WIPI-Mediated Autophagy and Longevity

WIPI proteins: essential PtdIns3P effectors at the nascent autophagosome

(2015) T. Proikas-Cezanne et al.   JOURNAL OF CELL SCIENCE

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

A novelWDR45mutation in a patient with static encephalopathy of childhood with neurodegeneration in adulthood (SENDA)

(2014) Tadashi Ozawa et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Longevity pathways converge on autophagy genes to regulate life span inCaenorhabditis elegans

(2014) Márton L. Tóth et al.   Autophagy

PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation

(2014) Y. Wu et al.   EMBO REPORTS

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

(2014) Hannah C. Dooley et al.   MOLECULAR CELL

Establishing a novel C. elegans model to investigate the role of autophagy in amyotrophic lateral sclerosis

(2013) Jia Li et al.   ACTA PHARMACOLOGICA SINICA

The twoC. elegansATG-16 homologs have partially redundant functions in the basal autophagy pathway

(2013) Hui Zhang et al.   Autophagy

WIPI β-propellers in autophagy-related diseases and longevity

(2013) Daniela Bakula et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Beta-propeller protein-associated neurodegeneration: a new X-linked dominant disorder with brain iron accumulation

(2013) Susan J. Hayflick et al.   BRAIN

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Reproduction, Fat Metabolism, and Life Span: What Is the Connection?

(2013) Malene Hansen et al.   Cell Metabolism

Dietary restriction in C. elegans: Recent advances

(2013) James R. Cypser et al.   EXPERIMENTAL GERONTOLOGY

De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood

(2013) Hirotomo Saitsu et al.   NATURE GENETICS

Exome Sequencing Reveals De Novo WDR45 Mutations Causing a Phenotypically Distinct, X-Linked Dominant Form of NBIA

(2012) Tobias B. Haack et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Autophagy genes promote apoptotic cell corpse clearance

(2012) Wei Zou et al.   Autophagy

Autophagy links lipid metabolism to longevity inC. elegans

(2012) Louis R. Lapierre et al.   Autophagy

It takes two to tango

(2012) Michael Thumm et al.   Autophagy

Myotubularin family phosphatase ceMTM3 is required for muscle maintenance by preventing excessive autophagy in Caenorhabditis elegans

(2012) Xiaokun Yu et al.   BMC CELL BIOLOGY

Regulation of longevity by the reproductive system

(2012) Adam Antebi   EXPERIMENTAL GERONTOLOGY

Depletion ofmboa-7, an enzyme that incorporates polyunsaturated fatty acids into phosphatidylinositol (PI), impairs PI 3-phosphate signaling inCaenorhabditis elegans

(2012) Hyeon-Cheol Lee et al.   GENES TO CELLS

Transcriptional networks that mediate signals from reproductive tissues to influence lifespan

(2012) Arjumand Ghazi   GENESIS

Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell

(2012) Wei Li et al.   JOURNAL OF CELL BIOLOGY

PI3K signalling: the path to discovery and understanding

(2012) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lessons from C. elegans: signaling pathways for longevity

(2012) Louis R. Lapierre et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy inC. elegans

(2011) Alexander Ruck et al.   Autophagy

Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation

(2011) Mario Mauthe et al.   Autophagy

The WD40 Repeat PtdIns(3)P-Binding Protein EPG-6 Regulates Progression of Omegasomes to Autophagosomes

(2011) Qun Lu et al.   DEVELOPMENTAL CELL

Freeze-fracture replica immunolabelling reveals human WIPI-1 and WIPI-2 as membrane proteins of autophagosomes

(2011) Tassula Proikas-Cezanne et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Canonical and non-canonical autophagy: variations on a common theme of self-eating?

(2011) Patrice Codogno et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Antigen Potency and Maximal Efficacy Reveal a Mechanism of Efficient T Cell Activation

(2011) O. Dushek et al.   Science Signaling

Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation

(2010) Hannah E.J. Polson et al.   Autophagy

Lifespan extension by suppression of autophagy genes inCaenorhabditis elegans

(2009) Yasufumi Hashimoto et al.   GENES TO CELLS

Dynamics and diversity in autophagy mechanisms: lessons from yeast

(2009) Hitoshi Nakatogawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of the aging process by autophagy

(2009) Antero Salminen et al.   TRENDS IN MOLECULAR MEDICINE

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics