Soluble TREM2 and Inflammatory Proteins in Alzheimer’s Disease Cerebrospinal Fluid

Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

(2019) Marc Suárez-Calvet et al.   Molecular Neurodegeneration

The neuroinflammatory biomarker YKL-40 for neurodegenerative diseases: advances in development

(2019) Filippo Baldacci et al.   Expert Review of Proteomics

Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease

(2019) Michael Ewers et al.   Science Translational Medicine

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

A new Alzheimer's disease cell model using B cells to induce beta amyloid plaque formation and increase TNF alpha expression

(2018) Mehrouz Dezfulian   INTERNATIONAL IMMUNOPHARMACOLOGY

Soluble TREM2 and biomarkers of central and peripheral inflammation in neurodegenerative disease

(2018) L.M. Bekris et al.   JOURNAL OF NEUROIMMUNOLOGY

Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain

(2018) Guillermo Carbajosa et al.   NEUROBIOLOGY OF AGING

Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer’s disease

(2018) Frederic Brosseron et al.   Alzheimers Research & Therapy

Current state of Alzheimer’s fluid biomarkers

(2018) José Luis Molinuevo et al.   ACTA NEUROPATHOLOGICA

Transforming Growth Factor Beta Type I Role in Neurodegeneration: Implications for Alzheimer´s Disease

(2018) Lisbell D. Estrada et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

CSF soluble TREM2 as a measure of immune response along the Alzheimer's disease continuum

(2018) Boris-Stephan Rauchmann et al.   NEUROBIOLOGY OF AGING

Soluble TREM2 induces inflammatory responses and enhances microglial survival

(2017) Li Zhong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy

(2017) Kevin A. Clayton et al.   Frontiers in Neuroscience

Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status

(2016) Laura Piccio et al.   ACTA NEUROPATHOLOGICA

sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers

(2016) Marc Suárez‐Calvet et al.   EMBO Molecular Medicine

Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer’s disease

(2016) Amanda Heslegrave et al.   Molecular Neurodegeneration

The dual roles of cytokines in Alzheimer’s disease: update on interleukins, TNF-α, TGF-β and IFN-γ

(2016) Cong Zheng et al.   Translational Neurodegeneration

Pro-inflammatory TNFα and IL-1β differentially regulate the inflammatory phenotype of brain microvascular endothelial cells

(2015) Simon J. O’Carroll et al.   Journal of Neuroinflammation

Anti-inflammatory Signaling in Microglia Exacerbates Alzheimer’s Disease-Related Pathology

(2015) Jean-Philippe Michaud et al.   NEURON

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

(2014) G. Kleinberger et al.   Science Translational Medicine

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

(2013) Sruti Rayaprolu et al.   Molecular Neurodegeneration

Clinical and multimodal biomarker correlates of ADNI neuropathological findings

(2013) Jon B Toledo et al.   Acta Neuropathologica Communications

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tumor Necrosis Factor-alpha and the Roles it Plays in Homeostatic and Degenerative Processes Within the Central Nervous System

(2011) Sara L. Montgomery et al.   Journal of Neuroimmune Pharmacology

Rescue of Progranulin Deficiency Associated with Frontotemporal Lobar Degeneration by Alkalizing Reagents and Inhibition of Vacuolar ATPase

(2011) A. Capell et al.   JOURNAL OF NEUROSCIENCE

Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects

(2009) Leslie M. Shaw et al.   ANNALS OF NEUROLOGY

Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation

(2008) Laura Piccio et al.   BRAIN

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Markers of endothelial dysfunction in older subjects with late onset Alzheimer's disease or vascular dementia

(2008) G. Zuliani et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON