Article
Biotechnology & Applied Microbiology
Yuanzhe Zhu, Huala Wu, Xi Yang, Zhijuan Xiong, Tiantian Zhao, Xin Gan
Summary: This study revealed that LINC00514 is upregulated in NSCLC and plays a role in the proliferation, migration, and invasion of NSCLC cells through activation of the Wnt/β-catenin pathway and EMT. Silencing LINC00514 restored the biological phenotypes of NSCLC cells by inhibiting the Wnt/β-catenin pathway. Additionally, silencing LINC00514 attenuated the growth of xenograft tumors in vivo.
Article
Biotechnology & Applied Microbiology
Tao Xueqin, Mei Jinhong, Huang Yuping
Summary: INHBA is highly expressed in breast cancer cells and acts as an oncogene by activating the Wnt/beta-catenin pathway, providing a potential therapeutic target for the treatment of breast cancer.
Article
Multidisciplinary Sciences
Jinshi Zhang, Wenjin Wei, Qinglin Zhong, Kaiming Feng, Ruijin Yang, Qiuhua Jiang
Summary: This study discovered a significant increase in BUB1 expression in glioma and its correlation with a high World Health Organization grade and poor prognosis in glioma patients. Additionally, BUB1 not only promotes glioma cell proliferation, migration, and infiltration but also triggers epithelial-mesenchymal transition through the activation of the Wnt/beta-catenin axis. Therefore, BUB1 may have the potential to serve as a target for GBM management.
Article
Oncology
Jiarui Yu, Wei Wang, Baolin Liu, Jinling Gu, Siyuan Chen, Yishuang Cui, Guogui Sun
Summary: T-96 inhibits the proliferation and migration of esophageal cancer cells through Wnt/beta-catenin pathway, leading to cell cycle arrest and apoptosis, providing a potential treatment for esophageal squamous cell carcinoma.
Article
Oncology
Qingchao Meng, Lei Li, Liping Wang
Summary: This study found that CBX8 is highly expressed in laryngeal squamous cell carcinoma (LSCC), and it induces the epithelial to mesenchymal transition (EMT) process by activating the Wnt/β-catenin signaling pathway, promoting LSCC cell proliferation and migration, and inhibiting apoptosis, resulting in poor prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jianlian Xie, Jun Zhou, Jiliang Xia, Ying Zeng, Guo Huang, Weihong Zeng, Tingyu Fan, Lili Li, Xi Zeng, Qian Tao
Summary: PLCD1 is frequently downregulated in renal cell carcinoma (RCC) due to promoter CpG methylation. Restoring PLCD1 expression inhibits RCC cell viability and migration, causes cell cycle arrest and apoptosis. Additionally, PLCD1 suppresses WNT/beta-catenin and EGFR-FAK-ERK signaling and the EMT program in RCC cells.
CLINICAL EPIGENETICS
(2023)
Article
Cell Biology
Cheng-Yu Tsai, Huey-Jiun Ko, Shean-Jaw Chiou, Xin-Yi Lin, Tsung-Hsien Chuang, Jiin-Tsuey Cheng, Yu-Feng Su, Joon-Khim Loh, Yi-Ren Hong
Summary: GSKIP functions as an oncogene in SH-SY5Y cells by promoting cell survival through EMT/MET and inhibiting cell migration and tumorigenesis via the Wnt/beta-catenin pathway.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2023)
Article
Anatomy & Morphology
Yange Wu, Wenxiu Chen, Bo Zhang, Hongxia Liu
Summary: This study found that ANKRD22 is highly expressed in papillary thyroid carcinoma and its knockdown can inhibit the growth and migration of cancer cells by regulating the Wnt/β-catenin signaling pathway.
Article
Oncology
Yanqiu Bao, Jingshu Cui, Yuyang Yue, Shuxia Cao, Xiangdan Li, Lan Liu
Summary: Ebp1 is highly expressed in malignant melanoma and is associated with clinical stage and lymph node metastases. Knockdown of Ebp1 inhibits cell proliferation, migration, and invasion in melanoma. Ebp1 may promote the proliferation and metastasis of melanoma cells through activation of the Wnt/β-catenin pathway.
CANCER CELL INTERNATIONAL
(2022)
Article
Microbiology
Chongyang Wang, Ruochen Hu, Liuyuan Duan, Qili Hou, Mengqing Yang, Ting Wang, Haijin Liu, Sa Xiao, Ruyi Dang, Juan Wang, Xinglong Wang, Shuxia Zhang, Zengqi Yang
Summary: This study showed that pseudorabies virus (PRV) infection activates the Wnt/beta-catenin signaling pathway, leading to enhanced virus proliferation and regulation of virus-induced autophagy. Inhibitors of this pathway can reduce PRV titers, while stimulation of the pathway can enhance PRV proliferation. These findings provide potential targets for the development of antiviral agents against PRV.
VETERINARY MICROBIOLOGY
(2022)
Article
Respiratory System
Xiaoshan Su, Junjie Chen, Xiaoping Lin, Xiaoyang Chen, Zhixing Zhu, Weijing Wu, Hai Lin, Jianming Wang, Xiangjia Ye, Yiming Zeng
Summary: This study identified that FERMT3 is downregulated in COPD patients and is associated with CSE-induced EMT. Overexpression of FERMT3 can inhibit CSE-induced EMT and regulate this process through the Wnt/beta-catenin signaling pathway.
RESPIRATORY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Yutao Li, Shanhe Wang, Wei Sun
Summary: SRY-box transcription factor 18 (SOX18) is expressed in dermal papilla cells (DPCs) of sheep hair follicles and plays a crucial role in promoting DPC proliferation through activating the Wnt/β-Catenin signaling pathway. Inhibition of the Wnt/β-Catenin signaling pathway can be rescued by SOX18, suggesting the essential role of SOX18 in governing DPC proliferation and hair growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Yinhua Jin, Teni Anbarchian, Peng Wu, Abby Sarkar, Matt Fish, Weng Chuan Peng, Roel Nusse
Summary: Cell proliferation is tightly regulated by various factors, including transcriptional repressors E2F7 and E2F8. In this study, it was discovered that Wnt/β-catenin signaling maintains active cell division in the liver through the transcription factor Tbx3. Tbx3 directly represses the transcription of E2f7 and E2f8, thereby promoting mitosis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Jun Zhang, Xian Zhang, Shasha Yang, Yanqiu Bao, Dongyuan Xu, Lan Liu
Summary: The study demonstrated that higher FOXH1 expression is associated with poor overall survival in lung cancer patients. Knockdown of FOXH1 inhibited lung cancer cell proliferation, migration, invasion, and cycle, highlighting FOXH1's potential as a therapeutic target in certain types of lung cancer.
CANCER CELL INTERNATIONAL
(2021)
Article
Biotechnology & Applied Microbiology
Zhi Fang, Min Zhong, Ling Zhou, Yi Le, Heng Wang, Ziling Fang
Summary: LRP8 is markedly overexpressed in NSCLC tissues and cell lines, correlating with poor clinicopathological characteristics and prognosis. Depletion of LRP8 suppresses proliferation, migration, invasion, and epithelial-mesenchymal transition of NSCLC cells, partly by inhibiting the Wnt/beta-catenin pathway.
Article
Biochemistry & Molecular Biology
Yanxia Fu, Yanhua Kong, Jun Li, Yi Wang, Mengdi Li, Ying Wang, Yinyin Wang, Fangli Ren, Jian Ni, Youlin Li, Zhijie Chang
JOURNAL OF CELLULAR BIOCHEMISTRY
(2020)
Article
Oncology
Hui Liu, Ann L. B. Seynhaeve, Rutger W. W. Brouwer, Wilfred F. J. van IJcken, Liu Yang, Yinyin Wang, Zhijie Chang, Timo L. M. ten Hagen
Article
Biochemistry & Molecular Biology
Pengfei Zhang, Chaonan Li, Hongchang Li, Lin Yuan, Hongmiao Dai, Zhiqiang Peng, Zhikang Deng, Zhijie Chang, Chun-Ping Cui, Lingqiang Zhang
CELL DEATH AND DIFFERENTIATION
(2020)
Article
Genetics & Heredity
Manli Zhang, Zhijie Chang, Yaping Tian, Longxia Wang, Yanping Lu
JOURNAL OF HUMAN GENETICS
(2020)
Article
Immunology
Sihan Liu, Yanxia Fu, Kunrong Mei, Yinan Jiang, Xiaojun Sun, Yinyin Wang, Fangli Ren, Congshan Jiang, Liesu Meng, Shemin Lu, Zhihai Qin, Chen Dong, Xinquan Wang, Zhijie Chang, Shigao Yang
Summary: The study found that in rheumatoid arthritis, soluble glycosylated interleukin-17 receptor D (sIL-17RD) exacerbates the disease by enhancing the proinflammatory response induced by TNF-alpha. The shedding of IL-17RD is regulated by the proteolytic enzyme TACE and is enhanced by TNF-alpha expression in macrophages, suggesting it may be a new target for the therapy of RA.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mengdi Li, Danhui Ma, Zhijie Chang
Summary: CREPT and p15RS are RPRD proteins that regulate cell proliferation and tumorigenesis, with opposite functions. Aberrant expression of both proteins is found in cancers. They both interact with RNA polymerase II, but CREPT also plays a key role in DNA damage repair.
Article
Multidisciplinary Sciences
Liu Yang, Haiyan Yang, Yunxiang Chu, Yunhao Song, Lidan Ding, Bingtao Zhu, Wanli Zhai, Xuning Wang, Yanshen Kuang, Fangli Ren, Baoqing Jia, Wei Wu, Xiongjun Ye, Yinyin Wang, Zhijie Chang
Summary: This study reveals the essential role of CREPT in maintaining murine intestinal stem cells, with its deficiency impairing cell proliferation and regeneration. The downregulation of Wnt signaling due to CREPT deletion is identified as a key mechanism affecting ISC function.
NATURE COMMUNICATIONS
(2021)
Article
Microbiology
Qingqing Qin, Guangyao Li, Lian Jin, Yu Huang, Yu Wang, Chunhong Wei, Zhihong Xu, Zhirui Yang, Haiyang Wang, Yi Li
Article
Oncology
Wanli Zhai, Xiongjun Ye, Yinyin Wang, Yarui Feng, Ying Wang, Yuting Lin, Lidan Ding, Liu Yang, Xuning Wang, Yanshen Kuang, Xinyuan Fu, Y. Eugene Chin, Baoqing Jia, Bingtao Zhu, Fangli Ren, Zhijie Chang
Summary: The study reveals that CREPT acts as a co-activator of STAT3 to enhance its transcriptional activity and promote tumorigenesis. CREPT interacts with phosphorylated STAT3 (p-STAT3) to recruit p300 to the promoters of STAT3-targeted genes, facilitating histone acetylation and RNA polymerase II recruitment. Depletion of p300 abolishes the enhanced STAT3 transcriptional activity mediated by CREPT.
BRITISH JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Jin Sun, Xia Wang, Rong-Gang Xu, Decai Mao, Da Shen, Xin Wang, Yuhao Qiu, Yuting Han, Xinyi Lu, Yutong Li, Qinyun Che, Li Zheng, Ping Peng, Xuan Kang, Ruibao Zhu, Yu Jia, Yinyin Wang, Lu-Ping Liu, Zhijie Chang, Jun-Yuan Ji, Zhao Wang, Qingfei Liu, Shao Li, Fang-Lin Sun, Jian-Quan Ni
Summary: The study identifies HP1c as an essential epigenetic regulator of gut homeostasis in Drosophila, demonstrating its role in suppressing Notch signaling by interacting with key components of the pathway. The depletion of HP1c in Drosophila can be rescued by expressing human HP1 gamma, indicating its functional similarity to HP1c in Drosophila.
Article
Biochemistry & Molecular Biology
Qiong Wu, Yaping Huang, Liya Gu, Zhijie Chang, Guo-Min Li
Summary: The study reveals that OTUB1 inhibits MSH2 ubiquitination and suggests that OTUB1 could be a potential biomarker for cancer etiology and therapy.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Dongdong Hao, Lian Jin, Xing Wen, Feifei Yu, Qi Xie, Hongwei Guo
Summary: The RING-type E3 ligase SDIR1 plays a key role in regulating ethylene response and promoting EIN3 accumulation, especially in response to temperature changes, enhancing plant adaptation under fluctuating environmental conditions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell & Tissue Engineering
Yanxia Fu, Jun Li, Mengdi Li, Junfeng Xu, Zheng Rong, Fangli Ren, Yinyin Wang, Jianqiu Sheng, Zhijie Chang
Summary: This study revealed the role of human umbilical cord mesenchymal stem cells (HUC-MSCs) in inhibiting tumorigenesis through regulating the inflammatory response.
STEM CELLS INTERNATIONAL
(2022)
Article
Plant Sciences
Renkang Guo, Xing Wen, Wei Zhang, Li Huang, Yang Peng, Lian Jin, Huihui Han, Linlin Zhang, Wenyang Li, Hongwei Guo
Summary: The molecular mechanisms underlying the antagonistic effects of the plant hormones ethylene and abscisic acid (ABA) on seed germination and early seedling establishment are unclear. This study uncovered an independent role for ETHYLENE INSENSITIVE 2 (EIN2) in regulating the ABA response, which depends on the positive regulator of ABA responses, HOOKLESS 1 (HLS1). Protein interaction assays supported a direct physical interaction between EIN2 and HLS1. The study revealed that EIN2 modulates ABA responses by repressing HLS1 function, independently of the canonical ethylene pathway.
Article
Medicine, Research & Experimental
Danhui Ma, Yutian Zou, Yunxiang Chu, Zhengsheng Liu, Gaochao Liu, Jun Chu, Mengdi Li, Jiayu Wang, Shi-yong Sun, Zhijie Chang