Fibrosis—a lethal component of systemic sclerosis

Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome

(2014) Wen-Xing Ding et al.   Autophagy

Mortality in systemic sclerosis

(2014) Mandana Nikpour et al.   CURRENT OPINION IN RHEUMATOLOGY

Interleukin-6 Signaling Drives Fibrosis in Unresolved Inflammation

(2014) Ceri A. Fielding et al.   IMMUNITY

A synthetic PPAR-γ agonist triterpenoid ameliorates experimental fibrosis: PPAR-γ-independent suppression of fibrotic responses

(2013) Jun Wei et al.   ANNALS OF THE RHEUMATIC DISEASES

Increased Expression of Endoplasmic Reticulum Stress and Unfolded Protein Response Genes in Peripheral Blood Mononuclear Cells From Patients With Limited Cutaneous Systemic Sclerosis and Pulmonary Arterial Hypertension

(2013) Stefania Lenna et al.   ARTHRITIS AND RHEUMATISM

Targeting Interleukin-6 in Rheumatoid Arthritis

(2013) Md Yuzaiful Md Yusof et al.   DRUGS

LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation

(2013) Norihiko Sakai et al.   FASEB JOURNAL

Evidence for progressive reduction and loss of telocytes in the dermal cellular network of systemic sclerosis

(2013) Mirko Manetti et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis

(2013) Yong Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

The Downregulation of microRNA let-7a Contributes to the Excessive Expression of Type I Collagen in Systemic and Localized Scleroderma

(2013) K. Makino et al.   JOURNAL OF IMMUNOLOGY

Race and Association With Disease Manifestations and Mortality in Scleroderma

(2013) Allan C. Gelber et al.   MEDICINE

Targeted therapies for systemic sclerosis

(2013) Christopher P. Denton et al.   Nature Reviews Rheumatology

Activation of MRTF-A-dependent gene expression with a small molecule promotes myofibroblast differentiation and wound healing

(2013) L. S. Velasquez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-150 Down-Regulation Contributes to the Constitutive Type I Collagen Overexpression in Scleroderma Dermal Fibroblasts via the Induction of Integrin β3

(2012) Noritoshi Honda et al.   AMERICAN JOURNAL OF PATHOLOGY

Outcomes of patients with systemic sclerosis-associated polyarthritis and myopathy treated with tocilizumab or abatacept: a EUSTAR observational study

(2012) Muriel Elhai et al.   ANNALS OF THE RHEUMATIC DISEASES

The Unfolded Protein Response in Secretory Cell Function

(2012) Kristin A. Moore et al.   Annual Review of Genetics

Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells

(2012) Jun Wei et al.   ARTHRITIS AND RHEUMATISM

Lysoglycerophospholipids in chronic inflammatory disorders: The PLA2/LPC and ATX/LPA axes

(2012) Ioanna Sevastou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Endoplasmic reticulum stress as a pro-fibrotic stimulus

(2012) Harikrishna Tanjore et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

Lipids and eicosanoids in fibrosis

(2012) Flavia V. Castelino   CURRENT OPINION IN RHEUMATOLOGY

The role of endoplasmic reticulum stress and the unfolded protein response in fibrosis

(2012) Stefania Lenna et al.   CURRENT OPINION IN RHEUMATOLOGY

Biomechanical regulation of mesenchymal cell function

(2012) Daniel J. Tschumperlin et al.   CURRENT OPINION IN RHEUMATOLOGY

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

(2012) Y. Liu-Chittenden et al.   GENES & DEVELOPMENT

Elevated Serum Levels of Arachidonoyl-lysophosphatidic Acid and Sphingosine 1-Phosphate in Systemic Sclerosis

(2012) Akira Tokumura et al.   International Journal of Medical Sciences

Fasudil, a Rho-Kinase Inhibitor, Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice

(2012) Chunguo Jiang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Telocytes in human skin - are they involved in skin regeneration?

(2012) Laura Ceafalan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis

(2012) Ioanna Nikitopoulou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Heat shock protein 90 inhibitor attenuates renal fibrosis through degradation of transforming growth factor-β type II receptor

(2012) Hyunjin Noh et al.   LABORATORY INVESTIGATION

Inhibition of Notch Signaling by a γ-Secretase Inhibitor Attenuates Hepatic Fibrosis in Rats

(2012) Yixiong Chen et al.   PLoS One

Focal adhesion kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts

(2012) X. Shi-wen et al.   RHEUMATOLOGY

The Hsp90 inhibitor 17-AAG represses calcium-induced cytokeratin 1 and 10 expression in HaCaT keratinocytes

(2012) Sadanori Miyoshi et al.   FEBS Open Bio

Dendritic cells a double-edge sword in autoimmune responses

(2012) Giada Amodio et al.   Frontiers in Immunology

Relaxin Regulates Myofibroblast Contractility and Protects against Lung Fibrosis

(2011) Xiangwei Huang et al.   AMERICAN JOURNAL OF PATHOLOGY

Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis

(2011) C. Dees et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis

(2011) Clara Dees et al.   ARTHRITIS AND RHEUMATISM

Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?

(2011) Jun Wei et al.   ARTHRITIS AND RHEUMATISM

Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma

(2011) Flavia V. Castelino et al.   ARTHRITIS AND RHEUMATISM

Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation

(2011) David Lagares et al.   ARTHRITIS AND RHEUMATISM

Insights into the pharmacological relevance of lysophospholipid receptors

(2011) Tetsuji Mutoh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Telocytes and putative stem cells in the lungs: electron microscopy, electron tomography and laser scanning microscopy

(2011) Laurentiu M. Popescu et al.   CELL AND TISSUE RESEARCH

Scleroderma-like properties of skin from caveolin-1-deficient mice

(2011) Remedios Castello-Cros et al.   CELL CYCLE

An update on an immune system that goes awry in systemic sclerosis

(2011) L. van Bon et al.   CURRENT OPINION IN RHEUMATOLOGY

Role of IL-13 in systemic sclerosis

(2011) Patrizia Fuschiotti   CYTOKINE

TGF-β signaling in fibrosis

(2011) Anna Biernacka et al.   GROWTH FACTORS

Myocardin-related Transcription Factor-A Complexes Activate Type I Collagen Expression in Lung Fibroblasts

(2011) Larry L. Luchsinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dendritic Cells and Damage-Associated Molecular Patterns: Endogenous Danger Signals Linking Innate and Adaptive Immunity

(2011) Gary Nace et al.   Journal of Innate Immunity

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling

(2011) Victor W Wong et al.   NATURE MEDICINE

Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities

(2011) Swati Bhattacharyya et al.   Nature Reviews Rheumatology

Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis

(2011) N. Washida et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition

(2011) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiogenesis and Vasculopathy in Systemic Sclerosis: Evolving Concepts

(2011) Bradley J. Rabquer et al.   Current Rheumatology Reports

Dendritic Cells: Novel Players in Fibrosis and Scleroderma

(2011) Theresa T. Lu   Current Rheumatology Reports

An Essential Role for Resident Fibroblasts in Experimental Lung Fibrosis Is Defined by Lineage-Specific Deletion of High-Affinity Type II Transforming Growth Factor β Receptor

(2010) Rachel K. Hoyles et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

MicroRNA-29, a key regulator of collagen expression in systemic sclerosis

(2010) Britta Maurer et al.   ARTHRITIS AND RHEUMATISM

Myocardin-Related Transcription Factor-A Controls Myofibroblast Activation and Fibrosis in Response to Myocardial Infarction

(2010) Eric M. Small et al.   CIRCULATION RESEARCH

Diagnosis and Classification of Systemic Sclerosis

(2010) Eric Hachulla et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer

(2010) Alexander Schultze et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

(2010) Fei Liu et al.   JOURNAL OF CELL BIOLOGY

Telocytes as supporting cells for myocardial tissue organization in developing and adult heart

(2010) Daniele Bani et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Poly(I:C) Drives Type I IFN- and TGFβ-Mediated Inflammation and Dermal Fibrosis Simulating Altered Gene Expression in Systemic Sclerosis

(2010) Giuseppina A. Farina et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α

