Regulation of cellular senescence via the FOXO4-p53 axis

Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/− ) mice

(2017) Anja Moncsek et al.   HEPATOLOGY

Targeting cellular senescence prevents age-related bone loss in mice

(2017) Joshua N Farr et al.   NATURE MEDICINE

Tetramer formation of tumor suppressor protein p53: Structure, function, and applications

(2016) Rui Kamada et al.   BIOPOLYMERS

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

Type 2 Diabetes and the Aging Pancreatic Beta Cell

(2016) Uma Gunasekaran et al.   Aging-US

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Characterization of the p300 Taz2–p53 TAD2 Complex and Comparison with the p300 Taz2–p53 TAD1 Complex

(2015) Lisa M. Miller Jenkins et al.   BIOCHEMISTRY

FoxO3a suppresses the senescence of cardiac microvascular endothelial cells by regulating the ROS-mediated cell cycle

(2015) Xu-Feng Qi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Acetylation of FoxO1 Activates Bim Expression to Induce Apoptosis in Response to Histone Deacetylase Inhibitor Depsipeptide Treatment

(2015) Yang Yang et al.   NEOPLASIA

Cleaved high molecular weight kininogen stimulates JNK/FOXO4/MnSOD pathway for induction of endothelial progenitor cell senescence

(2014) Xuemei Zhu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

The DNA-binding domain mediates both nuclear and cytosolic functions of p53

(2014) Ariele Viacava Follis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stressing the cell cycle in senescence and aging

(2013) Hollie Chandler et al.   CURRENT OPINION IN CELL BIOLOGY

The Small GTPase RALA Controls c-Jun N-terminal Kinase-mediated FOXO Activation by Regulation of a JIP1 Scaffold Complex

(2013) Maaike C. W. van den Berg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redox-Dependent Control of FOXO/DAF-16 by Transportin-1

(2013) Marrit Putker et al.   MOLECULAR CELL

Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling

(2013) A. Eijkelenboom et al.   Molecular Systems Biology

Senescent Cardiac Fibroblast Is Critical for Cardiac Fibrosis after Myocardial Infarction

(2013) Fuli Zhu et al.   PLoS One

Regulation of FOXOs and p53 by SIRT1 Modulators under Oxidative Stress

(2013) Yusuke S. Hori et al.   PLoS One

p53 N-terminal phosphorylation: a defining layer of complex regulation

(2012) L. M. M. Jenkins et al.   CARCINOGENESIS

The Intersection Between Aging and Cardiovascular Disease

(2012) Brian J. North et al.   CIRCULATION RESEARCH

Competitive Binding between Dynamic p53 Transactivation Subdomains to Human MDM2 Protein

(2012) Bing Shan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment

(2012) F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HMGB1-Facilitated p53 DNA Binding Occurs via HMG-Box/p53 Transactivation Domain Interaction, Regulated by the Acidic Tail

(2012) John P. Rowell et al.   STRUCTURE

Cleaved High-Molecular-Weight Kininogen Accelerates the Onset of Endothelial Progenitor Cell Senescence by Induction of Reactive Oxygen Species

(2011) Jihong Dai et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Interaction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 Tetramer

(2011) Eviatar Natan et al.   JOURNAL OF MOLECULAR BIOLOGY

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Structure of the human FOXO4-DBD–DNA complex at 1.9 Å resolution reveals new details of FOXO binding to the DNA

(2010) Evzen Boura et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Activation of Forkhead Box O Transcription Factors by Oncogenic BRAF Promotes p21cip1-Dependent Senescence

(2010) P. L. J. de Keizer et al.   CANCER RESEARCH

Pathways of oncogene-induced senescence in human melanocytic cells

(2010) Rajat Bansal et al.   CELL CYCLE

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

(2010) F. Rodier et al.   JOURNAL OF CELL SCIENCE

Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs

(2010) Malka Kitayner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

The relevance of protein-protein interactions for p53 function: the CPE contribution

(2010) M. R. Fernandez-Fernandez et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Two Distinct Motifs within the p53 Transactivation Domain Bind to the Taz2 Domain of p300 and Are Differentially Affected by Phosphorylation†

(2009) Lisa M. Miller Jenkins et al.   BIOCHEMISTRY

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

MDM2 Acts Downstream of p53 as an E3 Ligase to Promote FOXO Ubiquitination and Degradation

(2009) Wei Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation

(2009) Rosario Amato et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

BrafV600E cooperates with Pten loss to induce metastatic melanoma

(2009) David Dankort et al.   NATURE GENETICS

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

(2009) M. Olivier et al.   Cold Spring Harbor Perspectives in Biology

Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis

(2008) Veronique Nogueira et al.   CANCER CELL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Interaction of FOXO with β-Catenin Inhibits β-Catenin/T Cell Factor Activity

(2008) Diana Hoogeboom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical and Structural Characterization of an Intramolecular Interaction in FOXO3a and Its Binding with p53

(2008) Feng Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

(2008) Darren J. Baker et al.   NATURE CELL BIOLOGY

Mdm2 Induces Mono-Ubiquitination of FOXO4

(2008) Arjan B. Brenkman et al.   PLoS One

Structural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational Modification

(2008) Michael M. Brent et al.   STRUCTURE