Induction of Interleukin-10 Producing Dendritic Cells As a Tool to Suppress Allergen-Specific T Helper 2 Responses

Critical role of mammalian target of rapamycin for IL-10 dendritic cell induction by a flagellin A conjugate in preventing allergic sensitization

(2018) Stefan Schülke et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Different capacity of in vitro generated myeloid dendritic cells of newborns of healthy and allergic mothers to respond to probiotic strain E. coli O83:K24:H31

(2017) Lenka Súkeníková et al.   IMMUNOLOGY LETTERS

Conjugation of wildtype and hypoallergenic mugwort allergen Art v 1 to flagellin induces IL-10-DC and suppresses allergen-specific TH2-responses in vivo

(2017) Stefan Schülke et al.   Scientific Reports

Targeting of Immune Cells by Dual TLR2/7 Ligands Suppresses Features of Allergic Th2 Immune Responses in Mice

(2017) Jonathan Laiño et al.   Journal of Immunology Research

T cell derived IL-10 is dispensable for tolerance induction in a murine model of allergic airway inflammation

(2016) Stefanie Kunz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The phosphodiesterase 4 inhibitor roflumilast augments the Th17-promoting capability of dendritic cells by enhancing IL-23 production, and impairs their T cell stimulatory activity due to elevated IL-10

(2016) Matthias Bros et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A Fusion Protein Consisting of the Vaccine Adjuvant Monophosphoryl Lipid A and the Allergen Ovalbumin Boosts Allergen-Specific Th1, Th2, and Th17 ResponsesIn Vitro

(2016) Stefan Schülke et al.   Journal of Immunology Research

MPLA shows attenuated pro-inflammatory properties and diminished capacity to activate mast cells in comparison with LPS

(2015) S. Schülke et al.   ALLERGY

Regulatory functions of B cells in allergic diseases

(2014) F. Braza et al.   ALLERGY

Modulation of dendritic cell innate and adaptive immune functions by oral and sublingual immunotherapy

(2014) Pamela A. Frischmeyer-Guerrerio et al.   CLINICAL IMMUNOLOGY

Mechanisms of immune tolerance to allergens: role of IL-10 and Tregs

(2014) Cezmi A. Akdis et al.   JOURNAL OF CLINICAL INVESTIGATION

HLA Class I Molecules Regulate IFN-  Production Induced in NK Cells by Target Cells, Viral Products, or Immature Dendritic Cells through the Inhibitory Receptor ILT2/CD85j

(2014) E. Morel et al.   JOURNAL OF IMMUNOLOGY

Dendritic Cells Genetically Engineered to Express IL-10 Induce Long-Lasting Antigen-Specific Tolerance in Experimental Asthma

(2014) E. Henry et al.   JOURNAL OF IMMUNOLOGY

IL-10: The Master Regulator of Immunity to Infection

(2014) Kevin N. Couper et al.   JOURNAL OF IMMUNOLOGY

An aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress the Th17 response in allergic rhinitis patients

(2014) Ping Wei et al.   LABORATORY INVESTIGATION

Tolerogenic Dendritic Cells Derived from Donors with Natural Rubber Latex Allergy Modulate Allergen-Specific T-Cell Responses and IgE Production

(2014) Alejandro Escobar et al.   PLoS One

Prevention of Intestinal Allergy in Mice by rflaA:Ova Is Associated with Enforced Antigen Processing and TLR5-Dependent IL-10 Secretion by mDC

(2014) Stefan Schülke et al.   PLoS One

Effective treatment of allergic airway inflammation with Helicobacter pylori immunomodulators requires BATF3-dependent dendritic cells and IL-10

(2014) D. B. Engler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrant dendritic cell function conditions Th2-cell polarization in allergic rhinitis

(2013) C. Pilette et al.   ALLERGY

IgG4 production is confined to human IL-10–producing regulatory B cells that suppress antigen-specific immune responses

(2013) Willem van de Veen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-10 control of dendritic cells in the skin

(2013) Björn E. Clausen et al.   OncoImmunology

Innate and lymphocytic response of birch-allergic patients before and after sublingual immunotherapy

(2012) Giuseppe Guida et al.   ALLERGY AND ASTHMA PROCEEDINGS

Regulation of Immune Responses by mTOR

(2012) Jonathan D. Powell et al.   Annual Review of Immunology

Enhanced production of CCL18 by tolerogenic dendritic cells is associated with inhibition of allergic airway reactivity

(2012) Iris Bellinghausen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A specific role for TLR1 in protective TH17 immunity during mucosal infection

(2012) R. William DePaolo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effects of Helicobacter pylori, geohelminth infection and selected commensal bacteria on the risk of allergic disease and sensitization in 3-year-old Ethiopian children

(2011) A. Amberbir et al.   CLINICAL AND EXPERIMENTAL ALLERGY

A fusion protein of flagellin and ovalbumin suppresses the TH2 response and prevents murine intestinal allergy

(2011) Stefan Schülke et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells

(2011) Isabelle C. Arnold et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of IDO-Positive and IDO-Negative Human Dendritic Cells after Activation by Various Proinflammatory Stimuli

(2011) D. Von Bubnoff et al.   JOURNAL OF IMMUNOLOGY

First Results of Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Children

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Regulatory dendritic cells program generation of interleukin-4-producing alternative memory CD4 T cells with suppressive activity

(2010) X. Xu et al.   BLOOD

Dendritic cell and T cell responses in children with food allergy

(2010) P. A. Frischmeyer-Guerrerio et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Induction of anergic allergen-specific suppressor T cells using tolerogenic dendritic cells derived from children with allergies to house dust mites

(2010) Valentina Pacciani et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Targeting Toll-like receptors on dendritic cells modifies the TH2 response to peanut allergens in vitro

(2010) Pierre Pochard et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dendritic cells lentivirally engineered to overexpress interleukin-10 inhibit contact hypersensitivity responses, despite their partial activation induced by transduction-associated physical stress

(2010) Verena Besche et al.   JOURNAL OF GENE MEDICINE

Dendritic Cells from Mycobacteria-Infected Mice Inhibits Established Allergic Airway Inflammatory Responses to Ragweed via IL-10- and IL-12-Secreting Mechanisms

(2010) L. Bilenki et al.   JOURNAL OF IMMUNOLOGY

Birch Pollen Immunotherapy Leads to Differential Induction of Regulatory T Cells and Delayed Helper T Cell Immune Deviation

(2010) Christian Möbs et al.   JOURNAL OF IMMUNOLOGY

TLR2 Agonists Enhance CD8+Foxp3+ Regulatory T Cells and Suppress Th2 Immune Responses during Allergen Immunotherapy

(2010) Y.-G. Tsai et al.   JOURNAL OF IMMUNOLOGY

Fusion protein of TLR5-ligand and allergen potentiates activation and IL-10 secretion in murine myeloid DC

(2010) Stefan Schülke et al.   MOLECULAR IMMUNOLOGY

Suppression of Allergic Inflammation by Allergen-DNA-modified Dendritic Cells Depends on the Induction of Foxp3+Regulatory T Cells

(2010) Kui Wu et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Counter regulation of the high affinity IgE receptor, FcεRI, on human airway dendritic cells by IL-4 and IL-10

(2009) A. Faith et al.   ALLERGY

Induction of Type 2 T Helper Cell Allergen Tolerance by IL-10–Differentiated Regulatory Dendritic Cells

(2009) Xiuling Li et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Multifunctional Role of mTOR in Innate Immunity: Implications for Transplant Immunity

(2009) M. D. Säemann et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Seasonal changes in suppressive capacity of CD4+CD25+T cells from patients with hayfever are allergen-specific and may result in part from expansion of effector T cells among the CD25+population

(2009) A. E. Anderson et al.   CLINICAL AND EXPERIMENTAL ALLERGY

B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes forin vivofunction

(2009) Melanie A. Ruffner et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

LIPOPOLYSACCHARIDE STIMULATION OF DENDRITIC CELLS INDUCES INTERLEUKIN-10 PRODUCING ALLERGEN-SPECIFIC T CELLS IN VITRO BUT FAILS TO PREVENT ALLERGIC AIRWAY DISEASE

(2009) Birgit Ahrens et al.   EXPERIMENTAL LUNG RESEARCH

Engagement of TLR2 Does not Reverse the Suppressor Function of Mouse Regulatory T Cells, but Promotes Their Survival

(2009) Q. Chen et al.   JOURNAL OF IMMUNOLOGY

Sustained efficacy and immunogenicity of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine: analysis of a randomised placebo-controlled trial up to 6·4 years

(2009)   LANCET

Contextual Regulation of Inflammation: A Duet by Transforming Growth Factor-β and Interleukin-10

(2008) Ming O. Li et al.   IMMUNITY

Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity

(2008) James N. Francis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interferons modulate FcɛRI-dependent production of autoregulatory IL-10 by circulating human monocytoid dendritic cells

(2008) Trong Le et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Helicobacter pyloriColonization Is Inversely Associated with Childhood Asthma

(2008) Yu Chen et al.   JOURNAL OF INFECTIOUS DISEASES

The inhibitory receptor LILRB1 modulates the differentiation and regulatory potential of human dendritic cells

(2007) N. T. Young et al.   BLOOD