Cognitive impairment with diabetes mellitus and metabolic disease: innovative insights with the mechanistic target of rapamycin and circadian clock gene pathways

The Promises and Challenges of Erythropoietin for Treatment of Alzheimer’s Disease

(2019) Jiahong Sun et al.   NEUROMOLECULAR MEDICINE

Acute glucose fluctuation impacts microglial activity, leading to inflammatory activation or self-degradation

(2019) Cheng-Fang Hsieh et al.   Scientific Reports

Mechanisms Associated with Type 2 Diabetes as a Risk Factor for Alzheimer-Related Pathology

(2019) Men Su et al.   MOLECULAR NEUROBIOLOGY

Sick fat: the good and the bad of old and new circulating markers of adipose tissue inflammation

(2019) I. Barchetta et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Disruptions to the Limb Muscle Core Molecular Clock Coincide with Changes in Mitochondrial Quality Control following Androgen Depletion

(2019) Michael L. Rossetti et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Clock genes and cancer development in particular in endocrine tissues

(2019) Anna Angelousi et al.   ENDOCRINE-RELATED CANCER

Aldose reductase regulates hyperglycemia-induced HUVEC death via SIRT1/AMPK-α1/mTOR pathway

(2019) Pabitra B Pal et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Erythropoietin (EPO) haplotype associated with all-cause mortality in a cohort of Italian patients with Type-2 Diabetes

(2019) Alberto Montesano et al.   Scientific Reports

Combination of intravitreal bevacizumab and erythropoietin versus intravitreal bevacizumab alone for refractory diabetic macular edema: a randomized double-blind clinical trial

(2019) Morteza Entezari et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

The Rise of Molecules Able To Regenerate the Central Nervous System

(2019) Vinícius Barros Ribeiro da Silva et al.   JOURNAL OF MEDICINAL CHEMISTRY

Erythropoietin induces synaptogenesis and neurite repair after hypoxia ischemia-mediated brain injury in neonatal rats

(2019) Tao Xiong et al.   NEUROREPORT

17β-Estradiol Modulates SIRT1 and Halts Oxidative Stress-Mediated Cognitive Impairment in a Male Aging Mouse Model

(2019) Mehtab Khan et al.   Cells

The mechanistic target of rapamycin (mTOR) and the silent mating-type information regulation 2 homolog 1 (SIRT1): oversight for neurodegenerative disorders

(2018) Kenneth Maiese   BIOCHEMICAL SOCIETY TRANSACTIONS

Qiliqiangxin Rescues Mouse Cardiac Function by Regulating AGTR1/TRPV1-Mediated Autophagy in STZ-Induced Diabetes Mellitus

(2018) Jing Tong et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Novel Treatment Strategies for the Nervous System: Circadian Clock Genes, Non-coding RNAs, and Forkhead Transcription Factors

(2018) Kenneth Maiese   CURRENT NEUROVASCULAR RESEARCH

MECHANISMS IN ENDOCRINOLOGY: SGLT2 inhibitors: clinical benefits by restoration of normal diurnal metabolism?

(2018) Russell L Esterline et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Repeated Systemic Treatment with Rapamycin Affects Behavior and Amygdala Protein Expression in Rats

(2018) Martin Hadamitzky et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Qi Fu Yin–a Ming Dynasty Prescription for the Treatment of Dementia

(2018) Wei-Yi Ong et al.   MOLECULAR NEUROBIOLOGY

mTOR signaling regulates central and peripheral circadian clock function

(2018) Chidambaram Ramanathan et al.   PLoS Genetics

Inosine improves cognitive function and decreases aging-induced oxidative stress and neuroinflammation in aged female rats

(2018) Poonam Ruhal et al.   INFLAMMOPHARMACOLOGY

Protection of glucotoxicity by a tripeptide derivative of α-melanocyte-stimulating hormone in human epidermal keratinocytes

(2018) P Gkogkolou et al.   BRITISH JOURNAL OF DERMATOLOGY

AMPK Activation Ameliorates Alzheimer's Disease-Like Pathology and Spatial Memory Impairment in a Streptozotocin-Induced Alzheimer's Disease Model in Rats

(2018) Lai-Ling Du et al.   JOURNAL OF ALZHEIMERS DISEASE

The Cross-Talk Between Sphingolipids and Insulin-Like Growth Factor Signaling: Significance for Aging and Neurodegeneration

(2018) Henryk Jęśko et al.   MOLECULAR NEUROBIOLOGY

Sirtuins: Developing Innovative Treatments for Aged-Related Memory Loss and Alzheimer’s Disease

(2018) Kenneth Maiese   CURRENT NEUROVASCULAR RESEARCH

AMPK activation: Role in the signaling pathways of neuroinflammation and neurodegeneration

(2017) Christina Alves Peixoto et al.   EXPERIMENTAL NEUROLOGY

Alterations of Clock Gene RNA Expression in Brain Regions of a Triple Transgenic Model of Alzheimer’s Disease

(2017) Francesco Bellanti et al.   JOURNAL OF ALZHEIMERS DISEASE

Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model

(2017) Zhong-Hao Zhang et al.   JOURNAL OF NEUROSCIENCE

N-3 polyunsaturated fatty acids alleviate high glucose-mediated dysfunction of endothelial progenitor cells and prevent ischemic injuries both in vitro and in vivo

(2017) Shao-Chih Chiu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Melatonin alleviates adipose inflammation through elevating α-ketoglutarate and diverting adipose-derived exosomes to macrophages in mice

(2017) Zhenjiang Liu et al.   JOURNAL OF PINEAL RESEARCH

Time-of-Day Dependent Neuronal Injury After Ischemic Stroke: Implication of Circadian Clock Transcriptional Factor Bmal1 and Survival Kinase AKT

(2017) Mustafa Caglar Beker et al.   MOLECULAR NEUROBIOLOGY

Uncoupling genotoxic stress responses from circadian control increases susceptibility to mammary carcinogenesis

(2017) Mingzhu Fang et al.   Oncotarget

Neurodegeneration and the Circadian Clock

(2017) Suzanne Hood et al.   Frontiers in Aging Neuroscience

Drosophila Clock Is Required in Brain Pacemaker Neurons to Prevent Premature Locomotor Aging Independently of Its Circadian Function

(2017) Alexandra Vaccaro et al.   PLoS Genetics

Dammarane Sapogenins Ameliorates Neurocognitive Functional Impairment Induced by Simulated Long-Duration Spaceflight

(2017) Xiaorui Wu et al.   Frontiers in Pharmacology

Oxidative Stress-Responsive Apoptosis Inducing Protein (ORAIP) Plays a Critical Role in High Glucose-Induced Apoptosis in Rat Cardiac Myocytes and Murine Pancreatic β-Cells

(2017) Takako Yao et al.   Cells

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Knockdown of GSK3  increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells

(2016) K. A. Weikel et al.   BIOSCIENCE REPORTS

New perspectives on the involvement of mTOR in depression as well as in the action of antidepressant drugs

(2016) Zuleide M. Ignácio et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Circadian rhythm of autophagy proteins in hippocampus is blunted by sleep fragmentation

(2016) Yi He et al.   CHRONOBIOLOGY INTERNATIONAL

Erythropoietin and mTOR: A “One-Two Punch” for Aging-Related Disorders Accompanied by Enhanced Life Expectancy

(2016) Kenneth Maiese   CURRENT NEUROVASCULAR RESEARCH

Regeneration in the nervous system with erythropoietin

(2016) Kenneth Maiese   Frontiers in Bioscience-Landmark

Rapamycin Reduced Ischemic Brain Damage in Diabetic Animals Is Associated with Suppressions of mTOR and ERK1/2 Signaling

(2016) Ping Liu et al.   International Journal of Biological Sciences

Histone Deacetylase SIRT1 Controls Proliferation, Circadian Rhythm, and Lipid Metabolism during Liver Regeneration in Mice

(2016) Marina Maria Bellet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Erythropoietin and Its Derivates Modulate Mitochondrial Dysfunction after Diffuse Traumatic Brain Injury

(2016) Anne Millet et al.   JOURNAL OF NEUROTRAUMA

Melatonin and the pathologies of weakened or dysregulated circadian oscillators

(2016) Rüdiger Hardeland   JOURNAL OF PINEAL RESEARCH

The Akt/mTOR/p70S6K Pathway Is Involved in the Neuroprotective Effect of Erythropoietin on Hypoxic/Ischemic Brain Injury in a Neonatal Rat Model

(2016) Hyun Ju Lee et al.   Neonatology

Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTOR

(2016) Kenneth Maiese   Neural Regeneration Research

Prevention of β-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL

(2016) Yan Chen Shang et al.   Aging-US

Enhancing Beta-Catenin Activity via GSK3beta Inhibition Protects PC12 Cells against Rotenone Toxicity through Nurr1 Induction

(2016) Limin Zhang et al.   PLoS One

Sirtuins, aging, and cardiovascular risks

(2015) Gaia Favero et al.   AGE

Proline-rich AKT substrate of 40-kDa (PRAS40) in the pathophysiology of cancer

(2015) Ritu Malla et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sirtuins in vascular diseases: Emerging roles and therapeutic potential

(2015) Nunzia D'Onofrio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Sirtuin regulation in aging and injury

(2015) Ninu Poulose et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Effect of caloric restriction on the SIRT1/mTOR signaling pathways in senile mice

(2015) Lina Ma et al.   BRAIN RESEARCH BULLETIN

Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders

(2015) Kenneth Maiese   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

FoxO Transcription Factors and Regenerative Pathways in Diabetes Mellitus

(2015) Kenneth Maiese   CURRENT NEUROVASCULAR RESEARCH

Regulatory Effects of Caffeic Acid Phenethyl Ester on Neuroinflammation in Microglial Cells

(2015) Cheng-Fang Tsai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Reduced silent information regulator 1 signaling exacerbates myocardial ischemia-reperfusion injury in type 2 diabetic rats and the protective effect of melatonin

(2015) Liming Yu et al.   JOURNAL OF PINEAL RESEARCH

Icariin protects against intestinal ischemia–reperfusion injury

(2015) Feng Zhang et al.   JOURNAL OF SURGICAL RESEARCH

Rapamycin Increases Mortality indb/dbMice, a Mouse Model of Type 2 Diabetes

(2015) Kavithalakshmi Sataranatarajan et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Neuroprotective Effect of Erythropoietin on Rotenone-Induced Neurotoxicity in SH-SY5Y Cells Through the Induction of Autophagy

(2015) Wooyoung Jang et al.   MOLECULAR NEUROBIOLOGY

Quercetin is a potent anti-atherosclerotic compound by activation of SIRT1 signaling under oxLDL stimulation

(2015) Ching-Hsia Hung et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Novel applications of trophic factors, Wnt and WISP for neuronal repair and regeneration in metabolic disease

(2015) Kenneth Maiese   Neural Regeneration Research

Downregulation of canonical Wnt signaling in hippocampus of SAMP8 mice

(2015) Sergi Bayod et al.   NEUROBIOLOGY OF AGING

Erythropoietin Attenuates Advanced Glycation Endproducts-Induced Toxicity of Schwann Cells In Vitro

(2015) Ting Yu et al.   NEUROCHEMICAL RESEARCH

Methylene blue-induced neuronal protective mechanism against hypoxia-reoxygenation stress

(2015) M.-G. Ryou et al.   NEUROSCIENCE

New Insights for Oxidative Stress and Diabetes Mellitus

(2015) Kenneth Maiese   Oxidative Medicine and Cellular Longevity

Erythropoietin improves synaptic plasticity and memory deficits by decrease of the neurotransmitter release probability in the rat model of Alzheimer's disease

(2015) Parisa Esmaeili Tazangi et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Fasting activates macroautophagy in neurons of Alzheimer’s disease mouse model but is insufficient to degrade amyloid-beta

(2015) Xigui Chen et al.   Scientific Reports

Roles of microRNA-34a targeting SIRT1 in mesenchymal stem cells

(2015) Fengyun Zhang et al.   Stem Cell Research & Therapy

SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer

(2015) Kenneth Maiese   World Journal of Stem Cells

A Genome-Wide Scan Reveals Important Roles of DNA Methylation in Human Longevity by Regulating Age-Related Disease Genes

(2015) Fu-Hui Xiao et al.   PLoS One

Dietary restriction involves NAD+-dependent mechanisms and a shift toward oxidative metabolism

(2014) Natalie Moroz et al.   AGING CELL

Overnutrition, mTOR signaling, and cardiovascular diseases

(2014) Guanghong Jia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Taking aim at Alzheimer's disease through the mammalian target of rapamycin

(2014) Kenneth Maiese   ANNALS OF MEDICINE

Early molecular and behavioral response to lipopolysaccharide in the WAG/Rij rat model of absence epilepsy and depressive-like behavior, involves interplay between AMPK, AKT/mTOR pathways and neuroinflammatory cytokine release

(2014) Emilio Russo et al.   BRAIN BEHAVIOR AND IMMUNITY

Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy

(2014) Teng Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hypothalamic mTOR: The Rookie Energy Sensor

(2014) P. Martínez de Morentin et al.   CURRENT MOLECULAR MEDICINE

Cutting through the Complexities of mTOR for the Treatment of Stroke

(2014) Kenneth Maiese   CURRENT NEUROVASCULAR RESEARCH

WISP1: Clinical Insights for a Proliferative and Restorative Member of the CCN Family

(2014) Kenneth Maiese   CURRENT NEUROVASCULAR RESEARCH

WISP1 Is a Novel Adipokine Linked to Inflammation in Obesity

(2014) Veronica Murahovschi et al.   DIABETES

Adiponectin Stimulates Autophagy and Reduces Oxidative Stress to Enhance Insulin Sensitivity During High-Fat Diet Feeding in Mice

(2014) Ying Liu et al.   DIABETES

From neurogenesis to neuroprotection in the epilepsy: signalling by erythropoietin

(2014) Rolando Castaneda-Arellano   Frontiers in Bioscience-Landmark

AMPK is involved in mediation of erythropoietin influence on metabolic activity and reactive oxygen species production in white adipocytes

(2014) Li Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Erythropoietin, a Novel Versatile Player Regulating Energy Metabolism beyond the Erythroid System

(2014) Li Wang et al.   International Journal of Biological Sciences

Erythropoietin Action in Stress Response, Tissue Maintenance and Metabolism

(2014) Yuanyuan Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nicotinic Acid Increases Adiponectin Secretion from Differentiated Bovine Preadipocytes through G-Protein Coupled Receptor Signaling

(2014) Christina Kopp et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways

(2014) Anorut Jenwitheesuk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Insulin Receptor Substrate 1/2 (IRS1/2) Regulates Wnt/β-Catenin Signaling through Blocking Autophagic Degradation of Dishevelled2

(2014) Yongtao Geng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Knockdown Promotes Neural Differentiation and Attenuates the Heat Shock Response

(2014) Diana J. Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Compound K protects pancreatic islet cells against apoptosis through inhibition of the AMPK/JNK pathway in type 2 diabetic mice and in MIN6 β-cells

(2014) Feng Ying Guan et al.   LIFE SCIENCES

Circadian dysregulation of clock genes: clues to rapid treatments in major depressive disorder

(2014) B G Bunney et al.   MOLECULAR PSYCHIATRY

Driving neural regeneration through the mammalian target of rapamycin

(2014) Kenneth Maiese   Neural Regeneration Research

PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways

(2014) Xiaoxing Xiong et al.   NEUROBIOLOGY OF DISEASE

Resveratrol and cardiovascular health – Promising therapeutic or hopeless illusion?

(2014) Philip Chiu-Tsun Tang et al.   PHARMACOLOGICAL RESEARCH

Erythropoietin Protects Cardiomyocytes from Cell Death during Hypoxia/Reperfusion Injury through Activation of Survival Signaling Pathways

(2014) Asiya Parvin A et al.   PLoS One

Resveratrol Inhibits Breast Cancer Stem-Like Cells and Induces Autophagy via Suppressing Wnt/β-Catenin Signaling Pathway

(2014) Yujie Fu et al.   PLoS One

Protective Effect of Dl-3n-butylphthalide on Learning and Memory Impairment Induced by Chronic Intermittent Hypoxia-Hypercapnia Exposure

(2014) Jing-jing Min et al.   Scientific Reports

Glucagon-like peptide-1 analog-mediated protection against cholesterol-induced apoptosis via mammalian target of rapamycin activation in pancreaticβTC-6 cells 胰高血糖素样多肽-1类似物激活mTOR通路减轻胆固醇诱导的βTC-6细胞凋亡

(2014) Jiaqiang Zhou et al.   Journal of Diabetes

Aging increases CCN1 expression leading to muscle senescence

(2013) Jie Du et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Transcriptional Control of Antioxidant Defense by the Circadian Clock

(2013) Sonal A. Patel et al.   ANTIOXIDANTS & REDOX SIGNALING

Wnt pathway regulation by long-term moderate exercise in rat hippocampus

(2013) S. Bayod et al.   BRAIN RESEARCH

Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1

(2013) Gnanapragasam Arunachalam et al.   BRITISH JOURNAL OF PHARMACOLOGY

Tuberous Sclerosis Protein 2 (TSC2) Modulates CCN4 Cytoprotection During Apoptotic Amyloid Toxicity in Microglia

(2013) Yan Chen Shang et al.   CURRENT NEUROVASCULAR RESEARCH

Prevention of diabetes-induced cardiovascular complications upon treatment with antioxidants

(2013) Yan-Jun Xu et al.   HEART FAILURE REVIEWS

Intermittent Hypobaric Hypoxia Induces Neuroprotection in Kainate-Induced Oxidative Stress in Rats

(2013) Débora Coimbra Costa et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Intranasal formulation of erythropoietin (EPO) showed potent protective activity against amyloid toxicity in the Aβ25-35 non-transgenic mouse model of Alzheimer’s disease

(2013) Tangui Maurice et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Hypoxic macrophages impair autophagy in epithelial cells through Wnt1: relevance in IBD

(2013) D Ortiz-Masiá et al.   Mucosal Immunology

Erythropoietin exerts cell protective effect by activating PI3K/Akt and MAPK pathways in C6 Cells

(2013) Min-Soo Kwon et al.   NEUROLOGICAL RESEARCH

A Novel Strategy to Increase the Proliferative Potential of Adult Human β-Cells While Maintaining Their Differentiated Phenotype

(2013) Haytham Aly et al.   PLoS One

Rapamycin Treatment Improves Neuron Viability in an In Vitro Model of Stroke

(2013) Lauren Fletcher et al.   PLoS One

Metformin Induces Apoptosis through AMPK-Dependent Inhibition of UPR Signaling in ALL Lymphoblasts

(2013) Gilles M. Leclerc et al.   PLoS One

Role of protein tyrosine phosphatases in the modulation of insulin signaling and their implication in the pathogenesis of obesity-linked insulin resistance

(2013) Elaine Xu et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Wnt your brain be inflamed? Yes, it Wnt!

(2013) Bianca Marchetti et al.   TRENDS IN MOLECULAR MEDICINE

Erythropoietin, a novel repurposed drug: An innovative treatment for wound healing in patients with diabetes mellitus

(2013) Saher Hamed et al.   WOUND REPAIR AND REGENERATION

Role of Intensive Glucose Control in Development of Renal End Points in Type 2 Diabetes Mellitus

(2012) Steven G. Coca et al.   ARCHIVES OF INTERNAL MEDICINE

Mammalian target of rapamycin signaling in diabetic cardiovascular disease

(2012) Zhao Chong et al.   Cardiovascular Diabetology

Over-expression of circadian clock geneBmal1affects proliferation and the canonical Wnt pathway in NIH-3T3 cells

(2012) Fuwei Lin et al.   CELL BIOCHEMISTRY AND FUNCTION

Metformin preconditioning protects Daphnia pulex from lethal hypoxic insult involving AMPK, HIF and mTOR signaling

(2012) Bo Sheng et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

WISP1 (CCN4) Autoregulates its Expression and Nuclear Trafficking of β-Catenin during Oxidant Stress with Limited Effects upon Neuronal Autophagy

(2012) Shaohui Wang et al.   CURRENT NEUROVASCULAR RESEARCH

Wnt1 Inducible Signaling Pathway Protein 1 (WISP1) Targets PRAS40 to Govern β-Amyloid Apoptotic Injury of Microglia

(2012) Yan Chen Shang et al.   CURRENT NEUROVASCULAR RESEARCH

Fasting Glucose, Obesity, and Coronary Artery Calcification in Community-Based People Without Diabetes

(2012) M. K. Rutter et al.   DIABETES CARE

Novel directions for diabetes mellitus drug discovery

(2012) Kenneth Maiese et al.   Expert Opinion on Drug Discovery

Xanthigen Suppresses Preadipocyte Differentiation and Adipogenesis through Down-regulation of PPARγ and C/EBPs and Modulation of SIRT-1, AMPK, and FoxO Pathways

(2012) Ching-Shu Lai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The human glucagon-like peptide-1 analogue liraglutide regulates pancreatic beta-cell proliferation and apoptosis via an AMPK/mTOR/P70S6K signaling pathway

(2012) Xin-Yu Miao et al.   PEPTIDES

PRAS40 Is an Integral Regulatory Component of Erythropoietin mTOR Signaling and Cytoprotection

(2012) Zhao Zhong Chong et al.   PLoS One

The Vasculome of the Mouse Brain

(2012) Shuzhen Guo et al.   PLoS One

Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin

(2012) Zhao Zhong Chong et al.   PROGRESS IN NEUROBIOLOGY

mTOR: on target for novel therapeutic strategies in the nervous system

(2012) Kenneth Maiese et al.   TRENDS IN MOLECULAR MEDICINE

Activation of mTOR/p70S6 kinase by ANG II inhibits insulin-stimulated endothelial nitric oxide synthase and vasodilation

(2011) Jeong-a Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

(2011) Laura R. Pearce et al.   BIOCHEMICAL JOURNAL

The functions of mTOR in ischemic diseases

(2011) Seo-Kyoung Hwang et al.   BMB Reports

Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats

(2011) N Deblon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Proline-rich Akt substrate of 40kDa (PRAS40): A novel downstream target of PI3k/Akt signaling pathway

(2011) Haitao Wang et al.   CELLULAR SIGNALLING

Erythropoietin Employs Cell Longevity Pathways of SIRT1 to Foster Endothelial Vascular Integrity During Oxidant Stress

(2011) Jinling Hou et al.   CURRENT NEUROVASCULAR RESEARCH

Erythropoietin and Wnt1 Govern Pathways of mTOR, Apaf-1, and XIAP in Inflammatory Microglia

(2011) Yan Chen Shang et al.   CURRENT NEUROVASCULAR RESEARCH

EPO Relies upon Novel Signaling of Wnt1 that Requires Akt1, FoxO3a,GSK-3β, and β-Catenin to Foster Vascular Integrity during Experimental Diabetes

(2011) Zhao Zhong Chong et al.   CURRENT NEUROVASCULAR RESEARCH

Improvement of Cardiac Functions by Chronic Metformin Treatment Is Associated With Enhanced Cardiac Autophagy in Diabetic OVE26 Mice

(2011) Z. Xie et al.   DIABETES

Endogenous erythropoietin from astrocyte protects the oligodendrocyte precursor cell against hypoxic and reoxygenation injury

(2011) Shin Kato et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Mammalian Target of Rapamycin: Hitting the Bull's-Eye for Neurological Disorders

(2011) Zhao Zhong Chong et al.   Oxidative Medicine and Cellular Longevity

From oxygen to erythropoietin: Relevance of hypoxia for retinal development, health and disease

(2011) Christian Caprara et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Platelet dysfunction in vascular pathologies and how can it be treated

(2011) Nicoleta Alexandru et al.   THROMBOSIS RESEARCH

The Wnt/beta-catenin pathway is activated during advanced arterial aging in humans

(2010) Alexandre Marchand et al.   AGING CELL

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

(2010) Adem Kalender et al.   Cell Metabolism

Novel Avenues of Drug Discovery and Biomarkers for Diabetes Mellitus

(2010) Kenneth Maiese et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Erythropoietin treatment leads to reduced blood glucose levels and body mass: insights from murine models

(2010) Odelia Katz et al.   JOURNAL OF ENDOCRINOLOGY

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

(2009) Timothy R. Peterson et al.   CELL

Downregulation of cell survival signalling pathways and increased cell damage in hydrogen peroxide-treated human renal proximal tubular cells by alpha-erythropoietin

(2009) M. Andreucci et al.   CELL PROLIFERATION

FoxO proteins: cunning concepts and considerations for the cardiovascular system

(2009) Kenneth Maiese et al.   CLINICAL SCIENCE

Upregulation of the Mammalian Target of Rapamycin Complex 1 Pathway by Ras Homolog Enriched in Brain in Pancreatic  -Cells Leads to Increased  -Cell Mass and Prevention of Hyperglycemia

(2009) S. Hamada et al.   DIABETES

Specific Activation of mTORC1 by Rheb G-proteinin VitroInvolves Enhanced Recruitment of Its Substrate Protein

(2009) Tatsuhiro Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Target of Rapamycin Complex 1 (mTORC1) Activity Is Associated with Phosphorylation of Raptor by mTOR

(2009) Lifu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of mTOR Complex 1 (mTORC1) by Raptor Ser863and Multisite Phosphorylation

(2009) Kathryn G. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficacy of combined inhibition of mTOR and ERK/MAPK pathways in treating a tuberous sclerosis complex cell model

(2009) Ruifang Mi et al.   Journal of Genetics and Genomics

Short-Term Calorie Restriction in Male Mice Feminizes Gene Expression and Alters Key Regulators of Conserved Aging Regulatory Pathways

(2009) Preston Wayne Estep et al.   PLoS One

Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1

(2009) Y. Nakahata et al.   SCIENCE

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

(2008) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

Triple play: Promoting neurovascular longevity with nicotinamide, WNT, and erythropoietin in diabetes mellitus

(2008) Kenneth Maiese   BIOMEDICINE & PHARMACOTHERAPY

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL

Erythropoietin and Oxidative Stress

(2008) Kenneth Maiese et al.   CURRENT NEUROVASCULAR RESEARCH

Raves and risks for erythropoietin

(2008) Kenneth Maiese et al.   CYTOKINE & GROWTH FACTOR REVIEWS

mTOR Inhibition by Rapamycin Prevents  -Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes

(2008) M. Fraenkel et al.   DIABETES

Life Span Extension and Neuronal Cell Protection byDrosophilaNicotinamidase

(2008) Vitaly Balan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Wnt signaling pathway: Aging gracefully as a protectionist?

(2008) Kenneth Maiese et al.   PHARMACOLOGY & THERAPEUTICS