Inactivation of a Gα s –PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis

Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

(2014) Marcel Kool et al.   CANCER CELL

Transit-Amplifying Cells Orchestrate Stem Cell Activity and Tissue Regeneration

(2014) Ya-Chieh Hsu et al.   CELL

Coupling of Hedgehog and Hippo pathways promotes stem cell maintenance by stimulating proliferation

(2014) Jianhua Huang et al.   JOURNAL OF CELL BIOLOGY

The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog−driven medulloblastoma

(2014) Xuelian He et al.   NATURE MEDICINE

Gli Protein Activity Is Controlled by Multisite Phosphorylation in Vertebrate Hedgehog Signaling

(2014) Pawel Niewiadomski et al.   Cell Reports

Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2

(2013) Feng Yin et al.   CELL

cAMP/PKA signalling reinforces the LATS–YAP pathway to fully suppress YAP in response to actin cytoskeletal changes

(2013) Minchul Kim et al.   EMBO JOURNAL

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway

(2013) Morvarid Mohseni et al.   NATURE CELL BIOLOGY

Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification

(2013) Jean B Regard et al.   NATURE MEDICINE

Direct confocal acquisition of fluorescence from X-gal staining on thick tissue sections

(2013) Konstantin L. Levitsky et al.   Scientific Reports

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

mTOR Inhibition Prevents Epithelial Stem Cell Senescence and Protects from Radiation-Induced Mucositis

(2012) Ramiro Iglesias-Bartolome et al.   Cell Stem Cell

mTOR as a Molecular Target in HPV-Associated Oral and Cervical Squamous Carcinomas

(2012) A. A. Molinolo et al.   CLINICAL CANCER RESEARCH

A matter of life and death: self-renewal in stem cells

(2012) Elaine Fuchs et al.   EMBO REPORTS

Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice

(2012) Miki Nishio et al.   JOURNAL OF CLINICAL INVESTIGATION

A Genome-wide RNAi Screen Reveals a Trio-Regulated Rho GTPase Circuitry Transducing Mitogenic Signals Initiated by G Protein-Coupled Receptors

(2012) Jose P. Vaqué et al.   MOLECULAR CELL

Assembly of allosteric macromolecular switches: lessons from PKA

(2012) Susan S. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Hedgehog Signal Transduction Network

(2012) D. J. Robbins et al.   Science Signaling

Epithelial stem cells and implications for wound repair

(2012) Maksim V. Plikus et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Basal Cell Carcinomas Arise from Hair Follicle Stem Cells in Ptch1+/− Mice

(2011) Grace Ying Wang et al.   CANCER CELL

Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation

(2011) Karin Schlegelmilch et al.   CELL

Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells

(2011) Isaac Brownell et al.   Cell Stem Cell

Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin

(2011) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-Resident Adult Stem Cell Populations of Rapidly Self-Renewing Organs

(2010) Nick Barker et al.   Cell Stem Cell

The NF2 Tumor Suppressor, Merlin, Regulates Epidermal Development through the Establishment of a Junctional Polarity Complex

(2010) Andrew B. Gladden et al.   DEVELOPMENTAL CELL

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

Identification of the cell lineage at the origin of basal cell carcinoma

(2010) Khalil Kass Youssef et al.   NATURE CELL BIOLOGY

Assaying proliferation and differentiation capacity of stem cells using disaggregated adult mouse epidermis

(2010) Kim B Jensen et al.   Nature Protocols

Not Lost in Space: Trafficking in the Hedgehog Signaling Pathway

(2010) L. Milenkovic et al.   Science Signaling

YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation

(2009) A. Fernandez-L et al.   GENES & DEVELOPMENT

Epidermal homeostasis: a balancing act of stem cells in the skin

(2009) Cédric Blanpain et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A crucial role of WW45 in developing epithelial tissues in the mouse

(2008) Joo-Hyeon Lee et al.   EMBO JOURNAL

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT