Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

Cutting Edge: Soluble IL-6R Is Produced by IL-6R Ectodomain Shedding in Activated CD4 T Cells

(2014) E. M. Briso et al.   JOURNAL OF IMMUNOLOGY

IL-6 Regulates Neutrophil Trafficking during Acute Inflammation via STAT3

(2014) C. A. Fielding et al.   JOURNAL OF IMMUNOLOGY

Oncostatin M Receptor-  Signaling Limits Monocytic Cell Recruitment in Acute Inflammation

(2014) E. Hams et al.   JOURNAL OF IMMUNOLOGY

Therapeutic Targeting of IL-6 Trans Signaling Counteracts STAT3 Control of Experimental Inflammatory Arthritis

(2014) M. A. Nowell et al.   JOURNAL OF IMMUNOLOGY

In vivo effects of the anti-interleukin-6 receptor inhibitor tocilizumab on the B cell compartment

(2011) Petra Roll et al.   ARTHRITIS AND RHEUMATISM

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

(2011) Marina Lesina et al.   CANCER CELL

Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model*

(2011) Tanja Barkhausen et al.   CRITICAL CARE MEDICINE

Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11bhighGr1low macrophages

(2011) Gabriela Schiechl et al.   JOURNAL OF CLINICAL INVESTIGATION

ADAM17: a molecular switch to control inflammation and tissue regeneration

(2011) Jürgen Scheller et al.   TRENDS IN IMMUNOLOGY

Interleukin-6 Signaling in Liver-Parenchymal Cells Suppresses Hepatic Inflammation and Improves Systemic Insulin Action

(2010) F. Thomas Wunderlich et al.   Cell Metabolism

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

(2010) V. B. Matthews et al.   DIABETOLOGIA

IL-6: from its discovery to clinical applications

(2010) T. Kishimoto   INTERNATIONAL IMMUNOLOGY

Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation

(2010) Shigeru Kotake et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Loss of CD4 + T Cell IL-6R Expression during Inflammation Underlines a Role for IL-6 Trans Signaling in the Local Maintenance of Th17 Cells

(2010) Gareth W. Jones et al.   JOURNAL OF IMMUNOLOGY

Although IL-6 Trans-Signaling Is Sufficient To Drive Local Immune Responses, Classical IL-6 Signaling Is Obligate for the Induction of T Cell-Mediated Autoimmunity

(2010) R. Lissilaa et al.   JOURNAL OF IMMUNOLOGY

Differences in Wound Healing in Mice with Deficiency of IL-6 versus IL-6 Receptor

(2010) M. M. McFarland-Mancini et al.   JOURNAL OF IMMUNOLOGY

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

(2010) Eli A Stahl et al.   NATURE GENETICS

A role for IL-27p28 as an antagonist of gp130-mediated signaling

(2010) Jason S Stumhofer et al.   NATURE IMMUNOLOGY

Averting inflammation by targeting the cytokine environment

(2010) Manfred Kopf et al.   NATURE REVIEWS DRUG DISCOVERY

The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo

(2009) Joel M. Kremer et al.   ARTHRITIS AND RHEUMATISM

Predicting the development of RA in patients with early undifferentiated arthritis

(2009) Karim Raza et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

(2009) Julia Bollrath et al.   CANCER CELL

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer

(2009) Sergei I. Grivennikov et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Oncostatin M deficiency leads to thymic hypoplasia, accumulation of apoptotic thymocytes and glomerulonephritis

(2009) Eiji Esashi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

STAT3 as a prognostic marker in human gastric cancer

(2009) Cameron B Jackson et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Essential Roles of IL-6 Trans-Signaling in Colonic Epithelial Cells, Induced by the IL-6/Soluble-IL-6 Receptor Derived from Lamina Propria Macrophages, on the Development of Colitis-Associated Premalignant Cancer in a Murine Model

(2009) S. Matsumoto et al.   JOURNAL OF IMMUNOLOGY

Interleukin 27 attenuates collagen-induced arthritis

(2008) W Niedbala et al.   ANNALS OF THE RHEUMATIC DISEASES

IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial

(2008) P. Emery et al.   ANNALS OF THE RHEUMATIC DISEASES

Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease

(2008) N. Nishimoto et al.   BLOOD

STAT3 expression in gastric cancer indicates a poor prognosis

(2008) Dae-Young Kim et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial

(2008) Shumpei Yokota et al.   LANCET

Stat3 downstream genes serve as biomarkers in human lung carcinomas and chronic obstructive pulmonary disease

(2008) Peng Qu et al.   LUNG CANCER

gp130 signaling in bone cell biology: Multiple roles revealed by analysis of genetically altered mice

(2008) Natalie A. Sims   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours

(2008) Sandra Rebouissou et al.   NATURE

Actemra poised to launch IL-6 inhibitors

(2008) Lisa Melton et al.   NATURE BIOTECHNOLOGY

Ups and downs: The STAT1:STAT3 seesaw of Interferon and gp130 receptor signalling

(2008) Gabriella Regis et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

RADIATE: more treatment options for patients with an inadequate response to tumor necrosis factor antagonists

(2008) Ernest Choy   Nature clinical practice. Rheumatology