(2010) Curtis A Thorne et al.   Nature Chemical Biology

Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

(2010) Vivian Barry-Hamilton et al.   NATURE MEDICINE

Cellular and molecular aspects of vascular dysfunction in systemic sclerosis

(2010) Maria Trojanowska   Nature Reviews Rheumatology

PPARγ Downregulation by TGFß in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis

(2010) Jun Wei et al.   PLoS One

The skin of patients with systemic sclerosis softened during the treatment with anti-IL-6 receptor antibody tocilizumab

(2010) Y. Shima et al.   RHEUMATOLOGY

Rosiglitazone Abrogates Bleomycin-Induced Scleroderma and Blocks Profibrotic Responses Through Peroxisome Proliferator-Activated Receptor-γ

(2009) Minghua Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY

Effector CD8+ T cells in systemic sclerosis patients produce abnormally high levels of interleukin-13 associated with increased skin fibrosis

(2009) Patrizia Fuschiotti et al.   ARTHRITIS AND RHEUMATISM

Loss of peroxisome proliferator-activated receptor γ in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis

(2009) Mohit Kapoor et al.   ARTHRITIS AND RHEUMATISM

Autophagy eliminates a specific species of misfolded procollagen and plays a protective role in cell survival against ER stress

(2009) Yoshihito Ishida et al.   Autophagy

Peroxisome proliferator-activated receptor-γ abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator

(2009) Asish K. Ghosh et al.   FASEB JOURNAL

Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice

(2009) Kojiro Taura et al.   HEPATOLOGY

Fibrocyte CXCR4 regulation as a therapeutic target in pulmonary fibrosis

(2009) Borna Mehrad et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Increased Frequency and Compromised Function of T Regulatory Cells in Systemic Sclerosis (SSc) Is Related to a Diminished CD69 and TGFβ Expression

(2009) Timothy R. D. J. Radstake et al.   PLoS One

Cutaneous Chronic Graft-Versus-Host Disease Does Not Have the Abnormal Endothelial Phenotype or Vascular Rarefaction Characteristic of Systemic Sclerosis

(2009) Jo Nadine Fleming et al.   PLoS One

Enhanced interleukin‐10 production by dendritic cells upon stimulation with Toll‐like receptor 4 agonists in systemic sclerosis that is possibly implicated in CCL18 secretion

(2009) A. W. T. van Lieshout et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Pericytes and Perivascular Fibroblasts Are the Primary Source of Collagen-Producing Cells in Obstructive Fibrosis of the Kidney

(2008) Shuei-Liong Lin et al.   AMERICAN JOURNAL OF PATHOLOGY

Activation of Toll-Like Receptor 3 Augments Myofibroblast Differentiation

(2008) Hisatoshi Sugiura et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts

(2008) Alfiya Akhmetshina et al.   ARTHRITIS AND RHEUMATISM

Antifibroblast antibodies in systemic sclerosis induce fibroblasts to produce profibrotic chemokines, with partial exploitation of toll-like receptor 4

(2008) Serena Fineschi et al.   ARTHRITIS AND RHEUMATISM

Central role of dendritic cells in the regulation and deregulation of immune responses

(2008) F. Granucci et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

TLR9 is expressed in idiopathic interstitial pneumonia and its activation promotes in vitro myofibroblast differentiation

(2008) A. Meneghin et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Regulatory Effect of Extracellular Signal-Regulated Kinases (ERK) on Type I Collagen Synthesis in Human Dermal Fibroblasts Stimulated by IL-4 and IL-13

(2008) Rashpal K. Bhogal et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Surface morphology and mechanical properties of fibroblasts from scleroderma patients

(2008) Adam Reich et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Thiazolidinediones Downregulate Wnt/β-Catenin Signaling Via Multiple Mechanisms in Breast Cancer Cells

(2008) Pei-Shan Wang et al.   JOURNAL OF SURGICAL RESEARCH

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

(2008) Xaralabos Varelas et al.   NATURE CELL BIOLOGY

Molecular Subsets in the Gene Expression Signatures of Scleroderma Skin

(2008) Ausra Milano et al.   PLoS One

Critical regulation of TGF  signaling by Hsp90

(2008) K. H. Wrighton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA