Therapeutics of Neurotransmitters in Alzheimer’s Disease

Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

(2017) Rui Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

A slow excitatory postsynaptic current mediated by a novel metabotropic glutamate receptor in CA1 pyramidal neurons

(2017) Nengyin Sheng et al.   NEUROPHARMACOLOGY

Memantine Treatment in Patients with Mild to Moderate Alzheimer's Disease: Results of a Randomised, Double-Blind, Placebo-Controlled 6-Month Study

(2017) S. Bakchine et al.   JOURNAL OF ALZHEIMERS DISEASE

Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases

(2016) Bassem Sadek et al.   BEHAVIOURAL BRAIN RESEARCH

Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis

(2016) Ramesh Kandimalla et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Smad3 deficiency inhibits dentate gyrus LTP by enhancing GABAAneurotransmission

(2016) Mª Dolores Muñoz et al.   JOURNAL OF NEUROCHEMISTRY

α7-nAChR agonist enhances neural plasticity in the hippocampus via a GABAergic circuit

(2016) Matthew Townsend et al.   JOURNAL OF NEUROPHYSIOLOGY

Metabotropic and ionotropic glutamate receptors mediate the modulation of acetylcholine release at the frog neuromuscular junction

(2016) Andrei Tsentsevitsky et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neuronal histamine and cognitive symptoms in Alzheimer's disease

(2016) Armin Zlomuzica et al.   NEUROPHARMACOLOGY

Donepezil, an acetylcholine esterase inhibitor, and ABT-239, a histamine H 3 receptor antagonist/inverse agonist, require the integrity of brain histamine system to exert biochemical and procognitive effects in the mouse

(2016) Gustavo Provensi et al.   NEUROPHARMACOLOGY

Understanding Aspects of Aluminum Exposure in Alzheimer's Disease Development

(2015) Ramesh Kandimalla et al.   BRAIN PATHOLOGY

Adenosine A2Areceptors are necessary and sufficient to trigger memory impairment in adult mice

(2015) N Pagnussat et al.   BRITISH JOURNAL OF PHARMACOLOGY

Amyloid-  Impairs Synaptic Inhibition via GABAA Receptor Endocytosis

(2015) D. Ulrich   JOURNAL OF NEUROSCIENCE

Erratum: A2A adenosine receptor deletion is protective in a mouse model of Tauopathy

(2015) C Laurent et al.   MOLECULAR PSYCHIATRY

Modulation of excitatory neurotransmission by neuronal/glial signalling molecules: interplay between purinergic and glutamatergic systems

(2015) László Köles et al.   Purinergic Signalling

The human histaminergic system in neuropsychiatric disorders

(2015) Ling Shan et al.   TRENDS IN NEUROSCIENCES

Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss

(2015) J H Birnbaum et al.   Cell Death & Disease

Serotonin 6 receptor controls alzheimer’s disease and depression

(2015) Hyung-Mun Yun et al.   Oncotarget

CSF Ubiquitin As a Specific Biomarker in Alzheimer's Disease

(2014) Ramesh Kandimalla et al.   Current Alzheimer Research

A Randomized, Double-Blind, Placebo-Controlled, 16-Week Study of the H3 Receptor Antagonist, GSK239512 as a Monotherapy in Subjects with Mild-to-Moderate Alzheimer’s Disease

(2014) Richard Grove et al.   Current Alzheimer Research

Impaired spatial learning and reduced adult hippocampal neurogenesis in histamine H1-receptor knockout mice

(2014) Oliver Ambrée et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Pharmacological treatment of neuropsychiatric symptoms in Alzheimer's disease: a systematic review and meta-analysis

(2014) Jun Wang et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

(2014) Seonmi Jo et al.   NATURE MEDICINE

Modulation of behavior by the histaminergic system: Lessons from H1R-and H2R-deficient mice

(2014) Erich H. Schneider et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Modulation of behavior by the histaminergic system: Lessons from HDC-, H3R- and H4R-deficient mice

(2014) Erich H. Schneider et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Focus on GABAA receptor function

(2014) S. Nikolaus et al.   NUKLEARMEDIZIN-NUCLEAR MEDICINE

Neuronal failure in Alzheimer’s disease: a view through the oxidative stress looking-glass

(2014) David J. Bonda et al.   Neuroscience Bulletin

Phase I study on the pharmacokinetics and tolerance of ZT-1, a prodrug of huperzine A, for the treatment of Alzheimer's disease

(2013) Jing-ying Jia et al.   ACTA PHARMACOLOGICA SINICA

The Neglected Role of Histamine in Alzheimer’s Disease

(2013) Fatemeh Naddafi et al.   American Journal of Alzheimers Disease and Other Dementias

The histamine H3-receptor inverse agonist Pitolisant improves fear memory in mice

(2013) Christian Brabant et al.   BEHAVIOURAL BRAIN RESEARCH

The Safety, Tolerability, Pharmacokinetics and Cognitive Effects of GSK239512, a Selective Histamine H3 Receptor Antagonist in Patients with Mild to Moderate Alzheimer’s Disease: A Preliminary Investigation

(2013) Pradeep J. Nathan et al.   Current Alzheimer Research

Glutamate Receptors in Human Caudate Nucleus in Normal Aging and Alzheimer’s Disease

(2013) Konstantinos I. Tsamis et al.   Current Alzheimer Research

?7 Nicotinic Acetylcholine Receptors in Alzheimer's Disease: Neuroprotective, Neurotrophic or Both?

(2013)   CURRENT DRUG TARGETS

Sigma receptor modulators: a patent review

(2013) Simona Collina et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines

(2013) D. F. Silva et al.   HUMAN MOLECULAR GENETICS

Novel contribution of cell surface and intracellular M1-muscarinic acetylcholine receptors to synaptic plasticity in hippocampus

(2013) Abu Syed Md Anisuzzaman et al.   JOURNAL OF NEUROCHEMISTRY

Therapeutics of Alzheimer's disease: Past, present and future

(2013) R. Anand et al.   NEUROPHARMACOLOGY

Blockade of Tau Hyperphosphorylation and Aβ1–42 Generation by the Aminotetrahydrofuran Derivative ANAVEX2-73, a Mixed Muscarinic and σ1 Receptor Agonist, in a Nontransgenic Mouse Model of Alzheimer’s Disease

(2013) Valentine Lahmy et al.   NEUROPSYCHOPHARMACOLOGY

Memantine and Cholinesterase Inhibitors: Complementary Mechanisms in the Treatment of Alzheimer’s Disease

(2013) Chris G. Parsons et al.   NEUROTOXICITY RESEARCH

The histamine H1 receptor and recollection-based discrimination in a temporal order memory task in the mouse

(2013) Armin Zlomuzica et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Efficacy of Memantine, Donepezil, or Their Association in Moderate-Severe Alzheimer’s Disease: A Review of Clinical Trials

(2013) Ivana Molino et al.   TheScientificWorldJOURNAL

Memantine in patients with Alzheimer's disease receiving donepezil: new analyses of efficacy and safety for combination therapy

(2013) Alireza Atri et al.   Alzheimers Research & Therapy

Cotinine: A Potential New Therapeutic Agent against Alzheimer's disease

(2012) Valentina Echeverria et al.   CNS Neuroscience & Therapeutics

EHT0202 in Alzheimers Disease: A 3-Month, Randomized, Placebo- Controlled, Double-Blind Study

(2012) B. Vellas et al.   Current Alzheimer Research

Glutamate system, amyloid β peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology

(2012) Timothy Revett et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Functional roles of neurotransmitters and neuromodulators in the dorsal striatum

(2012) J. Do et al.   LEARNING & MEMORY

Alterations in the histaminergic system in Alzheimer's disease: a postmortem study

(2012) Ling Shan et al.   NEUROBIOLOGY OF AGING

Distribution of Serotonin Receptor of Type 6 (5-HT6) in Human Brain Post-mortem. A Pharmacology, Autoradiography and Immunohistochemistry Study

(2012) Donatella Marazziti et al.   NEUROCHEMICAL RESEARCH

Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior

(2012) Marina R. Picciotto et al.   NEURON

Donepezil and Memantine for Moderate-to-Severe Alzheimer's Disease

(2012) Robert Howard et al.   NEW ENGLAND JOURNAL OF MEDICINE

Memantine Inhibits α3β2-nAChRs-Mediated Nitrergic Neurogenic Vasodilation in Porcine Basilar Arteries

(2012) Reggie Hui-Chao Lee et al.   PLoS One

Neurotransmitter receptors and cognitive dysfunction in Alzheimer's disease and Parkinson's disease

(2012) Yunqi Xu et al.   PROGRESS IN NEUROBIOLOGY

The serotonergic system in ageing and Alzheimer's disease

(2012) José Julio Rodríguez et al.   PROGRESS IN NEUROBIOLOGY

Postsynaptic Receptors for Amyloid-β Oligomers as Mediators of Neuronal Damage in Alzheimer’s Disease

(2012) Margarita C. Dinamarca et al.   Frontiers in Physiology

Loss of Muscarinic M1 Receptor Exacerbates Alzheimer's Disease–Like Pathology and Cognitive Decline

(2011) Rodrigo Medeiros et al.   AMERICAN JOURNAL OF PATHOLOGY

Lack of Evidence for the Efficacy of Memantine in Mild Alzheimer Disease

(2011) Lon S. Schneider   ARCHIVES OF NEUROLOGY

Cholinergic influences on cortical development and adult neurogenesis

(2011) Elodie Bruel-Jungerman et al.   BEHAVIOURAL BRAIN RESEARCH

The histamine H3 receptor: from discovery to clinical trials with pitolisant

(2011) Jean-Charles Schwartz   BRITISH JOURNAL OF PHARMACOLOGY

Efficacy of memantine in delaying clinical worsening in Alzheimer's disease (AD): responder analyses of nine clinical trials with patients with moderate to severe AD

(2011) Rainer Hellweg et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Cholinergic modulation of amyloid precursor protein processing with emphasis on M1 muscarinic receptor: perspectives and challenges in treatment of Alzheimer’s disease

(2011) Abraham Fisher   JOURNAL OF NEUROCHEMISTRY

5-HT4 receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment

(2011) Fei Shen et al.   NEUROPHARMACOLOGY

EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors

(2011) Jos Prickaerts et al.   NEUROPHARMACOLOGY

Pharmacological characterizations of memantine-induced disruption of prepulse inhibition of the acoustic startle response in mice: Involvement of dopamine D2 and 5-HT2A receptors

(2010) Kota Nakaya et al.   BEHAVIOURAL BRAIN RESEARCH

The cholinergic system and hippocampal plasticity

(2010) Benjamin D. Drever et al.   BEHAVIOURAL BRAIN RESEARCH

Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): The development of ML169, an MLPCN probe

(2010) Paul R. Reid et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Nicotinic Acetylcholine Receptor Interaction with β -Amyloid: Molecular, Cellular, and Physiological Consequences

(2010) H. Parri et al.   Current Alzheimer Research

Double-Blind, Controlled Phase II Study of a 5-HT6 Receptor Antagonist, SB-742457, in Alzheimers Disease

(2010) G. Maher-Edwards et al.   Current Alzheimer Research

SB-742457 and donepezil in Alzheimer disease: a randomized, placebo-controlled study

(2010) Gareth Maher-Edwards et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

In the Adult Hippocampus, Chronic Nerve Growth Factor Deprivation Shifts GABAergic Signaling from the Hyperpolarizing to the Depolarizing Direction

(2010) L. Lagostena et al.   JOURNAL OF NEUROSCIENCE

Activation of Brain Histaminergic Neurotransmission: A Mechanism for Cognitive Effects of Memantine in Alzheimer's Disease

(2010) M. Motawaj et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Oxidative stress in Alzheimer disease: A possibility for prevention

(2010) David J. Bonda et al.   NEUROPHARMACOLOGY

In-vivo histamine H3 receptor antagonism activates cellular signaling suggestive of symptomatic and disease modifying efficacy in Alzheimer’s disease

(2010) R. Scott Bitner et al.   NEUROPHARMACOLOGY

Cerebrospinal fluid profile of amyloid β42 (Aβ42), hTau and ubiquitin in North Indian Alzheimer's disease patients

(2010) Ramesh JL. Kandimalla et al.   NEUROSCIENCE LETTERS

Le système histaminergique : une cible pour de nouveaux traitements des deficits cognitifs

(2010) Mouhammad Motawaj et al.   THERAPIE

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

(2009) Paula I. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Safety, tolerability, pharmacokinetics and pharmacodynamics of ascending single and multiple doses of lecozotan in healthy young and elderly subjects

(2009) Alain Patat et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Characterization of histamine H3 receptors in Alzheimer's Disease brain and amyloid over-expressing TASTPM mice

(2009) AD Medhurst et al.   BRITISH JOURNAL OF PHARMACOLOGY

Histamine H1 receptor knockout mice exhibit impaired spatial memory in the eight-arm radial maze

(2009) A Zlomuzica et al.   BRITISH JOURNAL OF PHARMACOLOGY

Efficacy of SSRIs on cognition of Alzheimer's disease patients treated with cholinesterase inhibitors

(2009) Luca Rozzini et al.   INTERNATIONAL PSYCHOGERIATRICS

Effect of a Serotonin Reuptake Inhibitor on Irritability, Apathy, and Psychotic Symptoms in Patients With Alzheimer's Disease

(2009) Haroon Siddique et al.   JOURNAL OF CLINICAL PSYCHIATRY

β-amyloid cortical deposits are accompanied by the loss of serotonergic neurons in the dog

(2009) Vanessa Bernedo et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Memogain is a Galantamine Pro-drug having Dramatically Reduced Adverse Effects and Enhanced Efficacy

(2009) Alfred Maelicke et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease

(2009) O L Lopez et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Adenosine A2A Receptor Blockade Prevents Synaptotoxicity and Memory Dysfunction Caused by  -Amyloid Peptides via p38 Mitogen-Activated Protein Kinase Pathway

(2009) P. M. Canas et al.   JOURNAL OF NEUROSCIENCE

Cafeína, receptores de adenosina, memoria y enfermedad de Alzheimer

(2009) Rodrigo A. Cunha   MEDICINA CLINICA

Potency, voltage-dependency, agonist concentration-dependency, blocking kinetics and partial untrapping of the uncompetitive N-methyl-d-aspartate (NMDA) channel blocker memantine at human NMDA (GluN1/GluN2A) receptors

(2009) Kate E. Gilling et al.   NEUROPHARMACOLOGY

Preclinical and clinical pharmacology of the GABAA receptor α5 subtype-selective inverse agonist α5IA

(2009) John R. Atack   PHARMACOLOGY & THERAPEUTICS

Functional Expression of Nicotinic Acetylcholine Receptors in Rat Neocortical Layer 5 Pyramidal Cells

(2008) Gerd Zolles et al.   CEREBRAL CORTEX

Alzheimer Disease and the Role of Free Radicals in the Pathogenesis of the Disease

(2008) George Perry et al.   CNS & Neurological Disorders-Drug Targets

Memantine Treatment in Patients with Mild to Moderate Alzheimers Disease Already Receiving a Cholinesterase Inhibitor: A Randomized, Double-Blind, Placebo-Controlled Trial

(2008) Anton Porsteinsson et al.   Current Alzheimer Research

Pharmacodynamics of Memantine: An Update

(2008) C. Parsons et al.   Current Neuropharmacology

The histamine H1-receptor mediates the motivational effects of novelty

(2008) A. Zlomuzica et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Etazolate, a neuroprotective drug linking GABAAreceptor pharmacology to amyloid precursor protein processing

(2008) Maryline Marcade et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid Pathology Is Associated with Progressive Monoaminergic Neurodegeneration in a Transgenic Mouse Model of Alzheimer's Disease

(2008) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

Episodic-like and procedural memory impairments in histamine H1 Receptor knockout mice coincide with changes in acetylcholine esterase activity in the hippocampus and dopamine turnover in the cerebellum

(2008) E. Dere et al.   NEUROSCIENCE

Cholinergic treatments with emphasis on M1 muscarinic agonists as potential disease-modifying agents for Alzheimer’s disease

(2008) Abraham Fisher   Neurotherapeutics

A role for the 5-HT1A, 5-HT4 and 5-HT6 receptors in learning and memory

(2008) M KING et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

5-HT7 receptors in the modulation of cognitive processes

(2007) Agata Cifariello et al.   BEHAVIOURAL BRAIN RESEARCH

Adenosine receptor antagonists for cognitive dysfunction: a review of animal studies

(2007) Reinaldo Naoto Takahashi   Frontiers in Bioscience-Landmark