Cellular senescence and tumor suppressor gene p16

Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16ink4a

(2011) Martin Kosar et al.   CELL CYCLE

Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer

(2011) Raffaella Di Micco et al.   NATURE CELL BIOLOGY

Sirtuins, Aging, and Medicine

(2011) Leonard Guarente   NEW ENGLAND JOURNAL OF MEDICINE

Histone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3

(2010) Ji-Won Jung et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor

(2010) Goedele N Maertens et al.   EMBO JOURNAL

Mammalian Polycomb-Like Pcl2/Mtf2 Is a Novel Regulatory Component of PRC2 That Can Differentially Modulate Polycomb Activity both at the Hox Gene Cluster and at Cdkn2a Genes

(2010) X. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular Interplay of the Noncoding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a

(2010) Kyoko L. Yap et al.   MOLECULAR CELL

ARF-induced downregulation of Mip130/LIN-9 protein levels mediates a positive feedback that leads to increased expression of p16Ink4a and p19Arf

(2010) J Song et al.   ONCOGENE

A Novel Zinc Finger Protein Zfp277 Mediates Transcriptional Repression of the Ink4a/Arf Locus through Polycomb Repressive Complex 1

(2010) Masamitsu Negishi et al.   PLoS One

Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf

(2009) Xiaohua Su et al.   EMBO JOURNAL

The transcription factor ZBP-89 suppresses p16 expression through a histone modification mechanism to affect cell senescence

(2009) Yunpeng Feng et al.   FEBS Journal

Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS

(2009) M. Barradas et al.   GENES & DEVELOPMENT

Real-time in vivo imaging of p16Ink4areveals cross talk with p53

(2009) Kimi Yamakoshi et al.   JOURNAL OF CELL BIOLOGY

Senescence of Cultured Porcine Coronary Arterial Endothelial Cells Is Associated with Accelerated Oxidative Stress and Activation of NFĸB

(2009) Mary Y.K. Lee et al.   JOURNAL OF VASCULAR RESEARCH

p53 Deficiency Leads to Compensatory Up-Regulation of p16INK4a

(2009) W. F. Leong et al.   MOLECULAR CANCER RESEARCH

Epigenetic Silencing of the p16INK4a Tumor Suppressor Is Associated with Loss of CTCF Binding and a Chromatin Boundary

(2009) Michael Witcher et al.   MOLECULAR CELL

The Ink4/Arf locus is a barrier for iPS cell reprogramming

(2009) Han Li et al.   NATURE

Several Distinct Polycomb Complexes Regulate and Co-Localize on the INK4a Tumor Suppressor Locus

(2009) Goedele N. Maertens et al.   PLoS One

A quantitative model for age-dependent expression of the p16INK4a tumor suppressor

(2009) D. Tsygankov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial turnover in liver is fastin vivoand is accelerated by dietary restriction: application of a simple dynamic model

(2008) Satomi Miwa et al.   AGING CELL

YY1 restrained cell senescence through repressing the transcription of p16

(2008) Xiuli Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

PPAR  accelerates cellular senescence by inducing p16INK4  expression in human diploid fibroblasts

(2008) Q. Gan et al.   JOURNAL OF CELL SCIENCE

SWI/SNF Mediates Polycomb Eviction and Epigenetic Reprogramming of the INK4b-ARF-INK4a Locus

(2008) S. K. Kia et al.   MOLECULAR AND CELLULAR BIOLOGY

Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice

(2008) D Zhang et al.   ONCOGENE

Decreased enzyme activities of chaperones PDI and BiP in aged mouse livers

(2007) Jonathan E. Nuss et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS