Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments

Human gut microbiome: hopes, threats and promises

(2018) Patrice D Cani   GUT

The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients

(2018) Vyara Matson et al.   SCIENCE

Paneth Cell Alterations in the Development and Phenotype of Crohn’s Disease

(2017) Thaddeus S. Stappenbeck et al.   GASTROENTEROLOGY

Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

(2017) Egle Cekanaviciute et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

(2017) V. Gopalakrishnan et al.   SCIENCE

Ubiquitously expressed Human Beta Defensin 1 (hBD1) forms bacteria-entrapping nets in a redox dependent mode of action

(2017) Judith Raschig et al.   PLoS Pathogens

Reduction Impairs the Antibacterial Activity but Benefits the LPS Neutralization Ability of Human Enteric Defensin 5

(2016) Cheng Wang et al.   Scientific Reports

Visualizing Attack of Escherichia coli by the Antimicrobial Peptide Human Defensin 5

(2015) Haritha R. Chileveru et al.   BIOCHEMISTRY

Disulphide-reduced psoriasin is a human apoptosis-inducing broad-spectrum fungicide

(2015) Kyaw Zaw Hein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crohn's disease-derived monocytes fail to induce Paneth cell defensins

(2015) Lioba F. Courth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paneth cell α-defensin 6 (HD-6) is an antimicrobial peptide

(2014) B O Schroeder et al.   Mucosal Immunology

Reduction of Human Defensin 5 Affords a High-Affinity Zinc-Chelating Peptide

(2013) Yunfei Zhang et al.   ACS Chemical Biology

Paneth Cells: Maestros of the Small Intestinal Crypts

(2013) Hans C. Clevers et al.   Annual Review of Physiology

Antimicrobial peptides and gut microbiota in homeostasis and pathology

(2013) Maureen J. Ostaff et al.   EMBO Molecular Medicine

Phylogenetic Analysis of Dysbiosis in Ulcerative Colitis During Remission

(2013) Mirjana Rajilić-Stojanović et al.   INFLAMMATORY BOWEL DISEASES

Antiviral Mechanisms of Human Defensins

(2013) Sarah S. Wilson et al.   JOURNAL OF MOLECULAR BIOLOGY

Cell-mediated reduction of human β-defensin 1: a major role for mucosal thioredoxin

(2013) S U Jaeger et al.   Mucosal Immunology

Dysbiosis—A consequence of Paneth cell dysfunction

(2013) Nita H. Salzman et al.   SEMINARS IN IMMUNOLOGY

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

(2012) John F. Cryan et al.   NATURE REVIEWS NEUROSCIENCE

Human  -Defensin 6 Promotes Mucosal Innate Immunity Through Self-Assembled Peptide Nanonets

(2012) H. Chu et al.   SCIENCE

The potter’s wheel: the host’s role in sculpting its microbiota

(2011) Charles L. Bevins et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Peptide gets in shape for self-defence

(2011) Robert I. Lehrer   NATURE

Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1

(2011) Bjoern O. Schroeder et al.   NATURE

Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis

(2011) Charles L. Bevins et al.   NATURE REVIEWS MICROBIOLOGY

Mucolytic Bacteria With Increased Prevalence in IBD Mucosa Augment In Vitro Utilization of Mucin by Other Bacteria

(2010) Chin Wen Png et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Anaerobic Infections

(2010) Elisabeth Nagy   DRUGS

Postgenomic strategies in antibacterial drug discovery

(2010) Heike Brötz-Oesterhelt et al.   Future Microbiology

Paneth's disease

(2010) Jan Wehkamp et al.   Journal of Crohns & Colitis

Enteric defensins are essential regulators of intestinal microbial ecology

(2009) Nita H Salzman et al.   NATURE IMMUNOLOGY

Modulation of the Intestinal Microbiota Alters Colitis-Associated Colorectal Cancer Susceptibility

(2009) Joshua M. Uronis et al.   PLoS One