Targeting Wnt/β‐catenin and PI3K/Akt/mTOR pathways in T‐cell acute lymphoblastic leukemia

PNU-74654 enhances the antiproliferative effects of 5-FU in breast cancer and antagonizes thrombin-induced cell growth via the Wnt pathway

(2019) Farzad Rahmani et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Wnt pathway targeting reduces triple‐negative breast cancer aggressiveness through miRNA regulation in vitro and in vivo

(2019) Samira Mohammadi‐Yeganeh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Loss of G3BP1 suppresses proliferation, migration, and invasion of esophageal cancer cells via Wnt/β‐catenin and PI3K/AKT signaling pathways

(2019) Li‐Na Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Key Roles of PTEN in T-Cell Acute Lymphoblastic Leukemia Development, Progression, and Therapeutic Response

(2019) Alberto M. Martelli et al.   Cancers

USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin

(2019) Lei Ji et al.   Nature Communications

T cell acute lymphoblastic leukemia (T-ALL): New insights into the cellular origins and infiltration mechanisms common and unique among hematologic malignancies

(2018) Eduardo Vadillo et al.   BLOOD REVIEWS

Genomics and pharmacogenomics of pediatric acute lymphoblastic leukemia

(2018) Chuan Wu et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Activation of WNT/β-catenin signaling results in resistance to a dual PI3K/mTOR inhibitor in colorectal cancer cells harboring PIK3CA mutations

(2018) Ye-Lim Park et al.   INTERNATIONAL JOURNAL OF CANCER

Therapeutic Targeting of mTOR in T-Cell Acute Lymphoblastic Leukemia: An Update

(2018) Camilla Evangelisti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The roles of Wnt/β-catenin pathway in tissue development and regenerative medicine

(2018) Maryam Majidinia et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase

(2018) Jianbiao Zhou et al.   Journal of Hematology & Oncology

Therapeutic potency of Wnt signaling antagonists in the pathogenesis of prostate cancer, current status and perspectives

(2018) Mehran Pashirzad et al.   JOURNAL OF CELLULAR PHYSIOLOGY

MicroRNA-590-5p functions as a tumor suppressor in breast cancer conferring inhibitory effects on cell migration, invasion, and epithelial-mesenchymal transition by downregulating the Wnt-β-catenin signaling pathway

(2018) Jin Gao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Wnt/β-catenin signaling cascade: A promising target for glioma therapy

(2018) Lu He et al.   JOURNAL OF CELLULAR PHYSIOLOGY

LncRNA miR143HG suppresses bladder cancer development through inactivating Wnt/β-catenin pathway by modulating miR-1275/AXIN2 axis

(2018) Hui Xie et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cancer stem cells (CSCs) in cancer progression and therapy

(2018) Masoud Najafi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Wnt signaling reprograms metabolism in dental pulp stem cells

(2018) Véronica Uribe‐Etxebarria et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Downregulation of long noncoding RNA DGCR5 contributes to the proliferation, migration, and invasion of cervical cancer by activating Wnt signaling pathway

(2018) Yun Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

T-ALL leukemia stem cell 'stemness' is epigenetically controlled by the master regulator SPI1

(2018) Haichuan Zhu et al.   eLife

CBP/Catenin antagonists: Targeting LSCs’ Achilles heel

(2017) Yong-Mi Kim et al.   EXPERIMENTAL HEMATOLOGY

Aberrant Signaling Pathways in T-Cell Acute Lymphoblastic Leukemia

(2017) Deborah Bongiovanni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IRS1/β-Catenin Axis Is Activated and Induces MYC Expression in Acute Lymphoblastic Leukemia Cells

(2017) Jaqueline Cristina Fernandes et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Phosphatidylinositol 3-kinase inhibition potentiates glucocorticoid response in B-cell acute lymphoblastic leukemia

(2017) Cecilia Evangelisti et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Role of Wnt/β-catenin signaling regulatory microRNAs in the pathogenesis of colorectal cancer

(2017) Farzad Rahmani et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Long non-coding RNA LINC00968 acts as oncogene in NSCLC by activating the Wnt signaling pathway

(2017) Yíng Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

PTEN loss and activation of K-RAS and β-catenin cooperate to accelerate prostate tumourigenesis

(2017) Matthew T Jefferies et al.   JOURNAL OF PATHOLOGY

Integration of hypoxic HIF-α signaling in blood cancers

(2017) L Schito et al.   ONCOGENE

MYC, Cell Competition, and Cell Death in Cancer: The Inseparable Triad

(2017) Simone Di Giacomo et al.   Genes

Safety, Tolerability, and Preliminary Efficacy of the Anti-Fibrotic Small Molecule PRI-724, a CBP/β-Catenin Inhibitor, in Patients with Hepatitis C Virus-related Cirrhosis: A Single-Center, Open-Label, Dose Escalation Phase 1 Trial

(2017) Kiminori Kimura et al.   EBioMedicine

Advances in understanding the acute lymphoblastic leukemia bone marrow microenvironment: From biology to therapeutic targeting

(2016) Francesca Chiarini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Improving nelarabine efficacy in T cell acute lymphoblastic leukemia by targeting aberrant PI3K/AKT/mTOR signaling pathway

(2016) Annalisa Lonetti et al.   Journal of Hematology & Oncology

β-Catenin is required for T-cell leukemia initiation and MYC transcription downstream of Notch1

(2016) C Gekas et al.   LEUKEMIA

Inhibition of β-Catenin to Overcome Endocrine Resistance in Tamoxifen-Resistant Breast Cancer Cell Line

(2016) Hye Sung Won et al.   PLoS One

BET inhibitors in the treatment of hematologic malignancies: current insights and future prospects

(2016) Hidayatullah Munshi et al.   OncoTargets and Therapy

OTX015 (MK-8628), a novel BET inhibitor, exhibits antitumor activity in non-small cell and small cell lung cancer models harboring different oncogenic mutations

(2016) Maria E. Riveiro et al.   Oncotarget

Secreted pyruvate kinase M2 facilitates cell migration via PI3K/Akt and Wnt/β-catenin pathway in colon cancer cells

(2015) Peng Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Leukemia stem cells in T-ALL require active Hif1α and Wnt signaling

(2015) Vincenzo Giambra et al.   BLOOD

Tankyrase Inhibition Blocks Wnt/ -Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer

(2015) O. Arques et al.   CLINICAL CANCER RESEARCH

CBP/catenin antagonist safely eliminates drug-resistant leukemia-initiating cells

(2015) Y Zhao et al.   ONCOGENE

Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

(2015) Eleonore Beurel et al.   PHARMACOLOGY & THERAPEUTICS

PI3K pan-inhibition impairs more efficiently proliferation and survival of T-cell acute lymphoblastic leukemia cell lines when compared to isoform-selective PI3K inhibitors

(2015) Annalisa Lonetti et al.   Oncotarget

Characterization of LEF1 High Expression and Novel Mutations in Adult Acute Lymphoblastic Leukemia

(2015) Xing Guo et al.   PLoS One

Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: Eliminating activity by targeting at different levels

(2015) Daniela Bressanin et al.   Oncotarget

A novel DAG-dependent mechanism links PKCɑ and Cyclin B1 regulating cell cycle progression

(2015) Alessandro Poli et al.   Oncotarget

Therapeutic Targeting of c-Myc in T-Cell Acute Lymphoblastic Leukemia (T-ALL)

(2015) Marie Loosveld et al.   Oncotarget

Wnt inhibition leads to improved chemosensitivity in paediatric acute lymphoblastic leukaemia

(2014) Smita Dandekar et al.   BRITISH JOURNAL OF HAEMATOLOGY

Targeting the MYC and PI3K Pathways Eliminates Leukemia-Initiating Cells in T-cell Acute Lymphoblastic Leukemia

(2014) S. Schubbert et al.   CANCER RESEARCH

Therapeutic potential of targeting mTOR in T-cell acute lymphoblastic leukemia (Review)

(2014) CAMILLA EVANGELISTI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The CREB-Binding Protein Inhibitor ICG-001 Suppresses Pancreatic Cancer Growth

(2014) M. D. Arensman et al.   MOLECULAR CANCER THERAPEUTICS

RNF43 is frequently mutated in colorectal and endometrial cancers

(2014) Marios Giannakis et al.   NATURE GENETICS

Deregulated WNT signaling in childhood T-cell acute lymphoblastic leukemia

(2014) O H Ng et al.   Blood Cancer Journal

Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6

(2014) Jennifer L Stamos et al.   eLife

 -Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL

(2013) D. Kaveri et al.   BLOOD

Notch and Wnt signaling in the emergence of hematopoietic stem cells

(2013) Anna Bigas et al.   BLOOD CELLS MOLECULES AND DISEASES

Activity of the pan-class I phosphoinositide 3-kinase inhibitor NVP-BKM120 in T-cell acute lymphoblastic leukemia

(2013) A Lonetti et al.   LEUKEMIA

Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention

(2013) J A McCubrey et al.   LEUKEMIA

Small-molecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia

(2013) E J Gang et al.   ONCOGENE

PIK3CA and APC mutations are synergistic in the development of intestinal cancers

(2013) D A Deming et al.   ONCOGENE

A Wnt-er Migration: The Confusing Role of  -Catenin in Melanoma Metastasis

(2013) M. R. Webster et al.   Science Signaling

Wnt Signaling in Normal and Malignant Hematopoiesis

(2013) W. Lento et al.   Cold Spring Harbor Perspectives in Biology

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Wnt/ -Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells

(2012) K. Hoffmeyer et al.   SCIENCE

Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia

(2011) E. Park et al.   BLOOD

Endogenous knockdown of survivin improves chemotherapeutic response in ALL models

(2011) D J Morrison et al.   LEUKEMIA

Pronounced Hypoxia in Models of Murine and Human Leukemia: High Efficacy of Hypoxia-Activated Prodrug PR-104

(2011) Juliana Benito et al.   PLoS One

The dual PI3K/mTOR inhibitor NVP-BGT226 induces cell cycle arrest and regulates Survivin gene expression in human pancreatic cancer cell lines

(2011) Wolfgang Glienke et al.   TUMOR BIOLOGY

Wnt signal transduction pathway and apoptosis: a review

(2010) Nives Pećina-Šlaus   Cancer Cell International

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

Chronic Hypoxia Activates the Akt and β-Catenin Pathways in Human Macrophages

(2009) Jun-o Deguchi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dual Inhibition of Class IA Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin as a New Therapeutic Option for T-Cell Acute Lymphoblastic Leukemia

(2009) F. Chiarini et al.   CANCER RESEARCH

Wnt-Related Molecules and Signaling Pathway Equilibrium in Hematopoiesis

(2009) Sachin Malhotra et al.   Cell Stem Cell

The canonical Wnt signaling pathway plays an important role in lymphopoiesis and hematopoiesis

(2008) Frank J. T. Staal et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

(2008) Ana Silva et al.   JOURNAL OF CLINICAL INVESTIGATION

A novel role for Lef-1, a central transcription mediator of Wnt signaling, in leukemogenesis

(2008) Konstantin Petropoulos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

(2008) Wei Guo et al.   NATURE