Rapamycin Increases Mortality indb/dbMice, a Mouse Model of Type 2 Diabetes

Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/− mice

(2016) Elena A. Komarova et al.   Aging-US

New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53−/− mice by delaying carcinogenesis

(2016) Maria Comas et al.   Aging-US

Rapamycin extends life span of Rb1+/− mice by inhibiting neuroendocrine tumors

(2016) Carolina B. Livi et al.   Aging-US

Rapamycin-induced metabolic defects are reversible in both lean and obese mice

(2016) Yuhong Liu et al.   Aging-US

How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story

(2015) Arlan Richardson et al.   EXPERIMENTAL GERONTOLOGY

Liver Damage, Inflammation, and Enhanced Tumorigenesis after Persistent mTORC1 Inhibition

(2014) Atsushi Umemura et al.   Cell Metabolism

Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the Liver Transcriptome

(2014) Wilson C. Fok et al.   PLoS One

mTOR inhibition improves immune function in the elderly

(2014) J. B. Mannick et al.   Science Translational Medicine

Late-life rapamycin treatment reverses age-related heart dysfunction

(2013) James M. Flynn et al.   AGING CELL

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

(2013) Richard A. Miller et al.   AGING CELL

eRapa Restores a Normal Life Span in a FAP Mouse Model

(2013) P. Hasty et al.   Cancer Prevention Research

Dietary restriction attenuates the accelerated aging phenotype of Sod1−/− mice

(2013) Yiqiang Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Rapamycin extends murine lifespan but has limited effects on aging

(2013) Frauke Neff et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapamycin Extends Life and Health in C57BL/6 Mice

(2013) Yiqiang Zhang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Rapamycin slows aging in mice

(2012) John E. Wilkinson et al.   AGING CELL

Aging, Diabetes, and the Public Health System in the United States

(2012) Carl J. Caspersen et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice

(2012) Vladimir N. Anisimov et al.   CELL CYCLE

Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence

(2012) Cecilia A. Hinojosa et al.   EXPERIMENTAL GERONTOLOGY

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C-Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival

(2012) F. J. Ramos et al.   Science Translational Medicine

Rapamycin treatment augments motor neuron degeneration in SOD1G93Amouse model of amyotrophic lateral sclerosis

(2011) Xiaojie Zhang et al.   Autophagy

Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats

(2011) N Deblon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dietary restriction but not rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALS

(2011) Arunabh Bhattacharya et al.   NEUROBIOLOGY OF AGING

Does Reduced IGF-1R Signaling in Igf1r+/− Mice Alter Aging?

(2011) Alex F. Bokov et al.   PLoS One

Sirolimus Therapy Predisposes to New-Onset Diabetes Mellitus After Renal Transplantation: A Long-Term Analysis of Various Treatment Regimens

(2011) E. Gyurus et al.   TRANSPLANTATION PROCEEDINGS

Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice

(2010) Vladimir N. Anisimov et al.   AMERICAN JOURNAL OF PATHOLOGY

Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue

(2010) V. P. Houde et al.   DIABETES

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A comprehensive map of the mTOR signaling network

(2010) Etienne Caron et al.   Molecular Systems Biology

Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening

(2009) Chen-Yu Liao et al.   AGING CELL

Reduced Incidence and Delayed Occurrence of Fatal Neoplastic Diseases in Growth Hormone Receptor/Binding Protein Knockout Mice

(2009) Y. Ikeno et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Simultaneous Inference in General Parametric Models

(2008) Torsten Hothorn et al.   BIOMETRICAL JOURNAL

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

(2008) Kevin J. Pearson et al.   Cell Metabolism

Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in Apc 716 mice

(2008) T. Fujishita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA