A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology

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Glial contributions to neurodegeneration in tauopathies

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Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer’s Disease

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Alzheimer's Disease Selective Vulnerability and Modeling in Transgenic Mice

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A current pharmacologic agent versus the promise of next generation therapeutics to ameliorate protein misfolding and/or aggregation diseases

(2016) Aleksandra Baranczak et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Adult mouse cortical cell taxonomy revealed by single cell transcriptomics

(2016) Bosiljka Tasic et al.   NATURE NEUROSCIENCE

A transcriptional signature of Alzheimer’s disease is associated with a metastable subproteome at risk for aggregation

(2016) Prajwal Ciryam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain

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A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimers disease

(2016) R. Freer et al.   Science Advances

3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice

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The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity

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Loss of calbindin-D 28K is associated with the full range of tangle pathology within basal forebrain cholinergic neurons in Alzheimer's disease

(2015) Saman S. Ahmadian et al.   NEUROBIOLOGY OF AGING

BAG3 facilitates the clearance of endogenous tau in primary neurons

(2015) Zhinian Lei et al.   NEUROBIOLOGY OF AGING

From Intrinsic Firing Properties to Selective Neuronal Vulnerability in Neurodegenerative Diseases

(2015) Francesco Roselli et al.   NEURON

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Glial and Neuronal Tau Pathology in Tauopathies

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Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

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Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

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Trans-Synaptic Spread of Tau Pathology In Vivo

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Age-related loss of calcium buffering and selective neuronal vulnerability in Alzheimer’s disease

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Selective Neuronal Vulnerability in Neurodegenerative Diseases: from Stressor Thresholds to Degeneration

(2011) Smita Saxena et al.   NEURON

The HSPB8-BAG3 chaperone complex is upregulated in astrocytes in the human brain affected by protein aggregation diseases

(2011) K. Seidel et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Aging as an Event of Proteostasis Collapse

(2011) R. C. Taylor et al.   Cold Spring Harbor Perspectives in Biology

Selective functional, regional, and neuronal vulnerability in frontotemporal dementia

(2008) William W Seeley   CURRENT OPINION IN NEUROLOGY

Adapting Proteostasis for Disease Intervention

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