Role of protein tyrosine phosphatases in the modulation of insulin signaling and their implication in the pathogenesis of obesity-linked insulin resistance

Protein tyrosine phosphatase 1B inhibits adipocyte differentiation and mediates TNFα action in obesity

(2013) Dan-Dan Song et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Protein tyrosine phosphatase variants in human hereditary disorders and disease susceptibilities

(2013) Wiljan J.A.J. Hendriks et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cembrane diterpenoids from the soft coral Sarcophyton trocheliophorum Marenzeller as a new class of PTP1B inhibitors

(2013) Lin-Fu Liang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Regulation of the SNARE-interacting protein Munc18c tyrosine phosphorylation in adipocytes by protein-tyrosine phosphatase 1B

(2013) Jesse Bakke et al.   Cell Communication and Signaling

Inducible liver-specific knockdown of protein tyrosine phosphatase 1B improves glucose and lipid homeostasis in adult mice

(2013) C. Owen et al.   DIABETOLOGIA

Heterogeneous nuclear ribonucleoprotein Q is a novel substrate of SH2 domain-containing phosphatase-2

(2013) N. Watanabe et al.   JOURNAL OF BIOCHEMISTRY

A Conserved Rod Domain Phosphotyrosine That Is Targeted by the Phosphatase PTP1B Promotes Keratin 8 Protein Insolubility and Filament Organization

(2013) Natasha T. Snider et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Cryptotanshinone as an Inhibitor of Oncogenic Protein Tyrosine Phosphatase SHP2 (PTPN11)

(2013) Wei Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

The LIM Domain Only 4 Protein Is a Metabolic Responsive Inhibitor of Protein Tyrosine Phosphatase 1B That Controls Hypothalamic Leptin Signaling

(2013) N. R. Pandey et al.   JOURNAL OF NEUROSCIENCE

Protein Tyrosine Phosphatase 1B Deficiency Ameliorates Murine Experimental Colitis via the Expansion of Myeloid-Derived Suppressor Cells

(2013) Jing Zhang et al.   PLoS One

Role of PTPα in the Destruction of Periodontal Connective Tissues

(2013) Dhaarmini Rajshankar et al.   PLoS One

LAR-RPTPs: synaptic adhesion molecules that shape synapse development

(2013) Ji Won Um et al.   TRENDS IN CELL BIOLOGY

The B55α-containing PP2A holoenzyme dephosphorylates FOXO1 in islet β-cells under oxidative stress

(2012) Ling Yan et al.   BIOCHEMICAL JOURNAL

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Insulin Activates Erk1/2 Signaling in the Dorsal Vagal Complex to Inhibit Glucose Production

(2012) Beatrice M. Filippi et al.   Cell Metabolism

Hepatocyte-Specific Ptpn6 Deletion Protects From Obesity-Linked Hepatic Insulin Resistance

(2012) E. Xu et al.   DIABETES

Hepatic Src Homology Phosphatase 2 Regulates Energy Balance in Mice

(2012) Naoto Nagata et al.   ENDOCRINOLOGY

PTP1B and TCPTP - nonredundant phosphatases in insulin signaling and glucose homeostasis

(2012) Tony Tiganis   FEBS Journal

Protein tyrosine phosphatase 1B (PTP1B) modulates palmitate-induced cytokine production in macrophage cells

(2012) Ahmad Nasimian et al.   INFLAMMATION RESEARCH

Modulation of Fatty Acid Synthase Degradation by Concerted Action of p38 MAP Kinase, E3 Ligase COP1, and SH2-Tyrosine Phosphatase Shp2

(2012) Jianxiu Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes

(2012) Sheng Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Involvement of protein tyrosine phosphatases and inflammation in hypothalamic insulin resistance associated with ageing: Effect of caloric restriction

(2012) Miriam García-San Frutos et al.   MECHANISMS OF AGEING AND DEVELOPMENT

T-Cell Protein Tyrosine Phosphatase Regulates Bone Resorption and Whole-Body Insulin Sensitivity through Its Expression in Osteoblasts

(2012) T. Zee et al.   MOLECULAR AND CELLULAR BIOLOGY

Functional interactions between the gut microbiota and host metabolism

(2012) Valentina Tremaroli et al.   NATURE

Adipocyte-Specific Protein Tyrosine Phosphatase 1B Deletion Increases Lipogenesis, Adipocyte Cell Size and Is a Minor Regulator of Glucose Homeostasis

(2012) Carl Owen et al.   PLoS One

Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase

(2012) Z. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential role of protein tyrosine phosphatase 1B in obesity-induced inflammation and peripheral insulin resistance during aging

(2011) Águeda González-Rodríguez et al.   AGING CELL

Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress

(2011) Abdelali Agouni et al.   BIOCHEMICAL JOURNAL

Substrate Specificity of Protein Tyrosine Phosphatases 1B, RPTPα, SHP-1, and SHP-2

(2011) Lige Ren et al.   BIOCHEMISTRY

Feedback on Fat: p62-mTORC1-Autophagy Connections

(2011) Jorge Moscat et al.   CELL

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Role for Insulin Signaling in Catecholaminergic Neurons in Control of Energy Homeostasis

(2011) A. Christine Könner et al.   Cell Metabolism

Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance

(2011) Kim Loh et al.   Cell Metabolism

Compartmentalized CDK2 is connected with SHP-1 and β-catenin and regulates insulin internalization

(2011) Annie Fiset et al.   CELLULAR SIGNALLING

Effects of Insulin on the Vasculature

(2011) Danna M. Breen et al.   Current Vascular Pharmacology

Fatty Acids, Obesity, and Insulin Resistance: Time for a Reevaluation

(2011) F. Karpe et al.   DIABETES

Effect of exposure to non-esterified fatty acid on progressive deterioration of insulin secretion in patients with Type 2 diabetes: a long-term follow-up study

(2011) S. Morita et al.   DIABETIC MEDICINE

Increased levels of the Akt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance

(2011) F. Andreozzi et al.   DIABETOLOGIA

T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice

(2011) K. Loh et al.   DIABETOLOGIA

Inhibition of the Protein Tyrosine Phosphatase SHP-1 Increases Glucose Uptake in Skeletal Muscle Cells by Augmenting Insulin Receptor Signaling and GLUT4 Expression

(2011) Sébastien Bergeron et al.   ENDOCRINOLOGY

Differential Regulation of Endoplasmic Reticulum Stress by Protein Tyrosine Phosphatase 1B and T Cell Protein Tyrosine Phosphatase

(2011) Ahmed Bettaieb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipose-specific deletion of Src homology phosphatase 2 does not significantly alter systemic glucose homeostasis

(2011) Ahmed Bettaieb et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

SHP2 Tyrosine Phosphatase Converts Parafibromin/Cdc73 from a Tumor Suppressor to an Oncogenic Driver

(2011) Atsushi Takahashi et al.   MOLECULAR CELL

The role of mitochondria in insulin resistance and type 2 diabetes mellitus

(2011) Julia Szendroedi et al.   Nature Reviews Endocrinology

PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

(2011) P. V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Free Fatty Acid-Induced PP2A Hyperactivity Selectively Impairs Hepatic Insulin Action on Glucose Metabolism

(2011) Thomas Galbo et al.   PLoS One

Tipping the Balance: the Pathophysiology of Obesity and Type 2 Diabetes Mellitus

(2011) Rachel L. McKenney et al.   SURGICAL CLINICS OF NORTH AMERICA

Obesity, insulin resistance and free fatty acids

(2011) Guenther Boden   Current Opinion in Endocrinology Diabetes and Obesity

Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition

(2010) Keertik Fulzele et al.   CELL

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Protein phosphatase-1 regulates Akt1 signal transduction pathway to control gene expression, cell survival and differentiation

(2010) L Xiao et al.   CELL DEATH AND DIFFERENTIATION

Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility

(2010) Jennifer W. Hill et al.   Cell Metabolism

SHP-1 inhibits β-catenin function by inducing its degradation and interfering with its association with TATA-binding protein

