Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers I: Abeta 42 Oligomer Binding to Specific Neuronal Receptors Is Displaced by Drug Candidates That Improve Cognitive Deficits

Genetic Modulation of Soluble A  Rescues Cognitive and Synaptic Impairment in a Mouse Model of Alzheimer's Disease

(2014) S. W. Fowler et al.   JOURNAL OF NEUROSCIENCE

New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF

(2013) Ting Yang et al.   Alzheimers & Dementia

Brain amyloid-β oligomers in ageing and Alzheimer’s disease

(2013) Sylvain E. Lesné et al.   BRAIN

Prion-like spreading of pathological α-synuclein in brain

(2013) Masami Masuda-Suzukake et al.   BRAIN

Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin

(2013) Hans Zempel et al.   EMBO JOURNAL

Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease

(2013) Shuko Takeda et al.   FASEB JOURNAL

FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer’s disease

(2013) Tae-In Kam et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

(2013) Ji Won Um et al.   NEURON

A Luminex Assay Detects Amyloid β Oligomers in Alzheimer’s Disease Cerebrospinal Fluid

(2013) Adrianna Z. Herskovits et al.   PLoS One

Metabotropic NMDA receptor function is required for  -amyloid-induced synaptic depression

(2013) H. W. Kessels et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Promiscuous Alzheimer's Amyloid: Yet Another Partner

(2013) I. Benilova et al.   SCIENCE

Human LilrB2 Is a  -Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer's Model

(2013) T. Kim et al.   SCIENCE

Amyloid-beta oligomerization in Alzheimer dementia versus high-pathology controls

(2012) Thomas J. Esparza et al.   ANNALS OF NEUROLOGY

Thy1-hAPPLond/Swe+mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function

(2012) Mehrdad Faizi et al.   Brain and Behavior

Amyloid beta peptide 1–42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures

(2011) I.L. Ferreira et al.   CELL CALCIUM

Linking Amyloid-ß and Tau: Amyloid-ß Induced Synaptic Dysfunction via Local Wreckage of the Neuronal Cytoskeleton

(2011) Hans Zempel et al.   Neurodegenerative Diseases

Purified high molecular weight synthetic Aβ(1–42) and biological Aβ oligomers are equipotent in rapidly inducing MTT formazan exocytosis

(2011) Adam M. Weidner et al.   NEUROSCIENCE LETTERS

Minocycline Recovers MTT-Formazan Exocytosis Impaired by Amyloid Beta Peptide

(2010) Peter Kreutzmann et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

(2010) Moustapha Cissé et al.   NATURE

Cognitive effects of cell-derived and synthetically derived Aβ oligomers

(2010) Miranda N. Reed et al.   NEUROBIOLOGY OF AGING

Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5

(2010) Marianne Renner et al.   NEURON

Inhibition of Alzheimer’s amyloid toxicity with a tricyclic pyrone moleculein vitroandin vivo

(2009) Hyun-Seok Hong et al.   JOURNAL OF NEUROCHEMISTRY

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Amyloid beta from axons and dendrites reduces local spine number and plasticity

(2009) Wei Wei et al.   NATURE NEUROSCIENCE

Protection against Aβ-mediated rapid disruption of synaptic plasticity and memory by memantine

(2009) Igor Klyubin et al.   NEUROBIOLOGY OF AGING

Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction

(2009) Jennifer L. Tomic et al.   NEUROBIOLOGY OF DISEASE

Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Aβ assembly forms throughout life

(2009) Ganesh M. Shankar et al.   NEUROBIOLOGY OF DISEASE

Syntheses of tricyclic pyrones and pyridinones and protection of Aβ-peptide induced MC65 neuronal cell death

(2008) Sandeep Rana et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Amyloid flirting with synaptic failure: Towards a comprehensive view of Alzheimer's disease pathogenesis

(2008) Elena Marcello et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Why Alzheimer’s is a disease of memory: The attack on synapses by Aß oligomers (ADDLs)

(2008) K. L. Viola et al.   Journal of Nutrition Health & Aging

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Aβ Mediated Diminution of MTT Reduction—An Artefact of Single Cell Culture?

(2008) Raik Rönicke et al.   PLoS One

Amyloid-  Dynamics Correlate with Neurological Status in the Injured Human Brain

(2008) D. L. Brody et al.   SCIENCE

Vaccination with soluble Aβ oligomers generates toxicity-neutralizing antibodies

(2003) Mary P. Lambert et al.   JOURNAL OF NEUROCHEMISTRY