Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways

Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats

(2016) Irina A. Vinogradova et al.   Aging-US

Antioxidant N-acetyl-L-cysteine ameliorates symptoms of premature aging associated with the deficiency of the circadian protein BMAL1

(2016) Roman V. Kondratov et al.   Aging-US

Deficiency of circadian protein CLOCK reduces lifespan and increases age-related cataract development in mice

(2016) Yuliya V. Dubrovsky et al.   Aging-US

BMAL1-dependent regulation of the mTOR signaling pathway delays aging

(2016) Rohini V. Khapre et al.   Aging-US

The biochemistry and cell biology of aging: metabolic regulation through mitochondrial signaling

(2014) Yun Chau Long et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Diurnal rhythms of autophagy: Implications for cell biology and human disease

(2014) Uma M. Sachdeva et al.   Autophagy

Longevity pathways converge on autophagy genes to regulate life span inCaenorhabditis elegans

(2014) Márton L. Tóth et al.   Autophagy

Autophagy activation by NFκB is essential for cell survival after heat shock

(2014) Mathieu Nivon et al.   Autophagy

Differential role of melatonin in restoration of age-induced alterations in daily rhythms of expression of various clock genes in suprachiasmatic nucleus of male Wistar rats

(2014) Ushodaya Mattam et al.   BIOGERONTOLOGY

The Role of Neuronal Insulin/Insulin-Like Growth Factor-1 Signaling for the Pathogenesis of Alzheimer’s Disease: Possible Therapeutic Implications

(2014) Johanna Zemva et al.   CNS & Neurological Disorders-Drug Targets

Insulin-FOXO3 Signaling Modulates Circadian Rhythms via Regulation of Clock Transcription

(2014) Inês Chaves et al.   CURRENT BIOLOGY

Reassessing the effects of histone deacetylase inhibitors on hippocampal memory and cognitive aging

(2014) James F. Castellano et al.   HIPPOCAMPUS

Autophagy in aging and in neurodegenerative disorders

(2014) Yogendra Rajawat et al.   Hormones-International Journal of Endocrinology and Metabolism

The Essential Role of p53-up-regulated Modulator of Apoptosis (Puma) and Its Regulation by FoxO3a Transcription Factor in β-Amyloid-induced Neuron Death

(2014) Rumana Akhter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diet-induced obesity accelerates the onset of terminal phenotypes in α-synuclein transgenic mice

(2014) Carola Rotermund et al.   JOURNAL OF NEUROCHEMISTRY

Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration

(2014) Lindsay J. Spielman et al.   JOURNAL OF NEUROIMMUNOLOGY

Melatonin attenuates prenatal dexamethasone-induced blood pressure increase in a rat model

(2014) You-Lin Tain et al.   Journal of the American Society of Hypertension

Circadian behavior is light-reprogrammed by plastic DNA methylation

(2014) Abdelhalim Azzi et al.   NATURE NEUROSCIENCE

Methylation mediates clock plasticity

(2014) Leonie Welberg   NATURE REVIEWS NEUROSCIENCE

Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy

(2014) A. J. Westwood et al.   NEUROLOGY

Epigenetic Regulation of Memory by Acetylation and Methylation of Chromatin: Implications in Neurological Disorders, Aging, and Addiction

(2014) Nilkantha Sen   NEUROMOLECULAR MEDICINE

Activation of MAPK and FoxO by Manganese (Mn) in Rat Neonatal Primary Astrocyte Cultures

(2014) Vernat Exil et al.   PLoS One

Melatonin in the Regulation of Liver Steatosis following Prenatal Glucocorticoid Exposure

(2014) Mao-Meng Tiao et al.   Biomed Research International

Clock-controlled output gene Dbp is a regulator of Arnt/Hif-1β gene expression in pancreatic islet β-cells

(2013) Hiroko Nakabayashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signalling: Figure 1

(2013) Fei Yin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Ketogenic essential amino acids replacement diet ameliorated hepatosteatosis with altering autophagy-associated molecules

(2013) Ling Xu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Sirtuin1 and autophagy protect cells from fluoride-induced cell stress

(2013) Maiko Suzuki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Impaired proteasomal degradation enhances autophagy via hypoxia signaling in Drosophila

(2013) Péter Lőw et al.   BMC CELL BIOLOGY

Epigenetics of Insulin Resistance: An Emerging Field in Translational Medicine

(2013) Silvia Sookoian et al.   Current Diabetes Reports

Tuberous Sclerosis Protein 2 (TSC2) Modulates CCN4 Cytoprotection During Apoptotic Amyloid Toxicity in Microglia

(2013) Yan Chen Shang et al.   CURRENT NEUROVASCULAR RESEARCH

WISP1 Neuroprotection Requires FoxO3a Post-Translational Modulation with Autoregulatory Control of SIRT1

(2013) Shaohui Wang et al.   CURRENT NEUROVASCULAR RESEARCH

SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells

(2013) Yedong Cheng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signaling in aged rats

(2013) Li Luo et al.   EXPERIMENTAL GERONTOLOGY

Region- and age-specific patterns of histone acetylation related to spatial and cued learning in the water maze

(2013) Malorie Dagnas et al.   HIPPOCAMPUS

FOXO3 determines the accumulation of α-synuclein and controls the fate of dopaminergic neurons in the substantia nigra

(2013) Emilda Pino et al.   HUMAN MOLECULAR GENETICS

Sirtuins' modulation of autophagy

(2013) Fanny Ng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

HDAC Inhibition Facilitates the Switch between Memory Systems in Young But Not Aged Mice

(2013) M. Dagnas et al.   JOURNAL OF NEUROSCIENCE

Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain

(2013) Natacha Coppieters et al.   NEUROBIOLOGY OF AGING

Histone deacetylase activity is altered in brain areas from aged rats

(2013) Gabriela dos Santos Sant’ Anna et al.   NEUROSCIENCE LETTERS

How to fix a broken clock

(2013) Analyne M. Schroeder et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Melatonin and Peripheral Circuitries: Insights on Appetite and Metabolism in Danio Rerio

(2013) Chiara Carla Piccinetti et al.   Zebrafish

Autophagic/lysosomal dysfunction in Alzheimer’s disease

(2013) Miranda E Orr et al.   Alzheimers Research & Therapy

Pathways to decoding the clinical potential of stress response FOXO-interaction networks for Huntington's disease: of gene prioritization and context dependence

(2013) Frédéric Parmentier et al.   Frontiers in Aging Neuroscience

Sirtuins: from metabolic regulation to brain aging

(2013) Wenzhen Duan   Frontiers in Aging Neuroscience

FoxO6 in glucose metabolism (FoxO6在葡萄糖代谢中的作用)

(2013) Dae Hyun Kim et al.   Journal of Diabetes

Loss of serum IGF-I input to the brain as an early biomarker of disease onset in Alzheimer mice

(2013) A Trueba-Sáiz et al.   Translational Psychiatry

Melatonin and the metabolic syndrome: a tool for effective therapy in obesity-associated abnormalities?

(2012) F. Nduhirabandi et al.   Acta Physiologica

Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: Impact on the aging process

(2012) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Autophagy and ageing: Insights from invertebrate model organisms

(2012) Eirini Lionaki et al.   AGEING RESEARCH REVIEWS

FoxOs in neural stem cell fate decision

(2012) Seung-Hyun Ro et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Protein phosphorylation-acetylation cascade connects growth factor deprivation to autophagy

(2012) Shu-Yong Lin et al.   Autophagy

Circadian regulation of autophagy rhythm through transcription factor C/EBPβ

(2012) Di Ma et al.   Autophagy

Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease

(2012) Cora O'Neill et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Melatonin administration differentially affects age-induced alterations in daily rhythms of lipid peroxidation and antioxidant enzymes in male rat liver

(2012) Pavan Kumar Manikonda et al.   BIOGERONTOLOGY

Gene regulation by melatonin linked to epigenetic phenomena

(2012) Ahmet Korkmaz et al.   GENE

FoxO6 regulates memory consolidation and synaptic function

(2012) D. A. M. Salih et al.   GENES & DEVELOPMENT

SIRT1 and CLOCK 3111T>C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity

(2012) M Garaulet et al.   INTERNATIONAL JOURNAL OF OBESITY

Histone Deacetylase-1 (HDAC1) Is a Molecular Switch between Neuronal Survival and Death

(2012) Farah H. Bardai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Autophagy by Metabolic and Stress Signaling Pathways in the Heart

(2012) Youngil Lee et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Melatonin-induced autophagy protects against human prion protein-mediated neurotoxicity

(2012) Jae-Kyo Jeong et al.   JOURNAL OF PINEAL RESEARCH

Melatonin suppresses proinflammatory mediators in lipopolysaccharide-stimulated CRL1999 cells via targeting MAPK, NF-κB, c/EBPβ, and p300 signaling

(2012) Dingbo Shi et al.   JOURNAL OF PINEAL RESEARCH

Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells

(2012) Jingshu Wang et al.   JOURNAL OF PINEAL RESEARCH

Genome-wide profiling in melatonin-exposed human breast cancer cell lines identifies differentially methylated genes involved in the anticancer effect of melatonin

(2012) Seung Eun Lee et al.   JOURNAL OF PINEAL RESEARCH

Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model

(2012) Zhong Wang et al.   JOURNAL OF PINEAL RESEARCH

The circadian clock and pathology of the ageing brain

(2012) Anna A. Kondratova et al.   NATURE REVIEWS NEUROSCIENCE

CREB-binding protein levels in the rat hippocampus fail to predict chronological or cognitive aging

(2012) Inês Tomás Pereira et al.   NEUROBIOLOGY OF AGING

The Anti-inflammatory Effect of Melatonin on Methamphetamine-Induced Proinflammatory Mediators in Human Neuroblastoma Dopamine SH-SY5Y Cell Lines

(2012) Kannika Permpoonputtana et al.   NEUROTOXICITY RESEARCH

Daily Rhythms of Plasma Melatonin, but Not Plasma Leptin or Leptin mRNA, Vary between Lean, Obese and Type 2 Diabetic Men

(2012) Simone Mäntele et al.   PLoS One

SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity

(2012) Hongying Yang et al.   PLoS One

Identification of Novel Interacting Partners of Sirtuin6

(2012) Oxana Polyakova et al.   PLoS One

GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy

(2012) S.-Y. Lin et al.   SCIENCE

Circadian autophagy rhythm: a link between clock and metabolism?

(2012) Di Ma et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Circadian rhythms and memory formation: regulation by chromatin remodeling

(2012) Saurabh Sahar et al.   Frontiers in Molecular Neuroscience

Post-transcriptional regulation of IGF1R by key microRNAs in long-lived mutant mice

(2011) Ruqiang Liang et al.   AGING CELL

Leptin boosts cellular metabolism by activating AMPK and the sirtuins to reduce tau phosphorylation and β-amyloid in neurons

(2011) Steven J. Greco et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Brain aging, Alzheimer's disease, and mitochondria

(2011) Russell H. Swerdlow   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Disruption of the circadian clock due to theClockmutation has discrete effects on aging and carcinogenesis

(2011) Marina P. Antoch et al.   CELL CYCLE

Basic Mechanisms Involved in the Anti-Cancer Effects of Melatonin

(2011) M. D. Mediavilla et al.   CURRENT MEDICINAL CHEMISTRY

Dissecting systemic control of metabolism and aging in the NAD World: The importance of SIRT1 and NAMPT-mediated NAD biosynthesis

(2011) Shin-ichiro Imai   FEBS LETTERS

Sirtuins at a glance

(2011) T. Nakagawa et al.   JOURNAL OF CELL SCIENCE

Age-Related Decline in Circadian Output

(2011) T. J. Nakamura et al.   JOURNAL OF NEUROSCIENCE

Melatonin: Both master clock output and internal time-giver in the circadian clocks network

(2011) Paul Pevet et al.   JOURNAL OF PHYSIOLOGY-PARIS

Melatonin attenuates kainic acid-induced neurotoxicity in mouse hippocampus via inhibition of autophagy and α-synuclein aggregation

(2011) Chia-Fu Chang et al.   JOURNAL OF PINEAL RESEARCH

Neurons from senescence-accelerated SAMP8 mice are protected against frailty by the sirtuin 1 promoting agents melatonin and resveratrol

(2011) Rosa Cristòfol et al.   JOURNAL OF PINEAL RESEARCH

Caloric restriction

(2011) John R. Speakman et al.   MOLECULAR ASPECTS OF MEDICINE

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype

(2011) Julie E. Simpson et al.   NEUROBIOLOGY OF AGING

Circadian regulation of mammalian target of rapamycin signaling in the mouse suprachiasmatic nucleus

(2011) R. Cao et al.   NEUROSCIENCE

Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease

(2011) Yuncheng Wu et al.   NEUROSIGNALS

Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats

(2011) Nady Braidy et al.   PLoS One

Does Reduced IGF-1R Signaling in Igf1r+/− Mice Alter Aging?

(2011) Alex F. Bokov et al.   PLoS One

Neurodegeneration in an animal model of Parkinson's disease is exacerbated by a high-fat diet

(2010) Jill K. Morris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Distribution Analysis of Deacetylase SIRT1 in Rodent and Human Nervous Systems

(2010) Sherry M. Zakhary et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Circadian regulation of cell cycle: Molecular connections between aging and the circadian clock

(2010) Rohini V. Khapre et al.   ANNALS OF MEDICINE

Epigenetic Control of Aging

(2010) Ursula Muñoz-Najar et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting Forkhead Box O1 from the Concept to Metabolic Diseases: Lessons from Mouse Models

(2010) Zhiyong Cheng et al.   ANTIOXIDANTS & REDOX SIGNALING

PI3K/Akt/mTOR signaling regulates glutamate transporter 1 in astrocytes

(2010) Xiaofeng Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of Longevinex (modified resveratrol) on cardioprotection and its mechanisms of action

(2010) Subhendu Mukherjee et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10

(2010) Gizem Donmez et al.   CELL

Circadian rhythms and cancer

(2010) Sigal Gery et al.   CELL CYCLE

Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes

(2010) Nirmala Hariharan et al.   CIRCULATION RESEARCH

AKT and TOR Signaling Set the Pace of the Circadian Pacemaker

(2010) Xiangzhong Zheng et al.   CURRENT BIOLOGY

Roles of FoxO1 and Sirt1 in the central regulation of food intake

(2010) Tsutomu Sasaki et al.   ENDOCRINE JOURNAL

Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via Agouti-Related Peptide

(2010) Tsutomu Sasaki et al.   ENDOCRINOLOGY

SIRT2 regulates NF- B-dependent gene expression through deacetylation of p65 Lys310

(2010) K. M. Rothgiesser et al.   JOURNAL OF CELL SCIENCE

Agrp Neurons Mediate Sirt1's Action on the Melanocortin System and Energy Balance: Roles for Sirt1 in Neuronal Firing and Synaptic Plasticity

(2010) M. O. Dietrich et al.   JOURNAL OF NEUROSCIENCE

Mammalian Target of Rapamycin Signaling Modulates Photic Entrainment of the Suprachiasmatic Circadian Clock

(2010) R. Cao et al.   JOURNAL OF NEUROSCIENCE

SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity

(2010) S. Michan et al.   JOURNAL OF NEUROSCIENCE

The mechanism for the neuroprotective effect of melatonin against methamphetamine-induced autophagy

(2010) Chutikorn Nopparat et al.   JOURNAL OF PINEAL RESEARCH

The molecular basis of longevity, and clinical implications

(2010) Francine Z. Marques et al.   MATURITAS

A novel pathway regulates memory and plasticity via SIRT1 and miR-134

(2010) Jun Gao et al.   NATURE

Cytosolic FoxO1: alive and killing

(2010) René H. Medema et al.   NATURE CELL BIOLOGY

Plasticity and specificity of the circadian epigenome

(2010) Selma Masri et al.   NATURE NEUROSCIENCE

Circadian rhythms and memory formation

(2010) Jason R. Gerstner et al.   NATURE REVIEWS NEUROSCIENCE

The histone methyltransferase MLL1 permits the oscillation of circadian gene expression

(2010) Sayako Katada et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

Spatial Memory Consolidation is Associated with Induction of Several Lysine-Acetyltransferase (Histone Acetyltransferase) Expression Levels and H2B/H4 Acetylation-Dependent Transcriptional Events in the Rat Hippocampus

(2010) Olivier Bousiges et al.   NEUROPSYCHOPHARMACOLOGY

Expanding the definition of hypothalamic obesity

(2010) I. Hochberg et al.   Obesity Reviews

SIRT1 Negatively Regulates the Mammalian Target of Rapamycin

(2010) Hiyaa Singhee Ghosh et al.   PLoS One

Circadian Integration of Metabolism and Energetics

(2010) J. Bass et al.   SCIENCE

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Circadian clocks: genes, sleep, and cognition

(2010) Charalambos P. Kyriacou et al.   TRENDS IN COGNITIVE SCIENCES

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer

(2010) Daniel Herranz et al.   Nature Communications

The role of epigenetics in aging and age-related diseases

(2009) Vincenzo Calvanese et al.   AGEING RESEARCH REVIEWS

Circadian temperature variation and ageing

(2009) Dietmar Weinert   AGEING RESEARCH REVIEWS

Expression of the Circadian Clock Gene Period2 in the Hippocampus: Possible Implications for Synaptic Plasticity and Learned Behaviour

(2009) Louisa M-C Wang et al.   ASN Neuro

Upregulation of Beclin-1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell death

(2009) Kyung-Jin Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of histone methylation multiplicities patterns in the brain of senescence-accelerated prone mouse 8

(2009) Chun Mei Wang et al.   BIOGERONTOLOGY

Effect of melatonin on age induced changes in daily serotonin rhythms in suprachiasmatic nucleus of male Wistar rat

(2009) Anita Jagota et al.   BIOGERONTOLOGY

Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation

(2009) Hyunkyung Jeong et al.   CELL

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

Calorie restriction and the exercise of chromatin

(2009) A. Vaquero et al.   GENES & DEVELOPMENT

Atg17 recruits Atg9 to organize the pre-autophagosomal structure

(2009) Takayuki Sekito et al.   GENES TO CELLS

FoxO Transcription Factors Promote Autophagy in Cardiomyocytes

(2009) Arunima Sengupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Autophagy by the p300 Acetyltransferase

(2009) In Hye Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of rhythmic melatonin administration on clock gene expression in the suprachiasmatic nucleus and the heart of hypertensive TGR(mRen2)27 rats

(2009) Michal Zeman et al.   JOURNAL OF HYPERTENSION

An evaluation of the neuroprotective effects of melatonin in an in vitro experimental model of age-induced neuronal apoptosis

(2009) Marta Tajes Orduña et al.   JOURNAL OF PINEAL RESEARCH

Melatonin preserves longevity protein (sirtuin 1) expression in the hippocampus of total sleep-deprived rats

(2009) Hung-Ming Chang et al.   JOURNAL OF PINEAL RESEARCH

Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway

(2009) M. Tajes et al.   JOURNAL OF PINEAL RESEARCH

Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer

(2009) Brittney Jung-Hynes et al.   JOURNAL OF PINEAL RESEARCH

Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response

(2009) Z. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Autophagy genes in immunity

(2009) Herbert W Virgin et al.   NATURE IMMUNOLOGY

NEU-P11, a novel melatonin agonist, inhibits weight gain and improves insulin sensitivity in high-fat/high-sucrose-fed rats

(2009) Meihua She et al.   PHARMACOLOGICAL RESEARCH

Hypothalamic Sirt1 Regulates Food Intake in a Rodent Model System

(2009) Işin Çakir et al.   PLoS One

Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1

(2009) Y. Nakahata et al.   SCIENCE

Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis

(2009) K. M. Ramsey et al.   SCIENCE

Impact of reduced insulin-like growth factor-1/insulin signaling on aging in mammals: novel findings

(2008) Andrzej Bartke   AGING CELL

Autophagy: Principles and significance in health and disease

(2008) Virginia Todde et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Role of melatonin in the epigenetic regulation of breast cancer

(2008) Ahmet Korkmaz et al.   BREAST CANCER RESEARCH AND TREATMENT

Frequent silencing of a putative tumor suppressor gene melatonin receptor 1 A (MTNR1A) in oral squamous-cell carcinoma

(2008) Erina Nakamura et al.   CANCER SCIENCE

The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

(2008) Yasukazu Nakahata et al.   CELL

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL

Melatonin, hormone of darkness and more – occurrence, control mechanisms, actions and bioactive metabolites

(2008) R. Hardeland   CELLULAR AND MOLECULAR LIFE SCIENCES

Non-Visual Photoreception: Sensing Light without Sight

(2008) Russell N. Van Gelder   CURRENT BIOLOGY

Clinically relevant concentrations of valproic acid modulate melatonin MT1 receptor, HDAC and MeCP2 mRNA expression in C6 glioma cells

(2008) Bora Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8

(2008) Toshimitsu Komatsu et al.   EXPERIMENTAL GERONTOLOGY

Akt-dependent regulation of NF- B is controlled by mTOR and Raptor in association with IKK

(2008) H. C. Dan et al.   GENES & DEVELOPMENT

Role of the GH/IGF-1 axis in lifespan and healthspan: Lessons from animal models

(2008) Darlene E. Berryman et al.   GROWTH HORMONE & IGF RESEARCH

Chromatin remodeling, metabolism and circadian clocks: The interplay of CLOCK and SIRT1

(2008) Benedetto Grimaldi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Decline of the Presynaptic Network, Including GABAergic Terminals, in the Aging Suprachiasmatic Nucleus of the Mouse

(2008) Maria Palomba et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Potential role of tryptophan derivatives in stress responses characterized by the generation of reactive oxygen and nitrogen species

(2008) Fabienne Peyrot et al.   JOURNAL OF PINEAL RESEARCH

Melatonin prevents the injury-induced decline of Akt/forkhead transcription factors phosphorylation

(2008) Phil-Ok Koh   JOURNAL OF PINEAL RESEARCH

Epigenetic targets for melatonin: induction of histone H3 hyperacetylation and gene expression in C17.2 neural stem cells

(2008) Rohita Sharma et al.   JOURNAL OF PINEAL RESEARCH

Evaluation of potential pro-survival pathways regulated by melatonin in a murine senescence model

(2008) Javier Gutierrez-Cuesta et al.   JOURNAL OF PINEAL RESEARCH

Melatonin attenuates methamphetamine-induced deactivation of the mammalian target of rapamycin signaling to induce autophagy in SK-N-SH cells

(2008) Patthara Kongsuphol et al.   JOURNAL OF PINEAL RESEARCH

The melatonin receptor MT1 is required for the differential regulatory actions of melatonin on neuronal ‘clock’ gene expression in striatal neurons in vitro

(2008) Marta Imbesi et al.   JOURNAL OF PINEAL RESEARCH

Prolonged Classical NF-κB Activation Prevents Autophagy uponE. coliStimulation In Vitro: A Potential Resolving Mechanism of Inflammation

(2008) Silke Schlottmann et al.   MEDIATORS OF INFLAMMATION

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Circadian oscillation of hippocampal MAPK activity and cAMP: implications for memory persistence

(2008) Kristin L Eckel-Mahan et al.   NATURE NEUROSCIENCE

Valproic Acid and CEBPα-Mediated Regulation of Adipokine Gene Expression in Hypothalamic Neurons and 3T3-L1 Adipocytes

(2008) Russell Brown et al.   NEUROENDOCRINOLOGY

Paths of Convergence: Sirtuins in Aging and Neurodegeneration

(2008) Li Gan et al.   NEURON

Melatonin inhibits amphetamine-induced increase in α-synuclein and decrease in phosphorylated tyrosine hydroxylase in SK–N–SH cells

(2008) Sirirat Klongpanichapak et al.   NEUROSCIENCE LETTERS

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of macroautophagy by mTOR and Beclin 1 complexes

(2007) Sophie Pattingre et al.   BIOCHIMIE

Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice

(2007) Pu Wu et al.   NEUROBIOLOGY OF AGING

Loss of responsiveness to melatonin in the aging mouse suprachiasmatic nucleus

(2006) Charlotte von Gall et al.   NEUROBIOLOGY OF AGING