Article
Pharmacology & Pharmacy
Jessica Wojciechowski, Vivek S. Purohit, Lutz O. Harnisch, Pinky Dua, Beesan Tan, Timothy Nicholas
Summary: This study aimed to establish the pharmacokinetic/pharmacodynamic relationship between domagrozumab and myostatin in pediatric patients with DMD. The refined model successfully described the concentration of both domagrozumab and myostatin, with predicted myostatin coverage consistently above 90%. The study provides insights into the regulation of myostatin and potential treatment options for pediatric patients with DMD.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Food Science & Technology
Rita Roque Bravo, Ana Carolina Faria, Andreia Machado Brito-da-Costa, Helena Carmo, Premysl Mladenka, Diana Dias da Silva, Fernando Remiao
Summary: This article provides a brief overview of the prevalence and patterns of cocaine use, its physical-chemical properties and methods for analysis, pharmacokinetics, pharmacodynamics, and multi-level toxicity.
Review
Biochemistry & Molecular Biology
Yue Gao, Yue Ding, Xin-ran Tai, Chen Zhang, Dong Wang
Summary: Ponatinib is a multi-target kinase inhibitor used for the treatment of leukemia and other diseases, but its significant cardiovascular toxicity poses a challenge to its clinical use. This article reviews the pharmacokinetics, targets, therapeutic potential, toxicity and production mechanism of ponatinib, and discusses methods to reduce its toxicity.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Respiratory System
Nan Zhang, Radojka M. Savic, Martin J. Boeree, Charles A. Peloquin, Marc Weiner, Norbert Heinrich, Erin Bliven-Sizemore, Patrick P. J. Phillips, Michael Hoelscher, William Whitworth, Glenn Morlock, James Posey, Jason E. Stout, William Mac Kenzie, Robert Aarnoutse, Kelly E. Dooley
Summary: Pyrazinamide is a potent sterilizing agent that can shorten the treatment duration for tuberculosis, and its optimal dose remains uncertain. Higher blood concentrations of pyrazinamide are associated with faster culture conversion time and higher conversion probability. Optimizing the use of pyrazinamide may enhance its microbiologic efficacy, but increasing the dose alone may not be enough to shorten tuberculosis treatment, requiring parallel increases in rifampicin dose.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Seiichiro Katagiri, SungGi Chi, Yosuke Minami, Kentaro Fukushima, Hirohiko Shibayama, Naoko Hosono, Takahiro Yamauchi, Takanobu Morishita, Takeshi Kondo, Masamitsu Yanada, Kazuhito Yamamoto, Junya Kuroda, Kensuke Usuki, Daigo Akahane, Akihiko Gotoh
Summary: This paper discusses the role of KIT mutations and the potential of precision medicine in acute myeloid leukemia (AML). New therapies targeting KIT mutations show promise as effective treatments for AML.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Polymer Science
Gaurav Awasthi, Sahil Shivgotra, Shibyendu Nikhar, Subramanian Sundarrajan, Seeram Ramakrishna, Pawan Kumar
Summary: Metal-organic frameworks (MOF) technology in biomedical applications faces challenges in selecting metal ions/organic linkers, synthesis techniques, water stability/solubility, toxicity, and biomolecule/drug tagging/conjugation. However, MOF technology offers interesting features such as biological or pharmacological activity, biocompatibility, limited toxicity, specific host-guest interactions, and environmental friendliness.
Review
Biochemistry & Molecular Biology
Robert A. Roth, Omar Kana, David Filipovic, Patricia E. Ganey
Summary: Hypotheses explaining the etiology of IDILI all involve changes in pharmacokinetics, which result in higher plasma drug concentrations or alterations in toxicodynamics that lower the toxicity threshold. Changes in pharmacokinetics can arise from alterations in drug metabolism or transporter polymorphisms. A lowered toxicity threshold may be caused by drug-induced mitochondrial injury, accumulation of toxic endogenous factors, or harmful immune responses. The newly developed interactive freeware, DemoTox-PK, allows users to visualize how these alterations can lead to a toxic reaction. The provided illustrations provide a framework for understanding idiosyncratic reactions and can stimulate further discussion, education, and research into the modes of action of IDILI.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2022)
Review
Pharmacology & Pharmacy
Meng Xu, Shuangshuang Wu, Yue Wang, Yundong Zhao, Ximin Wang, Changhong Wei, Xueying Liu, Feng Hao, Cheng Hu
Summary: High-dose methotrexate (HD-MTX) is an effective chemotherapy drug for children with acute lymphoblastic leukemia (ALL), but its toxicity is influenced by gene polymorphisms in the MTX metabolic pathway. The association of SLCO1B1 and ARID5B gene polymorphisms with MTX and MTX-related toxicity has been clearly described and should be evaluated before treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Yinggang Che, Dongbo Jiang, Leidi Xu, Yuanjie Sun, Yingtong Wu, Yang Liu, Ning Chang, Jiangjiang Fan, Hangtian Xi, Dan Qiu, Qing Ju, Jingyu Pan, Yong Zhang, Kun Yang, Jian Zhang
Summary: This study revealed the important impact of the ubiquitin-proteasome system on lung adenocarcinoma. Through bioinformatics and statistical analysis, a reliable prognostic risk model based on ubiquitination was constructed. The model stratification reflected the immune and mutation characteristics of patients with lung adenocarcinoma. Furthermore, targeting ubiquitin and proteasome could be a beneficial prospective treatment for this type of cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Boxu Ren, Marabeth Xin-Yi Kwah, Cuiliu Liu, Zhaowu Ma, Muthu K. Shanmugam, Lingwen Ding, Xiaoqiang Xiang, Paul Chi-Lui Ho, Lingzhi Wang, Pei Shi Ong, Boon Cher Goh
Summary: Despite its potential anticancer effects, resveratrol faces obstacles in clinical translation due to poor pharmacokinetics, low potency, and nephrotoxicity in certain patients. New strategies to enhance its bioavailability and develop more potent analogues are proposed to overcome these challenges and advance resveratrol in cancer therapy.
Review
Oncology
Amal Kamal Abdel-Aziz, Eman M. E. Dokla, Mona Kamal Saadeldin
Summary: This review critically discusses the opportunities and challenges of FLT3-targeted therapies and sheds light on their drug interactions as well as potential biomarkers. Furthermore, we focus on the molecular mechanisms underlying the resistance of FLT3 internal tandem duplication (FLT3-ITD) AMLs to FLT3 inhibitors alongside novel therapeutic strategies to reverse resistance. Ongoing preclinical research and clinical trials are actively directed towards devising rational personalized or patient-tailored combinatorial therapeutic regimens to effectively treat patients with FLT3 mutated AML.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Review
Integrative & Complementary Medicine
Yaxin Cheng, Yonghua Zhao, Ying Zheng
Summary: Triptolide, a bioactive compound from traditional Chinese herb Tripterygium Wilfordii Hook F, possesses immunosuppression and anti-inflammatory activity, making it a potential drug for the treatment of autoimmune diseases. However, its clinical application is limited due to toxicity issues. Research has summarized the pharmacodynamic effects and pharmacological mechanisms of triptolide in autoimmune diseases, as well as explored strategies to reduce its toxicity.
Editorial Material
Cell Biology
Ina Kirmes, Steven Zuryn
Summary: The integrity of mitochondrial DNA is crucial for energy synthesis. A recent study reveals a vicious cycle of mtDNA replication within dysfunctional mitochondria that propagates genomes with deleterious mutations.
NATURE CELL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ellen Niederberger, Michael J. Parnham
Summary: Lifestyle changes, particularly through exercise and diet, can impact physiological functions in the human body. Physiological changes induced by exercise and modified diet have the potential to affect the efficacy and toxicity of drugs. This impact may play an important role in common drugs with a narrow therapeutic window.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Yuanqin Su, Tianyuan Zhang, Ting Huang, Jianqing Gao
Summary: Mesenchymal stem cells have shown great potential as living carriers for targeted drug delivery, but face challenges due to their inherent limitations. Novel technologies, such as nanotechnology and genome engineering, are being developed to improve the efficiency and safety of the MSCs-DDS system. This review highlights recent advances, challenges, and potential technologies for enhancing MSCs-DDS.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Oncology
Rui Wang, Aashiq Hussain, Quanquan Guo, Meimei Ma
Summary: DNA is highly immunogenic and can activate the cGAS-STING pathway, which plays a crucial role in the pathogenesis and progression of neoplastic diseases. The modulation of cGAS-STING signaling holds great promise for cancer therapy, although there are disagreements on whether to activate or inhibit this pathway.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Ali Zarezadeh Mehrabadi, Faezeh Shahba, Hossein Khorramdelazad, Nazanin Aghamohammadi, Milad Karimi, Kowsar Bagherzadeh, Majid Khoshmirsafa, Ramin Massoumi, Reza Falak
Summary: IL-1 receptor accessory protein (IL-1RAP) plays a crucial role in inflammatory conditions and tumorigenesis in the tumor microenvironment. It is involved in the progression, metastasis, and angiogenesis of solid tumors and hematological malignancies.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Xiao Tang, Yujie Niu, Jinli Jian, Yuancheng Guo, Yin Wang, Yu Zhu, Bei Liu
Summary: Ferroptosis is an iron-dependent form of cell death that promotes tumor cell death by causing cell membrane rupture and accumulation of lipid peroxides. Extensive research has been conducted to explore the mechanism of ferroptosis inducers, but its role in hematological tumors is still limited.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Tanwei Yuan, Dominic Edelmann, Jakob N. Kather, Ziwen Fan, Katrin E. Tagscherer, Wilfried Roth, Melanie Bewerunge-Hudler, Alexander Brobeil, Matthias Kloor, Hendrik Blaeker, Barbara Burwinkel, Hermann Brenner, Michael Hoffmeister
Summary: The study aimed to analyze and validate previously published CpG-methylation-based prognostic biomarkers and prediction models for colorectal cancer (CRC) prognosis. The results showed that the discrimination ability of the models was insufficient and lacked clinical relevance.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)
Review
Oncology
Zhihui Duan, Dandan Yang, Ping Yuan, Xiaoming Dai, Guodong Chen, Daichao Wu
Summary: This article provides a comprehensive overview of therapeutic cancer vaccines, including their classification, clinical application, efficacy, and combination strategies with other therapies. It offers a valuable theoretical basis for the future clinical application and development of therapeutic cancer vaccines.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2024)