Copper Redox Cycling Inhibits Aβ Fibre Formation and Promotes Fibre Fragmentation, while Generating a Dityrosine Aβ Dimer

Direct Evidence of the Presence of Cross-Linked Aβ Dimers in the Brains of Alzheimer’s Disease Patients

(2018) Aurelio Vázquez de la Torre et al.   ANALYTICAL CHEMISTRY

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

Opposed Effects of Dityrosine Formation in Soluble and Aggregated α-Synuclein on Fibril Growth

(2017) Michael M. Wördehoff et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of key structural features of the elusive Cu–Aβ complex that generates ROS in Alzheimer’s disease

(2017) Clémence Cheignon et al.   Chemical Science

The Aggregation Paths and Products of Aβ42 Dimers Are Distinct from Those of the Aβ42 Monomer

(2016) Tiernan T. O’Malley et al.   BIOCHEMISTRY

Stabilization of native amyloid β-protein oligomers by Copper and Hydrogen peroxide Induced Cross-linking of Unmodified Proteins (CHICUP)

(2016) Thomas L. Williams et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Methionine oxidation reduces lag-times for amyloid-β(1–40) fiber formation but generates highly fragmented fibers

(2016) Miao Gu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer's disease?

(2016) Clémence Cheignon et al.   DALTON TRANSACTIONS

Ion Channel Formation by Amyloid-β42Oligomers but Not Amyloid-β40in Cellular Membranes

(2016) David C. Bode et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β and α-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing

(2016) Jeppe T. Pedersen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal-catalyzed oxidation of Aβ and the resulting reorganization of Cu binding sites promote ROS production

(2016) Clémence Cheignon et al.   Metallomics

Molecular mechanisms of protein aggregation from global fitting of kinetic models

(2016) Georg Meisl et al.   Nature Protocols

The involvement of dityrosine crosslinking in α-synuclein assembly and deposition in Lewy Bodies in Parkinson’s disease

(2016) Youssra K. Al-Hilaly et al.   Scientific Reports

Free Superoxide is an Intermediate in the Production of H2 O2 by Copper(I)-Aβ Peptide and O2

(2015) Karine Reybier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cu2+accentuates distinct misfolding of Aβ(1–40)and Aβ(1–42)peptides, and potentiates membrane disruption

(2015) Christian J. Matheou et al.   BIOCHEMICAL JOURNAL

A Comparison of Three Fluorophores for the Detection of Amyloid Fibers and Prefibrillar Oligomeric Assemblies. ThT (Thioflavin T); ANS (1-Anilinonaphthalene-8-sulfonic Acid); and bisANS (4,4′-Dianilino-1,1′-binaphthyl-5,5′-disulfonic Acid)

(2015) Nadine D. Younan et al.   BIOCHEMISTRY

Truncated Amyloid-β(11–40/42)from Alzheimer Disease Binds Cu2+with a Femtomolar Affinity and Influences Fiber Assembly

(2015) Joseph D. Barritt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High Resolution Structural Characterization of Aβ42 Amyloid Fibrils by Magic Angle Spinning NMR

(2015) Michael T. Colvin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

(2015) Yiling Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

(2015) Yiling Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Aβ dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies

(2014) Tiernan T. O’Malley et al.   BIOCHEMICAL JOURNAL

An integrated study of the affinities of the Aβ16 peptide for Cu(i) and Cu(ii): implications for the catalytic production of reactive oxygen species

(2014) Tessa R. Young et al.   Metallomics

Di-Tyrosine Cross-Link Decreases the Collisional Cross-Section of Aβ Peptide Dimers and Trimers in the Gas Phase: An Ion Mobility Study

(2014) Ewa Sitkiewicz et al.   PLoS One

The global prevalence of dementia: A systematic review and metaanalysis

(2013) Martin Prince et al.   Alzheimers & Dementia

Heme Binding Induces Dimerization and Nitration of Truncated β-Amyloid Peptide Aβ16 Under Oxidative Stress

(2013) Grégory Thiabaud et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Catalytically Active Copper-Amyloid-Beta State: Coordination Site Responsible for Reactive Oxygen Species Production

(2013) Laure-Estelle Cassagnes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthetic dityrosine-linked β-amyloid dimers form stable, soluble, neurotoxic oligomers

(2013) W. Mei Kok et al.   Chemical Science

A central role for dityrosine crosslinking of Amyloid-β in Alzheimer’s disease

(2013) Youssra K Al-Hilaly et al.   Acta Neuropathologica Communications

Cu(II) Affinity for the Alzheimer’s Peptide: Tyrosine Fluorescence Studies Revisited

(2012) Bruno Alies et al.   ANALYTICAL CHEMISTRY

Metal ions and amyloid fiber formation in neurodegenerative diseases. Copper, zinc and iron in Alzheimer's, Parkinson's and prion diseases

(2012) John H. Viles   COORDINATION CHEMISTRY REVIEWS

The rich electrochemistry and redox reactions of the copper sites in the cellular prion protein

(2012) Feimeng Zhou et al.   COORDINATION CHEMISTRY REVIEWS

Molecular-Level Examination of Cu2+Binding Structure for Amyloid Fibrils of 40-Residue Alzheimer’s β by Solid-State NMR Spectroscopy

(2011) Sudhakar Parthasarathy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A New Structural Model of Aβ40Fibrils

(2011) Ivano Bertini et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Disulfide-Linked Amyloid-β Peptide Dimer Forms a Protofibril-like Oligomer through a Distinct Pathway from Amyloid Fibril Formation

(2010) Takahiro Yamaguchi et al.   BIOCHEMISTRY

Molecular mechanism of Thioflavin-T binding to amyloid fibrils

(2010) Matthew Biancalana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Substoichiometric Levels of Cu2+Ions Accelerate the Kinetics of Fiber Formation and Promote Cell Toxicity of Amyloid-β from Alzheimer Disease

(2010) Claire J. Sarell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blood-Borne Amyloid-  Dimer Correlates with Clinical Markers of Alzheimer's Disease

(2010) V. L. Villemagne et al.   JOURNAL OF NEUROSCIENCE

Amyloid  -Protein Dimers Rapidly Form Stable Synaptotoxic Protofibrils

(2010) B. O'Nuallain et al.   JOURNAL OF NEUROSCIENCE

Control of Alzheimer's Amyloid Beta Toxicity by the High Molecular Weight Immunophilin FKBP52 and Copper Homeostasis in Drosophila

(2010) Reiko Sanokawa-Akakura et al.   PLoS One

Copper(II) Binding to Amyloid-β Fibrils of Alzheimer’s Disease Reveals a Picomolar Affinity: Stoichiometry and Coordination Geometry Are Independent of Aβ Oligomeric Form

(2009) Claire J. Sarell et al.   BIOCHEMISTRY

Aβ-mediated ROS production by Cu ions: Structural insights, mechanisms and relevance to Alzheimer's disease

(2009) Christelle Hureau et al.   BIOCHIMIE

Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid β peptide

(2009) W. Mei Kok et al.   CHEMICAL COMMUNICATIONS

Structural Studies of Copper(I) Complexes of Amyloid-β Peptide Fragments: Formation of Two-Coordinate Bis(histidine) Complexes

(2008) Richard A. Himes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amyloid β−Cu2+Complexes in both Monomeric and Fibrillar Forms Do Not Generate H2O2Catalytically but Quench Hydroxyl Radicals†

(2008) Rebecca C. Nadal et al.   BIOCHEMISTRY

Amyloid β-Protein Toxicity and the Pathogenesis of Alzheimer Disease

(2008) Bruce A. Yankner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid   Protein Dimer-Containing Human CSF Disrupts Synaptic Plasticity: Prevention by Systemic Passive Immunization

(2008) I. Klyubin et al.   JOURNAL OF NEUROSCIENCE

The Amyloid-β Peptide of Alzheimer’s Disease Binds CuIin a Linear Bis-His Coordination Environment: Insight into a Possible Neuroprotective Mechanism for the Amyloid-β Peptide

(2008) Jason Shearer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal swap between Zn7-metallothionein-3 and amyloid-β–Cu protects against amyloid-β toxicity

(2008) Gabriele Meloni et al.   Nature Chemical Biology

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Molecular structural basis for polymorphism in Alzheimer's  -amyloid fibrils

(2008) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA