhih-Ying Ciou, Yi-Ting Qiu, Shu-Ling Hsieh, Ming-Kuei Shih, Min-Hung Chen, Chao-Wen Tu, Chang-Wei Hsieh, Chih-Yao Hou
Summary: This study investigated the effects of egg white hydrolysate (EWH) on pasteurized liquid egg properties, showing that adding 1% of EWH can improve various properties of the sample while maintaining the cake structure and appearance acceptable to consumers. The hydrolyzation process resulted in up to 30.1% of EWH, demonstrating its potential for efficient use in the baking industry.
Article
Biochemistry & Molecular Biology
Eva Tvrda, Jan Kovac, Kristina Ferenczyova, Barbora Kalocayova, Michal Duracka, Filip Benko, Viera Almasiova, Monika Bartekova
Summary: The aim of this study is to investigate the effects of quercetin on testicular architecture and markers of oxidative, inflammatory, and apoptotic profile in Zucker diabetic fatty rats with Type 2 diabetes mellitus. The results showed that quercetin improved testicular appearance, stabilized antioxidant capacity, decreased lipid peroxidation, and reduced inflammation levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Edina da Luz Abreu, Camila Rodrigues Moro, Samia Hassan Husein Kanaan, Ricardo Bernardino de Paula, Camila Teixeira Herrera, Pedro Henrique Dorneles Costa, Franck Maciel Pecanha, Dalton Valentim Vassallo, Luciana Venturini Rossoni, Marta Miguel-Castro, Giulia Alessandra Wiggers
Summary: This study aimed to evaluate the potential antihypertensive effect of egg white hydrolysate (EWH) and its beneficial effects on blood vessels in rats with severe hypertension. The results showed that EWH significantly reduced blood pressure and improved vascular function. This effect may be attributed to the antioxidant and anti-inflammatory properties of EWH.
Article
Biochemistry & Molecular Biology
Mara Caputo, Yeshwant Kurhe, Sima Kumari, Emmelie Cansby, Manoj Amrutkar, Eli Scandalis, Sheri L. Booten, Marcus Stahlman, Jan Boren, Hanns-Ulrich Marschall, Mariam Aghajan, Margit Mahlapuu
Summary: This study identifies MST3 as a critical regulator of ectopic fat accumulation in human hepatocytes and shows that targeting MST3 signaling with ASOs can effectively mitigate NAFLD progression in obese mice. MST3 ASOs suppress lipogenic gene expression, reduce lipotoxicity-mediated oxidative and endoplasmic reticulum stress, and correlate with NAFLD severity in human liver biopsies. These findings suggest that MST3 inhibitors may offer a new strategy for treating NAFLD patients.
Article
Fisheries
Cuiyun Zou, Yuke Fang, Nuoyi Lin, Huifan Liu
Summary: This study investigated the anti-NAFLD effect of YZW-A in hybrid grouper fed a high-fat diet, showing improved growth performance and reduced lipid content in various tissues. YZW-A also modulated key factors of lipid metabolism and activated the AMPK pathway, suggesting its therapeutic potential for NAFLD treatment in fish.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Food Science & Technology
P. Suresh
Summary: This study optimized the antioxidant capacity of duck egg white hydrolysate using Flavourzyme(R) digestion, finding the optimal conditions for producing a natural antioxidant-rich hydrolysate. Analysis showed that the DEWH exhibited high levels of antioxidants and strong radical scavenging activities, indicating its potential for future applications in human nutrition and poultry farming.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Hsuan-Chih Huang, Pei-Ni Lee, Wen-Chih Huang, Hsin-Yi Yang
Summary: This study found that the dietary intake of dehulled adlay may slow down the progression of NAFLD by improving hepatic steatosis, inflammation, oxidative stress, and gut dysbiosis.
Article
Food Science & Technology
Lidiya C. Johny, Tanaji G. Kudre, P. V. Suresh
Summary: Chicken egg white protein hydrolysate produced using pineapple bromelain showed significant antioxidant activity, with strong scavenging activities against DPPH, ABTS, peroxyl and superoxide radicals. The integrity of the protein structure was confirmed through gel filtration chromatography, SDS-PAGE and FTIR analysis. These results suggest that the bioactive WEWPH could be a promising ingredient in health food and nutraceuticals.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2022)
Article
Medicine, Research & Experimental
Lingyan Ma, Yinhua Ni, Luting Hu, Yufeng Zhao, Liujie Zheng, Song Yang, Liyang Ni, Zhengwei Fu
Summary: Spermidine administration can reduce fat mass and plasma lipid profile in HFD-induced obese mice, improve hepatic steatosis, reduce adipose tissue inflammation, and enhance gut barrier function. Additionally, spermidine treatment also enhances thermogenic gene expression in brown adipose tissue.
Article
Food Science & Technology
Jae-Hyuk Byun, Ji Eun Shin, Yeung-Joon Choi, Se-Young Choung
Summary: TGPN significantly improved alcoholic fatty liver by decreasing liver index and lipid levels, increasing adiponectin level, and reducing liver fat accumulation. It activated AMP-activated protein kinase and its downstream pathway, promoting lipid metabolism and decreasing liver function markers, ultimately reducing liver cell damage.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Medicine, Research & Experimental
Chuanrui Ma, Zhongyan Wang, Ronglin Xia, Lingling Wei, Chao Zhang, Jing Zhang, Linna Zhao, Han Wu, Lin Kang, Shu Yang
Summary: The study shows that danthron can significantly improve obesity and associated hepatic steatosis by enhancing hepatic fatty acid oxidation, decreasing lipid synthesis, and promoting mitochondrial homeostasis. Danthron activates the AMPK and PPAR pathways through promoting the combination of RXR and PPAR for protection against obesity.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Jingjing Wei, Guozhong Tao, Baohui Xu, Kewei Wang, Junlin Liu, Chih-Hsin Chen, James C. Y. Dunn, Crawford Currie, Bomi Framroze, Karl G. Sylvester
Summary: Inflammatory bowel diseases (IBD) are chronic gastrointestinal diseases that greatly impact health and quality of life. current therapies do not provide a complete and permanent cure. This study investigated the effects of soluble protein hydrolysate (SPH) on gastrointestinal injury in a mouse model of colitis. The results showed that SPH treatment reduced disease activity index, colon tissue injury, and inflammatory cytokines, while increasing anti-inflammatory cytokines and anti-oxidative gene expression. These findings suggest that SPH may be a potential dietary intervention for IBD management.
Article
Chemistry, Multidisciplinary
Marina Parra-Robert, Muling Zeng, Ying Shu, Guillermo Fernandez-Varo, Meritxell Perramon, Diti Desai, Junhao Chen, Dongdong Guo, Xu Zhang, Manuel Morales-Ruiz, Jessica M. Rosenholm, Wladimiro Jimenez, Victor Puntes, Eudald Casals, Gregori Casals
Summary: A novel nanocomposite based on cerium oxide nanozymes was developed to improve metabolic phenotype in obese rats by reducing circulating fatty acid levels. The nanocomposite also showed amelioration of hepatic and adipose metabolic dysregulations, down-regulation of the PI3K/mTOR/AKT pathway, and reduction of inflammatory cytokines. The synthesis method, using aqueous solution, offers a potential scalable and safe nanomedicine for treating metabolic comorbidities associated with obesity.
Article
Biochemistry & Molecular Biology
Eva Bruna-Garcia, Beatriz Isabel Redondo, Marta Miguel Castro
Summary: This study extracted a new bioactive ingredient from Iberian ham trimming fat with high levels of antioxidants and MUFA. The new ingredient demonstrated better sensory characteristics and higher antioxidant capacity compared to the raw material.
Article
Medicine, Research & Experimental
Miguel M. Garcia, Miguel Molina-Alvarez, Carmen Rodriguez-Rivera, Nancy Paniagua, Ernesto Quesada, Jose Antonio Uranga, Maria Isabel Rodriguez-Franco, David Pascual, Carlos Goicoechea
Summary: Spinal glia plays a crucial role in the development and maintenance of chronic pain. The TLR4 signaling pathway is identified as a key trigger mechanism in pain. By using a CD14/TLR4 antagonist, researchers explored the effects of TLR4 inhibition on pain development and glia activation in different pain models. Their findings suggest that peripheral and central TLR4 have different roles in diverse types of pain.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Environmental Sciences
Laura Lopez-Gomez, Jaime Anton, Yolanda Lopez-Tofino, Bianca Pomana, Jose A. Uranga, Raquel Abalo
Summary: In this study, we used a rat model to investigate the effects of acetic acid stimulation and pretreatment with probiotics on visceral pain. The results showed that acetic acid stimulation decreased visceral sensitivity but increased colonic mucosa damage, while pretreatment with probiotics normalized visceral sensitivity but increased the number of macrophages.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Edina da Luz Abreu, Camila Rodrigues Moro, Samia Hassan Husein Kanaan, Ricardo Bernardino de Paula, Camila Teixeira Herrera, Pedro Henrique Dorneles Costa, Franck Maciel Pecanha, Dalton Valentim Vassallo, Luciana Venturini Rossoni, Marta Miguel-Castro, Giulia Alessandra Wiggers
Summary: This study aimed to evaluate the potential antihypertensive effect of egg white hydrolysate (EWH) and its beneficial effects on blood vessels in rats with severe hypertension. The results showed that EWH significantly reduced blood pressure and improved vascular function. This effect may be attributed to the antioxidant and anti-inflammatory properties of EWH.
Review
Nutrition & Dietetics
Marta Garces-Rimon, Diego Morales, Marta Miguel-Castro
Summary: This study reviewed the beneficial actions of legumes proteins and peptides, with a focus on their effects on metabolic syndrome. In vitro tests have shown the promising potential of bioactive hydrolysates and peptides from pulses, but only a few animal models have validated these effects. Further research, including clinical trials, is needed to clarify the effective health implications.
Article
Biochemistry & Molecular Biology
Caroline Silveira Martinez, Jose Antonio Uranga-Ocio, Franck Maciel Pecanha, Dalton Valentim Vassallo, Christopher Exley, Marta Miguel-Castro, Giulia Alessandra Wiggers
Summary: The study found that egg white hydrolysate (EWH) can protect rats from the effects of long-term exposure to high and low levels of aluminum in the diet on reproductive function. The supplementation of EWH can reduce inflammation and oxidative stress in the reproductive organs, and maintain normal sperm production and quality.
Article
Biochemistry & Molecular Biology
Miguel Lopez-Moreno, Estefania Jimenez-Moreno, Antonio Marquez Gallego, Gema Vera Pasamontes, Jose Antonio Uranga Ocio, Marta Garces-Rimon, Marta Miguel-Castro
Summary: In recent years, quinoa has been proposed as an emerging crop for functional food production. Quinoa hydrolysates obtained from the crop have shown in vitro biological activity. This study aimed to evaluate the beneficial effects of red quinoa hydrolysate on oxidative stress and cardiovascular health in an in vivo experimental model of hypertension. The results revealed that oral administration of red quinoa hydrolysate significantly reduced blood pressure and exhibited antioxidant effects, thereby ameliorating hypertension and its associated complications.
Article
Gastroenterology & Hepatology
Marta Castro, Marta Sofia Valero, Yolanda Lopez-Tofino, Laura Lopez-Gomez, Rocio Giron, Maria Isabel Martin-Fontelles, Jose A. Uranga, Raquel Abalo
Summary: This study investigated the effects of sepsis on gastrointestinal (GI) motility and histological damage in rats. The results showed that sepsis caused gastroparesis and intestinal motility disorders, as well as damage to multiple organs. Using radiographic methods for the first time, this study provided important information on the time-dependent changes in sepsis-induced GI dysmotility, which is crucial for its management.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Nutrition & Dietetics
Miguel Lopez-Moreno, Marta Garces-Rimon, Marta Miguel-Castro, Elia Fernandez-Martinez, Maria Teresa Iglesias Lopez
Summary: This study aimed to evaluate the effect of a one-year nutrition education course on cardiometabolic parameters in undergraduate health science students. The findings suggest that the nutrition intervention resulted in changes in dietary patterns, with increased consumption of vegetables, nuts and legumes, as well as improvements in HDL-cholesterol levels.
Article
Pharmacology & Pharmacy
Antonio Gonzalez, Soledad Garcia-Gomez-Heras, Raquel Franco-Rodriguez, Visitacion Lopez-Miranda, Esperanza Herradon
Summary: Cisplatin is a clinically proven drug for combating various cancers, but its use is limited by renal and cardiovascular toxicities. The activation of the inflammatory TLR4/NLRP3 pathway may play a crucial role in cisplatin-induced toxicity.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2023)
Article
Biochemistry & Molecular Biology
Gema Vera, Laura Lopez-Gomez, Rocio Giron, Maria Isabel Martin-Fontelles, Kulmira Nurgali, Raquel Abalo, Jose Antonio Uranga
Summary: This study evaluated the effects of a cannabinoid agonist on neuropathic and visceral pain induced by 5-FU. The results showed that cannabinoids can alleviate the pain and sensitivity changes caused by 5-FU, and this alleviating effect does not cause other adverse reactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Danize Aparecida Rizzetti, Patricia Corrales, Jose Antonio Uranga-Ocio, Gema Medina-Gomez, Franck Maciel Pecanha, Dalton Valentim Vassallo, Marta Miguel, Giulia Alessandra Wiggers
Summary: The study found that egg white hydrolysate (EWH) can prevent and treat lipid and glycemic metabolism disruption induced by mercury exposure. EWH intake improves antioxidant defenses, inhibits apoptotic pathways, and normalizes the gene expression levels of PPARs and adiponectin.