(2010) Mélanie Simoneau et al.   CELLULAR SIGNALLING

Insulin signaling in fatty acid and fat synthesis: a transcriptional perspective

(2010) Roger HF Wong et al.   CURRENT OPINION IN PHARMACOLOGY

T-Cell Protein Tyrosine Phosphatase Attenuates STAT3 and Insulin Signaling in the Liver to Regulate Gluconeogenesis

(2010) Atsushi Fukushima et al.   DIABETES

Prep1 Controls Insulin Glucoregulatory Function in Liver by Transcriptional Targeting of SHP1 Tyrosine Phosphatase

(2010) F. Oriente et al.   DIABETES

Taurine prevents free fatty acid-induced hepatic insulin resistance in association with inhibiting JNK1 activation and improving insulin signaling in vivo

(2010) Na Wu et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Modulation of hypothalamic PTP1B in the TNF-α-induced insulin and leptin resistance

(2010) Paty Karoll Picardi et al.   FEBS LETTERS

Enhancement of Insulin Responsiveness by Nitric Oxide-mediated Inactivation of Protein-tyrosine Phosphatases

(2010) Ming-Fo Hsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Purinergic Receptor-mediated Rapid Depletion of Nuclear Phosphorylated Akt Depends on Pleckstrin Homology Domain Leucine-rich Repeat Phosphatase, Calcineurin, Protein Phosphatase 2A, and PTEN Phosphatases

(2010) Oras Mistafa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered Glucose Homeostasis in Mice with Liver-specific Deletion of Src Homology Phosphatase 2

(2010) Kosuke Matsuo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice

(2010) Ryoichi Banno et al.   JOURNAL OF CLINICAL INVESTIGATION

Genomics, Type 2 Diabetes, and Obesity

(2010) Mark I. McCarthy   NEW ENGLAND JOURNAL OF MEDICINE

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

(2009) Timothy R. Peterson et al.   CELL

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

(2009) Lale Ozcan et al.   Cell Metabolism

An Emerging Role of mTOR in Lipid Biosynthesis

(2009) Mathieu Laplante et al.   CURRENT BIOLOGY

Mediator MED23 Links Insulin Signaling to the Adipogenesis Transcription Cascade

(2009) Wei Wang et al.   DEVELOPMENTAL CELL

Targeted Disruption of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Promotes Diet-Induced Hepatic Steatosis and Insulin Resistance

(2009) Elaine Xu et al.   ENDOCRINOLOGY

CNS Regulation of Glucose Homeostasis

(2009) Carol K. L. Lam et al.   PHYSIOLOGY

New Insights into mTOR Signaling: mTORC2 and Beyond

(2009) D. R. Alessi et al.   Science Signaling

HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms

(2008) Christy L. White et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Amino acid regulation of TOR complex 1

(2008) Joseph Avruch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Dynamic Functional Relay between Insulin Receptor Substrate 1 and 2 in Hepatic Insulin Signaling during Fasting and Feeding

(2008) Naoto Kubota et al.   Cell Metabolism

Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress

(2008) M. Delibegovic et al.   DIABETES

Insulin Regulates Glucagon-Like Peptide-1 Secretion from the Enteroendocrine L Cell

(2008) Gareth E. Lim et al.   ENDOCRINOLOGY

Protein tyrosine phosphatases in the JAK/STAT pathway

(2008) Dan Xu   Frontiers in Bioscience-Landmark

Protein-tyrosine Phosphatase 1B Expression Is Induced by Inflammationin Vivo

(2008) Janice M. Zabolotny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of Shp2 Tyrosine Phosphatase in Muscle Leads to Dilated Cardiomyopathy, Insulin Resistance, and Premature Death

(2008) F. Princen et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages

(2008) Hongmei Xu et al.   MOLECULAR IMMUNOLOGY

Dissection of the insulin signaling pathway via quantitative phosphoproteomics

(2008) M. Kruger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytosolic Protein Tyrosine Phosphatase-ε Is a Negative Regulator of Insulin Signaling in Skeletal Muscle

(2007) Shlomit Aga-Mizrachi et al.   ENDOCRINOLOGY

The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance

(2007) Gijs H. Goossens   PHYSIOLOGY & BEHAVIOR