Rapamycin Treatment Improves Neuron Viability in an In Vitro Model of Stroke

Rapamycin protects against middle cerebral artery occlusion induced focal cerebral ischemia in rats

(2011) Anjali Chauhan et al.   BEHAVIOURAL BRAIN RESEARCH

Mammalian Target of Rapamycin: Hitting the Bull's-Eye for Neurological Disorders

(2011) Zhao Zhong Chong et al.   Oxidative Medicine and Cellular Longevity

Stroke Declines From Third to Fourth Leading Cause of Death in the United States

(2011) Amytis Towfighi et al.   STROKE

Broadening the therapeutic scope for rapamycin treatment

(2010) Fiona M. Menzies et al.   Autophagy

Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia-ischemia

(2010) Silvia Carloni et al.   Autophagy

The protective effects of chitooligosaccharides against glucose deprivation-induced cell apoptosis in cultured cortical neurons through activation of PI3K/Akt and MEK/ERK1/2 pathways

(2010) Yanyan Xu et al.   BRAIN RESEARCH

Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway

(2010) Yajing Yuan et al.   BRAIN RESEARCH

Executive Summary: Heart Disease and Stroke Statistics—2010 Update

(2010) et al.   CIRCULATION

Mammalian Target of Rapamycin (mTOR): Conducting the Cellular Signaling Symphony

(2010) Kathryn G. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of mTOR Signaling in Controlling Mammalian Life Span: What a Fungicide Teaches Us About Longevity

(2010) Z. D. Sharp et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

PI-3-K and AKT: Onto the mitochondria☆

(2009) Bangyan L. Stiles   ADVANCED DRUG DELIVERY REVIEWS

Dissecting the role of mTOR: Lessons from mTOR inhibitors

(2009) Ryan J.O. Dowling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

TORC-Specific Phosphorylation of Mammalian Target of Rapamycin (mTOR): Phospho-Ser2481 Is a Marker for Intact mTOR Signaling Complex 2

(2009) J. Copp et al.   CANCER RESEARCH

Involvement of Akt in neurite outgrowth

(2009) Danielle E. Read et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Reperfusion for acute ischemic stroke: arterial revascularization and collateral therapeutics

(2009) David S Liebeskind   CURRENT OPINION IN NEUROLOGY

Growth suppressive cytokines and the AKT/mTOR pathway

(2009) Barbara Kroczynska et al.   CYTOKINE

Current Perspectives on Akt Akt-ivation and Akt-ions

(2009) Ronald W. Matheny et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Ischemic Postconditioning as a Novel Avenue to Protect against Brain Injury after Stroke

(2009) Heng Zhao   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival

(2009) Kuniyasu Niizuma et al.   JOURNAL OF NEUROCHEMISTRY

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Apoptotic Mechanisms After Cerebral Ischemia

(2009) Brad R.S. Broughton et al.   STROKE

Cellular oxygen sensing, signalling and how to survive translational arrest in hypoxia

(2008) M. Fähling   Acta Physiologica

Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1

(2008) M. Rosner et al.   HUMAN MOLECULAR GENETICS

Investigating the Mechanisms Underlying Neuronal Death in Ischemia Using In Vitro Oxygen-Glucose Deprivation: Potential Involvement of Protein SUMOylation

(2008) Helena Cimarosti et al.   NEUROSCIENTIST

Immunosuppression after traumatic or ischemic CNS damage: It is neuroprotective and illuminates the role of microglial cells

(2007) Nils P. Hailer   PROGRESS IN NEUROBIOLOGY