DNA Damage Response Factors from Diverse Pathways, Including DNA Crosslink Repair, Mediate Alternative End Joining

Preventing over-resection by DNA2 helicase/nuclease suppresses repair defects in Fanconi anemia cells

(2014) Kenneth K Karanja et al.   CELL CYCLE

Alternative end-joining pathway(s): Bricolage at DNA breaks

(2014) Philippe Frit et al.   DNA REPAIR

Non-homologous end joining often uses microhomology: Implications for alternative end joining

(2014) Nicholas R. Pannunzio et al.   DNA REPAIR

The Role of the Human Psoralen 4 (hPso4) Protein Complex in Replication Stress and Homologous Recombination

(2014) Mohammad Abbas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells

(2014) Thuy Vy Nguyen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Is Non-Homologous End-Joining Really an Inherently Error-Prone Process?

(2014) Mireille Bétermier et al.   PLoS Genetics

DNA2, a new player in telomere maintenance and tumor suppression

(2013) Weihang Chai et al.   CELL CYCLE

Break-induced replication: functions and molecular mechanism

(2013) Anna Malkova et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The absence of Ku but not defects in classical non-homologous end-joining is required to trigger PARP1-dependent end-joining

(2013) Wael Y. Mansour et al.   DNA REPAIR

FANCM and FAAP24 Maintain Genome Stability via Cooperative as Well as Unique Functions

(2013) Yucai Wang et al.   MOLECULAR CELL

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

(2013) Cristina Escribano-Díaz et al.   MOLECULAR CELL

Fanconi anaemia and the repair of Watson and Crick DNA crosslinks

(2013) Molly C. Kottemann et al.   NATURE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

(2013) Jiangbo Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Synthetic lethality between CCNE1 amplification and loss of BRCA1

(2013) D. Etemadmoghadam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells

(2013) L. N. Truong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells

(2013) Lorenzo Costantino et al.   SCIENCE

BRCA1 and CtIP suppress long-tract gene conversion between sister chromatids

(2013) Gurushankar Chandramouly et al.   Nature Communications

A Role for BLM in Double-Strand Break Repair Pathway Choice: Prevention of CtIP/Mre11-Mediated Alternative Nonhomologous End-Joining

(2013) Anastazja Grabarz et al.   Cell Reports

Microhomology-Mediated Mechanisms Underlie Non-Recurrent Disease-Causing Microdeletions of the FOXL2 Gene or Its Regulatory Domain

(2013) Hannah Verdin et al.   PLoS Genetics

Human Nuclease/Helicase DNA2 Alleviates Replication Stress by Promoting DNA End Resection

(2012) G. Peng et al.   CANCER RESEARCH

DNA2 and EXO1 in replication-coupled, homology-directed repair and in the interplay between HDR and the FA/BRCA network

(2012) Kenneth K. Karanja et al.   CELL CYCLE

A high-throughput, flow cytometry-based method to quantify DNA-end resection in mammalian cells

(2012) Josep V. Forment et al.   CYTOMETRY PART A

Okazaki Fragment Processing-independent Role for Human Dna2 Enzyme during DNA Replication

(2012) Julien P. Duxin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ring Finger Nuclear Factor RNF168 Is Important for Defects in Homologous Recombination Caused by Loss of the Breast Cancer Susceptibility Factor BRCA1

(2012) Meilen C. Muñoz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complex Cisplatin-Double Strand Break (DSB) Lesions Directly Impair Cellular Non-Homologous End-Joining (NHEJ) Independent of Downstream Damage Response (DDR) Pathways

(2012) Catherine R. Sears et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin

(2012) Céline Jacquemont et al.   Molecular Cancer

BRCA1 Functions Independently of Homologous Recombination in DNA Interstrand Crosslink Repair

(2012) Samuel F. Bunting et al.   MOLECULAR CELL

A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response

(2012) Britt Adamson et al.   NATURE CELL BIOLOGY

Microhomology Directs Diverse DNA Break Repair Pathways and Chromosomal Translocations

(2012) Diana D. Villarreal et al.   PLoS Genetics

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

Correct End Use during End Joining of Multiple Chromosomal Double Strand Breaks Is Influenced by Repair Protein RAD50, DNA-dependent Protein Kinase DNA-PKcs, and Transcription Context

(2011) Amanda Gunn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings

(2011) Thomas Helleday   Molecular Oncology

Induction and repair of DNA double strand breaks: The increasing spectrum of non-homologous end joining pathways

(2011) Emil Mladenov et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Homology-directed Fanconi anemia pathway cross-link repair is dependent on DNA replication

(2011) Koji Nakanishi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

Mechanism of Holliday junction resolution by the human GEN1 protein

(2010) U. Rass et al.   GENES & DEVELOPMENT

53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination

(2010) Anne Bothmer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Preventing Nonhomologous End Joining Suppresses DNA Repair Defects of Fanconi Anemia

(2010) Adele Adamo et al.   MOLECULAR CELL

Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4–ligase IV during chromosomal translocation formation

(2010) Deniz Simsek et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway

(2010) Yu Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ku70 Corrupts DNA Repair in the Absence of the Fanconi Anemia Pathway

(2010) P. Pace et al.   SCIENCE

ATM Limits Incorrect End Utilization during Non-Homologous End Joining of Multiple Chromosome Breaks

(2010) Nicole Bennardo et al.   PLoS Genetics

Complex landscapes of somatic rearrangement in human breast cancer genomes

(2009) Philip J. Stephens et al.   NATURE

Multiple functions of MRN in end-joining pathways during isotype class switching

(2009) Maria Dinkelmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of mammalian Mre11 in classical and alternative nonhomologous end joining

(2009) Anyong Xie et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells

(2009) Emilie Rass et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ku86 represses lethal telomere deletion events in human somatic cells

(2009) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination

(2009) Nasim A. Begum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Limiting the Persistence of a Chromosome Break Diminishes Its Mutagenic Potential

(2009) Nicole Bennardo et al.   PLoS Genetics

Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24

(2008) J. M. Kim et al.   BLOOD

Ku80 removal from DNA through double strand break–induced ubiquitylation

(2008) Lisa Postow et al.   JOURNAL OF CELL BIOLOGY

Identification of Holliday junction resolvases from humans and yeast

(2008) Stephen C. Y. Ip et al.   NATURE

MMEJ repair of double-strand breaks (director’s cut): deleted sequences and alternative endings

(2008) Mitch McVey et al.   TRENDS IN GENETICS

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics