Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

(2019) Rumani Singh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cadherin-11–mediated adhesion of macrophages to myofibroblasts establishes a profibrotic niche of active TGF-β

(2019) Monika Lodyga et al.   Science Signaling

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

(2019) Jamie N. Justice et al.   EBioMedicine

Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds

(2019) Christian F. Guerrero-Juarez et al.   Nature Communications

Emerging targets of disease-modifying therapy for systemic sclerosis

(2019) Elizabeth R. Volkmann et al.   Nature Reviews Rheumatology

PU.1 controls fibroblast polarization and tissue fibrosis

(2019) Thomas Wohlfahrt et al.   NATURE

Mechanical regulation of myofibroblast phenoconversion and collagen contraction

(2019) Boris Hinz et al.   EXPERIMENTAL CELL RESEARCH

Defining the Activated Fibroblast Population in Lung Fibrosis Using Single Cell Sequencing

(2019) Rebecca Peyser et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Cellular Senescence as a Mechanism and Target in Chronic Lung Diseases

(2019) Peter J Barnes et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Tcf21 lineage constitutes the lung lipofibroblast population

(2019) Juwon Park et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology

(2019) Sho Morioka et al.   IMMUNITY

Distinct fibroblast subsets drive inflammation and damage in arthritis

(2019) Adam P. Croft et al.   NATURE

Nintedanib for Systemic Sclerosis–Associated Interstitial Lung Disease

(2019) Oliver Distler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ephrins and Eph Receptor Signaling in Tissue Repair and Fibrosis

(2019) Brian Wu et al.   Current Rheumatology Reports

Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

(2019) Nona Farbehi et al.   eLife

Integrins in wound healing, fibrosis and tumor stroma: High potential targets for therapeutics and drug delivery

(2018) Jonas Schnittert et al.   ADVANCED DRUG DELIVERY REVIEWS

Apoptosis and Clearance of Apoptotic Cells

(2018) Shigekazu Nagata   Annual Review of Immunology

Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome

(2018) Paul Hiebert et al.   DEVELOPMENTAL CELL

Extracellular matrix as a driver of progressive fibrosis

(2018) Jeremy Herrera et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanosensing and fibrosis

(2018) Daniel J. Tschumperlin et al.   JOURNAL OF CLINICAL INVESTIGATION

Fibroblast heterogeneity: implications for human disease

(2018) Magnus D. Lynch et al.   JOURNAL OF CLINICAL INVESTIGATION

Strategies targeting cellular senescence

(2018) Yossi Ovadya et al.   JOURNAL OF CLINICAL INVESTIGATION

Resolution of organ fibrosis

(2018) Joon-Il Jun et al.   JOURNAL OF CLINICAL INVESTIGATION

Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart

(2018) Xing Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

The perivascular origin of pathological fibroblasts

(2018) Selene E. Di Carlo et al.   JOURNAL OF CLINICAL INVESTIGATION

Determinants of fibrosis progression and regression in NASH

(2018) Detlef Schuppan et al.   JOURNAL OF HEPATOLOGY

Therapeutic Targeting of TAZ and YAP by Dimethyl Fumarate in Systemic Sclerosis Fibrosis

(2018) Tetsuo Toyama et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin

(2018) Tracy Tabib et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations

(2018) Christina Philippeos et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

BH3 mimetics as anti-fibrotic therapy: Unleashing the mitochondrial pathway of apoptosis in myofibroblasts

(2018) Tobias Kuehl et al.   MATRIX BIOLOGY

New developments on skin fibrosis - Essential signals emanating from the extracellular matrix for the control of myofibroblasts

(2018) Jan-Niklas Schulz et al.   MATRIX BIOLOGY

Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage

(2018) Paula Gutierrez-Martinez et al.   NATURE CELL BIOLOGY

Two succeeding fibroblastic lineages drive dermal development and the transition from regeneration to scarring

(2018) Dongsheng Jiang et al.   NATURE CELL BIOLOGY

Metformin reverses established lung fibrosis in a bleomycin model

(2018) Sunad Rangarajan et al.   NATURE MEDICINE

Phenotype molding of stromal cells in the lung tumor microenvironment

(2018) Diether Lambrechts et al.   NATURE MEDICINE

Transient fibrosis resolves via fibroblast inactivation in the regenerating zebrafish heart

(2018) Héctor Sánchez-Iranzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials

(2018) Marsha C. Lampi et al.   Science Translational Medicine

Single-Cell Deconvolution of Fibroblast Heterogeneity in Mouse Pulmonary Fibrosis

(2018) Ting Xie et al.   Cell Reports

Matrix Stiffness: the Conductor of Organ Fibrosis

(2018) Alba Santos et al.   Current Rheumatology Reports

Lung transplantation in idiopathic pulmonary fibrosis

(2018) Anupam Kumar et al.   Expert Review of Respiratory Medicine

Rheumatoid arthritis

(2018) Josef S. Smolen et al.   Nature Reviews Disease Primers

Telomere dysfunction promotes transdifferentiation of human fibroblasts into myofibroblasts

(2018) Neetu Razdan et al.   AGING CELL

Quercetin Enhances Ligand-induced Apoptosis in Senescent IPF Fibroblasts and Reduces Lung Fibrosis In Vivo

(2018) Miriam S Hohmann et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Quercetin in Idiopathic Pulmonary Fibrosis: Another Brick in the Senolytic Wall.

(2018) Jacobo Sellarés et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts

(2018) Michael Schuliga et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Fibroblast state switching orchestrates dermal maturation and wound healing

(2018) Emanuel Rognoni et al.   Molecular Systems Biology

Tipping the balance

(2018) Liam Drew   NATURE

Mechanisms for the Resolution of Organ Fibrosis

(2018) Jeffrey C. Horowitz et al.   PHYSIOLOGY

Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair

(2018) Brett A. Shook et al.   SCIENCE

Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing

(2018) Michael Bartoschek et al.   Nature Communications

Unraveling SSc Pathophysiology; The Myofibroblast

(2018) Arjan van Caam et al.   Frontiers in Immunology

Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosisex vivo

(2017) Mareike Lehmann et al.   EUROPEAN RESPIRATORY JOURNAL

Licence to kill senescent cells in idiopathic pulmonary fibrosis?

(2017) Arnaud A. Mailleux et al.   EUROPEAN RESPIRATORY JOURNAL

Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/− ) mice

(2017) Anja Moncsek et al.   HEPATOLOGY

Inhibition of Bcl-2/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice

(2017) Jin Pan et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

β1 integrin–dependent Rac/group I PAK signaling mediates YAP activation of Yes-associated protein 1 (YAP1) via NF2/merlin

(2017) Hiba Sabra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Yap/Taz Deletion in Gli+Cell-Derived Myofibroblasts Attenuates Fibrosis

(2017) Ming Liang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Extracellular matrix alterations in senescent cells and their significance in tissue homeostasis

(2017) Eleni Mavrogonatou et al.   MATRIX BIOLOGY

ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis

(2017) David Lagares et al.   NATURE MEDICINE

Redefining the identity of cardiac fibroblasts

(2017) Michelle D. Tallquist et al.   Nature Reviews Cardiology

Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease

(2017) Ana L. Mora et al.   NATURE REVIEWS DRUG DISCOVERY

2016 FDA drug approvals

(2017) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

(2017) David Lagares et al.   Science Translational Medicine

αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis

(2017) I. R. Murray et al.   Nature Communications

YAP regulates cell mechanics by controlling focal adhesion assembly

(2017) Giorgia Nardone et al.   Nature Communications

The Soft- and Hard-Heartedness of Cardiac Fibroblasts: Mechanotransduction Signaling Pathways in Fibrosis of the Heart

(2017) Kate Herum et al.   Journal of Clinical Medicine

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

(2016) Yi Zhu et al.   AGING CELL

Mechanisms of Lung Fibrosis Resolution

(2016) Stephan W. Glasser et al.   AMERICAN JOURNAL OF PATHOLOGY

Does Breathing Amplify Fibrosis?

(2016) Boris Hinz et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Targeting Inhibitor of Apoptosis Proteins Protects from Bleomycin-Induced Lung Fibrosis

(2016) Shanna L. Ashley et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Prediction of improvement in skin fibrosis in diffuse cutaneous systemic sclerosis: a EUSTAR analysis

(2016) Rucsandra Dobrota et al.   ANNALS OF THE RHEUMATIC DISEASES

Myofibroblasts

(2016) Boris Hinz   EXPERIMENTAL EYE RESEARCH

RhoA/Rho-kinase activation promotes lung fibrosis in an animal model of systemic sclerosis

(2016) Yihua Bei et al.   EXPERIMENTAL LUNG RESEARCH

The matricellular protein CCN1 enhances TGF-β1/SMAD3-dependent profibrotic signaling in fibroblasts and contributes to fibrogenic responses to lung injury

(2016) Ashish R. Kurundkar et al.   FASEB JOURNAL

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy

(2016) Philippe Gascard et al.   GENES & DEVELOPMENT

Systemic PEGylated TRAIL treatment ameliorates liver cirrhosis in rats by eliminating activated hepatic stellate cells

(2016) Yumin Oh et al.   HEPATOLOGY

Hic-5 is required for myofibroblast differentiation by regulating mechanically dependent MRTF-A nuclear accumulation

(2016) Scott D. Varney et al.   JOURNAL OF CELL SCIENCE

Reversion of disease manifestations after HCV eradication

(2016) Adriaan J. van der Meer et al.   JOURNAL OF HEPATOLOGY

Fibroblast-Derived MMP-14 Regulates Collagen Homeostasis in Adult Skin

(2016) Paola Zigrino et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Idiopathic pulmonary fibrosis fibroblasts become resistant to Fas ligand-dependent apoptosis via the alteration of decoy receptor 3

(2016) Jintaek Im et al.   JOURNAL OF PATHOLOGY

The extracellular matrix - the under-recognized element in lung disease?

(2016) Janette K Burgess et al.   JOURNAL OF PATHOLOGY

YAP/TAZ Are Mechanoregulators of TGF- -Smad Signaling and Renal Fibrogenesis

(2016) S. G. Szeto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hyaluronan synthase 2 regulates fibroblast senescence in pulmonary fibrosis

(2016) Yuejuan Li et al.   MATRIX BIOLOGY

MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells

(2016) Chen Xi Li et al.   NATURE MATERIALS

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

(2016) Hong Jiang et al.   NATURE MEDICINE

Pioneering apoptosis-targeted cancer drug poised for FDA approval

(2016) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Control of YAP/TAZ Activity by Metabolic and Nutrient-Sensing Pathways

(2016) Giulia Santinon et al.   TRENDS IN CELL BIOLOGY

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3

(2016) Pam Speight et al.   Nature Communications

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

YAP1 Is a Driver of Myofibroblast Differentiation in Normal and Diseased Fibroblasts

(2015) Bram Piersma et al.   AMERICAN JOURNAL OF PATHOLOGY

Inhibition of Myocardin-Related Transcription Factor/Serum Response Factor Signaling Decreases Lung Fibrosis and Promotes Mesenchymal Cell Apoptosis

(2015) Thomas H. Sisson et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

(2015) Fei Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

MicroRNA-29a induces apoptosis via increasing the Bax:Bcl-2 ratio in dermal fibroblasts of patients with systemic sclerosis

(2015) Saeideh Jafarinejad-Farsangi et al.   AUTOIMMUNITY

Pharmacological Inhibition of Focal Adhesion Kinase Attenuates Cardiac Fibrosis in Mice Cardiac Fibroblast and Post-Myocardial-Infarction Models

(2015) Guang-Pu Fan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Microrna-21: A Central Regulator of Fibrotic Diseases Via Various Targets

(2015) Ying Huang et al.   CURRENT PHARMACEUTICAL DESIGN

miR-21 and cardiac fibrosis: another brick in the wall?: Figure 1

(2015) Elena Cavarretta et al.   EUROPEAN HEART JOURNAL

Integrin αvβ6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis

(2015) Zhen-Wei Peng et al.   HEPATOLOGY

Metabolic Reprogramming Is Required for Myofibroblast Contractility and Differentiation

(2015) Karen Bernard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Abl silencing reduced the inhibitory effects of TGF-β1 on apoptosis in systemic sclerosis dermal fibroblasts

(2015) Elham Karimizadeh et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Inhibitory effects of fasudil on renal interstitial fibrosis induced by unilateral ureteral obstruction

(2015) ITSUKO BABA et al.   Molecular Medicine Reports

PPARγ activation following apoptotic cell instillation promotes resolution of lung inflammation and fibrosis via regulation of efferocytosis and proresolving cytokines

(2015) Y-S Yoon et al.   Mucosal Immunology

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Diverse origins of the myofibroblast—implications for kidney fibrosis

(2015) Lucas L. Falke et al.   Nature Reviews Nephrology

Fibrosis — A Common Pathway to Organ Injury and Failure

(2015) Don C. Rockey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and isolation of a dermal lineage with intrinsic fibrogenic potential

(2015) Y. Rinkevich et al.   SCIENCE

Activation and regulation of the granulation tissue derived cells with stemness-related properties

(2015) Zelin Chen et al.   Stem Cell Research & Therapy

Myofibroblasts in Murine Cutaneous Fibrosis Originate From Adiponectin-Positive Intradermal Progenitors

(2015) Roberta Goncalves Marangoni et al.   Arthritis & Rheumatology

Expression of α-Smooth Muscle Actin Determines the Fate of Mesenchymal Stromal Cells

(2015) Nilesh P. Talele et al.   Stem Cell Reports

Systemic sclerosis

(2015) Yannick Allanore et al.   Nature Reviews Disease Primers

A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis

(2015) Xu Shiwen et al.   PLoS One

Tumor Necrosis Factor-α Accelerates the Resolution of Established Pulmonary Fibrosis in Mice by Targeting Profibrotic Lung Macrophages

(2014) Elizabeth F. Redente et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Reversal, maintenance or progression: What happens to the liver after a virologic cure of hepatitis C?

(2014) Youngmin A. Lee et al.   ANTIVIRAL RESEARCH

Cysteine cathepsins and extracellular matrix degradation

(2014) Marko Fonović et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Prostaglandin E2Inhibits α-Smooth Muscle Actin Transcription during Myofibroblast Differentiation via Distinct Mechanisms of Modulation of Serum Response Factor and Myocardin-related Transcription Factor-A

(2014) Loka R. K. Penke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Platelet-derived Growth Factor Primes Cancer-associated Fibroblasts for Apoptosis

(2014) Sumera Rizvi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation

(2014) Franco Klingberg et al.   JOURNAL OF CELL BIOLOGY

Fibrotic extracellular matrix activates a profibrotic positive feedback loop

(2014) Matthew W. Parker et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fibrosis—a lethal component of systemic sclerosis

(2014) Yuen Yee Ho et al.   Nature Reviews Rheumatology

Interstitial lung disease in connective tissue disease—mechanisms and management

(2014) Athol U. Wells et al.   Nature Reviews Rheumatology

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

(2014) Talmadge E. King et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance

(2014) L. Hecker et al.   Science Translational Medicine

Always cleave up your mess: targeting collagen degradation to treat tissue fibrosis

(2013) William McKleroy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Animal Models of Fibrotic Lung Disease

(2013) Bethany B. Moore et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Antifibrotic Effects of Focal Adhesion Kinase Inhibitor in Bleomycin-Induced Pulmonary Fibrosis in Mice

(2013) Katsuhiro Kinoshita et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

X-Linked Inhibitor of Apoptosis Regulates Lung Fibroblast Resistance to Fas-Mediated Apoptosis

(2013) Iyabode O. Ajayi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

High Mitochondrial Priming Sensitizes hESCs to DNA-Damage-Induced Apoptosis

(2013) Julia C. Liu et al.   Cell Stem Cell

The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance

(2013) E. L. Burnham et al.   EUROPEAN RESPIRATORY JOURNAL

LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation

(2013) Norihiko Sakai et al.   FASEB JOURNAL

Novel Rho/MRTF/SRF Inhibitors Block Matrix-stiffness and TGF-β–Induced Fibrogenesis in Human Colonic Myofibroblasts

(2013) Laura A. Johnson et al.   INFLAMMATORY BOWEL DISEASES

M2-like macrophages are responsible for collagen degradation through a mannose receptor–mediated pathway

(2013) Daniel H. Madsen et al.   JOURNAL OF CELL BIOLOGY

Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis

(2013) Yong Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Discoidin domain receptors in disease

(2013) Corina M. Borza et al.   MATRIX BIOLOGY

Matricellular Protein CCN1 Promotes Regression of Liver Fibrosis through Induction of Cellular Senescence in Hepatic Myofibroblasts

(2013) K.-H. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Differential topical susceptibility to TGFβ in intact and injured regions of the epithelium: key role in myofibroblast transition

(2013) Pam Speight et al.   MOLECULAR BIOLOGY OF THE CELL

Distinct fibroblast lineages determine dermal architecture in skin development and repair

(2013) Ryan R. Driskell et al.   NATURE

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

It has to be the αv: myofibroblast integrins activate latent TGF-β1

(2013) Boris Hinz   NATURE MEDICINE

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

(2013) Neil C Henderson et al.   NATURE MEDICINE

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation of MRTF-A-dependent gene expression with a small molecule promotes myofibroblast differentiation and wound healing

(2013) L. S. Velasquez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling interplay between transforming growth factor-β receptor and PI3K/AKT pathways in cancer

(2013) Long Zhang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Skin Progenitor Cells Contribute to Bleomycin-Induced Skin Fibrosis

(2013) Shangxi Liu et al.   Arthritis & Rheumatology

Mechanoregulation of the Myofibroblast in Wound Contraction, Scarring, and Fibrosis: Opportunities for New Therapeutic Intervention

(2013) Livingston Van De Water et al.   Advances in Wound Care

miR-21 Regulates Skin Wound Healing by Targeting Multiple Aspects of the Healing Process

(2012) Tao Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Adenoviral Gene Transfer of Endothelin-1 in the Lung Induces Pulmonary Fibrosis through the Activation of Focal Adhesion Kinase

(2012) David Lagares et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Patterns and predictors of change in outcome measures in clinical trials in scleroderma: An individual patient meta-analysis of 629 subjects with diffuse cutaneous systemic sclerosis

(2012) P. A. Merkel et al.   ARTHRITIS AND RHEUMATISM

Cardiac Fibrosis Revisited by MicroRNA Therapeutics

(2012) Thomas Thum et al.   CIRCULATION

The mechanical memory of lung myofibroblasts

(2012) Jenna L. Balestrini et al.   Integrative Biology

Fasudil, a Rho-Kinase Inhibitor, Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice

(2012) Chunguo Jiang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acid sphingomyelinase deficiency contributes to resistance of scleroderma fibroblasts to Fas-mediated apoptosis

(2012) Glady Hazitha Samuel et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Clinical evidence for the regression of liver fibrosis

(2012) Elizabeth L. Ellis et al.   JOURNAL OF HEPATOLOGY

Cellular Senescence Limits Regenerative Capacity and Allograft Survival

(2012) H. Braun et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL- and NKG2D-dependent manner

(2012) Andreas Glässner et al.   LABORATORY INVESTIGATION

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Fibrogenic cell reversion underlies fibrosis regression in liver

(2012) S. L. Friedman   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

(2012) T. Kisseleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relaxin Regulates Myofibroblast Contractility and Protects against Lung Fibrosis

(2011) Xiangwei Huang et al.   AMERICAN JOURNAL OF PATHOLOGY

Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation

(2011) David Lagares et al.   ARTHRITIS AND RHEUMATISM

Caspase-8 and Bid: Caught in the act between death receptors and mitochondria

(2011) Chahrazade Kantari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

Survivin expression induced by endothelin-1 promotes myofibroblast resistance to apoptosis

(2011) Jeffrey C. Horowitz et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Myocardin-Related Transcription Factors A and B Are Key Regulators of TGF-β1-Induced Fibroblast to Myofibroblast Differentiation

(2011) Beverly J. Crider et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling

(2011) Victor W Wong et al.   NATURE MEDICINE

Wound Contraction Is Attenuated by Fasudil Inhibition of Rho-Associated Kinase

(2011) Jennifer E. Bond et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy

(2011) T. N. Chonghaile et al.   SCIENCE

Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis

(2010) Yury Popov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Diminished Prostaglandin E2Contributes to the Apoptosis Paradox in Idiopathic Pulmonary Fibrosis

(2010) Toby M. Maher et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Dasatinib impairs long-term expansion of leukemic progenitors in a subset of acute myeloid leukemia cases

(2010) Lina Han et al.   ANNALS OF HEMATOLOGY

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Endothelin 1 contributes to the effect of transforming growth factor β1 on wound repair and skin fibrosis

(2010) David Lagares et al.   ARTHRITIS AND RHEUMATISM

Animal models of systemic sclerosis: Prospects and limitations

(2010) Christian Beyer et al.   ARTHRITIS AND RHEUMATISM

Incidence and mortality of interstitial lung disease in rheumatoid arthritis: A population-based study

(2010) Tim Bongartz et al.   ARTHRITIS AND RHEUMATISM

Regulation of myofibroblast activities: Calcium pulls some strings behind the scene

(2010) Lysianne Follonier Castella et al.   EXPERIMENTAL CELL RESEARCH

Clearance of apoptotic cells: implications in health and disease

(2010) Michael R. Elliott et al.   JOURNAL OF CELL BIOLOGY

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

(2010) Fei Liu et al.   JOURNAL OF CELL BIOLOGY

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

(2010) Joon-Il Jun et al.   NATURE CELL BIOLOGY

A chemical and phosphoproteomic characterization of dasatinib action in lung cancer

(2010) Jiannong Li et al.   Nature Chemical Biology

Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4+ CD8+ thymocytes

(2010) J. A. Ryan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual Role of CCR2 in the Constitution and the Resolution of Liver Fibrosis in Mice

(2009) Claudia Mitchell et al.   AMERICAN JOURNAL OF PATHOLOGY

Endothelin-1 and Transforming Growth Factor-β1 Independently Induce Fibroblast Resistance to Apoptosis via AKT Activation

(2009) Priya Kulasekaran et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Prostaglandin E2 induces fibroblast apoptosis by modulating multiple survival pathways

(2009) Steven K. Huang et al.   FASEB JOURNAL

Pharmacological inhibition of integrin αvβ3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis

(2009) Eleonora Patsenker et al.   HEPATOLOGY

Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages

(2009) Kamran Atabai et al.   JOURNAL OF CLINICAL INVESTIGATION

Basic fibroblast growth factor induces down-regulation of α-smooth muscle actin and reduction of myofibroblast areas in open skin wounds

(2009) Shigeki Ishiguro et al.   WOUND REPAIR AND REGENERATION

Tissue stiffness, latent TGF-β1 Activation, and mechanical signal transduction: Implications for the pathogenesis and treatment of fibrosis

(2009) Boris Hinz   Current Rheumatology Reports

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Inhibition of Integrin αvβ6, an Activator of Latent Transforming Growth Factor-β, Prevents Radiation-induced Lung Fibrosis

(2007) Khalid Puthawala et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

(2007) Gerald S. Horan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Apoptosis in Pulmonary Fibrosis: Too Much or Not Enough?

(2007) Cheryl L. Fattman   ANTIOXIDANTS & REDOX SIGNALING

Effect of Mycophenolate Mofetil on Pulmonary Function in Scleroderma-Associated Interstitial Lung Disease

(2007) Anthony J. Gerbino et al.   CHEST

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Use of mycophenolate mofetil to treat scleroderma-associated interstitial lung disease

(2007) Ana C. Zamora et al.   RESPIRATORY MEDICINE