New perspectives on the involvement of mTOR in depression as well as in the action of antidepressant drugs

Two cellular hypotheses explaining the initiation of ketamine's antidepressant actions: Direct inhibition and disinhibition

(2016) Oliver H. Miller et al.   NEUROPHARMACOLOGY

NMDA receptor activation regulates sociability by its effect on mTOR signaling activity

(2015) Jessica A. Burket et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Involvement of normalized NMDA receptor and mTOR-related signaling in rapid antidepressant effects of Yueju and ketamine on chronically stressed mice

(2015) Juanjuan Tang et al.   Scientific Reports

AMPA Receptor–mTOR Activation is Required for the Antidepressant-Like Effects of Sarcosine during the Forced Swim Test in Rats: Insertion of AMPA Receptor may Play a Role

(2015) Kuang-Ti Chen et al.   Frontiers in Behavioral Neuroscience

Differential effects of antidepressant drugs on mTOR signalling in rat hippocampal neurons

(2014) Sung Woo Park et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The role of mTOR in depression and antidepressant responses

(2014) Helena M. Abelaira et al.   LIFE SCIENCES

REDD1 is essential for stress-induced synaptic loss and depressive behavior

(2014) Kristie T Ota et al.   NATURE MEDICINE

Driving neural regeneration through the mammalian target of rapamycin

(2014) Kenneth Maiese   Neural Regeneration Research

Monoacylglycerol Lipase Inhibition Blocks Chronic Stress-Induced Depressive-Like Behaviors via Activation of mTOR Signaling

(2014) Peng Zhong et al.   NEUROPSYCHOPHARMACOLOGY

Epigenetic and epistatic interactions between serotonin transporter and brain-derived neurotrophic factor genetic polymorphism: Insights in depression

(2014) Z.M. Ignácio et al.   NEUROSCIENCE

GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine

(2014) Oliver H Miller et al.   eLife

mTOR signaling and its roles in normal and abnormal brain development

(2014) Nobuyuki Takei et al.   Frontiers in Molecular Neuroscience

Scopolamine Rapidly Increases Mammalian Target of Rapamycin Complex 1 Signaling, Synaptogenesis, and Antidepressant Behavioral Responses

(2013) Bhavya Voleti et al.   BIOLOGICAL PSYCHIATRY

Activation of Mammalian Target of Rapamycin and Synaptogenesis: Role in the Actions of Rapid-Acting Antidepressants

(2013) Jason M. Dwyer et al.   BIOLOGICAL PSYCHIATRY

Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex

(2013) W. Zhou et al.   EUROPEAN PSYCHIATRY

Glycine site N-methyl-D-aspartate receptor antagonist 7-CTKA produces rapid antidepressant-like effects in male rats

(2013) Wei-Li Zhu et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

GSK-3 Inhibition Potentiates the Synaptogenic and Antidepressant-Like Effects of Subthreshold Doses of Ketamine

(2013) Rong-Jian Liu et al.   NEUROPSYCHOPHARMACOLOGY

Effect of treadmill exercise on the BDNF-mediated pathway in the hippocampus of stressed rats

(2013) Zheng Huan Fang et al.   NEUROSCIENCE RESEARCH

Effects of lamotrigine on behavior, oxidative parameters and signaling cascades in rats exposed to the chronic mild stress model

(2013) Helena M. Abelaira et al.   NEUROSCIENCE RESEARCH

Pharmacological blockade of GluN2B-containing NMDA receptors induces antidepressant-like effects lacking psychotomimetic action and neurotoxicity in the perinatal and adult rodent brain

(2013) Juan M. Lima-Ojeda et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Antidepressant effects of AMPA and ketamine combination: role of hippocampal BDNF, synapsin, and mTOR

(2013) Luli Akinfiresoye et al.   PSYCHOPHARMACOLOGY

Imipramine reverses alterations in cytokines and BDNF levels induced by maternal deprivation in adult rats

(2012) Gislaine Z. Rus et al.   BEHAVIOURAL BRAIN RESEARCH

The Stability of NR2B in the Nucleus Accumbens Controls Behavioral and Synaptic Adaptations to Chronic Stress

(2012) Bo Jiang et al.   BIOLOGICAL PSYCHIATRY

Antidepressant Effects of the Muscarinic Cholinergic Receptor Antagonist Scopolamine: A Review

(2012) Wayne C. Drevets et al.   BIOLOGICAL PSYCHIATRY

Rapid and Longer-Term Antidepressant Effects of Repeated Ketamine Infusions in Treatment-Resistant Major Depression

(2012) James W. Murrough et al.   BIOLOGICAL PSYCHIATRY

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Tramadol Pretreatment Enhances Ketamine-Induced Antidepressant Effects and Increases Mammalian Target of Rapamycin in Rat Hippocampus and Prefrontal Cortex

(2012) Chun Yang et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Reduced phosphorylation of the mTOR signaling pathway components in the amygdala of rats exposed to chronic stress

(2012) Agata Chandran et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Acute administration of ketamine in rats increases hippocampal BDNF and mTOR levels during forced swimming test

(2012) Chun Yang et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression

(2011) Hiroyuki Koike et al.   BEHAVIOURAL BRAIN RESEARCH

Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure

(2011) Nanxin Li et al.   BIOLOGICAL PSYCHIATRY

Beyond the glutamate N-methyl D-aspartate receptor in major depressive disorder: the mTOR signaling pathway / Majör depresif bozuklukta glutamat N-metil-D-aspartat reseptörlerinin ötesi: mTOR sinyal yolağı

(2011) Beata Karolewicz et al.   KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY

Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice

(2011) E Beurel et al.   MOLECULAR PSYCHIATRY

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

Signaling pathways underlying the rapid antidepressant actions of ketamine

(2011) Ronald S. Duman et al.   NEUROPHARMACOLOGY

Long-Term Continuous Corticosterone Treatment Decreases VEGF Receptor-2 Expression in Frontal Cortex

(2011) Kristy R. Howell et al.   PLoS One

Rapid decrease in depressive symptoms with an N-methyl-d-aspartate antagonist in ECT-resistant major depression

(2011) Lobna Ibrahim et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder

(2011) Courtney S. Jernigan et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression

(2010) Nancy Diazgranados et al.   ARCHIVES OF GENERAL PSYCHIATRY

Replication of Scopolamine's Antidepressant Efficacy in Major Depressive Disorder: A Randomized, Placebo-Controlled Clinical Trial

(2010) Wayne C. Drevets et al.   BIOLOGICAL PSYCHIATRY

TOR on the brain

(2010) Michael G. Garelick et al.   EXPERIMENTAL GERONTOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Peripheral BDNF Produces Antidepressant-Like Effects in Cellular and Behavioral Models

(2010) Heath D Schmidt et al.   NEUROPSYCHOPHARMACOLOGY

Fluoxetine treatment induces dose dependent alterations in depression associated behavior and neural plasticity in female mice

(2010) Georgia E. Hodes et al.   NEUROSCIENCE LETTERS

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Biomarkers to Predict Antidepressant Response

(2010) Andrew F. Leuchter et al.   Current Psychiatry Reports

Brain-derived Neurotrophic Factor Enhances the Basal Rate of Protein Synthesis by Increasing Active Eukaryotic Elongation Factor 2 Levels and Promoting Translation Elongation in Cortical Neurons

(2009) Nobuyuki Takei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BDNF-Induced Changes in the Expression of the Translation Machinery in Hippocampal Neurons: Protein Levels and Dendritic mRNA

(2009) Bruno Manadas et al.   JOURNAL OF PROTEOME RESEARCH

mTOR signaling: At the crossroads of plasticity, memory and disease

(2009) Charles A. Hoeffer et al.   TRENDS IN NEUROSCIENCES

The Role of AMPA receptor modulation in the treatment of neuropsychiatric diseases

(2008) Carlos A. Zarate et al.   EXPERIMENTAL NEUROLOGY

An Innovative Design to Establish Proof of Concept of the Antidepressant Effects of the NR2B Subunit Selective N-Methyl-D-Aspartate Antagonist, CP-101,606, in Patients With Treatment-Refractory Major Depressive Disorder

(2008) Sheldon H. Preskorn et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Age-dependent effects of chronic stress on brain plasticity and depressive behavior

(2008) Erika Toth et al.   JOURNAL OF NEUROCHEMISTRY

Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders

(2008) Gerard Sanacora et al.   NATURE REVIEWS DRUG DISCOVERY

Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors

(2007) Sungho Maeng et al.   BIOLOGICAL PSYCHIATRY

Vascular endothelial growth factor (VEGF) signaling regulates hippocampal neurons by elevation of intracellular calcium and activation of calcium/calmodulin protein kinase II and mammalian target of rapamycin

(2007) Byung Woo Kim et al.   CELLULAR SIGNALLING