Microglial polarization in posttraumatic epilepsy: Potential mechanism and treatment opportunity

Seizure-induced microvascular injury is associated with impaired neurovascular coupling and blood-brain barrier dysfunction

(2019) Ofer Prager et al.   EPILEPSIA

High mobility group box 1 (HMGB1) as a novel frontier in epileptogenesis: From pathogenesis to therapeutic approaches

(2019) Yam Nath Paudel et al.   JOURNAL OF NEUROCHEMISTRY

Transplantation of mesenchymal stem cells genetically engineered to overexpress interleukin-10 promotes alternative inflammatory response in rat model of traumatic brain injury

(2019) S. T. Peruzzaro et al.   Journal of Neuroinflammation

Interleukin-10 inhibits interleukin-1β production and inflammasome activation of microglia in epileptic seizures

(2019) Yi Sun et al.   Journal of Neuroinflammation

Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy

(2019) Alberto Pauletti et al.   BRAIN

Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy

(2019) Annamaria Vezzani et al.   Nature Reviews Neurology

Neuroinflammation in Post-Traumatic Epilepsy: Pathophysiology and Tractable Therapeutic Targets

(2019) Rishabh Sharma et al.   Brain Sciences

Inhibition of HMGB1 mediates neuroprotection of traumatic brain injury by modulating the microglia/macrophage polarization

(2018) Tielei Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy

(2018) Tawfeeq Shekh-Ahmad et al.   BRAIN

Targeted intracerebral delivery of the anti-inflammatory cytokine IL13 promotes alternative activation of both microglia and macrophages after stroke

(2018) Somayyeh Hamzei Taj et al.   Journal of Neuroinflammation

Polarization of Microglia to the M2 Phenotype in a Peroxisome Proliferator-Activated Receptor Gamma–Dependent Manner Attenuates Axonal Injury Induced by Traumatic Brain Injury in Mice

(2018) Liang Wen et al.   JOURNAL OF NEUROTRAUMA

In search of antiepileptogenic treatments for post-traumatic epilepsy

(2018) Patricia G. Saletti et al.   NEUROBIOLOGY OF DISEASE

Xinnao Shutong Modulates the Neuronal Plasticity Through Regulation of Microglia/Macrophage Polarization Following Chronic Cerebral Hypoperfusion in Rats

(2018) Liye Wang et al.   Frontiers in Physiology

The Role of Astrocytes in Multiple Sclerosis

(2018) Gerald Ponath et al.   Frontiers in Immunology

Induction of Interleukin-10 Producing Dendritic Cells As a Tool to Suppress Allergen-Specific T Helper 2 Responses

(2018) Stefan Schülke   Frontiers in Immunology

Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures

(2018) Carole Sousa et al.   EMBO REPORTS

Targeting neurodegeneration to prevent post-traumatic epilepsy

(2018) Idrish Ali et al.   NEUROBIOLOGY OF DISEASE

Inhibition of MyD88 Signaling Skews Microglia/Macrophage Polarization and Attenuates Neuronal Apoptosis in the Hippocampus After Status Epilepticus in Mice

(2018) Jin-Tao Liu et al.   Neurotherapeutics

Damage-Associated Molecular Patterns in Inflammatory Diseases

(2018) Jong Seong Roh et al.   Immune Network

Transcriptional profiling identifies novel regulators of macrophage polarization

(2018) Kimberline Y. Gerrick et al.   PLoS One

Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration

(2018) Dinesh Upadhya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early Microglial Activation Following Closed-Head Concussive Injury Is Dominated by Pro-Inflammatory M-1 Type

(2018) Sindhu K. Madathil et al.   Frontiers in Neurology

Decreased levels of active uPA and KLK8 assessed by [111 In]MICA-401 binding correlate with the seizure burden in an animal model of temporal lobe epilepsy

(2017) Stephan Missault et al.   EPILEPSIA

Intracerebral delivery of the M2 polarizing cytokine interleukin 13 using mesenchymal stem cell implants in a model of temporal lobe epilepsy in mice

(2017) Idrish Ali et al.   EPILEPSIA

Interleukin-1 Receptor in Seizure Susceptibility after Traumatic Injury to the Pediatric Brain

(2017) Bridgette D. Semple et al.   JOURNAL OF NEUROSCIENCE

Changes in Apparent Fiber Density and Track-Weighted Imaging Metrics in White Matter following Experimental Traumatic Brain Injury

(2017) David K. Wright et al.   JOURNAL OF NEUROTRAUMA

Differences in white matter structure between seizure prone (FAST) and seizure resistant (SLOW) rat strains

(2017) Pragati Sharma et al.   NEUROBIOLOGY OF DISEASE

Mesenchymal Stem Cells Overexpressing Interleukin-10 Promote Neuroprotection in Experimental Acute Ischemic Stroke

(2017) Masataka Nakajima et al.   Molecular Therapy-Methods & Clinical Development

NOX2 drives M1-like microglial/macrophage activation and neurodegeneration following experimental traumatic brain injury

(2016) Alok Kumar et al.   BRAIN BEHAVIOR AND IMMUNITY

Human Neural Stem Cell Transplantation-Mediated Alteration of Microglial/Macrophage Phenotypes after Traumatic Brain Injury

(2016) Junling Gao et al.   CELL TRANSPLANTATION

Environmental enrichment delays limbic epileptogenesis and restricts pathologic synaptic plasticity

(2016) Meng Yang et al.   EPILEPSIA

Treatment of traumatic brain injury with anti-inflammatory drugs

(2016) Peter J. Bergold   EXPERIMENTAL NEUROLOGY

Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages

(2016) Caroline Guglielmetti et al.   GLIA

Neuroinflammation: the devil is in the details

(2016) Damon J. DiSabato et al.   JOURNAL OF NEUROCHEMISTRY

Microglial/Macrophage Polarization Dynamics following Traumatic Brain Injury

(2016) Alok Kumar et al.   JOURNAL OF NEUROTRAUMA

Environmental enrichment imparts disease-modifying and transgenerational effects on genetically-determined epilepsy and anxiety

(2016) Gabi Dezsi et al.   NEUROBIOLOGY OF DISEASE

Cell-Based Delivery of Interleukin-13 Directs Alternative Activation of Macrophages Resulting in Improved Functional Outcome after Spinal Cord Injury

(2016) Dearbhaile Dooley et al.   Stem Cell Reports

Complex alterations in microglial M1/M2 markers during the development of epilepsy in two mouse models

(2015) Melissa J. Benson et al.   EPILEPSIA

New Insights on Astrocyte Ion Channels: Critical for Homeostasis and Neuron-Glia Signaling

(2015) M. L. Olsen et al.   JOURNAL OF NEUROSCIENCE

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability

(2015) Annamaria Vezzani et al.   NEUROPHARMACOLOGY

Concise Review: Prospects of Bone Marrow Mononuclear Cells and Mesenchymal Stem Cells for Treating Status Epilepticus and Chronic Epilepsy

(2015) Satish Agadi et al.   STEM CELLS

Immunity and Inflammation in Epilepsy

(2015) Annamaria Vezzani et al.   Cold Spring Harbor Perspectives in Medicine

Role of Astrocytes in Epilepsy

(2015) D. A. Coulter et al.   Cold Spring Harbor Perspectives in Medicine

Inflammation and Neuroprotection in Traumatic Brain Injury

(2015) Kara N. Corps et al.   JAMA Neurology

Rosiglitazone Suppresses In Vitro Seizures in Hippocampal Slice by Inhibiting Presynaptic Glutamate Release in a Model of Temporal Lobe Epilepsy

(2015) Shi-Bing Wong et al.   PLoS One

Abnormal microglial activation in theCstb−/−mouse, a model for progressive myoclonus epilepsy, EPM1

(2014) Olesya Okuneva et al.   GLIA

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Subtypes of Post-Traumatic Epilepsy: Clinical, Electrophysiological, and Imaging Features

(2014) Puneet K. Gupta et al.   JOURNAL OF NEUROTRAUMA

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

Novel astrocyte targets

(2014) Vincenzo Crunelli et al.   NEUROSCIENTIST

Novel mGluR5 Positive Allosteric Modulator Improves Functional Recovery, Attenuates Neurodegeneration, and Alters Microglial Polarization after Experimental Traumatic Brain Injury

(2014) David J. Loane et al.   Neurotherapeutics

Bone Marrow Mesenchymal Stromal Cells Drive Protective M2 Microglia Polarization After Brain Trauma

(2014) Elisa R. Zanier et al.   Neurotherapeutics

Encapsulated galanin-producing cells attenuate focal epileptic seizures in the hippocampus

(2013) Litsa Nikitidou et al.   EPILEPSIA

Induction of oxidative and nitrosative damage leads to cerebrovascular inflammation in an animal model of mild traumatic brain injury induced by primary blast

(2013) P.M. Abdul-Muneer et al.   FREE RADICAL BIOLOGY AND MEDICINE

How stem cells speak with host immune cells in inflammatory brain diseases

(2013) Stefano Pluchino et al.   GLIA

Microglia/Macrophage Polarization Dynamics in White Matter after Traumatic Brain Injury

(2013) Guohua Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Progressive Neurodegeneration After Experimental Brain Trauma

(2013) David J. Loane et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy

(2013) F.M. Noe et al.   NEUROBIOLOGY OF DISEASE

The PPARγ agonist rosiglitazone prevents neuronal loss and attenuates development of spontaneous recurrent seizures through BDNF/TrkB signaling following pilocarpine-induced status epilepticus

(2013) Sun Hong et al.   NEUROCHEMISTRY INTERNATIONAL

Factors regulating microglia activation

(2013) Katrin Kierdorf et al.   Frontiers in Cellular Neuroscience

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Intravenous multipotent adult progenitor cell therapy after traumatic brain injury: modulation of the resident microglia population

(2012) Peter A Walker et al.   Journal of Neuroinflammation

Transplantation of Mesenchymal Stem Cells Promotes an Alternative Pathway of Macrophage Activation and Functional Recovery after Spinal Cord Injury

(2012) Hideaki Nakajima et al.   JOURNAL OF NEUROTRAUMA

Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states

(2012) Alok Kumar et al.   NEUROBIOLOGY OF AGING

Glycyrrhizic acid affords robust neuroprotection in the postischemic brain via anti-inflammatory effect by inhibiting HMGB1 phosphorylation and secretion

(2012) Seung-Woo Kim et al.   NEUROBIOLOGY OF DISEASE

Excessive Activation of mTOR in Postnatally Generated Granule Cells Is Sufficient to Cause Epilepsy

(2012) Raymund Y.K. Pun et al.   NEURON

The essential adaptors of innate immune signaling

(2012) Huihui Chen et al.   Protein & Cell

Brain Infiltration of Leukocytes Contributes to the Pathophysiology of Temporal Lobe Epilepsy

(2011) M. Zattoni et al.   JOURNAL OF NEUROSCIENCE

IL-1β is induced in reactive astrocytes in the somatosensory cortex of rats with genetic absence epilepsy at the onset of spike-and-wave discharges, and contributes to their occurrence

(2011) Demet Akin et al.   NEUROBIOLOGY OF DISEASE

Pioglitazone attenuates mitochondrial dysfunction, cognitive impairment, cortical tissue loss, and inflammation following traumatic brain injury

(2010) Andrew Sauerbeck et al.   EXPERIMENTAL NEUROLOGY

Proinflammatory Clearance of Apoptotic Neutrophils Induces an IL-12lowIL-10high Regulatory Phenotype in Macrophages

(2010) A. A. Filardy et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

Blood–brain barrier breakdown as a therapeutic target in traumatic brain injury

(2010) Dan Shlosberg et al.   Nature Reviews Neurology

Human mesenchymal stem cell grafts engineered to release adenosine reduce chronic seizures in a mouse model of CA3-selective epileptogenesis

(2009) Tianfu Li et al.   EPILEPSY RESEARCH

Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain

(2009) Carol A. Colton   Journal of Neuroimmune Pharmacology

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

(2009) Ravid Shechter et al.   PLOS MEDICINE

PPARγ agonist rosiglitazone is neuroprotective after traumatic brain injury via anti-inflammatory and anti-oxidative mechanisms

(2008) Jae-Hyuk Yi et al.   BRAIN RESEARCH