RhoA and Rac1 GTPases Differentially Regulate Agonist-Receptor Mediated Reactive Oxygen Species Generation in Platelets

Differential Roles of the NADPH-Oxidase 1 and 2 in Platelet Activation and ThrombosisSignificance

(2016) M. Keegan Delaney et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Arachidonic Acid Induces Direct Interaction of the p67phox-Rac Complex with the Phagocyte Oxidase Nox2, Leading to Superoxide Production

(2014) Rumi Matono et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Platelet NOX, a novel target for anti-thrombotic treatment

(2014) Pasquale Pignatelli et al.   THROMBOSIS AND HAEMOSTASIS

The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation

(2013) Joseph E. Aslan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

p21 Activated Kinase Signaling Coordinates Glycoprotein Receptor VI–Mediated Platelet Aggregation, Lamellipodia Formation, and Aggregate Stability Under Shear

(2013) Joseph E. Aslan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

RhoG Protein Regulates Glycoprotein VI-Fc Receptor γ-Chain Complex-mediated Platelet Activation and Thrombus Formation

(2013) Soochong Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RhoG Protein Regulates Platelet Granule Secretion and Thrombus Formation in Mice

(2013) Robert Goggs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors

(2013) Xuan Zhou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The novel NOX inhibitor 2-acetylphenothiazine impairs collagen-dependent thrombus formation in a GPVI-dependent manner

(2012) D Vara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Rational Design of Small Molecule Inhibitors Targeting RhoA Subfamily Rho GTPases

(2012) Xun Shang et al.   CHEMISTRY & BIOLOGY

Rational Design of Small Molecule Inhibitors Targeting the Rac GTPase-p67phox Signaling Axis in Inflammation

(2012) Emily E. Bosco et al.   CHEMISTRY & BIOLOGY

Inside-out, outside-in, and inside–outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction

(2012) Bo Shen et al.   CURRENT OPINION IN CELL BIOLOGY

ITAM receptor-mediated generation of reactive oxygen species in human platelets occurs via Syk-dependent and Syk-independent pathways

(2012) J. F. ARTHUR et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis

(2011) I. Pleines et al.   BLOOD

Gene Targeting Implicates Cdc42 GTPase in GPVI and Non-GPVI Mediated Platelet Filopodia Formation, Secretion and Aggregation

(2011) Huzoor Akbar et al.   PLoS One

A Novel Small Molecule 1,2,3,4,6-penta-O-galloyl-α-D-glucopyranose Mimics the Antiplatelet Actions of Insulin

(2011) Rehana Perveen et al.   PLoS One

Inherited Human gp91 phox Deficiency Is Associated With Impaired Isoprostane Formation and Platelet Dysfunction

(2010) Pasquale Pignatelli et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Differential phosphorylation of myosin light chain (Thr)18 and (Ser)19 and functional implications in platelets

(2010) T. M. GETZ et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Rac1-mediated signaling plays a central role in secretion-dependent platelet aggregation in human blood stimulated by atherosclerotic plaque

(2010) Suman Dwivedi et al.   Journal of Translational Medicine

G Protein Subunit G 13 Binds to Integrin  IIb 3 and Mediates Integrin "Outside-In" Signaling

(2010) H. Gong et al.   SCIENCE

RhoA effector mDia1 is required for PI 3-kinase-dependent actin remodeling and spreading by thrombin in platelets

(2009) Guangxun Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Unraveling a novel Rac1-mediated signaling pathway that regulates cofilin dephosphorylation and secretion in thrombin-stimulated platelets

(2009) D. Pandey et al.   BLOOD

Direct Activation of RhoA by Reactive Oxygen Species Requires a Redox-Sensitive Motif

(2009) Amir Aghajanian et al.   PLoS One

Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK-dependent integrin outside-in retractile signaling pathway

(2008) P. Flevaris et al.   BLOOD

Spatially distinct production of reactive oxygen species regulates platelet activation

(2008) Nadia Bakdash et al.   FREE RADICAL BIOLOGY AND MEDICINE