Article
Pharmacology & Pharmacy
Marika Musielak, Agnieszka Bos-Liedke, Oliwia Piwocka, Katarzyna Kowalska, Roksana Markiewicz, Barbara Szymkowiak, Pawel Bakun, Wiktoria M. Suchorska
Summary: In this study, the role of gold nanoparticles in enhancing the response of breast cancer cells to ionizing radiation was assessed by comparing 2D and 3D models. It was found that the PEG chain plays an important role in the efficiency of gold nanoparticles in sensitizing cells to ionizing radiation, indicating that gold nanoparticles are a promising agent for combined treatment with radiotherapy.
Article
Materials Science, Ceramics
Yagiz Yedekci, Emre Gedik, Zafer Evis, Lale Dogan, Gokhan Ozyigit, Murat Gurkaynak
Summary: Zinc-doped hydroxyapatite nanoparticles were synthesized and used to inhibit the proliferation of breast cancer cells in combination with ionizing radiation. Low-rate Zinc-doped HA enhanced the radiation effect on breast cancer cells, showing anti-proliferation and apoptosis-inducing properties.
INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Yao Chen, Shuya Liu, Yin Liao, Hanshan Yang, Zhuo Chen, Yuru Hu, Shaozhi Fu, Jingbo Wu
Summary: In this study, albumin-modified gold nanoparticles (Alb-GNPs) were prepared and their radiosensitizing effects and biotoxicity in human non-small-cell lung carcinoma tumor-bearing mice models were observed. The prepared nanoparticles (Alb-GNPs) showed excellent colloidal stability and biocompatibility with a mean size of 205.06 +/- 1.03 nm. Clone formation experiments demonstrated that Alb-GNPs exerted excellent radiosensitization with a higher sensitization enhancement ratio (SER) of 1.432 compared to X-ray alone. Alb-GNPs could accumulate favorably in tumors and their combination with radiotherapy exhibited a greater radiosensitizing effect and anti-tumor activity. Additionally, no toxicity or abnormal irritating response was observed with the application of Alb-GNPs.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Materials Science, Biomaterials
Changhe Shi, Zhongwen Yuan, Ting Liu, Leung Chan, Tianfeng Chen, Jianfu Zhao
Summary: In this study, a selenium-containing ruthenium complex (RuSe) was designed as a radiosensitizer to enhance the killing effect of radiotherapy on nasopharyngeal carcinoma cells. The results showed that RuSe, compared to RuC, could potentiate the lethality of radiotherapy by inducing ROS over-production, decreasing mitochondrial membrane potential, and arresting the cell cycle. Furthermore, RuSe was superior to RuC in inducing apoptotic cell death. This study demonstrates an effective and safe strategy for the application of RuSe complexes to cancer-targeted chemo/radiotherapy and sheds light on the potential mechanisms of selenium-containing drugs as radiotherapy sensitizers.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Biochemistry & Molecular Biology
Nhan Hau Tran, Vyacheslav Ryzhov, Andrey Volnitskiy, Dmitry Amerkanov, Fedor Pack, Aleksander M. Golubev, Alexandr Arutyunyan, Anastasiia Spitsyna, Vladimir Burdakov, Dmitry Lebedev, Andrey L. Konevega, Tatiana Shtam, Yaroslav Marchenko
Summary: In this study, the potential of iron oxide nanoparticles as radiosensitizers in glioblastoma cells was evaluated. The results showed that the nanoparticles can significantly enhance the effect of X-ray irradiation, while having a weaker or no effect on gamma and proton irradiation. The findings suggest that the nanoparticles may enhance radiation therapy by generating secondary electrons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Wenxin Zhang, Xiaodie Li, Jialin Zeng, Xin Wen, Chao Zhang, Yinan Zhang, Jian He, Lihua Yang
Summary: This study demonstrated a dual-channel parallel free radicals-amplifying radiation therapy strategy for neuroblastoma. By releasing atovaquone (ATO) and Fe3+ in response to the tumor microenvironment, this strategy improved the effectiveness of radiation therapy by inhibiting tumor cell respiration and consuming tumor-overexpressed GSH.
MATERIALS TODAY BIO
(2023)
Article
Oncology
Wen-Kyle Wong, Francisco D. C. Guerra Liberal, Stephen J. McMahon
Summary: This study investigated the radiosensitizing effect of DDR inhibitors on human breast cancer cells. The main finding was that radiosensitization by DDR inhibition was more prominent when combined with fractionated IR. Moreover, DDR inhibition impeded the repair of IR-induced DNA double-strand breaks.
