The Role of Astrocytes in Multiple Sclerosis

Dimethyl fumarate influences innate and adaptive immunity in multiple sclerosis

(2018) Martin Diebold et al.   JOURNAL OF AUTOIMMUNITY

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Astrocytic tight junctions control inflammatory CNS lesion pathogenesis

(2017) Sam Horng et al.   JOURNAL OF CLINICAL INVESTIGATION

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Neuroprotection by IFN-γ via astrocyte-secreted IL-6 in acute neuroinflammation

(2017) Lijie Sun et al.   Oncotarget

Effects of fumarates on inflammatory human astrocyte responses and oligodendrocyte differentiation

(2017) Dylan A. Galloway et al.   Annals of Clinical and Translational Neurology

The NRF2 transcriptional target, OSGIN1, contributes to monomethyl fumarate-mediated cytoprotection in human astrocytes

(2017) Melanie S. Brennan et al.   Scientific Reports

Safety concerns and risk management of multiple sclerosis therapies

(2016) P. Soelberg Sorensen   ACTA NEUROLOGICA SCANDINAVICA

An updated histological classification system for multiple sclerosis lesions

(2016) Tanja Kuhlmann et al.   ACTA NEUROPATHOLOGICA

Myelin phagocytosis by astrocytes after myelin damage promotes lesion pathology

(2016) Gerald Ponath et al.   BRAIN

The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting

(2016) Christopher S. von Bartheld et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

Fingolimod failure in progressive MS INFORMS future trials

(2016) Andrew L. Smith et al.   Nature Reviews Neurology

Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor

(2016) Joel Kaye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical proteomic map of dimethyl fumarate–sensitive cysteines in primary human T cells

(2016) Megan M. Blewett et al.   Science Signaling

Alterations of the human gut microbiome in multiple sclerosis

(2016) Sushrut Jangi et al.   Nature Communications

Chemical proteomic map of dimethyl fumarate–sensitive cysteines in primary human T cells

(2016) Megan M. Blewett et al.   Science Signaling

Astrocytes: a central element in neurological diseases

(2015) Milos Pekny et al.   ACTA NEUROPATHOLOGICA

Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells

(2015) Amanda L. Hernandez et al.   JOURNAL OF CLINICAL INVESTIGATION

DMF, but not other fumarates, inhibits NF-κB activity in vitro in an Nrf2-independent manner

(2015) Geoffrey O. Gillard et al.   JOURNAL OF NEUROIMMUNOLOGY

Fingolimod induces neuroprotective factors in human astrocytes

(2015) Franziska S. Hoffmann et al.   Journal of Neuroinflammation

Astrocyte barriers to neurotoxic inflammation

(2015) Michael V. Sofroniew   NATURE REVIEWS NEUROSCIENCE

Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli

(2015) William J. Housley et al.   Science Translational Medicine

Control of autoimmune CNS inflammation by astrocytes

(2015) Veit Rothhammer et al.   Seminars in Immunopathology

Astrocytes Control Synapse Formation, Function, and Elimination

(2015) Won-Suk Chung et al.   Cold Spring Harbor Perspectives in Biology

NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review

(2015) Ruey-Horng Shih et al.   Frontiers in Molecular Neuroscience

B Cells in the Multiple Sclerosis Central Nervous System: Trafficking and Contribution to CNS-Compartmentalized Inflammation

(2015) Laure Michel et al.   Frontiers in Immunology

Dimethyl Fumarate and Monoethyl Fumarate Exhibit Differential Effects on KEAP1, NRF2 Activation, and Glutathione Depletion In Vitro

(2015) Melanie S. Brennan et al.   PLoS One

Fingolimod may support neuroprotection via blockade of astrocyte nitric oxide

(2014) Emanuela Colombo et al.   ANNALS OF NEUROLOGY

Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis

(2014) Roy Y. Kim et al.   JOURNAL OF NEUROIMMUNOLOGY

Gender Differences in Multiple Sclerosis

(2014) Sabina Luchetti et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Astrocyte-Derived BDNF Supports Myelin Protein Synthesis after Cuprizone-Induced Demyelination

(2014) C. G. Fulmer et al.   JOURNAL OF NEUROSCIENCE

Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial

(2014) Peter A Calabresi et al.   LANCET NEUROLOGY

Genetic and epigenetic fine mapping of causal autoimmune disease variants

(2014) Kyle Kai-How Farh et al.   NATURE

Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation

(2014) Lior Mayo et al.   NATURE MEDICINE

Human Astrocytes: Secretome Profiles of Cytokines and Chemokines

(2014) Sung S. Choi et al.   PLoS One

B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes

(2014) J. N. H. Stern et al.   Science Translational Medicine

The gut microbiota influences blood-brain barrier permeability in mice

(2014) V. Braniste et al.   Science Translational Medicine

Potential Roles of HDAC Inhibitors in Mitigating Ischemia-induced Brain Damage and Facilitating Endogenous Regeneration and Recovery

(2013) Emily Fessler et al.   CURRENT PHARMACEUTICAL DESIGN

Environmental factors in multiple sclerosis

(2013) Alberto Ascherio   Expert Review of Neurotherapeutics

The astrocyte in multiple sclerosis revisited

(2013) Celia F. Brosnan et al.   GLIA

Immune Players in the CNS: The Astrocyte

(2013) Cathy J. Jensen et al.   Journal of Neuroimmune Pharmacology

Dual effects of daily FTY720 on human astrocytes in vitro: relevance for neuroinflammation

(2013) Celina Wu et al.   Journal of Neuroinflammation

Estrogen Mediates Neuroprotection and Anti-Inflammatory Effects during EAE through ER  Signaling on Astrocytes But Not through ER  Signaling on Astrocytes or Neurons

(2013) R. D. Spence et al.   JOURNAL OF NEUROSCIENCE

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

(2013) Ashley H Beecham et al.   NATURE GENETICS

Act1 mediates IL-17–induced EAE pathogenesis selectively in NG2+ glial cells

(2013) Zizhen Kang et al.   NATURE NEUROSCIENCE

Reactive Oxygen Species from Human Astrocytes Induced Functional Impairment and Oxidative Damage

(2013) Wen S. Sheng et al.   NEUROCHEMICAL RESEARCH

Inhibitory effect of a 2,4-bis(4-hydroxyphenyl)-2-butenal diacetate on neuro-inflammatory reactions via inhibition of STAT1 and STAT3 activation in cultured astrocytes and microglial BV-2 cells

(2013) Jin A. Kim et al.   NEUROPHARMACOLOGY

IL-1β induces GFAP expression in vitro and in vivo and protects neurons from traumatic injury-associated apoptosis in rat brain striatum via NFκB/Ca2+–calmodulin/ERK mitogen-activated protein kinase signaling pathway

(2013) C. Sticozzi et al.   NEUROSCIENCE

Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology

(2013) Conor Mc Guire et al.   TRENDS IN MOLECULAR MEDICINE

Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination

(2012) Wolfgang Brück et al.   ACTA NEUROPATHOLOGICA

Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination

(2012) Thomas Skripuletz et al.   BRAIN

NF- B, the first quarter-century: remarkable progress and outstanding questions

(2012) M. S. Hayden et al.   GENES & DEVELOPMENT

Interleukin-6, a Major Cytokine in the Central Nervous System

(2012) María Erta et al.   International Journal of Biological Sciences

Environmental Risk Factors for Multiple Sclerosis: A Review with a Focus on Molecular Mechanisms

(2012) Cullen O’Gorman et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Multiple sclerosis

(2012) Alyssa Nylander et al.   JOURNAL OF CLINICAL INVESTIGATION

Innate immunity in the central nervous system

(2012) Richard M. Ransohoff et al.   JOURNAL OF CLINICAL INVESTIGATION

Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration

(2012) Emanuela Colombo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The chemokine, macrophage inflammatory protein-2γ, reduces the expression of glutamate transporter-1 on astrocytes and increases neuronal sensitivity to glutamate excitotoxicity

(2012) Jie Fang et al.   Journal of Neuroinflammation

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Progressive multiple sclerosis: pathology and pathogenesis

(2012) Hans Lassmann et al.   Nature Reviews Neurology

Placebo-Controlled Trial of Oral Laquinimod for Multiple Sclerosis

(2012) Giancarlo Comi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Placebo-Controlled Phase 3 Study of Oral BG-12 or Glatiramer in Multiple Sclerosis

(2012) Robert J. Fox et al.   NEW ENGLAND JOURNAL OF MEDICINE

Placebo-Controlled Phase 3 Study of Oral BG-12 for Relapsing Multiple Sclerosis

(2012) Ralf Gold et al.   NEW ENGLAND JOURNAL OF MEDICINE

Doβ-Defensins and Other Antimicrobial Peptides Play a Role in Neuroimmune Function and Neurodegeneration?

(2012) Wesley M. Williams et al.   TheScientificWorldJOURNAL

Central nervous system rather than immune cell-derived BDNF mediates axonal protective effects early in autoimmune demyelination

(2011) De-Hyung Lee et al.   ACTA NEUROPATHOLOGICA

Modulation of Autoimmune Demyelination by Laquinimod via Induction of Brain-Derived Neurotrophic Factor

(2011) Jan Thöne et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis

(2011) Jeffrey A. Cohen et al.   ANNALS OF NEUROLOGY

Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis

(2011) R. A. Linker et al.   BRAIN

Impaired neurosteroid synthesis in multiple sclerosis

(2011) Farshid Noorbakhsh et al.   BRAIN

Fumaric acid and its esters: An emerging treatment for multiple sclerosis with antioxidative mechanism of action

(2011) R. Gold et al.   CLINICAL IMMUNOLOGY

Gp130-Dependent Astrocytic Survival Is Critical for the Control of Autoimmune Central Nervous System Inflammation

(2011) F. Haroon et al.   JOURNAL OF IMMUNOLOGY

Multiple sclerosis: BAFF and CXCL13 in cerebrospinal fluid

(2011) Samia Ragheb et al.   Multiple Sclerosis Journal

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

(2011) Kerstin Berer et al.   NATURE

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Neuroprotection mediated through estrogen receptor-  in astrocytes

(2011) R. D. Spence et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis

(2010) Roberta Magliozzi et al.   ANNALS OF NEUROLOGY

An introduction to the molecular basics of aryl hydrocarbon receptor biology

(2010) Josef Abel et al.   BIOLOGICAL CHEMISTRY

Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis

(2010) Sergio E. Baranzini et al.   BRAIN

IL-6: Regulator of Treg/Th17 balance

(2010) Akihiro Kimura et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions

(2010) Ruben Van Doorn et al.   GLIA

Laquinimod interferes with migratory capacity of T cells and reduces IL-17 levels, inflammatory demyelination and acute axonal damage in mice with experimental autoimmune encephalomyelitis

(2010) Christiane Wegner et al.   JOURNAL OF NEUROIMMUNOLOGY

Astrocytes as aide-mémoires

(2010) Mirko Santello et al.   NATURE

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

(2010) Ludwig Kappos et al.   NEW ENGLAND JOURNAL OF MEDICINE

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

(2010) J. W. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

The cuprizone animal model: new insights into an old story

(2009) Markus Kipp et al.   ACTA NEUROPATHOLOGICA

Inactivation of astroglial NF-κB promotes survival of retinal neurons following ischemic injury

(2009) Galina Dvoriantchikova et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Selective estrogen receptor modulators decrease the production of interleukin-6 and interferon-γ-inducible protein-10 by astrocytes exposed to inflammatory challengein vitro

(2009) M. Cerciat et al.   GLIA

B Cell Receptor and BAFF Receptor Signaling Regulation of B Cell Homeostasis

(2009) W. N. Khan   JOURNAL OF IMMUNOLOGY

Transgenic Inhibition of Astroglial NF- B Improves Functional Outcome in Experimental Autoimmune Encephalomyelitis by Suppressing Chronic Central Nervous System Inflammation

(2009) R. Brambilla et al.   JOURNAL OF IMMUNOLOGY

The astrocytic response in early experimental autoimmune encephalomyelitis occurs across both the grey and white matter compartments

(2009) Hong Pham et al.   JOURNAL OF NEUROIMMUNOLOGY

A new cross-talk between the aryl hydrocarbon receptor and RelB, a member of the NF-κB family

(2008) Christoph F.A. Vogel et al.   BIOCHEMICAL PHARMACOLOGY

Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis

(2008) Monica Marta et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Modulation of astrocytic metabolic phenotype by proinflammatory cytokines

(2008) Mathilde Gavillet et al.   GLIA

S1P1 Receptor Signaling Overrides Retention Mediated by Gαi-Coupled Receptors to Promote T Cell Egress

(2008) Trung H.M. Pham et al.   IMMUNITY

Gap Junctions Couple Astrocytes and Oligodendrocytes

(2008) Jennifer L. Orthmann-Murphy et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury

(2008) J. E. Herrmann et al.   JOURNAL OF NEUROSCIENCE