Chemical Mechanisms of Nanoparticle Radiosensitization and Radioprotection: A Review of Structure-Function Relationships Influencing Reactive Oxygen Species

Label-free detection of hydrogen peroxide-induced oxidative stress in human retinal pigment epithelium cells via laser tweezers Raman spectroscopy

(2019) Yang Chen et al.   Biomedical Optics Express

Cytotoxicity, dose-enhancement and radiosensitization of glioblastoma cells with rare earth nanoparticles

(2019) Victor M. Lu et al.   Artificial Cells Nanomedicine and Biotechnology

Copper Oxide Nanoparticles Induce Enhanced Radiosensitizing Effect via Destructive Autophagy

(2019) Yao-Wen Jiang et al.   ACS Biomaterials-Science & Engineering

Treatment of multiple brain metastases using gadolinium nanoparticles and radiotherapy: NANO-RAD, a phase I study protocol

(2019) Camille Verry et al.   BMJ Open

Challenges and Contradictions of Metal Nano-Particle Applications for Radio-Sensitivity Enhancement in Cancer Therapy

(2019) Eva Pagáčová et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cross-Correlative Single-Cell Analysis Reveals Biological Mechanisms of Nanoparticle Radiosensitization

(2019) Tyron Turnbull et al.   ACS Nano

Separation of charge carriers and generation of reactive oxygen species by TiO2 nanoparticles mixed with differently-coated gold nanorods under light irradiation

(2019) Hui Zhang et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

X-ray radiation enhancement of gold- TiO2 nanocomposites

(2019) M.C. Molina Higgins et al.   APPLIED SURFACE SCIENCE

Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in Carcinogenesis

(2019) Natalia Siwecka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NBTXR3, a first-in-class radioenhancer hafnium oxide nanoparticle, plus radiotherapy versus radiotherapy alone in patients with locally advanced soft-tissue sarcoma (Act.In.Sarc): a multicentre, phase 2–3, randomised, controlled trial

(2019) Sylvie Bonvalot et al.   LANCET ONCOLOGY

Cellular Stress Responses in Radiotherapy

(2019) Kim et al.   Cells

A quantitative study of intercellular heterogeneity in gold nanoparticle uptake across multiple cell lines

(2019) Tyron Turnbull et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The Yin-Yang Regulation of Reactive Oxygen Species and MicroRNAs in Cancer

(2019) Kamesh R. Babu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

High Z nanoparticles and radiotherapy: a critical view

(2019) Florent Vilotte et al.   LANCET ONCOLOGY

Gold nanoparticle enhanced proton therapy: A Monte Carlo simulation of the effects of proton energy, nanoparticle size, coating material, and coating thickness on dose and radiolysis yield

(2019) Dylan Peukert et al.   MEDICAL PHYSICS

Quantification of hydroxyl radicals and solvated electrons produced by irradiated gold nanoparticles suggests a crucial role of interfacial water

(2018) Manon Gilles et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

The role of folic acid-conjugated polyglycerol coated iron oxide nanoparticles on radiosensitivity with clinical electron beam (6 MeV) on human cervical carcinoma cell line: In vitro study

(2018) Hamid Fakhimikabir et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Potential relationship between the biological effects of low-dose irradiation and mitochondrial ROS production

(2018) Kasumi Kawamura et al.   JOURNAL OF RADIATION RESEARCH

Unraveling the cell-type dependent radiosensitizing effects of gold through the development of a multifunctional gold nanoparticle

(2018) James R. Nicol et al.   Nanomedicine-Nanotechnology Biology and Medicine

Aquaporin Membrane Channels in Oxidative Stress, Cell Signaling, and Aging: Recent Advances and Research Trends

(2018) Grazia Tamma et al.   Oxidative Medicine and Cellular Longevity

Metallic nanoparticle radiosensitisation of ion radiotherapy: A review

(2018) Dylan Peukert et al.   Physica Medica-European Journal of Medical Physics

Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells

(2018) Yan Liu et al.   Theranostics

Insight Into the Molecular Dynamic Simulation Studies of Reactive Oxygen Species in Native Skin Membrane

(2018) Dharmendra K. Yadav et al.   Frontiers in Pharmacology

A gold nanoparticle system for enhancement of radiotherapy and simultaneous monitoring of reactive-oxygen-species formation

(2018) Jihye Choi et al.   NANOTECHNOLOGY

Tumor microenvironment-manipulated radiocatalytic sensitizer based on bismuth heteropolytungstate for radiotherapy enhancement

(2018) Ruyi Zhou et al.   BIOMATERIALS

Validation and investigation of reactive species yields of Geant4‐ DNA chemistry models

(2018) Dylan Peukert et al.   MEDICAL PHYSICS

Mitochondria, Oxidative Stress and Innate Immunity

(2018) Yuxin Chen et al.   Frontiers in Physiology

ROS and the DNA damage response in cancer

(2018) Upadhyayula Sai Srinivas et al.   Redox Biology

The contribution of hydrogen peroxide to the radiosensitizing effect of gold nanoparticles

(2018) Talat Tariq Khalil et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Titanium Dioxide Nanoparticles as Radiosensitisers: An In vitro and Phantom-Based Study

(2017) Esho Qasho Youkhana et al.   International Journal of Medical Sciences

A Systems Biological View of Life-and-Death Decision with Respect to Endoplasmic Reticulum Stress—The Role of PERK Pathway

(2017) Margita Márton et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles

(2017) Ahmed Abdal Dayem et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Efficacy of radiosensitizing doped titania nanoparticles under hypoxia and preparation of an embolic microparticle

(2017) Rachel Morrison et al.   International Journal of Nanomedicine

Gold nanoparticles and electroporation impose both separate and synergistic radiosensitizing effects in HT-29 tumor cells: an in vitro study

(2017) Zohre Rezaee et al.   International Journal of Nanomedicine

68Ga-radiolabeled AGuIX nanoparticles as dual-modality imaging agents for PET/MRI-guided radiation therapy

(2017) Penelope Bouziotis et al.   Nanomedicine

X-Ray responsive nanoparticles with triggered release of nitrite, a precursor of reactive nitrogen species, for enhanced cancer radiosensitization

(2017) Fang Liu et al.   Nanoscale

Radiosensitization by gold nanoparticles: Will they ever make it to the clinic?

(2017) Lei Cui et al.   RADIOTHERAPY AND ONCOLOGY

Mitochondria-targeting Au nanoclusters enhance radiosensitivity of cancer cells

(2017) Xu Fang et al.   Journal of Materials Chemistry B

Hafnium-doped hydroxyapatite nanoparticles with ionizing radiation for lung cancer treatment

(2016) Min-Hua Chen et al.   Acta Biomaterialia

Permeability across lipid membranes

(2016) Wataru Shinoda   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Reactive oxygen species acts as executor in radiation enhancement and autophagy inducing by AgNPs

(2016) Hao Wu et al.   BIOMATERIALS

First-in-Human Study Testing a New Radioenhancer Using Nanoparticles (NBTXR3) Activated by Radiation Therapy in Patients with Locally Advanced Soft Tissue Sarcomas

(2016) Sylvie Bonvalot et al.   CLINICAL CANCER RESEARCH

X-ray-responsive selenium nanoparticles for enhanced cancer chemo-radiotherapy

(2016) Bo Yu et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Characterization of titanium dioxide nanoparticles modified with polyacrylic acid and H2O2 for use as a novel radiosensitizer

(2016) Kenta Morita et al.   FREE RADICAL RESEARCH

Endoplasmic Reticulum Stress and Associated ROS

(2016) Hafiz Zeeshan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma

(2016) Pei Dang Liu et al.   International Journal of Nanomedicine

MRI-guided clinical 6-MV radiosensitization of glioma using a unique gadolinium-based nanoparticles injection

(2016) Camille Verry et al.   Nanomedicine

LET-dependent radiosensitization effects of gold nanoparticles for proton irradiation

(2016) Sha Li et al.   NANOTECHNOLOGY

ROS and ROS-Mediated Cellular Signaling

(2016) Jixiang Zhang et al.   Oxidative Medicine and Cellular Longevity

First proof of bismuth oxide nanoparticles as efficient radiosensitisers on highly radioresistant cancer cells

(2016) Callum Stewart et al.   Physica Medica-European Journal of Medical Physics

Potential of using cerium oxide nanoparticles for protecting healthy tissue during accelerated partial breast irradiation (APBI)

(2016) Zi Ouyang et al.   Physica Medica-European Journal of Medical Physics

Titanium peroxide nanoparticles enhanced cytotoxic effects of X-ray irradiation against pancreatic cancer model through reactive oxygen species generation in vitro and in vivo

(2016) Masao Nakayama et al.   Radiation Oncology

Efficient free radical generation against cancer cells by low-dose X-ray irradiation with a functional SPC delivery nanosystem

(2016) Yiran Shao et al.   Journal of Materials Chemistry B

Detecting Aquaporin Function and Regulation

(2016) Ana Madeira et al.   Frontiers in Chemistry

Origin and evolution of metabolic sub-cellular compartmentalization in eukaryotes

(2015) Toni Gabaldón et al.   BIOCHIMIE

Impairing the radioresistance of cancer cells by hydrogenated nanodiamonds

(2015) Romain Grall et al.   BIOMATERIALS

PEGylated ceria nanoparticles used for radioprotection on human liver cells under γ-ray irradiation

(2015) Hong Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer

(2015) Gissela Borrego-Soto et al.   GENETICS AND MOLECULAR BIOLOGY

Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells

(2015) Ravi Singh et al.   International Journal of Nanomedicine

Enhancement of radiotherapy by ceria nanoparticles modified with neogambogic acid in breast cancer cells

(2015) Feng Chen et al.   International Journal of Nanomedicine

Radiosensitivity enhancement of radioresistant glioblastoma by epidermal growth factor receptor antibody-conjugated iron-oxide nanoparticles

(2015) Alexandros Bouras et al.   JOURNAL OF NEURO-ONCOLOGY

Enhanced production of reactive oxygen species by gadolinium oxide nanoparticles under core–inner-shell excitation by proton or monochromatic X-ray irradiation: implication of the contribution from the interatomic de-excitation-mediated nanoradiator effect to dose enhancement

(2015) Seung-Jun Seo et al.   RADIATION AND ENVIRONMENTAL BIOPHYSICS

DNA Damage Response Factors from Diverse Pathways, Including DNA Crosslink Repair, Mediate Alternative End Joining

(2015) Sean M. Howard et al.   PLoS Genetics

Pharmacological potential of bioactive engineered nanomaterials

(2014) Fanny Caputo et al.   BIOCHEMICAL PHARMACOLOGY

ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis

(2014) Y Shi et al.   CELL DEATH AND DIFFERENTIATION

Gold nanoparticles functionalization notably decreases radiosensitization through hydroxyl radical production under ionizing radiation

(2014) Manon Gilles et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Reactive oxygen species-related activities of nano-iron metal and nano-iron oxides

(2014) Haohao Wu et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Mechanistic characterization of titanium dioxide nanoparticle-induced toxicity using electron spin resonance

(2014) Meng Li et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Electron spin resonance spectroscopy for the study of nanomaterial-mediated generation of reactive oxygen species

(2014) Weiwei He et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Superparamagnetic Iron Oxide Nanoparticles as Novel X-ray Enhancer for Low-Dose Radiation Therapy

(2014) Stefanie Klein et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Investigation of gold nanoparticle radiosensitization mechanisms using a free radical scavenger and protons of different energies

(2014) J C G Jeynes et al.   PHYSICS IN MEDICINE AND BIOLOGY

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Hafnium oxide nanoparticles: toward an in vitro predictive biological effect?

(2014) Julie Marill et al.   Radiation Oncology

Hypoxia and Cellular Localization Influence the Radiosensitizing Effect of Gold Nanoparticles (AuNPs) in Breast Cancer Cells

(2014) Lei Cui et al.   RADIATION RESEARCH

Therapeutic gold, silver, and platinum nanoparticles

(2014) Miko Yamada et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Cerium oxide nanoparticles in cancer

(2014) Ying Gao et al.   OncoTargets and Therapy

Chemoradiotherapeutic wrinkled mesoporous silica nanoparticles for use in cancer therapy

(2014) Imalka Munaweera et al.   APL Materials

Surface-Enhanced Raman Spectroscopy for Real-Time Monitoring of Reactive Oxygen Species-Induced DNA Damage and Its Prevention by Platinum Nanoparticles

(2013) Sajanlal R. Panikkanvalappil et al.   ACS Nano

Oxidized silicon nanoparticles for radiosensitization of cancer and tissue cells

(2013) Stefanie Klein et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Radiosensitization by gold nanoparticles

(2013) B. Jeremic et al.   Clinical & Translational Oncology

Effects of Ligustrazine on DNA damage and apoptosis induced by irradiation

(2013) Hong Zheng et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Effect of Silver Nanomaterials on the Activity of Thiol-Containing Antioxidants

(2013) Yu-Ting Zhou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Lipid peroxidation end product 4-hydroxy-trans-2-nonenal triggers unfolded protein response and heme oxygenase-1 expression in PC12 cells: Roles of ROS and MAPK pathways

(2013) Meng-Han Lin et al.   TOXICOLOGY

Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation

(2013) Kyeong-Nam Yu et al.   TOXICOLOGY IN VITRO

Adsorption and dissociation of H2O on Au(111) surface: A DFT study

(2013) Ruiqiu Liu   Computational and Theoretical Chemistry

Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity

(2013) Amruta Manke et al.   Biomed Research International

Gold Nanoparticle-Enhanced and Size-Dependent Generation of Reactive Oxygen Species from Protoporphyrin IX

(2012) Maung Kyaw Khaing Oo et al.   ACS Nano

Unfolded protein response to autophagy as a promising druggable target for anticancer therapy

(2012) Dong Hoon Suh et al.   Annals of the New York Academy of Sciences

Oxidative chemistry of fluorescent dyes: implications in the detection of reactive oxygen and nitrogen species

(2012) Balaraman Kalyanaraman   BIOCHEMICAL SOCIETY TRANSACTIONS

Cellular uptake and reactive oxygen species modulation of cerium oxide nanoparticles in human monocyte cell line U937

(2012) Megan S. Lord et al.   BIOMATERIALS

Gold nanoparticles as novel agents for cancer therapy

(2012) S Jain et al.   BRITISH JOURNAL OF RADIOLOGY

Hydroxyl Radical Generation Theory: A Possible Explanation of Unexplained Actions of Mammalian Catalase

(2012) Madhur M. Goyal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nanoscale radiotherapy with hafnium oxide nanoparticles

(2012) Laurence Maggiorella et al.   Future Oncology

Chemical Enhancement by Nanomaterials under X-ray Irradiation

(2012) Neal N. Cheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Physical basis and biological mechanisms of gold nanoparticle radiosensitization

(2012) Karl T. Butterworth et al.   Nanoscale

Phototoxicity of nano titanium dioxides in HaCaT keratinocytes—Generation of reactive oxygen species and cell damage

(2012) Jun-Jie Yin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effect of Gold Nanoparticle Aggregation on Cell Uptake and Toxicity

(2011) Alexandre Albanese et al.   ACS Nano

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

Generation of reactive oxygen species induced by gold nanoparticles under x-ray and UV Irradiations

(2011) Masaki Misawa et al.   Nanomedicine-Nanotechnology Biology and Medicine

Singlet Oxygen Sensor Green®: Photochemical Behavior in Solution and in a Mammalian Cell

(2011) Anita Gollmer et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles

(2011) Stephen J. McMahon et al.   Scientific Reports

Surface-Charge-Dependent Cell Localization and Cytotoxicity of Cerium Oxide Nanoparticles

(2010) Atul Asati et al.   ACS Nano

p53, Oxidative Stress, and Aging

(2010) Dongping Liu et al.   ANTIOXIDANTS & REDOX SIGNALING

Detection and manipulation of mitochondrial reactive oxygen species in mammalian cells

(2010) Marleen Forkink et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Nitric oxide and reactive oxygen species in the nucleus revisitedThis review is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.

(2010) Chantale Provost et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

2′,7′-Dichlorodihydrofluorescein as a fluorescent probe for reactive oxygen species measurement: Forty years of application and controversy

(2010) Xiuping Chen et al.   FREE RADICAL RESEARCH

Cell-Specific Radiosensitization by Gold Nanoparticles at Megavoltage Radiation Energies

(2010) Suneil Jain et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Nuclear Targeting of Gold Nanoparticles in Cancer Cells Induces DNA Damage, Causing Cytokinesis Arrest and Apoptosis

(2010) Bin Kang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cerium oxide nanoparticles protect gastrointestinal epithelium from radiation-induced damage by reduction of reactive oxygen species and upregulation of superoxide dismutase 2

(2010) Jimmie Colon et al.   Nanomedicine-Nanotechnology Biology and Medicine

Targeting nanoparticles to cancer

(2010) M. Wang et al.   PHARMACOLOGICAL RESEARCH

Fabrication of gold nanoparticles for targeted therapy in pancreatic cancer

(2009) Chitta Ranjan Patra et al.   ADVANCED DRUG DELIVERY REVIEWS

DNA damage and p53-mediated growth arrest in human cells treated with platinum nanoparticles

(2009) PV Asharani et al.   Nanomedicine

Caspase-mediated Bak Activation and CytochromecRelease during Intrinsic Apoptotic Cell Death in Jurkat Cells

(2008) Mary E. Shawgo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Tumor Growth by Endohedral Metallofullerenol Nanoparticles Optimized as Reactive Oxygen Species Scavenger

(2008) J.-J. Yin et al.   MOLECULAR PHARMACOLOGY

Enhancement of Radiation Cytotoxicity in Breast-Cancer Cells by Localized Attachment of Gold Nanoparticles

(2008) Tao Kong et al.   Small