Review
Pharmacology & Pharmacy
Wei Liu, Bo Chen, Haocheng Zheng, Yun Xing, Guiyuan Chen, Peijie Zhou, Liting Qian, Yuanzeng Min
Summary: Nanomedicine has provided effective approaches for improving the efficiency of radiotherapy and reducing its side effects, with metal nanoparticles proving to be ideal radiosensitizers. The use of nanoparticles can help facilitate the delivery of radiosensitizing drugs to tumor sites, enhancing anti-tumor responses.
Review
Chemistry, Physical
Wenjing Xiao, Lin Zhao, Yang Sun, Xiao Yang, Qinrui Fu
Summary: This review provides a comprehensive overview of the recently reported studies on stimuli-responsive nanomaterials for tumor radio-sensitization, including endogenous and exogenous responses, dual stimuli-response, and multi stimuli-response approaches. It also discusses the challenges and perspectives related to stimuli-responsive nanomaterials for tumor radio-sensitization.
Article
Biophysics
Kenta Morita, Yuya Nishimura, Satoko Nakamura, Yuki Arai, Chiya Numako, Kazuyoshi Sato, Masao Nakayama, Hiroaki Akasaka, Ryohei Sasaki, Chiaki Ogino, Akihiko Kondo
Summary: Polyacrylic acid-modified titanium peroxide nanoparticles (PAA-TiOx NPs) act as efficient carriers of H2O2 into cancer cells, enhancing their radiosensitivity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Nanoscience & Nanotechnology
Anqi Zhang, Lei Gao
Summary: Radiotherapy is an important method for treating malignant tumors. Enhancing its therapeutic gain ratio through physical techniques is the current direction of radiotherapy. The combination of hyperthermia and radiotherapy can improve the radiosensitivity of tumor cells and has significant clinical value. Nanomaterials have attracted widespread attention in tumor hyperthermia research and show great potential. This article summarizes the sensitizing mechanisms and effects of gold nanotechnology and provides an overview of the advancements of other nanoparticles in radiation therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Oncology
Emilie Thivat, Melanie Casile, Juliette Moreau, Ioana Molnar, Sandrine Dufort, Khalide Seddik, Geraldine Le Duc, Olivier De Beaumont, Markus Loeffler, Xavier Durando, Julian Biau
Summary: This study aims to determine the recommended dose of AGuIX as a radiosensitizer in combination with radiotherapy and TMZ, as well as to assess the efficacy of the combination. The study design is a multicenter, randomized, open-label, non-comparative therapeutic trial, expected to recruit 66 patients. Secondary objectives include assessing the pharmacokinetics, distribution of nanoparticles, tolerance of the combination, neurological status, overall survival, response to treatment, and progression-free survival.
Article
Biochemistry & Molecular Biology
Sung-Won Shin, Kyungmi Yang, Miso Lee, Jiyoung Moon, Arang Son, Yeeun Kim, Suha Choi, Do-hyung Kim, Changhoon Choi, Nohyun Lee, Hee Chul Park
Summary: The study found that MFN may overcome radioresistance by alleviating hypoxia and enhancing antitumor immunity in the tumor microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Polymer Science
Jinfeng Lin, Mingming Yin, Xiaoming Liu, Fanling Meng, Liang Luo
Summary: This review provides an overview of functional polymer-based nanomaterials for radiosensitization in recent years. Different types of polymer nanomaterials, including polymeric micelles, dendrimers, polymeric nanospheres, nanoscale coordination polymers, polymersomes, and nanogels, are discussed in terms of their action mechanisms, drug loading methods, targeting efficiencies, impact on therapeutic effects, and biocompatibility. Polymeric nano-radiosensitizers have the potential to improve the efficacy of radiotherapy and minimize damage to healthy tissues.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Nanoscience & Nanotechnology
Boyi Yu, Xuanyi Lu, Xianglong Feng, Ting Zhao, Jiaxin Li, Yudie Lu, Fei Ye, Xiongxiong Liu, Xiaogang Zheng, Zheyu Shen, Xiaodong Jin, Weiqiang Chen, Qiang Li
Summary: This study found that GONs can be used as radiosensitizers to enhance the sensitivity of 4T1 breast cancer cells to X-ray irradiation, improving the killing effect and immune activation of radiotherapy. Fractionated X-ray irradiation combined with GONs demonstrated the most significant tumor growth inhibition and activation of the antitumor immune response.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)