Phosphatidylinositol 3-kinase inhibition potentiates glucocorticoid response in B-cell acute lymphoblastic leukemia

Clinical use of PI3K inhibitors in B-cell lymphoid malignancies: today and tomorrow

(2017) I. B. Greenwell et al.   Expert Review of Anticancer Therapy

Nuclear Localization of Diacylglycerol Kinase Alpha in K562 Cells Is Involved in Cell Cycle Progression

(2017) Alessandro Poli et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Effects of pharmacological and genetic disruption of CXCR4 chemokine receptor function in B-cell acute lymphoblastic leukaemia

(2016) Shubhchintan Randhawa et al.   BRITISH JOURNAL OF HAEMATOLOGY

Targeting the Breast Cancer Kinome

(2016) Samantha M. Miller et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Non-Conventional Effects of Glucocorticoids in Cancer

(2016) Simra Azher et al.   JOURNAL OF CELLULAR PHYSIOLOGY

MED28 Regulates Epithelial-Mesenchymal Transition Through NFκB in Human Breast Cancer Cells

(2016) Chun-Yin Huang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Lack of glucocorticoid-induced leucine zipper (GILZ) deregulates B-cell survival and results in B-cell lymphocytosis in mice

(2015) S. Bruscoli et al.   BLOOD

The paradoxical role of IL-10 in immunity and cancer

(2015) Mark H. Mannino et al.   CANCER LETTERS

Efficacy of phosphatidylinositol-3 kinase inhibitors with diverse isoform selectivity profiles for inhibiting the survival of chronic lymphocytic leukemia cells

(2015) Elisa Göckeritz et al.   INTERNATIONAL JOURNAL OF CANCER

Critical Role of AMPK/FoxO3A Axis in Globular Adiponectin-Induced Cell Cycle Arrest and Apoptosis in Cancer Cells

(2015) Anup Shrestha et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Different Effects of p52SHC1 and p52SHC3 on the Cell Cycle of Neurons and Neural Stem Cells

(2015) Ning Tang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

BMP-2 Induced Expression of PLCβ1 That is a Positive Regulator of Osteoblast Differentiation

(2015) Giulia Ramazzotti et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Dexamethasone Downregulates SLC7A5 Expression and Promotes Cell Cycle Arrest, Autophagy and Apoptosis in BeWo Cells

(2015) Bin He et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The phosphoinositide-3-kinase (PI3K)-delta and gamma inhibitor, IPI-145 (Duvelisib), overcomes signals from the PI3K/AKT/S6 pathway and promotes apoptosis in CLL

(2015) K Balakrishnan et al.   LEUKEMIA

PI3K pan-inhibition impairs more efficiently proliferation and survival of T-cell acute lymphoblastic leukemia cell lines when compared to isoform-selective PI3K inhibitors

(2015) Annalisa Lonetti et al.   Oncotarget

Opposing regulation of BIM and BCL2 controls glucocorticoid-induced apoptosis of pediatric acute lymphoblastic leukemia cells

(2014) D. Jing et al.   BLOOD

IPI-145 antagonizes intrinsic and extrinsic survival signals in chronic lymphocytic leukemia cells

(2014) S. Dong et al.   BLOOD

Disturbed CXCR4/CXCL12 axis in paediatric precursor B-cell acute lymphoblastic leukaemia

(2014) Lieke C. J. van den Berk et al.   BRITISH JOURNAL OF HAEMATOLOGY

Preclinical and Early Clinical Evaluation of the Oral AKT Inhibitor, MK-2206, for the Treatment of Acute Myelogenous Leukemia

(2014) M. Y. Konopleva et al.   CLINICAL CANCER RESEARCH

Phosphoinositide 3-kinase inhibitors in lymphoma

(2014) Emily Curran et al.   CURRENT OPINION IN ONCOLOGY

Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels

(2014) A. M. Gomes et al.   HAEMATOLOGICA

EMP1, a novel poor prognostic factor in pediatric leukemia regulates prednisolone resistance, cell proliferation, migration and adhesion

(2014) I M Ariës et al.   LEUKEMIA

PI3K and cancer: lessons, challenges and opportunities

(2014) David A. Fruman et al.   NATURE REVIEWS DRUG DISCOVERY

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

(2014) Lynne Chantranupong et al.   Cell Reports

Targeting the PI3K/mTOR Pathway in Pediatric Hematologic Malignancies

(2014) Sarah K. Tasian et al.   Frontiers in Oncology

Proliferation of PTEN-deficient haematopoietic tumour cells is not affected by isoform-selective inhibition of p110β PI3-kinase and requires blockade of all class 1 PI3K activity

(2013) Chloe Stengel et al.   BRITISH JOURNAL OF HAEMATOLOGY

Direct Reversal of Glucocorticoid Resistance by AKT Inhibition in Acute Lymphoblastic Leukemia

(2013) Erich Piovan et al.   CANCER CELL

Chemical genomic screening identifies LY294002 as a modulator of glucocorticoid resistance in MLL-rearranged infant ALL

(2013) J A P Spijkers-Hagelstein et al.   LEUKEMIA

Has MRD monitoring superseded other prognostic factors in adult ALL?

(2012) M. Bruggemann et al.   BLOOD

Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment

(2012) Olga Frolova et al.   CANCER BIOLOGY & THERAPY

Targeting Nonclassical Oncogenes for Therapy in T-ALL

(2012) Prem S. Subramaniam et al.   CANCER CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

The PI3K/PKB signaling module as key regulator of hematopoiesis: implications for therapeutic strategies in leukemia

(2011) R. Polak et al.   BLOOD

Phosphorylated CXCR4 is associated with poor survival in adults with B-acute lymphoblastic leukemia

(2011) Sergej Konoplev et al.   CANCER

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Glucocorticoid resistance in paediatric acute lymphoblastic leukaemia

(2011) Vivek A Bhadri et al.   JOURNAL OF PAEDIATRICS AND CHILD HEALTH

Silencing of ETV6/RUNX1 abrogates PI3K/AKT/mTOR signaling and impairs reconstitution of leukemia in xenografts

(2011) G Fuka et al.   LEUKEMIA

Synergistic activity of rapamycin and dexamethasone in vitro and in vivo in acute lymphoblastic leukemia via cell-cycle arrest and apoptosis

(2011) Chong Zhang et al.   LEUKEMIA RESEARCH

Ligand-Independent Phosphorylation of the Glucocorticoid Receptor Integrates Cellular Stress Pathways with Nuclear Receptor Signaling

(2011) A. J. Galliher-Beckley et al.   MOLECULAR AND CELLULAR BIOLOGY

Activation of Akt is associated with poor prognosis and chemotherapeutic resistance in pediatric B-precursor acute lymphoblastic leukemia

(2011) Naoto Morishita et al.   PEDIATRIC BLOOD & CANCER

Biology of acute lymphoblastic leukemia (ALL): Clinical and therapeutic relevance

(2011) Carlos Graux   TRANSFUSION AND APHERESIS SCIENCE

Phosphatidylinositol 3-kinase-  inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals

(2010) S. E. M. Herman et al.   BLOOD

The role of FKBP5 in cancer aetiology and chemoresistance

(2010) L Li et al.   BRITISH JOURNAL OF CANCER

CXCL12 (SDF-1)/CXCR4 Pathway in Cancer

(2010) B. A. Teicher et al.   CLINICAL CANCER RESEARCH

BIM is a prognostic biomarker for early prednisolone response in pediatric acute lymphoblastic leukemia

(2010) Nan Jiang et al.   EXPERIMENTAL HEMATOLOGY

Glucocorticoid use in acute lymphoblastic leukaemia

(2010) Hiroto Inaba et al.   LANCET ONCOLOGY

MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo

(2010) H. Hirai et al.   MOLECULAR CANCER THERAPEUTICS

A Phase I Study of the Mammalian Target of Rapamycin Inhibitor Sirolimus and MEC Chemotherapy in Relapsed and Refractory Acute Myelogenous Leukemia

(2009) A. E. Perl et al.   CLINICAL CANCER RESEARCH

Translational control by RGS2

(2009) Chau H. Nguyen et al.   JOURNAL OF CELL BIOLOGY

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

(2008) Ana Silva et al.   JOURNAL OF CLINICAL INVESTIGATION

CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers

(2008) J A Burger et al.   LEUKEMIA

Relapsed acute lymphoblastic leukemia: Current status and future opportunities

(2008) Theresa M. Harned et al.   Current Oncology Reports