Tau association with synaptic vesicles causes presynaptic dysfunction

Caspase-2 cleavage of tau reversibly impairs memory

(2016) Xiaohui Zhao et al.   NATURE MEDICINE

Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease

(2016) Amit K. Chouhan et al.   Acta Neuropathologica Communications

Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease

(2015) Sophie Sokolow et al.   JOURNAL OF NEUROCHEMISTRY

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Pathological Tau Disrupts Ongoing Network Activity

(2015) Noa Menkes-Caspi et al.   NEURON

Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca++ dysregulation

(2015) Jochen Martin Decker et al.   Acta Neuropathologica Communications

α-Synuclein Multimers Cluster Synaptic Vesicles and Attenuate Recycling

(2014) Lina Wang et al.   CURRENT BIOLOGY

Tau promotes neurodegeneration through global chromatin relaxation

(2014) Bess Frost et al.   NATURE NEUROSCIENCE

Rescue of tau-induced synaptic transmission pathology by paclitaxel

(2014) Hadas Erez et al.   Frontiers in Cellular Neuroscience

Association of MAPT haplotypes with Alzheimer’s disease risk and MAPT brain gene expression levels

(2014) Mariet Allen et al.   Alzheimers Research & Therapy

Fast and Efficient Drosophila melanogaster Gene Knock-Ins Using MiMIC Transposons

(2014) Sven Vilain et al.   G3-Genes Genomes Genetics

Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer’s disease model

(2013) Manuela Polydoro et al.   ACTA NEUROPATHOLOGICA

Tau Loss Attenuates Neuronal Network Hyperexcitability in Mouse and Drosophila Genetic Models of Epilepsy

(2013) J. K. Holth et al.   JOURNAL OF NEUROSCIENCE

Antisense Reduction of Tau in Adult Mice Protects against Seizures

(2013) S. L. DeVos et al.   JOURNAL OF NEUROSCIENCE

Overexpression of synapsin Ia in the rat calyx of Held accelerates short-term plasticity and decreases synaptic vesicle volume and active zone area

(2013) Mariya Vasileva et al.   Frontiers in Cellular Neuroscience

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

(2013) Jiajie Diao et al.   eLife

Electrophysiological changes precede morphological changes to frontal cortical pyramidal neurons in the rTg4510 mouse model of progressive tauopathy

(2012) Johanna L. Crimins et al.   ACTA NEUROPATHOLOGICA

The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System

(2012) Hwan-Ching Tai et al.   AMERICAN JOURNAL OF PATHOLOGY

Extensive p-Tau Pathology and SDS-Stable p-Tau Oligomers in Alzheimer's Cortical Synapses

(2012) Kristen M. Henkins et al.   BRAIN PATHOLOGY

Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β

(2012) Justin M. Nussbaum et al.   NATURE

Human P301L-Mutant Tau Expression in Mouse Entorhinal-Hippocampal Network Causes Tau Aggregation and Presynaptic Pathology but No Cognitive Deficits

(2012) Julie A. Harris et al.   PLoS One

High-frequency neural activity and human cognition: Past, present and possible future of intracranial EEG research

(2012) Jean-Philippe Lachaux et al.   PROGRESS IN NEUROBIOLOGY

Synaptic Vesicle Endocytosis

(2012) Y. Saheki et al.   Cold Spring Harbor Perspectives in Biology

Synaptic Vesicle Pools and Dynamics

(2012) A. A. Alabi et al.   Cold Spring Harbor Perspectives in Biology

Homeostatic responses by surviving cortical pyramidal cells in neurodegenerative tauopathy

(2011) Johanna L. Crimins et al.   ACTA NEUROPATHOLOGICA

Alpha-synuclein synaptic pathology and its implications in the development of novel therapeutic approaches to cure Parkinson's disease

(2011) Arianna Bellucci et al.   BRAIN RESEARCH

Loss of Skywalker Reveals Synaptic Endosomes as Sorting Stations for Synaptic Vesicle Proteins

(2011) Valerie Uytterhoeven et al.   CELL

Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant

(2011) A. Sydow et al.   JOURNAL OF NEUROSCIENCE

Unknown

(2011) Adriana Ferreira et al.   MOLECULAR MEDICINE

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

How synapsin I may cluster synaptic vesicles

(2011) Oleg Shupliakov et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Cortical gamma responses: Searching high and low

(2010) Nathan E. Crone et al.   INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease

(2010) Austen J. Milnerwood et al.   TRENDS IN NEUROSCIENCES

The proline-rich domain of tau plays a role in interactions with actin

(2009) Hai He et al.   BMC CELL BIOLOGY

Role of the H1 haplotype of microtubule-associated protein tau (MAPT) gene in Greek patients with Parkinson's disease

(2009) Nikolaos Refenes et al.   BMC Neurology

Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs

(2009) A.B. Rocher et al.   EXPERIMENTAL NEUROLOGY

Co-Localization of Amyloid Beta and Tau Pathology in Alzheimer's Disease Synaptosomes

(2008) Jeffrey A. Fein et al.   AMERICAN JOURNAL OF PATHOLOGY

Synaptic Vesicles Are Constitutively Active Fusion Machines that Function Independently of Ca 2+

(2008) Matthew Holt et al.   CURRENT BIOLOGY