New paradigms in chronic intestinal inflammation and colon cancer: role of melatonin

Taming the beast within: resveratrol suppresses colitis and prevents colon cancer

(2016) Lorne J. Hofseth et al.   Aging-US

Basic Mechanisms Involved in the Anti-Cancer Effects of Melatonin

(2011) M. D. Mediavilla et al.   CURRENT MEDICINAL CHEMISTRY

Proinflammatory Cytokines in the Pathogenesis of Inflammatory Bowel Diseases

(2011) Warren Strober et al.   GASTROENTEROLOGY

ER stress is implicated in mitochondrial dysfunction-induced apoptosis of pancreatic beta cells

(2011) June Woo Lee et al.   MOLECULES AND CELLS

Mitochondrial TRAP1 regulates the unfolded protein response in the endoplasmic reticulum

(2011) Kana Takemoto et al.   NEUROCHEMISTRY INTERNATIONAL

The Nuclear Hormone Receptor PPARγas a Therapeutic Target in Major Diseases

(2011) Martina Victoria Schmidt et al.   TheScientificWorldJOURNAL

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

Autophagy Signaling Through Reactive Oxygen Species

(2010) Ju Huang et al.   ANTIOXIDANTS & REDOX SIGNALING

The life span-prolonging effect of Sirtuin-1 is mediated by autophagy

(2010) Eugenia Morselli et al.   Autophagy

Melatonin: A pleiotropic molecule regulating inflammation

(2010) Flavia Radogna et al.   BIOCHEMICAL PHARMACOLOGY

SIRT1 and p53, effect on cancer, senescence and beyond

(2010) Jingjie Yi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Resveratrol and rapamycin: are they anti-aging drugs?

(2010) Matt Kaeberlein   BIOESSAYS

The Role of T cell PPAR γ in mice with experimental inflammatory bowel disease

(2010) Amir J Guri et al.   BMC GASTROENTEROLOGY

Resveratrol Suppresses Colitis and Colon Cancer Associated with Colitis

(2010) X. Cui et al.   Cancer Prevention Research

Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis

(2010) Takahisa Nakamura et al.   CELL

NF-κB Signaling Pathway, Inflammation and Colorectal Cancer

(2010) Soly Wang et al.   Cellular & Molecular Immunology

Clinical Uses of Melatonin: Evaluation of Human Trials

(2010) E.J. Sanchez-Barcelo et al.   CURRENT MEDICINAL CHEMISTRY

Autophagy regulation by p53

(2010) Maria Chiara Maiuri et al.   CURRENT OPINION IN CELL BIOLOGY

Dietary conjugated linoleic acid and n-3 polyunsaturated fatty acids in inflammatory bowel disease

(2010) Josep Bassaganya-Riera et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

A systems biology viewpoint on autophagy in health and disease

(2010) Alan Huett et al.   CURRENT OPINION IN GASTROENTEROLOGY

Endoplasmic reticulum stress: implications for inflammatory bowel disease pathogenesis

(2010) Arthur Kaser et al.   CURRENT OPINION IN GASTROENTEROLOGY

Melatonin Expresses Powerful Anti-inflammatory and Antioxidant Activities Resulting in Complete Improvement of Acetic-Acid-Induced Colitis in Rats

(2010) Gulgun Tahan et al.   DIGESTIVE DISEASES AND SCIENCES

Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model

(2010) Jie Li et al.   EUROPEAN JOURNAL OF CANCER

Modulation of inflammatory changes in early stages of colon cancer through activation of PPARγ by diclofenac

(2010) Jasmeet Kaur et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Sleep disturbances and inflammatory bowel disease: a potential trigger for disease flare?

(2010) Garth R Swanson et al.   Expert Review of Clinical Immunology

Recently identified and potential targets for colon cancer treatment

(2010) Michael A Lea   Future Oncology

Inflammation and Colon Cancer

(2010) Janoš Terzić et al.   GASTROENTEROLOGY

Interferon-gamma-expressing cells are a major source of interleukin-21 in inflammatory bowel diseases

(2010) Massimiliano Sarra et al.   INFLAMMATORY BOWEL DISEASES

Mechanisms by which inflammation may increase intestinal cancer risk in inflammatory bowel disease

(2010) Pamela M. OʼConnor et al.   INFLAMMATORY BOWEL DISEASES

Role of different inflammatory and tumor biomarkers in the development of ulcerative colitis-associated carcinogenesis

(2010) E. Talero et al.   INFLAMMATORY BOWEL DISEASES

News from the “5th international meeting on inflammatory bowel diseases” CAPRI 2010

(2010) Giovanni Latella et al.   Journal of Crohns & Colitis

Melatonin protects N2a against ischemia/reperfusion injury through autophagy enhancement

(2010) Yanchun Guo et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

The mechanism for the neuroprotective effect of melatonin against methamphetamine-induced autophagy

(2010) Chutikorn Nopparat et al.   JOURNAL OF PINEAL RESEARCH

Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease

(2010) Giuseppe Paradies et al.   JOURNAL OF PINEAL RESEARCH

The inhibition of apoptosis by melatonin in VSC4.1 motoneurons exposed to oxidative stress, glutamate excitotoxicity, or TNF-α toxicity involves membrane melatonin receptors

(2010) Arabinda Das et al.   JOURNAL OF PINEAL RESEARCH

Melatonin and celecoxib improve the outcomes in hamsters with experimental pancreatic cancer

(2010) Francisco J. Padillo et al.   JOURNAL OF PINEAL RESEARCH

Melatonin induces pro-apoptotic signaling pathway in human pancreatic carcinoma cells (PANC-1)

(2010) Anna Leja-Szpak et al.   JOURNAL OF PINEAL RESEARCH

Melatonin suppresses cyclosporine A-induced autophagy in rat pituitary GH3 cells

(2010) Yeong-Min Yoo et al.   JOURNAL OF PINEAL RESEARCH

Melatonin ameliorates cerulein-induced pancreatitis by the modulation of nuclear erythroid 2-related factor 2 and nuclear factor-kappaB in rats

(2010) Kyung Hee Jung et al.   JOURNAL OF PINEAL RESEARCH

p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation

(2010) R. Scherz-Shouval et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling

(2010) K. R. Holloway et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Melatonin attenuates clock gene Cryptochrome1, which may aggravates mouse anti-type II collagen antibody-induced arthritis

(2010) Jihye Bang et al.   RHEUMATOLOGY INTERNATIONAL

Melatonin: Action as antioxidant and potential applications in human disease and aging

(2010) Dominique Bonnefont-Rousselot et al.   TOXICOLOGY

p53 and ARF: unexpected players in autophagy

(2010) Gregor M. Balaburski et al.   TRENDS IN CELL BIOLOGY

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

(2010) E Wirawan et al.   Cell Death & Disease

Aging and cancer cell biology, 2009

(2009) Judith Campisi et al.   AGING CELL

Inhibition of Autophagy Potentiates Sulforaphane-Induced Apoptosis in Human Colon Cancer Cells

(2009) Takeshi Nishikawa et al.   ANNALS OF SURGICAL ONCOLOGY

Regulation of yeast sirtuins by NAD+ metabolism and calorie restriction

(2009) Shu-Ping Lu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

“Clocks” in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging

(2009) Shin-ichiro Imai   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

SIRT1-dependent regulation of chromatin and transcription: Linking NAD+ metabolism and signaling to the control of cellular functions

(2009) Tong Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Nutrient-dependent regulation of PGC-1α's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5

(2009) John E. Dominy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin

(2009) Russel J. Reiter et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Chemosensitization and Immunosensitization of Resistant Cancer Cells to Apoptosis and Inhibition of Metastasis by the Specific NF-κB Inhibitor DHMEQ

(2009) Alina Katsman et al.   CURRENT PHARMACEUTICAL DESIGN

SIRT1 controls circadian clock circuitry and promotes cell survival: a connection with age-related neoplasms

(2009) Brittney Jung-Hynes et al.   FASEB JOURNAL

Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals

(2009) Bruno Martin et al.   IMMUNITY

Role of NF-κB activation in intestinal immune homeostasis

(2009) Andy Wullaert   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

SirT1 Is an Inhibitor of Proliferation and Tumor Formation in Colon Cancer

(2009) Neha Kabra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol (Trans-3,5,4'-trihydroxystilbene) Induces Silent Mating Type Information Regulation-1 and Down-Regulates Nuclear Transcription Factor- B Activation to Abrogate Dextran Sulfate Sodium-Induced Colitis

(2009) U. P. Singh et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Melatonin preserves longevity protein (sirtuin 1) expression in the hippocampus of total sleep-deprived rats

(2009) Hung-Ming Chang et al.   JOURNAL OF PINEAL RESEARCH

Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway

(2009) M. Tajes et al.   JOURNAL OF PINEAL RESEARCH

Visualization of melatonin’s multiple mitochondrial levels of protection against mitochondrial Ca2+-mediated permeability transition and beyond in rat brain astrocytes

(2009) Mei-Jie Jou et al.   JOURNAL OF PINEAL RESEARCH

Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer

(2009) Brittney Jung-Hynes et al.   JOURNAL OF PINEAL RESEARCH

Autophagy upregulation and loss of NF-κB in oxidative stress-related immunodeficient SAMP8 mice

(2009) Beatriz Caballero et al.   MECHANISMS OF AGEING AND DEVELOPMENT

SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer

(2009) Katsuhiko Nosho et al.   MODERN PATHOLOGY

Endoplasmic reticulum stress and intestinal inflammation

(2009) A Kaser et al.   Mucosal Immunology

Role of PPAR-gamma in inflammation. Prospects for therapeutic intervention by food components

(2009) Harry Martin   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment

(2008) Meghan B. Azad et al.   ANTIOXIDANTS & REDOX SIGNALING

Chemopreventive agents induce oxidative stress in cancer cells leading to COX-2 overexpression and COX-2-independent cell death

(2008) Yu Sun et al.   CARCINOGENESIS

Terpenoids: natural inhibitors of NF-κB signaling with anti-inflammatory and anticancer potential

(2008) A. Salminen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats

(2008) Takuji Tanaka et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Innate immune signalling at intestinal mucosal surfaces: a fine line between host protection and destruction

(2008) Elke Cario   CURRENT OPINION IN GASTROENTEROLOGY

Rosiglitazone for Active Ulcerative Colitis: A Randomized Placebo-Controlled Trial

(2008) James D. Lewis et al.   GASTROENTEROLOGY

Involvement of Protective Autophagy in TRAIL Resistance of Apoptosis-defective Tumor Cells

(2008) Jie Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line

(2008) Javier Martín-Renedo et al.   JOURNAL OF PINEAL RESEARCH

Melatonin usage in ulcerative colitis: a case report

(2008) M. D. Maldonado et al.   JOURNAL OF PINEAL RESEARCH

Matrix metalloproteinase-9 and metalloproteinase-2 activity and expression is reduced by melatonin during experimental colitis

(2008) Emanuela Esposito et al.   JOURNAL OF PINEAL RESEARCH

Evaluation of potential pro-survival pathways regulated by melatonin in a murine senescence model

(2008) Javier Gutierrez-Cuesta et al.   JOURNAL OF PINEAL RESEARCH

Melatonin represses oxidative stress-induced activation of the MAP kinase and mTOR signaling pathways in H4IIE hepatoma cells through inhibition of Ras

(2008) Scot R. Kimball et al.   JOURNAL OF PINEAL RESEARCH

Melatonin protects against experimental reflux esophagitis

(2008) Shawon Lahiri et al.   JOURNAL OF PINEAL RESEARCH

Melatonin attenuates methamphetamine-induced deactivation of the mammalian target of rapamycin signaling to induce autophagy in SK-N-SH cells

(2008) Patthara Kongsuphol et al.   JOURNAL OF PINEAL RESEARCH

Melatonin attenuates lipopolysaccharide-induced acute lung inflammation in sleep-deprived mice

(2008) Yang-Deok Lee et al.   JOURNAL OF PINEAL RESEARCH

PCAF Acetylates β-Catenin and Improves Its Stability

(2008) Xinjian Ge et al.   MOLECULAR BIOLOGY OF THE CELL

Period 2 Mutation Accelerates ApcMin/+ Tumorigenesis

(2008) P. A. Wood et al.   MOLECULAR CANCER RESEARCH

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY

Melatonin prevents ischemic brain injury through activation of the mTOR/p70S6 kinase signaling pathway

(2008) Phil-Ok Koh   NEUROSCIENCE LETTERS

The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth

(2008) Ron Firestein et al.   PLoS One

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA