The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease

Soluble TREM2 and Inflammatory Proteins in Alzheimer’s Disease Cerebrospinal Fluid

(2020) Boris-Stephan Rauchmann et al.   JOURNAL OF ALZHEIMERS DISEASE

Changes in synaptic proteins precede neurodegeneration markers in preclinical Alzheimer’s disease cerebrospinal fluid

(2019) Alberto Lleó et al.   MOLECULAR & CELLULAR PROTEOMICS

Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis

(2019) Christopher M. Henstridge et al.   NATURE REVIEWS NEUROSCIENCE

Lowering of Amyloid-Beta by β-Secretase Inhibitors — Some Informative Failures

(2019) David S. Knopman   NEW ENGLAND JOURNAL OF MEDICINE

Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease

(2019) Christopher H. van Dyck et al.   JAMA Neurology

Cerebrospinal fluid and plasma biomarker trajectories with increasing amyloid deposition in Alzheimer's disease

(2019) Sebastian Palmqvist et al.   EMBO Molecular Medicine

Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology

(2018) Erik Portelius et al.   ACTA NEUROPATHOLOGICA

2018 Alzheimer's disease facts and figures

(2018)   Alzheimers & Dementia

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Anti-Amyloid-β Monoclonal Antibodies for Alzheimer’s Disease: Pitfalls and Promise

(2018) Christopher H. van Dyck   BIOLOGICAL PSYCHIATRY

Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach

(2018) Erika Bereczki et al.   BRAIN

Molecular biomarkers of Alzheimer's disease: progress and prospects

(2018) Tammaryn Lashley et al.   Disease Models & Mechanisms

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

(2018) Erika N. Cline et al.   JOURNAL OF ALZHEIMERS DISEASE

Quantitative EEG power and synchronization correlate with Alzheimer's disease CSF biomarkers

(2018) Una Smailovic et al.   NEUROBIOLOGY OF AGING

Dendritic Tau in Alzheimer’s Disease

(2018) Arne Ittner et al.   NEURON

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau

(2018) Joseph McInnes et al.   NEURON

Cognition comes of age: comments on the new FDA draft guidance for early Alzheimer’s disease

(2018) John E. Harrison   Alzheimers Research & Therapy

Prospects for strain-specific immunotherapy in Alzheimer’s disease and tauopathies

(2018) Alice Bittar et al.   npj Vaccines

Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer’s disease

(2018) Eleanor K. Pickett et al.   ACTA NEUROPATHOLOGICA

The intact postsynaptic protein neurogranin is reduced in brain tissue from patients with familial and sporadic Alzheimer’s disease

(2018) Hlin Kvartsberg et al.   ACTA NEUROPATHOLOGICA

OUP accepted manuscript

(2018)   AGE AND AGEING

Efficacy of Souvenaid in Mild Alzheimer's Disease: Results from a Randomized, Controlled Trial

(2018) Philip Scheltens et al.   JOURNAL OF ALZHEIMERS DISEASE

Synapse Stability in the Precuneus Early in the Progression of Alzheimer's Disease

(2018) Stephen W. Scheff et al.   JOURNAL OF ALZHEIMERS DISEASE

Synaptic Change in the Posterior Cingulate Gyrus in the Progression of Alzheimer's Disease

(2018) Stephen W. Scheff et al.   JOURNAL OF ALZHEIMERS DISEASE

Development and In Vivo Preclinical Imaging of Fluorine-18-Labeled Synaptic Vesicle Protein 2A (SV2A) PET Tracers

(2018) Cristian C. Constantinescu et al.   MOLECULAR IMAGING AND BIOLOGY

Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross-seeding behavior

(2018) Gaurav Ghag et al.   PROTEIN SCIENCE

Synthesis and in Vivo Evaluation of a Novel PET Radiotracer for Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) in Nonhuman Primates

(2018) Songye Li et al.   ACS Chemical Neuroscience

Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology

(2018) Åsa Sandelius et al.   Alzheimers & Dementia

Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Emma Nichols et al.   LANCET NEUROLOGY

A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology

(2018) Hongjun Fu et al.   NATURE NEUROSCIENCE

Complementing Tau: New Data Show that the Complement System Is Involved in Degeneration in Tauopathies

(2018) Caitlin Davies et al.   NEURON

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

(2018) Borislav Dejanovic et al.   NEURON

Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease

(2018) Alexandra Litvinchuk et al.   NEURON

Sigma-2 Receptor/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex

(2018) Aladdin Riad et al.   Scientific Reports

Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer’s disease: results of a randomized, double-blind, placebo-controlled phase 2a study

(2018) Philip Scheltens et al.   Alzheimers Research & Therapy

Therapeutics of Neurotransmitters in Alzheimer’s Disease

(2017) Ramesh Kandimalla et al.   JOURNAL OF ALZHEIMERS DISEASE

Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP

(2017) Zemin Wang et al.   JOURNAL OF NEUROSCIENCE

EEG spectral analysis as a putative early prognostic biomarker in nondemented, amyloid positive subjects

(2017) Alida A. Gouw et al.   NEUROBIOLOGY OF AGING

Distinct phenotypes of three-repeat and four-repeat human tau in a transgenic model of tauopathy

(2017) Megan A. Sealey et al.   NEUROBIOLOGY OF DISEASE

Identification of the gene that codes for the σ2receptor

(2017) Assaf Alon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

(2017) Qiaoqiao Shi et al.   Science Translational Medicine

Tau association with synaptic vesicles causes presynaptic dysfunction

(2017) Lujia Zhou et al.   Nature Communications

Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status

(2016) Laura Piccio et al.   ACTA NEUROPATHOLOGICA

Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia

(2016) Erika Bereczki et al.   Alzheimers & Dementia

Meta-analysis of synaptic pathology in Alzheimer's disease reveals selective molecular vesicular machinery vulnerability

(2016) Martijn C. de Wilde et al.   Alzheimers & Dementia

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers

(2016) Marc Suárez‐Calvet et al.   EMBO Molecular Medicine

Human tau increases amyloid β plaque size but not amyloid β-mediated synapse loss in a novel mouse model of Alzheimer's disease

(2016) Rosemary J. Jackson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Non-Fibrillar Oligomeric Amyloid-β within Synapses

(2016) Eleanor K. Pickett et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer’s disease

(2016) Amanda Heslegrave et al.   Molecular Neurodegeneration

Increased CSF neurogranin concentration is specific to Alzheimer disease

(2016) Henrietta Wellington et al.   NEUROLOGY

Imaging synaptic density in the living human brain

(2016) Sjoerd J. Finnema et al.   Science Translational Medicine

Binding Sites for Amyloid-β Oligomers and Synaptic Toxicity

(2016) Levi M. Smith et al.   Cold Spring Harbor Perspectives in Medicine

Diagnostic and Prognostic Utility of the Synaptic Marker Neurogranin in Alzheimer Disease

(2016) Rawan Tarawneh et al.   JAMA Neurology

Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

(2015) Kirsten L. Viola et al.   ACTA NEUROPATHOLOGICA

Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease

(2015) Hlin Kvartsberg et al.   Alzheimers & Dementia

Cerebrospinal fluid neurogranin: relation to cognition and neurodegeneration in Alzheimer’s disease

(2015) Erik Portelius et al.   BRAIN

Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer’s disease

(2015) Laura T. Haas et al.   BRAIN

Pathological Tau Disrupts Ongoing Network Activity

(2015) Noa Menkes-Caspi et al.   NEURON

SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer’s disease

(2014) Ann Brinkmalm et al.   Molecular Neurodegeneration

Single App knock-in mouse models of Alzheimer's disease

(2014) Takashi Saito et al.   NATURE NEUROSCIENCE

Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer's disease: association with cognitive impairment

(2014) David R. Whitfield et al.   NEUROBIOLOGY OF AGING

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

The Effect of Souvenaid on Functional Brain Network Organisation in Patients with Mild Alzheimer’s Disease: A Randomised Controlled Study

(2014) Hanneke de Waal et al.   PLoS One

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity

(2014) Nicholas J. Izzo et al.   PLoS One

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers I: Abeta 42 Oligomer Binding to Specific Neuronal Receptors Is Displaced by Drug Candidates That Improve Cognitive Deficits

(2014) Nicholas J. Izzo et al.   PLoS One

Eyes-closed task-free electroencephalography in clinical trials for Alzheimer’s disease: an emerging method based upon brain dynamics

(2014) Elisabeth CW van Straaten et al.   Alzheimers Research & Therapy

The identification of mitochondrial DNA variants in glioblastoma multiforme

(2014) Ka Yu Yeung et al.   Acta Neuropathologica Communications

Brain amyloid-β oligomers in ageing and Alzheimer’s disease

(2013) Sylvain E. Lesné et al.   BRAIN

Dissecting phenotypic traits linked to human resilience to Alzheimer’s pathology

(2013) Beatriz G. Perez-Nievas et al.   BRAIN

The synaptic plasticity and memory hypothesis: encoding, storage and persistence

(2013) T. Takeuchi et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Promiscuous Alzheimer's Amyloid: Yet Another Partner

(2013) I. Benilova et al.   SCIENCE

Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain

(2013) E. Hudry et al.   Science Translational Medicine

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System

(2012) Hwan-Ching Tai et al.   AMERICAN JOURNAL OF PATHOLOGY

Amyloid-beta oligomerization in Alzheimer dementia versus high-pathology controls

(2012) Thomas J. Esparza et al.   ANNALS OF NEUROLOGY

Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-β

(2012) Robert M. Koffie et al.   BRAIN

Effects of acetylcholinesterase inhibitors and memantine on resting-state electroencephalographic rhythms in Alzheimer’s disease patients

(2012) Claudio Babiloni et al.   CLINICAL NEUROPHYSIOLOGY

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Soluble forms of tau are toxic in Alzheimer’s disease

(2012) Katherine Kopeikina et al.   Translational Neuroscience

Homeostatic responses by surviving cortical pyramidal cells in neurodegenerative tauopathy

(2011) Johanna L. Crimins et al.   ACTA NEUROPATHOLOGICA

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Tau Accumulation Causes Mitochondrial Distribution Deficits in Neurons in a Mouse Model of Tauopathy and in Human Alzheimer's Disease Brain

(2011) Katherine J. Kopeikina et al.   AMERICAN JOURNAL OF PATHOLOGY

Reversibility of Tau-Related Cognitive Defects in a Regulatable FTD Mouse Model

(2011) Astrid Sydow et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Tau Protein Is Required for Amyloid  -Induced Impairment of Hippocampal Long-Term Potentiation

(2011) O. A. Shipton et al.   JOURNAL OF NEUROSCIENCE

Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant

(2011) A. Sydow et al.   JOURNAL OF NEUROSCIENCE

Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

(2011) E. D. Roberson et al.   JOURNAL OF NEUROSCIENCE

Different β-amyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity

(2011) Fuxiang Bao et al.   NEUROBIOLOGY OF AGING

Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site

(2011) Jinbin Xu et al.   Nature Communications

The Alzheimer's Disease Neuroimaging Initiative positron emission tomography core

(2010) William J. Jagust et al.   Alzheimers & Dementia

Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease

(2010) Lisa Mosconi et al.   Annals of the New York Academy of Sciences

Neurogranin in cerebrospinal fluid as a marker of synaptic degeneration in Alzheimer's disease

(2010) Annika Thorsell et al.   BRAIN RESEARCH

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

(2010) Moustapha Cissé et al.   NATURE

Probing the Biology of Alzheimer's Disease in Mice

(2010) Karen H. Ashe et al.   NEURON

Disease progression meta-analysis model in Alzheimer's disease

(2009) Kaori Ito et al.   Alzheimers & Dementia

Changes in cognitive domains during three years in patients with Alzheimer's disease treated with donepezil

(2009) Cecilia M Persson et al.   BMC Neurology

Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs

(2009) A.B. Rocher et al.   EXPERIMENTAL NEUROLOGY

Age-Dependent Impairment of Cognitive and Synaptic Function in the htau Mouse Model of Tau Pathology

(2009) M. Polydoro et al.   JOURNAL OF NEUROSCIENCE

Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI

(2009) Susan M. Landau et al.   NEUROBIOLOGY OF AGING

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice

(2009) K. V. Kuchibhotla et al.   SCIENCE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease

(2008) Tara L. Spires-Jones et al.   NEUROBIOLOGY OF DISEASE

Rivastigmine effects on EEG spectra and three-dimensional LORETA functional imaging in Alzheimer’s disease

(2008) Lorena R. R. Gianotti et al.   PSYCHOPHARMACOLOGY

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE

Loss of VGLUT1 and VGLUT2 in the prefrontal cortex is correlated with cognitive decline in Alzheimer disease

(2007) Alireza Kashani et al.   NEUROBIOLOGY OF AGING