Article
Oncology
Peng Liu, Fuao Cao, Jinke Sui, Yonggang Hong, Qizhi Liu, XianHua Gao, Haifeng Gong, Liqiang Hao, Zheng Lou, Wei Zhang
Summary: The study identified that miR-142-3p acts as a tumor suppressor in colorectal cancer by directly targeting CTNNB1 and inhibiting Wnt signaling activation. Overexpression of miR-142-3p repressed cell proliferation and reduced beta-catenin levels, suggesting its potential as a therapeutic target for CRC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Hu Han, Yan Li, Wan Qin, Lu Wang, Han Yin, Beibei Su, Xianglin Yuan
Summary: The study found that miR-199b-3p is significantly up-regulated in CTx-resistant colorectal cancer cells. Inhibiting miR-199b-3p can improve the sensitivity of CTx-resistant cells to CTx by regulating the Wnt/β-catenin signaling pathway. Mouse models confirmed that down-regulating miR-199b-3p can restore the inhibitory effect of CTx on tumor growth.
CANCER CELL INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Cyrollah Disoma, Yuzheng Zhou, Shanni Li, Jian Peng, Zanxian Xia
Summary: The Wnt/β-catenin signaling pathway plays a crucial role in colorectal carcinogenesis, but no clinically approved therapies targeting this pathway currently exist. New modulators of the pathway are involved not only in cancer initiation but also in chemoresistance, epithelial-mesenchymal transition, and cancer stem cell renewal. CDX2 shows potential as a promising molecular target for colorectal cancer therapeutics, although further studies are needed to determine its significance. Overall, the regulation of the Wnt/β-catenin signaling pathway remains complex and not fully understood, posing a major barrier to the development of targeted chemotherapeutic agents.
Review
Medicine, Research & Experimental
Yong Ji, Jian Lv, Di Sun, Yufeng Huang
Summary: This review explores the significant role of the Wnt/β-catenin signaling pathway in colorectal cancer tumorigenesis, metastasis, and recurrence, as well as its potential value in diagnosis and therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Oncology
Jinlai Wei, Xiangru Zheng, Wenjun Li, Xiaoli Li, Zhongxue Fu
Summary: This study found that Sestrin2 inhibits the progression of colorectal cancer by suppressing cell proliferation, migration, and colony formation. It also affects the cancer stemness properties. This is achieved through downregulation of the Wnt signaling pathway. The findings suggest that Sestrin2 could be a promising therapeutic target for colorectal cancer.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Yung-Fu Wu, Chih-Yang Wang, Wan-Chun Tang, Yu-Cheng Lee, Hoang Dang Khoa Ta, Li-Chia Lin, Syu-Ruei Pan, Yi-Chun Ni, Gangga Anuraga, Kuen-Haur Lee
Summary: Colorectal cancer is a heterogeneous disease with genetic and epigenetic changes, and molecular assessment along with biomarker use for prognosis is gaining attention. This study identifies high mRNA levels of 10 upregulated genes in CRC cells and datasets, showing correlation with worse prognosis in CRC patients. CTNNB1 is found to be a key factor in the interaction with upregulated CRC-associated genes, particularly regulating NKD2, FOXQ1, and CEMIP, which when inhibited, can suppress CRC cell growth, providing efficient biomarkers for prognosis and a new molecular interaction network for CRC.
Article
Pharmacology & Pharmacy
Sha Zeng, Li Chen, Qiang Sun, Hui Zhao, Han Yang, Shan Ren, Maolun Liu, Xianli Meng, Haibo Xu
Summary: The study shows that Scutellarin can suppress colitis-associated cancer in mice by inhibiting the Wnt/β-catenin signaling pathway, leading to alleviation of pathological symptoms.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Environmental Sciences
Yuzhuo Chen, Zhirong Yang, Xingqiang He, Wanglong Zhu, Yujun Wang, Jiaofeng Li, Zhengyu Han, Jie Wen, Wei Liu, Yuhan Yang, Kun Zhang
Summary: Proanthocyanidins (PC) have powerful antioxidant and anti-aging effects, and play an important role in tumor cell growth, drug resistance, recurrence, and metastasis. Recent studies have found that PC exhibits inhibitory effects on colorectal cancer stem cells (CSCs) through the Wnt/β-catenin pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wei Li, Xi Yang, Xiaowei Liu, Hao Deng, Xiaohui He, Wenbin Zhang, Yisong Shen, Xiang Li, Qiwang Peng, Debing Liu
Summary: This study reveals that SETDB1 is highly expressed in colorectal cancer and is associated with poor prognosis. SETDB1 promotes invasion and metastasis of colorectal cancer through direct methylation of beta-catenin in the Wnt/beta-catenin pathway. The activation of the Wnt/beta-catenin pathway can decrease the metastatic ability mediated by SETDB1.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2023)
Article
Chemistry, Multidisciplinary
Yanmei Zhang, Zixuan Wang, Qifan Hu, Hao Luo, Bingchuan Lu, Yunhe Gao, Zhi Qiao, Yongsen Zhou, Yongcong Fang, Jin Gu, Ting Zhang, Zhuo Xiong
Summary: This study identifies a new biomaterial and method for inducing and enriching colorectal cancer stem cells (CSCs) using three-dimensional bioprinting. The use of GelMA-nanoclay hydrogels promotes the formation of spheroids expressing stemness markers and enhances the self-renewal, differentiation, and tumorigenic capacity of cancer cells in vitro and in vivo. The study also demonstrates that spheroids from GelMA-nanoclay hydrogels have increased stemness and sensitivity to anti-CSC compounds compared to traditional methods. This research is significant for facilitating effective CSC-targeting drug screening.
Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.
Article
Agriculture, Multidisciplinary
Hui Zhao, Shun Tang, Qiu Tao, Tianqi Ming, Jiarong Lei, Yuanjing Liang, Yuhui Peng, Minmin Wang, Maolun Liu, Han Yang, Shan Ren, Haibo Xu
Summary: Overwhelming evidence supports the role of the Wnt/beta-catenin signaling pathway in colorectal cancer (CRC) pathogenesis. Ursolic acid (UA), a pentacyclic triterpenoid found in various fruits and plants, has shown potent anticancer activity against CRC, although its mechanism of action is not fully understood. This study aimed to investigate the effects of UA on CRC and its impact on the Wnt/beta-catenin signaling pathway. The study demonstrated that UA significantly inhibited proliferation, migration, and clonality, induced apoptosis, and arrested the cell cycle in CRC cells. Moreover, UA suppressed tumor growth, improved pathological features, induced apoptosis, and arrested the cell cycle in CRC tissue, by diminishing the Wnt/beta-catenin signaling pathway. These findings suggest that UA has the potential to inhibit the malignant phenotype of CRC by attenuating the Wnt/beta-catenin signaling axis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Microbiology
Xiang Li, Jiepeng Huang, Tingting Yu, Xiaoting Fang, Liqin Lou, Shijun Xin, Ling Ji, Feizhao Jiang, Yongliang Lou
Summary: This study demonstrates that Fusobacterium nucleatum abundance is significantly higher in CRC tissues and is closely associated with CRC progression. F. nucleatum enhances CRC cell proliferation and migration through activating Cdk5 and the Wnt/beta-catenin signaling pathway, revealing a novel mechanism for CRC development.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Oncology
Peng-Sheng Lai, Wei-Min Chang, Ying-Yin Chen, Yi-Feng Lin, Hui-Fen Liao, Chung-Yu Chen
Summary: The study suggests that miR-762 may serve as a potential biomarker for promoting colorectal cancer cell growth and invasion, possibly through the Wnt/beta-catenin signaling pathway.
Article
Cell Biology
Hang Tian, Lei Hou, Yumei Xiong, Qiuju Cheng
Summary: The study showed that DEX can inhibit OC development by upregulating miR-185 expression and deactivating the SOX9/Wnt/beta-catenin signaling pathway. MiR-185 targeted SOX9, and interfering with miR-185 expression affected HO-8910 cell proliferation, invasion, migration, and apoptosis. SOX9 knockdown repressed OC development and the Wnt/beta-catenin pathway.
Article
Biochemistry & Molecular Biology
Seyed Isaac Hashemy, Hamed Amiri, Hossein Hosseini, Farzaneh Sadeghzadeh, Muslem Mohammed Mosa Jaseem, Masoud Homayouni Tabrizi
Summary: Chitosan-lecithin nanoparticles modified with polyethylene glycol (PEG) and folic acid (FA) were used to deliver allicin (AC) to colon cancer cells. The nanoparticles showed excellent encapsulation efficiency and stability. The AC-loaded nanoparticles exhibited strong antioxidant, antibacterial, apoptotic and anti-angiogenesis effects. AC-PLCF-NPs have great potential as a therapeutic agent for colon cancer treatment.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Fariba Kokabi, Safieh Ebrahimi, Farshad Mirzavi, Nazanin Ghiasi Nooghabi, Seyedeh Fatemeh Hashemi, Seyed Isaac Hashemy
Summary: Diabetes is the world's fastest-growing disease characterized by persistent hyperglycemia and chronic complications. Substance P and its receptor system have been found to be involved in diabetes pathogenesis and can have both destructive and protective effects on the disease. Understanding the functional relevance of this system in diabetes may lead to new therapeutic options for diabetes and its associated chronic conditions.
Article
Oncology
Alessandro Gregori, Cecilia Bergonzini, Mjriam Capula, Giulia Mantini, Fatemeh Khojasteh-Leylakoohi, Annalisa Comandatore, Ghazaleh Khalili-Tanha, Alireza Khooei, Luca Morelli, Amir Avan, Erik H. Danen, Thomas Schmidt, Elisa Giovannetti
Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and chemoresistant cancer, with a stiff stroma surrounding it playing a role in chemoresistance. High expression of the mechanical sensor ITGA2 correlated with a poor prognosis in PDAC patients, and increased matrix stiffness led to the expression of ITGA2 and chemoresistance to gemcitabine. ITGA2 could be a potential therapeutic target to overcome gemcitabine resistance.
Article
Biochemistry & Molecular Biology
Safieh Ebrahimi, Farshad Mirzavi, Seyed Isaac Hashemy, Maryam Khaleghi Ghadiri, Walter Stummer, Ali Gorji
Summary: This study evaluated the potential anti-cancer synergy of aprepitant, a neurokinin-1 receptor antagonist, and 5-aminolevulinic acid (5-ALA) on U-87 human GBM cells. The combination treatment of aprepitant and 5-ALA showed significant growth inhibitory, pro-apoptotic, and anti-migratory effects on GBM cells. These effects were more prominent than either drug used alone. The findings provide a basis for further research on the combination of aprepitant and 5-ALA as a novel therapeutic approach for GBM.
Article
Biochemistry & Molecular Biology
Marika A. Franczak, Oliwia Krol, Gabriela Harasim, Agata Jedrzejewska, Nadia Zaffaroni, Carlotta Granchi, Filippo Minutolo, Amir Avan, Elisa Giovannetti, Ryszard T. Smolenski, Godefridus J. Peters
Summary: Malignant mesothelioma (MM) is a highly aggressive and resistant tumor. In this study, the cytotoxicity of new inhibitors of glucose transporter type 1 (GLUT-1) and lactate dehydrogenase-A (LDH-A) in relation to ATP/NAD+ metabolism, glycolysis and mitochondrial respiration was investigated. The inhibitors showed cytotoxicity in MM cells, associated with a decrease in ATP and NAD+, and were most effective in cells with the highest metabolic modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Negin Alavi, Parvaneh Maghami, Azar Fani Pakdel, Majid Rezaei, Amir Avan
Summary: The activity of core-shell ZnO nanoparticles containing Oxaliplatin was evaluated through in vitro studies and in vivo mouse models of colorectal cancer. Synthesis of ZnO NPs and ZnO-Gd NPs@polymer shell was achieved through co-precipitation and exploiting Gd's oxophilicity, respectively. The biophysical properties of the NPs were analyzed using various techniques, and the antiproliferative activity and antitumor activity of ZnO-Gd-OXA were determined through MTT assay and xenograft mouse model. The results showed the inhibition of tumor growth and potential for further research on this novel treatment agent for colorectal cancer.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Endocrinology & Metabolism
Sanaz Salaramoli, Hamed Amiri, Hamid Reza Joshaghani, Mahmoud Hosseini, Seyed Isaac Hashemy
Summary: Parkinson's disease is a common degenerative disease that affects the elderly, and oxidative stress is one of the main causes. This study found that Selenium Nano Particles (SeNPs) can protect brain cells from oxidative stress and improve motor function.
METABOLIC BRAIN DISEASE
(2023)
Article
Pharmacology & Pharmacy
Sanaz Akbari, Reza Assaran Darban, Hossein Javid, Ali Esparham, Seyed Isaac Hashemy
Summary: The study aimed to investigate the combined effect and mechanism of action of Hesperidin and AP on prostate cancer cells. The results showed that Hesperidin and AP reduced cell viability and increased apoptosis. Additionally, they affected gene expression levels.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sanaz Salaramoli, Hamid Reza Joshaghani, Mahmoud Hosseini, Seyed Isaac Hashemy
Summary: This study investigated the potential protective role of selenium (Se) in a pre-clinical Parkinson's disease (PD) rat model. The results showed that Se administration increased the expression of selenoproteins, reduced the accumulation of alpha-synuclein in the brain, and improved PD-induced motor deficits. These findings suggest that Se may be a potential therapeutic option for PD treatment.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Materials Science, Ceramics
Zohreh Efati, S. Shirin Shahangian, Majid Darroudi, Hamed Amiri, Seyed Isaac Hashemy, Mahmoud Reza Aghamaali
Summary: This study describes a green synthesis method for zinc oxide nanoparticles (ZnO-NPs) using Lepidium sativum L. seed extract as a capping agent, and evaluates their anticancer activities against human colorectal cancer cells. The results demonstrate the significant cytotoxic effect of ZnO-NPs on cancer cells and their potential as a novel therapeutic agent for colorectal cancer treatment.
CERAMICS INTERNATIONAL
(2023)
Article
Biochemical Research Methods
Nima Ghoreyshi, Atefeh Ghahremanloo, Hossein Javid, Masoud Homayouni Tabrizi, Seyed Isaac Hashemy
Summary: In this study, PLGA-based curcumin nanoparticles modified with folic acid and chitosan (curcumin-PLGA-CS-FA) were prepared and their effects on the redox status of glioblastoma tumor cells were evaluated. The results showed that curcumin nanoparticles could modulate the antioxidant-oxidant balance and might be effective in the prevention and treatment of glioblastoma.
PHYTOCHEMICAL ANALYSIS
(2023)
Article
Oncology
Maryam Alaei, Seyedeh Elnaz Nazari, Ghazaleh Pourali, AliReza Asadnia, Mehrdad Moetamani-Ahmadi, Hamid Fiuji, Hamid Tanzadehpanah, Fereshteh Asgharzadeh, Fatemeh Babaei, Fatemeh Khojasteh-Leylakoohi, Ibrahim Saeed Gataa, Mohammad Ali Kiani, Gordon A. Ferns, Alfred King-yin Lam, Seyed Mahdi Hassanian, Majid Khazaei, Elisa Giovannetti, Amir Avan
Summary: In this study, the potential of targeting the enzyme cytochrome P450 (CYP450) using lopinavir/ritonavir in colorectal cancer (CRC) was explored. Experimental methods were employed to assess the effects of lopinavir/ritonavir on CRC, and it was found that inhibiting CYP450 reduced cell proliferation, induced cell death, and suppressed cell migration. Lopinavir/ritonavir also inhibited tumor growth and fibrosis. These findings suggest that targeting CYP450 with lopinavir/ritonavir has therapeutic potential in CRC and further research in this area is needed.
Article
Chemistry, Medicinal
Seyedeh Elnaz Nazari, Alex Tarnava, Nima Khalili-Tanha, Mahdieh Darroudi, Ghazaleh Khalili-Tanha, Amir Avan, Majid Khazaei, Tyler W. Lebaron
Summary: This study aimed to investigate the therapeutic potential of hydrogen-rich water (HRW) on muscle atrophy. The results showed that HRW could improve muscle atrophy in an immobilized condition and promote muscle recovery and rehabilitation.
Review
Neurosciences
Sanaz Salaramoli, Hamid Reza Joshaghani, Seyed Isaac Hashemy
Summary: Finding reliable biomarkers is crucial for assessing Parkinson's disease (PD). Saliva, as a bodily fluid, may serve as a potential source of biomarkers for PD. In this article, we reviewed publications on salivary proteins in PD patients and their potential as biomarkers. We identified that the proportion of α-Syn in its oligomeric form is higher in PD patients' saliva, making it a potent biomarker for PD. PD patients also showed lower salivary concentrations of DJ-1 and alpha-amylase, while substance P level was moderate. Despite decreased salivary flow rate, high levels of heme oxygenase and acetylcholinesterase could be used as noninvasive biomarkers. Salivary miRNAs (miR-153, miR-223, miR-874, and miR-145-3p) were identified as novel diagnostic biomarkers that deserve further attention.
NEUROLOGY RESEARCH INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Hossein Javid, Hamed Amiri, Seyedeh Fatemeh Hashemi, Amirali Reihani, Ali Esparham, Seyed Isaac Hashemy
Summary: Ovarian cancer is a common cancer among women, and its treatment and survival rates are still in need of improvement. Nanotechnology, specifically selenium-doped cerium oxide nanoparticles (CONPs), shows potential for anti-cancer effects in ovarian cancer cell lines.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
