Diversity of intervertebral disc cells: phenotype and function

Large residual strains are present in the intervertebral disc annulus fibrosus in the unloaded state

(2012) A.J. Michalek et al.   JOURNAL OF BIOMECHANICS

The enigma that is the nucleus pulposus cell: the search goes on

(2012) W Mark Erwin   ARTHRITIS RESEARCH & THERAPY

Identification of cell surface-specific markers to target human nucleus pulposus cells: Expression of carbonic anhydrase XII varies with age and degeneration

(2011) Karen A. Power et al.   ARTHRITIS AND RHEUMATISM

Hypoxia activates the notch signaling pathway in cells of the intervertebral disc: Implications in degenerative disc disease

(2011) Akihiko Hiyama et al.   ARTHRITIS AND RHEUMATISM

The Epidemiology of low back pain

(2011) D. Hoy et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Physical Stimulation of Chondrogenic Cells In Vitro: A Review

(2011) Sibylle Grad et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

The response of foetal annulus fibrosus cells to growth factors: modulation of matrix synthesis by TGF-β1 and IGF-1

(2011) Anthony J. Hayes et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Morphology of the human vertebral endplate

(2011) Azucena G. Rodriguez et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Interactions of environmental conditions and mechanical loads have influence on matrix turnover by nucleus pulposus cells

(2011) Cornelia Neidlinger-Wilke et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Characteristics of Stem Cells Derived from the Degenerated Human Intervertebral Disc Cartilage Endplate

(2011) Lan-Tao Liu et al.   PLoS One

Hedgehog signaling is required for formation of the notochord sheath and patterning of nuclei pulposi within the intervertebral discs

(2011) K.-S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intercellular Signaling Pathways Active During and After Growth and Differentiation of the Lumbar Vertebral Growth Plate

(2011) Chitra Lekha Dahia et al.   SPINE

Human Disc Nucleus Properties and Vertebral Endplate Permeability

(2011) Azucena G. Rodriguez et al.   SPINE

Mitochondrial gene expression in the human annulus: in vivo data from annulus cells and selectively harvested senescent annulus cells

(2011) Helen E. Gruber et al.   Spine Journal

Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells

(2011) Devina Purmessur et al.   ARTHRITIS RESEARCH & THERAPY

Characterization of the human nucleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differentiation

(2010) Ben M. Minogue et al.   ARTHRITIS AND RHEUMATISM

Senescent vs. non-senescent cells in the human annulus in vivo: Cell harvest with laser capture microdissection and gene expression studies with microarray analysis

(2010) Helen E Gruber et al.   BMC BIOTECHNOLOGY

Toward an understanding of the role of notochordal cells in the adult intervertebral disc: From discord to accord

(2010) Makarand V. Risbud et al.   DEVELOPMENTAL DYNAMICS

Differential response of human bone marrow stromal cells to either TGF-β1 or rhGDF-5

(2010) Benjamin Gantenbein-Ritter et al.   EUROPEAN SPINE JOURNAL

Immunohistochemical identification of notochordal markers in cells in the aging human lumbar intervertebral disc

(2010) Christoph Weiler et al.   EUROPEAN SPINE JOURNAL

Debating the Value of Spine Surgery*

(2010) Edward N Hanley et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Multipotential Differentiation of Human Anulus Fibrosus Cells

(2010) Gang Feng et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

The relationship between the Wnt/β-catenin and TGF-β/BMP signals in the intervertebral disc cell

(2010) Akihiko Hiyama et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Human intervertebral disc internal strain in compression: The effect of disc region, loading position, and degeneration

(2010) Grace D. O'Connell et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Co-culture induces mesenchymal stem cell differentiation and modulation of the degenerate human nucleus pulposus cell phenotype

(2010) Sandra Strassburg et al.   Regenerative Medicine

Differential Gene Expression Profiling of Metalloproteinases and Their Inhibitors

(2010) Ying Cui et al.   SPINE

Isolation and Characterization of Mesenchymal Stromal Cells From Human Degenerated Nucleus Pulposus

(2010) Juan F. Blanco et al.   SPINE

Annulus cells from more degenerated human discs show modified gene expression in 3D culture compared with expression in cells from healthier discs

(2010) Helen E. Gruber et al.   Spine Journal

Differential expression level of cytokeratin 8 in cells of the bovine nucleus pulposus complicates the search for specific intervertebral disc cell markers

(2010) Audrey Gilson et al.   ARTHRITIS RESEARCH & THERAPY

Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes

(2010) Ben M Minogue et al.   ARTHRITIS RESEARCH & THERAPY

Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype

(2010) Casey L Korecki et al.   Stem Cell Research & Therapy

Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration

(2009) Aneta J. Pockert et al.   ARTHRITIS AND RHEUMATISM

Expression of Laminin Isoforms, Receptors, and Binding Proteins Unique to Nucleus Pulposus Cells of Immature Intervertebral Disc

(2009) Jun Chen et al.   CONNECTIVE TISSUE RESEARCH

Sensitivity of notochordal disc cells to mechanical loading: an experimental animal study

(2009) Thorsten Guehring et al.   EUROPEAN SPINE JOURNAL

The epidemiology, economic burden, and pharmacological treatment of chronic low back pain in France, Germany, Italy, Spain and the UK: a literature-based review

(2009) Melissa Juniper et al.   EXPERT OPINION ON PHARMACOTHERAPY

Environmental regulation of notochordal gene expression in nucleus pulposus cells

(2009) Anshu Rastogi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

In vivo remodeling of intervertebral discs in response to short- and long-term dynamic compression

(2009) Karin Wuertz et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Injury-induced sequential transformation of notochordal nucleus pulposus to chondrogenic and fibrocartilaginous phenotype in the mouse

(2009) Fan Yang et al.   JOURNAL OF PATHOLOGY

The internal mechanical functioning of intervertebral discs and articular cartilage, and its relevance to matrix biology

(2009) Michael A. Adams et al.   MATRIX BIOLOGY

Variations in gene and protein expression in human nucleus pulposus in comparison with annulus fibrosus and cartilage cells: potential associations with aging and degeneration

(2009) J. Rutges et al.   OSTEOARTHRITIS AND CARTILAGE

Identification of phenotypic discriminating markers for intervertebral disc cells and articular chondrocytes

(2009) J. Clouet et al.   RHEUMATOLOGY

Comparison of Animal Discs Used in Disc Research to Human Lumbar Disc

(2009) Jesse C. Beckstein et al.   SPINE

Differential Phenotype of Intervertebral Disc Cells

(2009) Daisuke Sakai et al.   SPINE

Intercellular Signaling Pathways Active During Intervertebral Disc Growth, Differentiation, and Aging

(2009) Chitra Lekha Dahia et al.   SPINE

Differentiation of Intervertebral Notochordal Cells Through Live Automated Cell Imaging System In Vitro

(2009) Joo Han Kim et al.   SPINE

Identification of Cell Proliferation Zones, Progenitor Cells and a Potential Stem Cell Niche in the Intervertebral Disc Region

(2009) Helena B. Henriksson et al.   SPINE

A Phenotypic Comparison of Proteoglycan Production of Intervertebral Disc Cells Isolated from Rats, Rabbits, and Bovine Tails; Which Animal Model is Most Suitable to Study Tissue Engineering and Biological Repair of Human Disc Disorders?

(2009) Tsuyoshi Miyazaki et al.   TISSUE ENGINEERING PART A

Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: Implications for disk degeneration and chordoma formation

(2008) Kyung-Suk Choi et al.   DEVELOPMENTAL DYNAMICS

Repair, regenerative and supportive therapies of the annulus fibrosus: achievements and challenges

(2008) Johannes Leendert Bron et al.   EUROPEAN SPINE JOURNAL

Future perspectives of cell-based therapy for intervertebral disc disease

(2008) Daisuke Sakai   EUROPEAN SPINE JOURNAL

Zonal variations in cytoskeletal element organization, mRNA and protein expression in the intervertebral disc

(2008) Siyuan Li et al.   JOURNAL OF ANATOMY

Intervertebral disc cell response to dynamic compression is age and frequency dependent

(2008) Casey L. Korecki et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

ISSLS Prize Winner: Integrating Theoretical and Experimental Methods for Functional Tissue Engineering of the Annulus Fibrosus

(2008) Nandan L. Nerurkar et al.   SPINE

Age-Related Changes in the Extracellular Matrix of Nucleus Pulposus and Anulus Fibrosus of Human Intervertebral Disc

(2008) Kern Singh et al.   SPINE

Notochordal cells stimulate migration of cartilage end plate chondrocytes of the intervertebral disc in in vitro cell migration assays

(2008) Ki-Won Kim et al.   Spine Journal

Adipose-derived mesenchymal stem cells from the sand rat: transforming growth factor beta and 3D co-culture with human disc cells stimulate proteoglycan and collagen type I rich extracellular matrix

(2008) Hazel Tapp et al.   ARTHRITIS RESEARCH & THERAPY