The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration
Authors
Keywords
-
Journal
Nature Reviews Cardiology
Volume -, Issue -, Pages -
Publisher
Springer Nature America, Inc
Online
2018-08-16
DOI
10.1038/s41569-018-0063-3
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration
- (2018) Shiro Yui et al. Cell Stem Cell
- α-Catenin-dependent cytoskeletal tension controls Yap activity in the heart
- (2018) Alexia Vite et al. DEVELOPMENT
- Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development
- (2018) Yang Xiao et al. DEVELOPMENTAL CELL
- The epicardium as a hub for heart regeneration
- (2018) Jingli Cao et al. Nature Reviews Cardiology
- YAP repression of theWNT3gene controls hESC differentiation along the cardiac mesoderm lineage
- (2017) Conchi Estarás et al. GENES & DEVELOPMENT
- Epicardial YAP/TAZ orchestrate an immunosuppressive response following myocardial infarction
- (2017) Vimal Ramjee et al. JOURNAL OF CLINICAL INVESTIGATION
- Hippo Pathway: An Emerging Regulator of Craniofacial and Dental Development
- (2017) J. Wang et al. JOURNAL OF DENTAL RESEARCH
- Hippo pathway deficiency reverses systolic heart failure after infarction
- (2017) John P. Leach et al. NATURE
- Dystrophin–glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation
- (2017) Yuka Morikawa et al. NATURE
- The extracellular matrix protein agrin promotes heart regeneration in mice
- (2017) Elad Bassat et al. NATURE
- Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest
- (2017) Richard J. Mills et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth
- (2017) Chiara V. Ragni et al. Nature Communications
- VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer
- (2017) Shi Jiao et al. Nature Communications
- YAP/TAZ at the Roots of Cancer
- (2016) Francesca Zanconato et al. CANCER CELL
- Opposing Roles of Wnt Inhibitors IGFBP-4 and Dkk1 in Cardiac Ischemia by Differential Targeting of LRP5/6 and β-cateninClinical Perspective
- (2016) Da Wo et al. CIRCULATION
- Regulation of Myocardial Cell Growth and Death by the Hippo Pathway
- (2016) Shohei Ikeda et al. CIRCULATION JOURNAL
- NF2 Activates Hippo Signaling and Promotes Ischemia/Reperfusion Injury in the HeartNovelty and Significance
- (2016) Takahisa Matsuda et al. CIRCULATION RESEARCH
- Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth
- (2016) Zhiqiang Lin et al. DEVELOPMENTAL CELL
- Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury
- (2016) Ge Tao et al. NATURE
- Hippo Signaling Mediators Yap and Taz Are Required in the Epicardium for Coronary Vasculature Development
- (2016) Anamika Singh et al. Cell Reports
- ERG Activates the YAP1 Transcriptional Program and Induces the Development of Age-Related Prostate Tumors
- (2015) Liem T. Nguyen et al. CANCER CELL
- miR-206 Mediates YAP-Induced Cardiac Hypertrophy and SurvivalNovelty and Significance
- (2015) Yanfei Yang et al. CIRCULATION RESEARCH
- Distinct Polarity Cues Direct Taz/Yap and TGFβ Receptor Localization to Differentially Control TGFβ-Induced Smad Signaling
- (2015) Masahiro Narimatsu et al. DEVELOPMENTAL CELL
- Dynamic changes in the cardiac methylome during postnatal development
- (2015) Choon Boon Sim et al. FASEB JOURNAL
- A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis
- (2015) Toshiro Moroishi et al. GENES & DEVELOPMENT
- Hippo Component TAZ Functions as a Co-repressor and Negatively Regulates ΔNp63Transcription through TEA Domain (TEAD) Transcription Factor
- (2015) Ivette Valencia-Sama et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer
- (2015) Alex Gregorieff et al. NATURE
- A gp130–Src–YAP module links inflammation to epithelial regeneration
- (2015) Koji Taniguchi et al. NATURE
- ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation
- (2015) Gabriele D’Uva et al. NATURE CELL BIOLOGY
- Systemic and Cardiac Depletion of M2 Macrophage through CSF-1R Signaling Inhibition Alters Cardiac Function Post Myocardial Infarction
- (2015) Anne-Laure Leblond et al. PLoS One
- Deregulation of the Hippo pathway in soft-tissue sarcoma promotes FOXM1 expression and tumorigenesis
- (2015) T. S. Karin Eisinger-Mathason et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice
- (2015) Yuka Morikawa et al. Science Signaling
- A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice
- (2015) Ying Tian et al. Science Translational Medicine
- Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice
- (2015) Yuka Morikawa et al. Science Signaling
- Hippo Pathway Effectors Control Cardiac Progenitor Cell Fate by Acting as Dynamic Sensors of Substrate Mechanics and Nanostructure
- (2014) Diogo Mosqueira et al. ACS Nano
- The alteration of Hippo/YAP signaling in the development of hypertrophic cardiomyopathy
- (2014) Pei Wang et al. BASIC RESEARCH IN CARDIOLOGY
- A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer
- (2014) Shi Jiao et al. CANCER CELL
- The Oxygen-Rich Postnatal Environment Induces Cardiomyocyte Cell-Cycle Arrest through DNA Damage Response
- (2014) Bao N. Puente et al. CELL
- YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response
- (2014) Luca Azzolin et al. CELL
- VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex
- (2014) Wenjing Zhang et al. CELL RESEARCH
- Cardiac-Specific YAP Activation Improves Cardiac Function and Survival in an Experimental Murine MI Model
- (2014) Zhiqiang Lin et al. CIRCULATION RESEARCH
- Macro advances in microRNAs and myocardial regeneration
- (2014) Jun Wang et al. CURRENT OPINION IN CARDIOLOGY
- How to make a cardiomyocyte
- (2014) D. Spater et al. DEVELOPMENT
- The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease
- (2014) X. Varelas DEVELOPMENT
- Curcumin Promotes KLF5 Proteasome Degradation through Downregulating YAP/TAZ in Bladder Cancer Cells
- (2014) Yang Gao et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Macrophages are required for neonatal heart regeneration
- (2014) Arin B. Aurora et al. JOURNAL OF CLINICAL INVESTIGATION
- Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase
- (2014) Biao Ma et al. NATURE CELL BIOLOGY
- Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development
- (2014) Fabienne Lescroart et al. NATURE CELL BIOLOGY
- Downstream of Mutant KRAS, the Transcription Regulator YAP Is Essential for Neoplastic Progression to Pancreatic Ductal Adenocarcinoma
- (2014) W. Zhang et al. Science Signaling
- Pax3 and Hippo Signaling Coordinate Melanocyte Gene Expression in Neural Crest
- (2014) Lauren J. Manderfield et al. Cell Reports
- The Yes-associated protein controls the cell density regulation of Hedgehog signaling
- (2014) M Tariki et al. Oncogenesis
- A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors
- (2013) Mariaceleste Aragona et al. CELL
- The Hippo Pathway Is Activated and Is a Causal Mechanism for Adipogenesis in Arrhythmogenic Cardiomyopathy
- (2013) Suet Nee Chen et al. CIRCULATION RESEARCH
- Hippo signaling impedes adult heart regeneration
- (2013) T. Heallen et al. DEVELOPMENT
- Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration
- (2013) Jinhu Wang et al. DEVELOPMENTAL BIOLOGY
- Hypoxia inducible factor-1 is activated by transcriptional co-activator with PDZ-binding motif (TAZ) versus WWdomain-containing oxidoreductase (WWOX) in hypoxic microenvironment of bone metastasis from breast cancer
- (2013) Paola Bendinelli et al. EUROPEAN JOURNAL OF CANCER
- The Hippo pathway: regulators and regulations
- (2013) F.-X. Yu et al. GENES & DEVELOPMENT
- TRIB2 Acts Downstream of Wnt/TCF in Liver Cancer Cells to Regulate YAP and C/EBPα Function
- (2013) Jiayi Wang et al. MOLECULAR CELL
- Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2
- (2013) Yasuhiro Maejima et al. NATURE MEDICINE
- Hippo pathway effector Yap promotes cardiac regeneration
- (2013) Mei Xin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Switch Enhancers Interpret TGF-β and Hippo Signaling to Control Cell Fate in Human Embryonic Stem Cells
- (2013) Tobias A. Beyer et al. Cell Reports
- YAP Promotes Breast Cell Proliferation and Survival Partially through Stabilizing the KLF5 Transcription Factor
- (2012) Xu Zhi et al. AMERICAN JOURNAL OF PATHOLOGY
- β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis
- (2012) Joseph Rosenbluh et al. CELL
- Role of TAZ as Mediator of Wnt Signaling
- (2012) Luca Azzolin et al. CELL
- The Fire Within: Cardiac Inflammatory Signaling in Health and Disease
- (2012) Matthew Coggins et al. CIRCULATION RESEARCH
- The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors
- (2012) A. Acharya et al. DEVELOPMENT
- Distinct Compartments of the Proepicardial Organ Give Rise to Coronary Vascular Endothelial Cells
- (2012) Tamar C. Katz et al. DEVELOPMENTAL CELL
- A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling
- (2012) Masamichi Imajo et al. EMBO JOURNAL
- Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis
- (2012) B. Zhao et al. GENES & DEVELOPMENT
- Hepatitis B virus X protein modulates oncogene yes-associated protein by CREB to promote growth of hepatoma cells
- (2012) Tao Zhang et al. HEPATOLOGY
- Yes-associated Protein Isoform 1 (Yap1) Promotes Cardiomyocyte Survival and Growth to Protect against Myocardial Ischemic Injury
- (2012) Dominic P. Del Re et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth
- (2012) Makiko Fujii et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Restriction of intestinal stem cell expansion and the regenerative response by YAP
- (2012) Evan R. Barry et al. NATURE
- YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29
- (2012) Karen Tumaneng et al. NATURE CELL BIOLOGY
- Transduction of mechanical and cytoskeletal cues by YAP and TAZ
- (2012) Georg Halder et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Cardiac Regeneration from Activated Epicardium
- (2012) Bram van Wijk et al. PLoS One
- YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy
- (2012) A. von Gise et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family
- (2012) E. R. Porrello et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- C/EBP Transcription Factors Mediate Epicardial Activation During Heart Development and Injury
- (2012) G. N. Huang et al. SCIENCE
- Molecular determinants of cardiac specification
- (2011) C. Lopez-Sanchez et al. CARDIOVASCULAR RESEARCH
- Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation
- (2011) Karin Schlegelmilch et al. CELL
- Yes-associated protein 1 regulates the stability of ΔNp63α
- (2011) Aditi Chatterjee et al. CELL CYCLE
- Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila
- (2011) B. G. Fernandez et al. DEVELOPMENT
- Hippo pathway regulation by cell morphology and stress fibers
- (2011) K.-I. Wada et al. DEVELOPMENT
- Modulating F-actin organization induces organ growth by affecting the Hippo pathway
- (2011) Leticia Sansores-Garcia et al. EMBO JOURNAL
- Role of YAP/TAZ in mechanotransduction
- (2011) Sirio Dupont et al. NATURE
- De novo cardiomyocytes from within the activated adult heart after injury
- (2011) Nicola Smart et al. NATURE
- Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size
- (2011) T. Heallen et al. SCIENCE
- Transient Regenerative Potential of the Neonatal Mouse Heart
- (2011) E. R. Porrello et al. SCIENCE
- Executive Summary: Heart Disease and Stroke Statistics—2010 Update
- (2010) et al. CIRCULATION
- The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals
- (2010) Nailing Zhang et al. DEVELOPMENTAL CELL
- The Hippo Pathway Regulates Wnt/β-Catenin Signaling
- (2010) Xaralabos Varelas et al. DEVELOPMENTAL CELL
- The Hippo Signaling Pathway in Development and Cancer
- (2010) Duojia Pan DEVELOPMENTAL CELL
- The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway
- (2010) Xaralabos Varelas et al. DEVELOPMENTAL CELL
- TAZ as a novel enhancer of MyoD-mediated myogenic differentiation
- (2010) Hana Jeong et al. FASEB JOURNAL
- TEAD-1 Overexpression in the Mouse Heart Promotes an Age-dependent Heart Dysfunction
- (2010) Richard W. Tsika et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Energy Metabolic Phenotype of the Cardiomyocyte During Development, Differentiation, and Postnatal Maturation
- (2010) Gary D Lopaschuk et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice
- (2010) Dominic P. Del Re et al. JOURNAL OF CLINICAL INVESTIGATION
- Primary contribution to zebrafish heart regeneration by gata4 + cardiomyocytes
- (2010) Kazu Kikuchi et al. NATURE
- Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation
- (2010) Chris Jopling et al. NATURE
- Both TEAD-Binding and WW Domains Are Required for the Growth Stimulation and Oncogenic Transformation Activity of Yes-Associated Protein
- (2009) B. Zhao et al. CANCER RESEARCH
- Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways
- (2009) Claudio Alarcón et al. CELL
- Tumor Suppressor Ras-Association Domain Family 1 Isoform A Is a Novel Regulator of Cardiac Hypertrophy
- (2009) Delvac Oceandy et al. CIRCULATION
- Heart Disease and Stroke Statistics—2010 Update
- (2009) et al. CIRCULATION
- TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition
- (2009) Heng Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- MST Kinases Monitor Actin Cytoskeletal Integrity and Signal via c-Jun N-Terminal Kinase Stress-Activated Kinase To Regulate p21Waf1/Cip1 Stability
- (2009) R. M. Densham et al. MOLECULAR AND CELLULAR BIOLOGY
- EGR-1 forms a complex with YAP-1 and upregulates Bax expression in irradiated prostate carcinoma cells
- (2009) M Zagurovskaya et al. ONCOGENE
- Evidence for Cardiomyocyte Renewal in Humans
- (2009) Olaf Bergmann et al. SCIENCE
- Human angiomotin-like 1 associates with an angiomotin protein complex through its coiled-coil domain and induces the remodeling of the actin cytoskeleton
- (2009) Valérie Gagné et al. CELL MOTILITY AND THE CYTOSKELETON
- Lats2 Is a Negative Regulator of Myocyte Size in the Heart
- (2008) Yutaka Matsui et al. CIRCULATION RESEARCH
- The Hippo–YAP pathway: new connections between regulation of organ size and cancer
- (2008) Bin Zhao et al. CURRENT OPINION IN CELL BIOLOGY
- Wnt3a-mediated chemorepulsion controls movement patterns of cardiac progenitors and requires RhoA function
- (2008) Q. Yue et al. DEVELOPMENT
- A New Kid on the TGFβ Block: TAZ Controls Smad Nucleocytoplasmic Shuttling
- (2008) Katharine H. Wrighton et al. DEVELOPMENTAL CELL
- TEAD mediates YAP-dependent gene induction and growth control
- (2008) B. Zhao et al. GENES & DEVELOPMENT
- Yap1 Phosphorylation by c-Abl Is a Critical Step in Selective Activation of Proapoptotic Genes in Response to DNA Damage
- (2008) Dan Levy et al. MOLECULAR CELL
- PML, YAP, and p73 Are Components of a Proapoptotic Autoregulatory Feedback Loop
- (2008) Eleonora Lapi et al. MOLECULAR CELL
- TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
- (2008) Xaralabos Varelas et al. NATURE CELL BIOLOGY
- Mechanisms Underlying Acute Protection From Cardiac Ischemia-Reperfusion Injury
- (2008) Elizabeth Murphy et al. PHYSIOLOGICAL REVIEWS
- -Catenin downregulation attenuates ischemic cardiac remodeling through enhanced resident precursor cell differentiation
- (2008) L. C. Zelarayan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More