Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention

GSK-3 inhibition in vitro and in vivo enhances antitumor effect of sorafenib in renal cell carcinoma (RCC)

(2012) Hisashi Kawazoe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CaMKII  , a critical regulator of CML stem/progenitor cells, is a target of the natural product berbamine

(2012) Y. Gu et al.   BLOOD

Targeting of GSK3  promotes imatinib-mediated apoptosis in quiescent CD34+ chronic myeloid leukemia progenitors, preserving normal stem cells

(2012) G. Reddiconto et al.   BLOOD

Peripheral T-lymphocytes express WNT7A and its restoration in leukemia-derived lymphoblasts inhibits cell proliferation

(2012) Alejandra B Ochoa-Hernández et al.   BMC CANCER

Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib

(2012) Ling Li et al.   CANCER CELL

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

The Mck1 GSK-3 kinase inhibits the activity of Clb2-Cdk1 post-nuclear division

(2012) Jennifer McQueen et al.   CELL CYCLE

Genetic and Pharmacologic Inhibition of β-Catenin Targets Imatinib-Resistant Leukemia Stem Cells in CML

(2012) Florian H. Heidel et al.   Cell Stem Cell

The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemia

(2012) Versha Banerji et al.   JOURNAL OF CLINICAL INVESTIGATION

Optimal induction of myeloma cell death requires dual blockade of phosphoinositide 3-kinase and mTOR signalling and is determined by translocation subtype

(2012) C Stengel et al.   LEUKEMIA

γ-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of β-catenin

(2012) R G Morgan et al.   LEUKEMIA

Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency

(2012) J S Blackburn et al.   LEUKEMIA

Cytotoxic activity of the novel Akt inhibitor, MK-2206, in T-cell acute lymphoblastic leukemia

(2012) C Simioni et al.   LEUKEMIA

Impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients is associated with a blockade in the deactivation of the Notch signaling pathway

(2012) S Xu et al.   LEUKEMIA

PI3K/mTOR inhibition upregulates NOTCH-MYC signalling leading to an impaired cytotoxic response

(2012) C Shepherd et al.   LEUKEMIA

GSK3 is a regulator of RAR-mediated differentiation

(2012) K Gupta et al.   LEUKEMIA

Downregulation of Mcl-1 through GSK-3β activation contributes to arsenic trioxide-induced apoptosis in acute myeloid leukemia cells

(2012) R Wang et al.   LEUKEMIA

Small molecule antibody targeting HLA class I inhibits myeloma cancer stem cells by repressing pluripotency-associated transcription factors

(2012) A Ikegame et al.   LEUKEMIA

Myeloma cells inhibit non-canonical wnt co-receptor ror2 expression in human bone marrow osteoprogenitor cells: effect of wnt5a/ror2 pathway activation on the osteogenic differentiation impairment induced by myeloma cells

(2012) M Bolzoni et al.   LEUKEMIA

WNT7A Regulates Tumor Growth and Progression in Ovarian Cancer through the WNT/ -Catenin Pathway

(2012) S. Yoshioka et al.   MOLECULAR CANCER RESEARCH

Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma

(2012) Luca Busino et al.   NATURE CELL BIOLOGY

Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways

(2012) Jian Huang et al.   NATURE MEDICINE

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

(2012) Keisuke Ito et al.   NATURE MEDICINE

Thr 163 Phosphorylation Causes Mcl-1 Stabilization when Degradation Is Independent of the Adjacent GSK3-Targeted Phosphodegron, Promoting Drug Resistance in Cancer

(2012) Shanna K. Nifoussi et al.   PLoS One

 -Arrestin2 mediates the initiation and progression of myeloid leukemia

(2012) M. Fereshteh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GSK3: a key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer disease

(2012) Chong Gao et al.   REVIEWS IN THE NEUROSCIENCES

Controlling embryonic stem cell proliferation and pluripotency: the role of PI3K- and GSK-3-dependent signalling

(2011) Melanie J. Welham et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Wnt Inhibitor Screen Reveals Iron Dependence of  -Catenin Signaling in Cancers

(2011) S. Song et al.   CANCER RESEARCH

Wnt5a Suppresses Epithelial Ovarian Cancer by Promoting Cellular Senescence

(2011) B. G. Bitler et al.   CANCER RESEARCH

AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias

(2011) Stephen M. Sykes et al.   CELL

Context-dependent regulation of Musashi-mediated mRNA translation and cell cycle regulation.

(2011) Melanie C. MacNicol et al.   CELL CYCLE

The Medicinal Chemistry of Novel Iron Chelators for the Treatment of Cancer

(2011) Zaklina Kovacevic et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Overexpression of Glycogen Synthase Kinase-3 in Ovarian Carcinoma Cells With Acquired Paclitaxel Resistance

(2011) Yunfeng Fu et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Adenomatous Polyposis Coli (APC) Regulates Multiple Signaling Pathways by Enhancing Glycogen Synthase Kinase-3 (GSK-3) Activity

(2011) Alexander J. Valvezan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice

(2011) W. Timothy O’Brien et al.   JOURNAL OF CLINICAL INVESTIGATION

Convergence of the Mammalian Target of Rapamycin Complex 1- and Glycogen Synthase Kinase 3- -Signaling Pathways Regulates the Innate Inflammatory Response

(2011) H. Wang et al.   JOURNAL OF IMMUNOLOGY

Acquired Radioresistance of Cancer and the AKT/GSK3β/cyclin D1 Overexpression Cycle

(2011) Tsutomu SHIMURA   JOURNAL OF RADIATION RESEARCH

The controversial role of the Hedgehog pathway in normal and malignant hematopoiesis

(2011) B G Mar et al.   LEUKEMIA

p53 and Notch signaling in chronic lymphocytic leukemia: clues to identifying novel therapeutic strategies

(2011) R G Wickremasinghe et al.   LEUKEMIA

Notch induces human T-cell receptor γδ+ thymocytes to differentiate along a parallel, highly proliferative and bipotent CD4 CD8 double-positive pathway

(2011) S Van Coppernolle et al.   LEUKEMIA

Silencing of ETV6/RUNX1 abrogates PI3K/AKT/mTOR signaling and impairs reconstitution of leukemia in xenografts

(2011) G Fuka et al.   LEUKEMIA

Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic effects in T-cell acute lymphoblastic leukemia

(2011) C Evangelisti et al.   LEUKEMIA

MRK003, a γ-secretase inhibitor exhibits promising in vitro pre-clinical activity in multiple myeloma and non-Hodgkin's lymphoma

(2011) V Ramakrishnan et al.   LEUKEMIA

Involvement of the Syk–mTOR pathway in follicular lymphoma cell invasion and angiogenesis

(2011) S Fruchon et al.   LEUKEMIA

Notch3-mediated regulation of MKP-1 levels promotes survival of T acute lymphoblastic leukemia cells

(2011) M Masiero et al.   LEUKEMIA

Notch signaling in mammalian hematopoietic stem cells

(2011) K V Pajcini et al.   LEUKEMIA

Dysregulation of TNFα-induced necroptotic signaling in chronic lymphocytic leukemia: suppression of CYLD gene by LEF1

(2011) P Liu et al.   LEUKEMIA

The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia

(2011) L Willems et al.   LEUKEMIA

Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway

(2011) A M Martelli et al.   LEUKEMIA

The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cells

(2011) J Asano et al.   LEUKEMIA

Dll1/Notch activation accelerates multiple myeloma disease development by promoting CD138+ MM-cell proliferation

(2011) D Xu et al.   LEUKEMIA

AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications

(2011) C Grimaldi et al.   LEUKEMIA

Heterogeneous sensitivity of human acute myeloid leukemia to β-catenin down-modulation

(2011) A Gandillet et al.   LEUKEMIA

Notch is an essential upstream regulator of NF-κB and is relevant for survival of Hodgkin and Reed–Sternberg cells

(2011) R Schwarzer et al.   LEUKEMIA

Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy

(2011) L S Steelman et al.   LEUKEMIA

GSK3 inhibitors enhance retinoic acid receptor activity and induce the differentiation of retinoic acid-sensitive myeloid leukemia cells

(2011) J Si et al.   LEUKEMIA

Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development

(2011) T C Luis et al.   LEUKEMIA

The miRNA-17∼92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation

(2011) E Rao et al.   LEUKEMIA

Intracellular reactive oxygen species are essential for PI3K/Akt/mTOR-dependent IL-7-mediated viability of T-cell acute lymphoblastic leukemia cells

(2011) A Silva et al.   LEUKEMIA

Glycogen synthase kinase-3 (GSK-3) inhibition induces apoptosis in leukemic cells through mitochondria-dependent pathway

(2011) Mohammad Reza Mirlashari et al.   LEUKEMIA RESEARCH

GSK3β inactivation induces apoptosis of leukemia cells by repressing the function of c-Myb

(2011) Fangfang Zhou et al.   MOLECULAR BIOLOGY OF THE CELL

Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells

(2011) Derk ten Berge et al.   NATURE CELL BIOLOGY

Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation

(2011) S. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of Glycogen Synthase Kinase-3β in Arsenic Trioxide–Induced p21 Expression

(2011) Huei-Sheng Huang et al.   TOXICOLOGICAL SCIENCES

Pharmaceutical inhibition of glycogen synthetase kinase-3  reduces multiple myeloma-induced bone disease in a novel murine plasmacytoma xenograft model

(2010) W. G. Gunn et al.   BLOOD

Glycogen Synthase Kinase-3 regulates multiple myeloma cell growth and bortezomib-induced cell death

(2010) Francesco Piazza et al.   BMC CANCER

β-Catenin Mediates the Establishment and Drug Resistance of MLL Leukemic Stem Cells

(2010) Jenny Yeung et al.   CANCER CELL

mTOR Activation Induces Tumor Suppressors that Inhibit Leukemogenesis and Deplete Hematopoietic Stem Cells after Pten Deletion

(2010) Jae Y. Lee et al.   Cell Stem Cell

Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain

(2010) Marc P. M. Soutar et al.   JOURNAL OF NEUROCHEMISTRY

The Wnt/β-catenin pathway regulates growth and maintenance of colonospheres

(2010) Shailender S Kanwar et al.   Molecular Cancer

Glycogen synthase kinase 3 beta: can it be a target for oral cancer

(2010) Rajakishore Mishra   Molecular Cancer

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival

(2010) Sushma Gurumurthy et al.   NATURE

Regulation of myeloid leukaemia by the cell-fate determinant Musashi

(2010) Takahiro Ito et al.   NATURE

SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling

(2010) K. R. Holloway et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Wnt/ -Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML

(2010) Y. Wang et al.   SCIENCE

Dysregulation of Frizzled 6 is a critical component of B-cell leukemogenesis in a mouse model of chronic lymphocytic leukemia

(2009) Q.-L. Wu et al.   BLOOD

Involvement of GSK-3 in Regulation of Murine Embryonic Stem Cell Self-Renewal Revealed by a Series of Bisindolylmaleimides

(2009) Heather K. Bone et al.   CHEMISTRY & BIOLOGY

Role of Glycogen Synthase Kinase-3β in Cardioprotection

(2009) Magdalena Juhaszova et al.   CIRCULATION RESEARCH

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

Glycogen synthase kinase 3  missplicing contributes to leukemia stem cell generation

(2009) A. E. Abrahamsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysregulated gene expression networks in human acute myelogenous leukemia stem cells

(2009) R. Majeti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abnormalities in brain structure and behavior in GSK-3alpha mutant mice

(2009) Oksana Kaidanovich-Beilin et al.   Molecular Brain

Glycogen Synthase Kinase-3 and Cancer: Good Cop, Bad Cop?

(2008) Satish Patel et al.   CANCER CELL

Cyclooxygenase-2 Inhibition Inhibits c-Met Kinase Activity and Wnt Activity in Colon Cancer

(2008) J. B. Tuynman et al.   CANCER RESEARCH

t-Darpp Promotes Cancer Cell Survival by Up-regulation of Bcl2 through Akt-Dependent Mechanism

(2008) A. Belkhiri et al.   CANCER RESEARCH

TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

(2008) Chong Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NUMB controls p53 tumour suppressor activity

(2008) Ivan N. Colaluca et al.   NATURE

PML targeting eradicates quiescent leukaemia-initiating cells

(2008) Keisuke Ito et al.   NATURE

Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy

(2008) Zhong Wang et al.   NATURE

Phosphorylation by p38 MAPK as an Alternative Pathway for GSK3  Inactivation

(2008) T. M. Thornton et al.   SCIENCE