Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer

Structural insights into NHEJ: Building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time

(2014) Gareth J. Williams et al.   DNA REPAIR

The spatial organization of non-homologous end joining: From bridging to end joining

(2014) Takashi Ochi et al.   DNA REPAIR

DNA double-strand break repair pathway choice and cancer

(2014) Tomas Aparicio et al.   DNA REPAIR

A role for XLF in DNA repair and recombination in human somatic cells

(2014) Farjana Jahan Fattah et al.   DNA REPAIR

Alternative end-joining pathway(s): Bricolage at DNA breaks

(2014) Philippe Frit et al.   DNA REPAIR

Genetic factors in individual radiation sensitivity

(2014) Sabine Hornhardt et al.   DNA REPAIR

DNA-PK: A dynamic enzyme in a versatile DSB repair pathway

(2014) Anthony J. Davis et al.   DNA REPAIR

Holliday junction resolution: Regulation in space and time

(2014) Joao Matos et al.   DNA REPAIR

Some causes of inter-laboratory variation in the results of comet assay

(2014) Nikolai P. Sirota et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy

(2014) C. Liu et al.   NUCLEIC ACIDS RESEARCH

Is Non-Homologous End-Joining Really an Inherently Error-Prone Process?

(2014) Mireille Bétermier et al.   PLoS Genetics

Comet assay to measure DNA repair: approach and applications

(2014) Amaya Azqueta et al.   Frontiers in Genetics

Locoregional recurrence in patients with HER2 positive breast cancer

(2013) Janaina Brollo et al.   BREAST

Genomic classifications and radiotherapy for breast cancer

(2013) Anna Britten et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Distinct Functions of Human Cohesin-SA1 and Cohesin-SA2 in Double-Strand Break Repair

(2013) X. Kong et al.   MOLECULAR AND CELLULAR BIOLOGY

RPA Coordinates DNA End Resection and Prevents Formation of DNA Hairpins

(2013) Huan Chen et al.   MOLECULAR CELL

Radiation-induced stress response in peripheral blood of breast cancer patients differs between patients with severe acute skin reactions and patients with no side effects to radiotherapy

(2013) Sara Skiöld et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Homologous recombination mediates cellular resistance and fraction size sensitivity to radiation therapy

(2013) Navita Somaiah et al.   RADIOTHERAPY AND ONCOLOGY

Double-Strand Break Repair Assays Determine Pathway Choice and Structure of Gene Conversion Events in Drosophila melanogaster

(2013) Anthony T. Do et al.   G3-Genes Genomes Genetics

DNA Double-Strand Break Repair as Determinant of Cellular Radiosensitivity to Killing and Target in Radiation Therapy

(2013) Emil Mladenov et al.   Frontiers in Oncology

BRCA1 promoter methylation in peripheral blood DNA was identified in sporadic breast cancer and controls

(2012) Rémy Bosviel et al.   Cancer Epidemiology

The descriptive epidemiology of female breast cancer: An international comparison of screening, incidence, survival and mortality

(2012) Danny R. Youlden et al.   Cancer Epidemiology

Urinary 8-Oxoguanine as a Predictor of Survival in Patients Undergoing Radiotherapy

(2012) K. Roszkowski et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Urinary biomarkers of oxidative status

(2012) Dora Il'yasova et al.   CLINICA CHIMICA ACTA

APLF promotes the assembly and activity of non-homologous end joining protein complexes

(2012) Gabrielle J Grundy et al.   EMBO JOURNAL

The power of DNA double-strand break (DSB) repair testing to predict breast cancer susceptibility

(2012) Marlen Keimling et al.   FASEB JOURNAL

Role of non-homologous end joining in V(D)J recombination

(2012) Shruti Malu et al.   IMMUNOLOGIC RESEARCH

Molecular nature of radiation injury and DNA repair disorders associated with radiosensitivity

(2012) Yuji Masuda et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs

(2012) Shruti Malu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Comet-assay parameters as rapid biomarkers of exposure to dietary/environmental compounds—An in vitro feasibility study on spermatozoa and lymphocytes

(2012) A. Baumgartner et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Homologous recombination and its regulation

(2012) L. Krejci et al.   NUCLEIC ACIDS RESEARCH

8-Hydroxydeoxyguanosine: Not mere biomarker for oxidative stress, but remedy for oxidative stress-implicated gastrointestinal diseases

(2012) Chan-Young Ock   WORLD JOURNAL OF GASTROENTEROLOGY

A radiation-induced gene expression signature as a tool to predict acute radiotherapy-induced adverse side effects

(2011) Claudia Mayer et al.   CANCER LETTERS

Understanding the limitations of radiation-induced cell cycle checkpoints

(2011) Dorothee Deckbar et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Genetic variation in radiation-induced cell death

(2011) D. A. Smirnov et al.   GENOME RESEARCH

Ku Regulates Signaling to DNA Damage Response Pathways through the Ku70 von Willebrand A Domain

(2011) V. L. Fell et al.   MOLECULAR AND CELLULAR BIOLOGY

hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity

(2011) Derek J. Richard et al.   NUCLEIC ACIDS RESEARCH

Regulatory networks integrating cell cycle control with DNA damage checkpoints and double-strand break repair

(2011) P. Langerak et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Gamma-H2AX-Based Dose Estimation for Whole and Partial Body Radiation Exposure

(2011) Simon Horn et al.   PLoS One

Combined low initial DNA damage and high radiation-induced apoptosis confers clinical resistance to long-term toxicity in breast cancer patients treated with high-dose radiotherapy

(2011) Luis Henríquez-Hernández et al.   Radiation Oncology

Prediction of normal tissue toxicity as part of the individualized treatment with radiotherapy in oncology patients

(2011) Luis Alberto Henríquez-Hernández et al.   SURGICAL ONCOLOGY-OXFORD

Application of the comet assay method in clinical studies

(2011) Petra Fikrová et al.   WIENER KLINISCHE WOCHENSCHRIFT

DNA repair and synthetic lethality

(2011) Gong‐she Guo et al.   International Journal of Oral Science

BCR-ABL stimulates mutagenic homologous DNA double-strand break repair via the DNA-end-processing factor CtIP

(2010) Daniela Salles et al.   CARCINOGENESIS

BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair

(2010) P. J. O'Donovan et al.   CARCINOGENESIS

BRCA1 role in the mitigation of radiotoxicity and chromosomal instability through repair of clustered DNA lesions

(2010) Jessica M. Hair et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Histone  H2AX and Poly(ADP-Ribose) as Clinical Pharmacodynamic Biomarkers

(2010) C. E. Redon et al.   CLINICAL CANCER RESEARCH

DNA-PKcs regulates a single-stranded DNA endonuclease activity of Artemis

(2010) Jiafeng Gu et al.   DNA REPAIR

Breast Cancer Subtypes and the Risk of Local and Regional Relapse

(2010) K. David Voduc et al.   JOURNAL OF CLINICAL ONCOLOGY

Eviction Notice: New Insights into Rad51 Removal from DNA during Homologous Recombination

(2010) Ashley B. Williams et al.   MOLECULAR CELL

DNA repair and the origins of urinary oxidized 2'-deoxyribonucleosides

(2010) M. D. Evans et al.   MUTAGENESIS

Ku is a 5′-dRP/AP lyase that excises nucleotide damage near broken ends

(2010) Steven A. Roberts et al.   NATURE

hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex

(2010) Derek J. Richard et al.   NUCLEIC ACIDS RESEARCH

Rad51 Inhibits Translocation Formation by Non-Conservative Homologous Recombination in Saccharomyces cerevisiae

(2010) Glenn M. Manthey et al.   PLoS One

XLF Regulates Filament Architecture of the XRCC4·Ligase IV Complex

(2010) Michal Hammel et al.   STRUCTURE

H2AX: functional roles and potential applications

(2009) Jennifer S. Dickey et al.   CHROMOSOMA

Variation in the measurement of DNA damage by comet assay measured by the ECVAG  inter-laboratory validation trial

(2009) L. Forchhammer et al.   MUTAGENESIS

Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats

(2009) Bancinyane L. Sibanda et al.   NATURE

Genetic variations in DNA repair genes, radiosensitivity to cancer and susceptibility to acute tissue reactions in radiotherapy-treated cancer patients

(2008) Dimitry A. Chistiakov et al.   ACTA ONCOLOGICA

DNA Double-Strand Break Repair of Blood Lymphocytes and Normal Tissues Analysed in a Preclinical Mouse Model: Implications for Radiosensitivity Testing

(2008) C. E. Rube et al.   CLINICAL CANCER RESEARCH

A sensitive test for the detection of specific DSB repair defects in primary cells from breast cancer specimens

(2008) Marlen Keimling et al.   INTERNATIONAL JOURNAL OF CANCER

The comet assay in human biomonitoring: gene-environment interactions

(2008) M. Dusinska et al.   MUTAGENESIS

 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

(2008) A. Kinner et al.   NUCLEIC ACIDS RESEARCH