Molecular Mechanisms and Genetics of Oxidative Stress in Alzheimer’s Disease

Zn2+ Aggravates Tau Aggregation and Neurotoxicity

(2019) Xuexia Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hydroperoxide and carboxyl groups preferential location in oxidized biomembranes experimentally determined by small angle X-ray scattering: Implications in membrane structure

(2018) Raffaela De Rosa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Calcium signaling and molecular mechanisms underlying neurodegenerative diseases

(2018) Ekaterina Pchitskaya et al.   CELL CALCIUM

RhoA regulates Drp1 mediated mitochondrial fission through ROCK to protect cardiomyocytes

(2018) Cameron S. Brand et al.   CELLULAR SIGNALLING

Free Heme and Amyloid-β: A Fatal Liaison in Alzheimer’s Disease

(2018) Elisabeth Chiziane et al.   JOURNAL OF ALZHEIMERS DISEASE

Heme and hemoglobin suppress amyloid β–mediated inflammatory activation of mouse astrocytes

(2018) Sitara B. Sankar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disturbances in the control of capillary flow in an aged APP swe /PS1ΔE9 model of Alzheimer's disease

(2018) Eugenio Gutiérrez-Jiménez et al.   NEUROBIOLOGY OF AGING

Aging-associated changes in cerebral vasculature and blood flow as determined by quantitative optical coherence tomography angiography

(2018) Yuandong Li et al.   NEUROBIOLOGY OF AGING

Glutathione-mimetic D609 alleviates memory deficits and reduces amyloid-β deposition in an AβPP/PS1 transgenic mouse model

(2018) Hui Yang et al.   NEUROREPORT

Oxidative insults disrupt OPA1-mediated mitochondrial dynamics in cultured mammalian cells

(2018) Iraselia Garcia et al.   REDOX REPORT

The redox kinetics of the amyloid-β-Cu complex and its biological implications

(2018) Paul Girvan et al.   BIOCHEMISTRY

Amyloid-β42 Activates the Expression of BACE1 Through the JNK Pathway

(2018) Michela Guglielmotto et al.   JOURNAL OF ALZHEIMERS DISEASE

The BACE1-PSEN-AβPP Regulatory Axis has an Ancient Role in Response to Low Oxygen/Oxidative Stress

(2018) Seyyed Hani Moussavi Nik et al.   JOURNAL OF ALZHEIMERS DISEASE

DNMT1 and Sp1 competitively regulate the expression of BACE1 in A2E-mediated photo-oxidative damage in RPE cells

(2018) Peirong Huang et al.   NEUROCHEMISTRY INTERNATIONAL

Copper Redox Cycling Inhibits Aβ Fibre Formation and Promotes Fibre Fragmentation, while Generating a Dityrosine Aβ Dimer

(2018) Miao Gu et al.   Scientific Reports

Synaptic ATPases system of rat frontal cerebral cortex during aging

(2018) Federica Ferrari et al.   NEUROSCIENCE LETTERS

Discovery of 1-(3-(benzyloxy)pyridin-2-yl)-3-(2-(piperazin-1-yl)ethyl)urea: A new modulator for amyloid beta-induced mitochondrial dysfunction

(2017) Ahmed Elkamhawy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

4-Hydroxynonenal (HNE) modified proteins in metabolic diseases

(2017) José Pedro Castro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Is there correlation between Aβ-heme peroxidase activity and the peptide aggregation state? A literature review combined with hypothesis

(2017) Reza Khodarahmi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Apolipoprotein E4 Elicits Lysosomal Cathepsin D Release, Decreased Thioredoxin-1 Levels, and Apoptosis

(2017) Torbjörn Persson et al.   JOURNAL OF ALZHEIMERS DISEASE

Covalent modifications of the amyloid beta peptide by hydroxynonenal: Effects on metal ion binding by monomers and insights into the fibril topology

(2017) G. Grasso et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Local Klotho Enhances Neuronal Progenitor Proliferation in the Adult Hippocampus

(2017) Felipe Salech et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease

(2017) Athanassios Fragoulis et al.   Redox Biology

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

(2017) Ana I. Rojo et al.   Redox Biology

Vitamin E Paradox in Alzheimer's Disease: It Does Not Prevent Loss of Cognition and May Even Be Detrimental

(2017) Ana Lloret et al.   JOURNAL OF ALZHEIMERS DISEASE

Lipid Oxidation and Modification of Amyloid-β (Aβ) in vitro and in vivo

(2017) Grace Ellis et al.   JOURNAL OF ALZHEIMERS DISEASE

Increased Iron and Free Radical Generation in Preclinical Alzheimer Disease and Mild Cognitive Impairment

(2017) Mark A. Smith et al.   JOURNAL OF ALZHEIMERS DISEASE

Oxidative stress affects processing of amyloid precursor protein in vascular endothelial cells

(2017) Abebe Muche et al.   PLoS One

Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability

(2017) Thomas Briston et al.   Scientific Reports

Serum clusterin level in children with atopic dermatitis

(2016) In Suk Sol et al.   ALLERGY AND ASTHMA PROCEEDINGS

Stabilization of native amyloid β-protein oligomers by Copper and Hydrogen peroxide Induced Cross-linking of Unmodified Proteins (CHICUP)

(2016) Thomas L. Williams et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Methionine oxidation reduces lag-times for amyloid-β(1–40) fiber formation but generates highly fragmented fibers

(2016) Miao Gu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Do glutathione levels decline in aging human brain?

(2016) Junchao Tong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Co-immunoprecipitation with Tau Isoform-specific Antibodies Reveals Distinct Protein Interactions and Highlights a Putative Role for 2N Tau in Disease

(2016) Chang Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative stress decreases microtubule growth and stability in ventricular myocytes

(2016) Benjamin M.L. Drum et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Melatonin as an antioxidant: under promises but over delivers

(2016) Russel J. Reiter et al.   JOURNAL OF PINEAL RESEARCH

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Metal-catalyzed oxidation of Aβ and the resulting reorganization of Cu binding sites promote ROS production

(2016) Clémence Cheignon et al.   Metallomics

Ameliorative Effects of Antioxidants on the Hippocampal Accumulation of Pathologic Tau in a Rat Model of Blast-Induced Traumatic Brain Injury

(2016) Xiaoping Du et al.   Oxidative Medicine and Cellular Longevity

Binding Sites for Amyloid-β Oligomers and Synaptic Toxicity

(2016) Levi M. Smith et al.   Cold Spring Harbor Perspectives in Medicine

The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy

(2016) Urmi Sengupta et al.   EBioMedicine

Circadian clock proteins control adaptation to novel environment and memory formation

(2016) Anna A.Kondratova et al.   Aging-US

RhoA and Rac1 GTPases Differentially Regulate Agonist-Receptor Mediated Reactive Oxygen Species Generation in Platelets

(2016) Huzoor Akbar et al.   PLoS One

Cu2+accentuates distinct misfolding of Aβ(1–40)and Aβ(1–42)peptides, and potentiates membrane disruption

(2015) Christian J. Matheou et al.   BIOCHEMICAL JOURNAL

Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease

(2015) Sandra I. Mota et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Metformin increases APP expression and processing via oxidative stress, mitochondrial dysfunction and NF-κB activation: Use of insulin to attenuate metformin's effect

(2015) Pasquale Picone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5–Nrf2 pathway

(2015) D Jimenez-Blasco et al.   CELL DEATH AND DIFFERENTIATION

Role of RAGE in Alzheimer’s Disease

(2015) Zhiyou Cai et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

DNA Damage and Oxidant-Antioxidant Status in Blood of Patients with Head and Neck Cancer

(2015) Jaroslaw Milonski et al.   DNA AND CELL BIOLOGY

Melatonin: an ancient molecule that makes oxygen metabolically tolerable

(2015) Lucien C. Manchester et al.   JOURNAL OF PINEAL RESEARCH

Increased Alzheimer's disease–like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy

(2015) Gururaj Joshi et al.   NEUROBIOLOGY OF AGING

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

(2015) Karen F.S. Bell et al.   Nature Communications

Clusterin expression level correlates with increased oxidative stress in asthmatics

(2014) Hyouk-Soo Kwon et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Key roles of Arg5, Tyr10 and His residues in Aβ–heme peroxidase: Relevance to Alzheimer’s disease

(2014) Naihao Lu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aβ dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies

(2014) Tiernan T. O’Malley et al.   BIOCHEMICAL JOURNAL

The Chaperone Activity of Clusterin is Dependent on Glycosylation and Redox Environment

(2014) Philipp Rohne et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Circadian modulation of proteasome activities and removal of carbonylated proteins

(2014) Audrey Desvergne et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Neuroprotective Effect of Klotho is Mediated via Regulation of Members of the Redox System

(2014) Ella Zeldich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MFN1 deacetylation activates adaptive mitochondrial fusion and protects metabolically challenged mitochondria

(2014) J.-Y. Lee et al.   JOURNAL OF CELL SCIENCE

Impaired OMA1-dependent cleavage of OPA1 and reduced DRP1 fission activity combine to prevent mitophagy in cells that are dependent on oxidative phosphorylation

(2014) Thomas D. B. MacVicar et al.   JOURNAL OF CELL SCIENCE

Treatment of sleep apnoea syndrome decreases cognitive decline in patients with Alzheimer's disease

(2014) Anne-Cécile Troussière et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Extended Wakefulness: Compromised Metabolics in and Degeneration of Locus Ceruleus Neurons

(2014) J. Zhang et al.   JOURNAL OF NEUROSCIENCE

Oxidative Stress in Alzheimer’s Disease: Why Did Antioxidant Therapy Fail?

(2014) Torbjörn Persson et al.   Oxidative Medicine and Cellular Longevity

Impact of oxidative stress on the cytoskeleton of pancreatic epithelial cells

(2014) WEI-GUO HU et al.   Experimental and Therapeutic Medicine

Aβ and tau toxicities in Alzheimer’s are linked via oxidative stress-induced p38 activation: Protective role of vitamin E

(2014) E. Giraldo et al.   Redox Biology

Interaction between Amyloid-β Peptide and Heme Probed by Electrochemistry and Atomic Force Microscopy

(2013) Yanli Zhou et al.   ACS Chemical Neuroscience

Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes

(2013) Mohammed Mahidur Rahman et al.   AGING CELL

Heme Binding Induces Dimerization and Nitration of Truncated β-Amyloid Peptide Aβ16 Under Oxidative Stress

(2013) Grégory Thiabaud et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: Redox proteomics analysis of human brain

(2013) Fabio Di Domenico et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial permeability transition pore is a potential drug target for neurodegeneration

(2013) Valasani Koteswara Rao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Molecular Chaperone Apolipoprotein J/Clusterin as a Sensor of Oxidative Stress: Implications in Therapeutic Approaches - A Mini-Review

(2013) Ioannis P. Trougakos   GERONTOLOGY

Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration

(2013) Erik S. Musiek et al.   JOURNAL OF CLINICAL INVESTIGATION

Identifying, By First-Principles Simulations, Cu[Amyloid-β] Species Making Fenton-Type Reactions in Alzheimer’s Disease

(2013) Giovanni La Penna et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Cyclophilin D Deficiency Rescues Axonal Mitochondrial Transport in Alzheimer’s Neurons

(2013) Lan Guo et al.   PLoS One

Mild Oxidative Stress Induces Redistribution of BACE1 in Non-Apoptotic Conditions and Promotes the Amyloidogenic Processing of Alzheimer’s Disease Amyloid Precursor Protein

(2013) Jiang-Li Tan et al.   PLoS One

Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice

(2013) C. B. Peek et al.   SCIENCE

Toward clinical application of the Keap1–Nrf2 pathway

(2013) Takafumi Suzuki et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Synthetic dityrosine-linked β-amyloid dimers form stable, soluble, neurotoxic oligomers

(2013) W. Mei Kok et al.   Chemical Science

Sleep Quality and Preclinical Alzheimer Disease

(2013) Yo-El S. Ju et al.   JAMA Neurology

Oxidative modification of lipoic acid by HNE in Alzheimer disease brain

(2013) Sarita S. Hardas et al.   Redox Biology

A central role for dityrosine crosslinking of Amyloid-β in Alzheimer’s disease

(2013) Youssra K Al-Hilaly et al.   Acta Neuropathologica Communications

Over-expression of human clusterin increases stress resistance and extends lifespan in Drosophila melanogaster

(2012) Young-Nam Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cytosolic Ca2+regulates the energization of isolated brain mitochondria by formation of pyruvate through the malate–aspartate shuttle

(2012) Frank Norbert Gellerich et al.   BIOCHEMICAL JOURNAL

Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway

(2012) François Mouton-Liger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Iron deficiency on neuronal function

(2012) Pablo Muñoz et al.   BIOMETALS

Melatonin-mitochondria Interplay in Health and Disease

(2012) Dario Acuna Castroviejo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Heme oxygenase-1 posttranslational modifications in the brain of subjects with Alzheimer disease and mild cognitive impairment

(2012) Eugenio Barone et al.   FREE RADICAL BIOLOGY AND MEDICINE

SIRT3 interacts with the daf-16 homolog FOXO3a in the Mitochondria, as well as increases FOXO3a Dependent Gene expression

(2012) Kristi Muldoon Jacobs et al.   International Journal of Biological Sciences

SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status

(2012) Wei Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of total oxidative status in adult attention deficit hyperactivity disorder and its diagnostic implications

(2012) Salih Selek et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Peroxiredoxins are conserved markers of circadian rhythms

(2012) Rachel S. Edgar et al.   NATURE

Nuclear localization of Klotho in brain: an anti-aging protein

(2012) Dwight C. German et al.   NEUROBIOLOGY OF AGING

Increased oxidative stress in patients with depression and its relationship to treatment

(2012) Cecilia P. Chung et al.   PSYCHIATRY RESEARCH

Peroxynitrite-Induced Nitrative and Oxidative Modifications Alter Tau Filament Formation

(2011) Laurel Vana et al.   BIOCHEMISTRY

Photo-activated phase separation in giant vesicles made from different lipid mixtures

(2011) Christopher K. Haluska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Evaluation of urinary biomarkers of oxidative/nitrosative stress in adolescents and adults with Down syndrome

(2011) Carlos Campos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease

(2011) Patrizia Mecocci et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Clusterin protects H9c2 cardiomyocytes from oxidative stress-induced apoptosisviaAkt/GSK-3β signaling pathway

(2011) Hyoung-Oh Jun et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover

(2011) Xiongwei Zhu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Structural Basis for Increased Toxicity of Pathological Aβ42:Aβ40Ratios in Alzheimer Disease

(2011) Kris Pauwels et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutagenesis Mapping of the Presenilin 1 Calcium Leak Conductance Pore

(2011) Omar Nelson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Regulation of Wakefulness and Senescence-Like Phenotype in Wake Neurons

(2011) L. Panossian et al.   JOURNAL OF NEUROSCIENCE

Heme–Cu Bound Aβ Peptides: Spectroscopic Characterization, Reactivity, and Relevance to Alzheimer’s Disease

(2011) Debajyoti Pramanik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Differential regulation of BACE1 expression by oxidative and nitrosative signals

(2011) Young-Don Kwak et al.   Molecular Neurodegeneration

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype

(2011) Julie E. Simpson et al.   NEUROBIOLOGY OF AGING

Plasma clusterin concentration is associated with longitudinal brain atrophy in mild cognitive impairment

(2011) Madhav Thambisetty et al.   NEUROIMAGE

Estrogen protects against amyloid-β toxicity by estrogen receptor α-mediated inhibition of Daxx translocation

(2011) Laura Mateos et al.   NEUROSCIENCE LETTERS

Hypoxia Due to Cardiac Arrest Induces a Time-Dependent Increase in Serum Amyloid β Levels in Humans

(2011) Henrik Zetterberg et al.   PLoS One

Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway

(2010) John D. Hayes et al.   ANTIOXIDANTS & REDOX SIGNALING

Association of Plasma Clusterin Concentration With Severity, Pathology, and Progression in Alzheimer Disease

(2010) Madhav Thambisetty et al.   ARCHIVES OF GENERAL PSYCHIATRY

Hydralazine Modifies Aβ Fibril Formation and Prevents Modification by Lipidsin Vitro

(2010) Mukesh Maheshwari et al.   BIOCHEMISTRY

The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia

(2010) Jessica M. Mc Donald et al.   BRAIN

Protein levels of heat shock proteins 27, 32, 60, 70, 90 and thioredoxin-1 in amnestic mild cognitive impairment: An investigation on the role of cellular stress response in the progression of Alzheimer disease

(2010) Fabio Di Domenico et al.   BRAIN RESEARCH

Impact of aging on diurnal expression patterns of CLOCK and BMAL1 in the mouse brain

(2010) Cathy A. Wyse et al.   BRAIN RESEARCH

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

(2010) Inna Kuperstein et al.   EMBO JOURNAL

Substoichiometric Levels of Cu2+Ions Accelerate the Kinetics of Fiber Formation and Promote Cell Toxicity of Amyloid-β from Alzheimer Disease

(2010) Claire J. Sarell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex

(2010) Mubeen A. Ansari et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Nrf2-encoding NFE2L2 haplotypes influence disease progression but not risk in Alzheimer's disease and age-related cataract

(2010) Malin von Otter et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's disease

(2010) Rita De Gasperi et al.   Molecular Neurodegeneration

Oxidation of methionine 35 reduces toxicity of the amyloid beta-peptide(1–42) in neuroblastoma cells (IMR-32) via enzyme methionine sulfoxide reductase A expression and function

(2010) Francesco Misiti et al.   NEUROCHEMISTRY INTERNATIONAL

ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling

(2010) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Sirolimus on Calcineurin Inhibitor-Induced Nephrotoxicity Using Renal Expression of KLOTHO, an Antiaging Gene

(2010) Dong He Han et al.   TRANSPLANTATION

The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation?

(2010) Kerensa Broersen et al.   Alzheimers Research & Therapy

Biomarkers of oxidative and nitrosative damage in Alzheimer's disease and mild cognitive impairment

(2009) Francesca Mangialasche et al.   AGEING RESEARCH REVIEWS

Human and rodent amyloid-β peptides differentially bind heme: Relevance to the human susceptibility to Alzheimer’s disease

(2009) Hani Atamna et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Copper(II) Binding to Amyloid-β Fibrils of Alzheimer’s Disease Reveals a Picomolar Affinity: Stoichiometry and Coordination Geometry Are Independent of Aβ Oligomeric Form

(2009) Claire J. Sarell et al.   BIOCHEMISTRY

Mitochondrial permeability transition pore in Alzheimer's disease: Cyclophilin D and amyloid beta

(2009) Heng Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

(2009) Paula I. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Aβ-mediated ROS production by Cu ions: Structural insights, mechanisms and relevance to Alzheimer's disease

(2009) Christelle Hureau et al.   BIOCHIMIE

Dendritic pathology in Alzheimer's disease

(2009) S.J. Baloyannis   JOURNAL OF THE NEUROLOGICAL SCIENCES

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease

(2009) Velandai Srikanth et al.   NEUROBIOLOGY OF AGING

Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model

(2009) Heng Du et al.   NEUROBIOLOGY OF AGING

Oxidative stress promotes JNK-dependent amyloidogenic processing of normally expressed human APP by differential modification of α-, β- and γ-secretase expression

(2009) Ricardo Quiroz-Baez et al.   NEUROCHEMISTRY INTERNATIONAL

Levels of reduced and oxidized coenzymeQ-10 and 8-hydroxy-2′-deoxyguanosine in the cerebrospinal fluid of patients with living Parkinson's disease demonstrate that mitochondrial oxidative damage and/or oxidative DNA damage contributes to the neurodegenerative process

(2009) Chiaki Isobe et al.   NEUROSCIENCE LETTERS

Increased Hippocampal Expression of the Divalent Metal Transporter 1 (DMT1) mRNA Variants 1B and +IRE and DMT1 Protein After NMDA-Receptor Stimulation or Spatial Memory Training

(2009) Paola Haeger et al.   NEUROTOXICITY RESEARCH

Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease

(2009) K. Kanninen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of hypoxia-inducible factor-1α by NF-κB

(2008) Patrick van Uden et al.   BIOCHEMICAL JOURNAL

Oligomer-specific Aβ toxicity in cell models is mediated by selective uptake

(2008) Sidhartha M. Chafekar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Association between enzymatic and non-enzymatic antioxidant defense mechanism with apolipoprotein E genotypes in Alzheimer disease

(2008) Hadi Kharrazi et al.   CLINICAL BIOCHEMISTRY

Peripheral levels of glutathione and protein oxidation as markers in the development of Alzheimer's disease from Mild Cognitive Impairment

(2008) Paloma Bermejo et al.   FREE RADICAL RESEARCH

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

JNK and ERK1/2 pathways have a dual opposite effect on the expression of BACE1

(2008) Elena Tamagno et al.   NEUROBIOLOGY OF AGING

Redox proteomic identification of 4-Hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: Insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease

(2008) Tanea Reed et al.   NEUROBIOLOGY OF DISEASE

Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks

(2008) Kishore V. Kuchibhotla et al.   NEURON

Oxidative stress and cognitive ability in adults with Down syndrome

(2008) Andre Strydom et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES

Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey

(2007) James A. Duce et al.   GLIA

Hypoxia increases Aβ generation by altering β- and γ-cleavage of APP

(2007) Liang Li et al.   NEUROBIOLOGY OF AGING

Activation of MKK6, an upstream activator of p38, in Alzheimer's disease

(2003) Xiongwei Zhu et al.   JOURNAL OF NEUROCHEMISTRY

Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

(2003) Craig S. Atwood et al.   JOURNAL OF NEUROCHEMISTRY