Cellular senescence: a view throughout organismal life

Cellular senescence: Immunosurveillance and future immunotherapy

(2018) Dominick G.A. Burton et al.   AGEING RESEARCH REVIEWS

Is DNA damage indispensable for stress-induced senescence?

(2018) Anna Bielak-Zmijewska et al.   MECHANISMS OF AGEING AND DEVELOPMENT

SIPS as a model to study age-related changes in proteolysis and aggregate formation

(2018) Christiane Ott et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

Human peripheral late/exhausted memory B cells express a senescent-associated secretory phenotype and preferentially utilize metabolic signaling pathways

(2017) Daniela Frasca et al.   EXPERIMENTAL GERONTOLOGY

Senescence and aging: Causes, consequences, and therapeutic avenues

(2017) Domhnall McHugh et al.   JOURNAL OF CELL BIOLOGY

Downregulation of SMP30 in senescent human lens epithelial cells

(2017) Shuning Li et al.   Molecular Medicine Reports

Hutchinson–Gilford Progeria Syndrome: A Premature Aging Disease

(2017) Muhammad Saad Ahmed et al.   MOLECULAR NEUROBIOLOGY

Senescent cells: an emerging target for diseases of ageing

(2017) Bennett G. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

The role of cellular senescence in ageing of the placenta

(2017) Lynne S. Cox et al.   PLACENTA

Spatial and Temporal Control of Senescence

(2017) Yoko Ito et al.   TRENDS IN CELL BIOLOGY

A cytokine signal inhibitor for rheumatoid arthritis enhances cancer metastasis via depletion of NK cells in an experimental lung metastasis mouse model of colon cancer

(2017) Hideki Shimaoka et al.   Oncology Letters

Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway

(2017) Valentina Rapisarda et al.   Cell Reports

Macrophages are necessary for epimorphic regeneration in African spiny mice

(2017) Jennifer Simkin et al.   eLife

Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas-Induced Apoptosis-Transgenic Mice

(2017) Chia-Lung Wu et al.   Arthritis & Rheumatology

Cellular Senescence: A Translational Perspective

(2017) James L. Kirkland et al.   EBioMedicine

Effect of Nitric Oxide on Human Corneal Epithelial Cell Viability and Corneal Wound Healing

(2017) Joo-Hee Park et al.   Scientific Reports

Robust, universal biomarker assay to detect senescent cells in biological specimens

(2016) Konstantinos Evangelou et al.   AGING CELL

Cellular senescence impact on immune cell fate and function

(2016) Rita Vicente et al.   AGING CELL

Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells

(2016) Brandon M. Hall et al.   Aging-US

Immunosenescence of microglia and macrophages: impact on the ageing central nervous system

(2016) Khalil S. Rawji et al.   BRAIN

Aging of the immune system: Focus on inflammation and vaccination

(2016) Marcello Pinti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Targeting Senescent Cells: Possible Implications for Delaying Skin Aging: A Mini-Review

(2016) Michael C. Velarde et al.   GERONTOLOGY

Effects of senescent lens epithelial cells on the severity of age-related cortical cataract in humans

(2016) Qiuli Fu et al.   MEDICINE

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion

(2016) Aharon Helman et al.   NATURE MEDICINE

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Senescence of T Lymphocytes: Implications for Enhancing Human Immunity

(2016) Arne N. Akbar et al.   TRENDS IN IMMUNOLOGY

Comparative Study of Injury Models for Studying Muscle Regeneration in Mice

(2016) David Hardy et al.   PLoS One

Infection susceptibility and immune senescence with advancing age replicated in accelerated agingLmnaDhemice

(2015) Lijun Xin et al.   AGING CELL

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Recurrent turnover of senescent cells during regeneration of a complex structure

(2015) Maximina H Yun et al.   eLife

The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-β signaling

(2014) Erawan Borkham-Kamphorst et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Senescent cells: SASPected drivers of age-related pathologies

(2014) Yossi Ovadya et al.   BIOGERONTOLOGY

HLA-G-mediated NK cell senescence promotes vascular remodeling: implications for reproduction

(2014) Sumati Rajagopalan   Cellular & Molecular Immunology

Physiological and pathological consequences of cellular senescence

(2014) Dominick G. A. Burton et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Macrophages modulate adult zebrafish tail fin regeneration

(2014) T. A. Petrie et al.   DEVELOPMENT

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Cellular senescence and its effector programs

(2014) R. Salama et al.   GENES & DEVELOPMENT

Proinflammatory status influences NK cells subsets in the elderly

(2014) Carmen Campos et al.   IMMUNOLOGY LETTERS

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Senescence induced by RECQL4 dysfunction contributes to Rothmund–Thomson syndrome features in mice

(2014) H Lu et al.   Cell Death & Disease

Aging increases CCN1 expression leading to muscle senescence

(2013) Jie Du et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

Cell fusion induced by ERVWE1 or measles virus causes cellular senescence

(2013) A. Chuprin et al.   GENES & DEVELOPMENT

Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson's disease?

(2013) S. J. Chinta et al.   JOURNAL OF INTERNAL MEDICINE

Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future

(2013) Steven E Kahn et al.   LANCET

Macrophages are required for adult salamander limb regeneration

(2013) James W. Godwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

(2012) Diana Jurk et al.   AGING CELL

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Zmpste24−/− Mouse Model for Senescent Wound Healing Research

(2012) Parag Butala et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Astrocyte Senescence as a Component of Alzheimer’s Disease

(2012) Rekha Bhat et al.   PLoS One

Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling

(2012) S. Rajagopalan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem cell depletion in Hutchinson-Gilford progeria syndrome

(2011) Ylva Rosengardten et al.   AGING CELL

The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses

(2011) Ramachander V.N. Turaga et al.   CELL CYCLE

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

Hutchinson-gilford progeria is a skeletal dysplasia

(2011) Catherine M Gordon et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Old cells under attack

(2011) Daniel S. Peeper   NATURE

Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets

(2011) Joon-Il Jun et al.   NATURE REVIEWS DRUG DISCOVERY

Up-Regulation of NDRG2 in Senescent Lens Epithelial Cells Contributes to Age-Related Cataract in Human

(2011) Zi-Feng Zhang et al.   PLoS One

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Rothmund-Thomson syndrome

(2010) Lidia Larizza et al.   Orphanet Journal of Rare Diseases

A Senescence-Like Cell-Cycle Arrest Occurs During Megakaryocytic Maturation: Implications for Physiological and Pathological Megakaryocytic Proliferation

(2010) Rodolphe Besancenot et al.   PLOS BIOLOGY

DNA damage response and cellular senescence in tissues of aging mice

(2009) Chunfang Wang et al.   AGING CELL

The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis

(2008) Meltem Muftuoglu et al.   HUMAN GENETICS

Hyperinsulinemia and insulin resistance in Wrn null mice fed a diabetogenic diet

(2008) Gina Moore et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing

(2008) Paola Scaffidi et al.   NATURE CELL BIOLOGY

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY