The Neuroprotective Effect of Klotho is Mediated via Regulation of Members of the Redox System

Klotho interferes with a novel FGF-signalling pathway and insulin/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans

(2016) Marie-Thérèse Château et al.   Aging-US

Role of Mitochondria in Neurodegenerative Diseases: Mitochondria as a Therapeutic Target in Alzheimer's Disease

(2016) P. Hemachandra Reddy   CNS SPECTRUMS

Life Extension Factor Klotho Enhances Cognition

(2014) Dena B. Dubal et al.   Cell Reports

Expression of klotho mRNA and protein in rat brain parenchyma from early postnatal development into adulthood

(2013) Sarah M. Clinton et al.   BRAIN RESEARCH

Klotho Ameliorates Chemically Induced Endoplasmic Reticulum (ER) Stress Signaling

(2013) Srijita Banerjee et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Enhanced Phosphatidylinositol 3-kinase (PI3K)/Akt Signaling Has Pleiotropic Targets in Hippocampal Neurons Exposed to Iron-induced Oxidative Stress

(2013) Romina María Uranga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hippocampal gene expression dysregulation of Klotho, nuclear factor kappa B and tumor necrosis factor in temporal lobe epilepsy patients

(2013) Marcelo Teocchi et al.   Journal of Neuroinflammation

The Antiaging Protein Klotho Enhances Oligodendrocyte Maturation and Myelination of the CNS

(2013) C.-D. Chen et al.   JOURNAL OF NEUROSCIENCE

Klotho upregulation contributes to the neuroprotection of ligustilide in an Alzheimer's disease mouse model

(2013) Xi Kuang et al.   NEUROBIOLOGY OF AGING

Klotho in the cerebrospinal fluid of adults with and without Alzheimer's disease

(2013) Richard D. Semba et al.   NEUROSCIENCE LETTERS

PTEN-regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-treated colorectal cancer cells

(2013) H Luo et al.   Cell Death & Disease

FoxO3a is activated and executes neuron death via Bim in response to β-amyloid

(2013) P Sanphui et al.   Cell Death & Disease

Transgenic Overexpression of Peroxiredoxin-2 Attenuates Ischemic Neuronal Injury Via Suppression of a Redox-Sensitive Pro-Death Signaling Pathway

(2012) Yu Gan et al.   ANTIOXIDANTS & REDOX SIGNALING

The antioxidant enzyme peroxiredoxin and its protective role in neurological disorders

(2012) Hong Zhu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Small-molecule Klotho enhancers as novel treatment of neurodegeneration

(2012) Carmela R Abraham et al.   Future Medicinal Chemistry

Neuroprotective effects of PrxI over-expression in an in vitro human Alzheimer's disease model

(2012) Annamaria Cimini et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Nuclear localization of Klotho in brain: an anti-aging protein

(2012) Dwight C. German et al.   NEUROBIOLOGY OF AGING

Glutamate Induces Mitochondrial Dynamic Imbalance and Autophagy Activation: Preventive Effects of Selenium

(2012) Santosh Kumari et al.   PLoS One

Mitochondria-Specific Accumulation of Amyloid β Induces Mitochondrial Dysfunction Leading to Apoptotic Cell Death

(2012) Moon-Yong Cha et al.   PLoS One

Thioredoxin Reductase Deficiency Potentiates Oxidative Stress, Mitochondrial Dysfunction and Cell Death in Dopaminergic Cells

(2012) Pamela Lopert et al.   PLoS One

Inhibition of Bax protects neuronal cells from oligomeric Aβ neurotoxicity

(2012) W Kudo et al.   Cell Death & Disease

Promoter methylation and age-related downregulation of Klotho in rhesus monkey

(2011) Gwendalyn D. King et al.   AGE

Identification of novel small molecules that elevate Klotho expression

(2011) Gwendalyn D. King et al.   BIOCHEMICAL JOURNAL

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

(2011) M. J. Calkins et al.   HUMAN MOLECULAR GENETICS

Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice

(2011) Shigehiro Doi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF-23 signaling and regulating FGF-23 expression in bone

(2011) Simon Wöhrle et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Oxidative Stress in Neurodegenerative Diseases: Mechanisms and Therapeutic Perspectives

(2011) Ailton Melo et al.   Oxidative Medicine and Cellular Longevity

Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites

(2011) Darragh B. Freir et al.   Nature Communications

CNS Peroxiredoxins and Their Regulation in Health and Disease

(2010) Karen F.S. Bell et al.   ANTIOXIDANTS & REDOX SIGNALING

Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis

(2010) Sergio E. Baranzini et al.   BRAIN

Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons

(2010) S Tobaben et al.   CELL DEATH AND DIFFERENTIATION

Does oxidative stress contribute to the pathology of Friedreich’s ataxia? A radical question

(2010) Jeffrey S. Armstrong et al.   FASEB JOURNAL

Changes in the expression of mitochondrial peroxiredoxin and thioredoxin in neurons and glia and their protective effects in experimental cerebral ischemic damage

(2010) In Koo Hwang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanism for the protective effect of resveratrol against oxidative stress-induced neuronal death

(2010) Masayuki Fukui et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular mechanisms of neurodegeneration in Alzheimer's disease

(2010) L. Crews et al.   HUMAN MOLECULAR GENETICS

The interrelationship between mitochondrial dysfunction and transcriptional dysregulation in Huntington disease

(2010) Youngnam N. Jin et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Melatonin Potentiates the Neuroprotective Properties of Resveratrol Against Beta-Amyloid-Induced Neurodegeneration by Modulating AMP-Activated Protein Kinase Pathways

(2010) Kyoung Ja Kwon et al.   Journal of Clinical Neurology

Loss of Kitlowprogenitors, reduced stem cell factor and high oxidative stress underlie gastric dysfunction in progeric mice

(2010) Ferenc Izbeki et al.   JOURNAL OF PHYSIOLOGY-LONDON

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

Post-Treatment with Voltage-Gated Na+ Channel Blocker Attenuates Kainic Acid-Induced Apoptosis in Rat Primary Hippocampal Neurons

(2010) Arabinda Das et al.   NEUROCHEMICAL RESEARCH

Tetrahydrocurcumin confers protection against amyloid β-induced toxicity

(2010) Shilpa Mishra et al.   NEUROREPORT

Klotho and aging

(2009) Makoto Kuro-o   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Regulation of Renal Outer Medullary Potassium Channel and Renal K+ Excretion by Klotho

(2009) S.-K. Cha et al.   MOLECULAR PHARMACOLOGY

Protective effect of selaginellin on glutamate-induced cytotoxicity and apoptosis in differentiated PC12 cells

(2009) Chen-Jing Wang et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Peroxiredoxin II preserves cognitive function against age-linked hippocampal oxidative damage

(2009) Sun-Uk Kim et al.   NEUROBIOLOGY OF AGING

LKB1 Is Necessary for Akt-Mediated Phosphorylation of Proapoptotic Proteins

(2008) D. Zhong et al.   CANCER RESEARCH

FoxO transcription factors in the maintenance of cellular homeostasis during aging

(2008) Dervis AM Salih et al.   CURRENT OPINION IN CELL BIOLOGY

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

(2008) Sofia Papadia et al.   NATURE NEUROSCIENCE

Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice

(2008) M. Shiozaki et al.   NEUROSCIENCE

Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1

(2008) S.-K. Cha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey

(2007) James A. Duce et al.   GLIA

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

(2007) Fernanda G. De Felice et al.   NEUROBIOLOGY OF AGING