Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages

Oxidative stress and its impact on neurons and glia in multiple sclerosis lesions

(2016) Hans Lassmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Immature monocytes recruited to the ischemic mouse brain differentiate into macrophages with features of alternative activation

(2016) Francesc Miró-Mur et al.   BRAIN BEHAVIOR AND IMMUNITY

In Vivo Interleukin-13-Primed Macrophages Contribute to Reduced Alloantigen-Specific T Cell Activation and Prolong Immunological Survival of Allogeneic Mesenchymal Stem Cell Implants

(2016) Chloé J. Hoornaert et al.   STEM CELLS

TREM2 regulates microglial cell activation in response to demyelination in vivo

(2015) Claudia Cantoni et al.   ACTA NEUROPATHOLOGICA

Adoptive transfer of M2 macrophages promotes locomotor recovery in adult rats after spinal cord injury

(2015) Shan-Feng Ma et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Early Inflammatory Responses following Cell Grafting in the CNS Trigger Activation of the Subventricular Zone: A Proposed Model of Sequential Cellular Events

(2015) Jelle Praet et al.   CELL TRANSPLANTATION

Lentivirus technologies for modulation of the immune system

(2015) Benjamin C Houghton et al.   CURRENT OPINION IN PHARMACOLOGY

Oncostatin M protects against demyelination by inducing a protective microglial phenotype

(2015) Kris Janssens et al.   GLIA

TREM2 sustains microglial expansion during aging and response to demyelination

(2015) Pietro Luigi Poliani et al.   JOURNAL OF CLINICAL INVESTIGATION

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

(2015) Antoine Lampron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Attenuation of acute stroke injury in rat brain by minocycline promotes blood–brain barrier remodeling and alternative microglia/macrophage activation during recovery

(2015) Yirong Yang et al.   Journal of Neuroinflammation

MSX3 Switches Microglia Polarization and Protects from Inflammation-Induced Demyelination

(2015) Z. Yu et al.   JOURNAL OF NEUROSCIENCE

CCR2 Antagonism Alters Brain Macrophage Polarization and Ameliorates Cognitive Dysfunction Induced by Traumatic Brain Injury

(2015) J. M. Morganti et al.   JOURNAL OF NEUROSCIENCE

Neuronal Interleukin-4 as a Modulator of Microglial Pathways and Ischemic Brain Damage

(2015) X. Zhao et al.   JOURNAL OF NEUROSCIENCE

Pathological mechanisms in progressive multiple sclerosis

(2015) Don H Mahad et al.   LANCET NEUROLOGY

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Longitudinal monitoring of metabolic alterations in cuprizone mouse model of multiple sclerosis using 1H-magnetic resonance spectroscopy

(2015) Jasmien Orije et al.   NEUROIMAGE

In vivoquantitative magnetization transfer imaging correlates with histology during de- and remyelination in cuprizone-treated mice

(2015) Laura Turati et al.   NMR IN BIOMEDICINE

Cuprizone-induced demyelination and demyelination-associated inflammation result in different proton magnetic resonance metabolite spectra

(2015) Jelle Praet et al.   NMR IN BIOMEDICINE

Alternatively activated microglia and macrophages in the central nervous system

(2015) Rafael Franco et al.   PROGRESS IN NEUROBIOLOGY

MRI in the Diagnosis and Monitoring of Multiple Sclerosis: An Update

(2015) M. P. Wattjes et al.   Clinical Neuroradiology

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Distinct spatial distribution of microglia and macrophages following mesenchymal stem cell implantation in mouse brain

(2014) Debbie Le Blon et al.   IMMUNOLOGY AND CELL BIOLOGY

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Cellular and molecular neuropathology of the cuprizone mouse model: Clinical relevance for multiple sclerosis

(2014) Jelle Praet et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Cranial Irradiation Alters the Brain’s Microenvironment and Permits CCR2+ Macrophage Infiltration

(2014) Josh M. Morganti et al.   PLoS One

Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned

(2014) Viktoria Gudi et al.   Frontiers in Cellular Neuroscience

Interleukin-4- and Interleukin-13-Mediated Alternatively Activated Macrophages: Roles in Homeostasis and Disease

(2013) Steven J. Van Dyken et al.   Annual Review of Immunology

The Benefits and Detriments of Macrophages/Microglia in Models of Multiple Sclerosis

(2013) Khalil S. Rawji et al.   Clinical & Developmental Immunology

Role of Microglia in CNS Autoimmunity

(2013) Tobias Goldmann et al.   Clinical & Developmental Immunology

IL-13Rα1 is a surface marker for M2 macrophages influencing their differentiation and function

(2013) Mermagya Dhakal et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Can we switch microglia's phenotype to foster neuroprotection? Focus on multiple sclerosis

(2013) Debora Giunti et al.   IMMUNOLOGY

Interleukin-13/Interleukin-4-induced oxidative stress contributes to death of prothrombinkringle-2 (pKr-2)-activated microglia

(2013) So-Yoon Won et al.   JOURNAL OF NEUROIMMUNOLOGY

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Multimodal imaging of subventricular zone neural stem/progenitor cells in the cuprizone mouse model reveals increased neurogenic potential for the olfactory bulb pathway, but no contribution to remyelination of the corpus callosum

(2013) Caroline Guglielmetti et al.   NEUROIMAGE

Quantitative MRI and ultrastructural examination of the cuprizone mouse model of demyelination

(2013) Jonathan D. Thiessen et al.   NMR IN BIOMEDICINE

Targeting the Shift from M1 to M2 Macrophages in Experimental Autoimmune Encephalomyelitis Mice Treated with Fasudil

(2013) Chunyun Liu et al.   PLoS One

Deep Gray Matter Demyelination Detected by Magnetization Transfer Ratio in the Cuprizone Model

(2013) Sveinung Fjær et al.   PLoS One

Origin and differentiation of microglia

(2013) Florent Ginhoux et al.   Frontiers in Cellular Neuroscience

Microglia and monocyte-derived macrophages: functionally distinct populations that act in concert in CNS plasticity and repair

(2013) Anat London et al.   Frontiers in Cellular Neuroscience

Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination

(2012) Thomas Skripuletz et al.   BRAIN

Cell Type-Associated Differences in Migration, Survival, and Immunogenicity following Grafting in CNS Tissue

(2012) Jelle Praet et al.   CELL TRANSPLANTATION

Quantitative and phenotypic analysis of mesenchymal stromal cell graft survival and recognition by microglia and astrocytes in mouse brain

(2012) Nathalie De Vocht et al.   IMMUNOBIOLOGY

Immune surveillance in the central nervous system

(2012) Shalina S Ousman et al.   NATURE NEUROSCIENCE

Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice

(2012) K. Kawahara et al.   NEUROSCIENCE

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria

(2011) Chris H. Polman et al.   ANNALS OF NEUROLOGY

Preactive Multiple Sclerosis Lesions Offer Novel Clues for Neuroprotective Therapeutic Strategies

(2011) Johannes M. van Noort et al.   CNS & Neurological Disorders-Drug Targets

Identification of a microglia phenotype supportive of remyelination

(2011) Marta Olah et al.   GLIA

Role of glial cells in innate immunity and their role in CNS demyelination

(2011) Subramaniam Sriram   JOURNAL OF NEUROIMMUNOLOGY

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

(2011) Marco Prinz et al.   NATURE NEUROSCIENCE

State-of-the-art gene-based therapies: the road ahead

(2011) Mark A. Kay   NATURE REVIEWS GENETICS

Repertoire of microglial and macrophage responses after spinal cord injury

(2011) Samuel David et al.   NATURE REVIEWS NEUROSCIENCE

Characterisation of microglia during de- and remyelination: Can they create a repair promoting environment?

(2011) Elke Verena Voß et al.   NEUROBIOLOGY OF DISEASE

Assessment of lesion pathology in a new animal model of MS by multiparametric MRI and DTI

(2011) Susann Boretius et al.   NEUROIMAGE

Recent Developments in Imaging of Multiple Sclerosis

(2011) Guy Poloni et al.   NEUROLOGIST

Magnetic resonance imaging and histological evidence for the blockade of cuprizone-induced demyelination in C57BL/6 mice

(2011) P. Chandran et al.   NEUROSCIENCE

Demyelination and remyelination in anatomically distinct regions of the corpus callosum following cuprizone intoxication

(2011) Andrew J. Steelman et al.   NEUROSCIENCE RESEARCH

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Spatial and Temporal Profiles of Growth Factor Expression during CNS Demyelination Reveal the Dynamics of Repair Priming

(2011) Viktoria Gudi et al.   PLoS One

Recent Advances in Lentiviral Vector Development and Applications

(2010) Janka Mátrai et al.   MOLECULAR THERAPY

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Selective Chemokine Receptor Usage by Central Nervous System Myeloid Cells in CCR2-Red Fluorescent Protein Knock-In Mice

(2010) Noah Saederup et al.   PLoS One

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

The cuprizone animal model: new insights into an old story

(2009) Markus Kipp et al.   ACTA NEUROPATHOLOGICA

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

Regional differences between grey and white matter in cuprizone induced demyelination

(2009) Viktoria Gudi et al.   BRAIN RESEARCH

The MT pool size ratio and the DTI radial diffusivity may reflect the myelination in shiverer and control mice

(2009) Xiawei Ou et al.   NMR IN BIOMEDICINE

Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer

(2009) Yogeshkumar Malam et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Effects of dietary intervention on MRI activity, de- and remyelination in the cuprizone model for demyelination

(2008) Øivind Torkildsen et al.   EXPERIMENTAL NEUROLOGY

17β-estradiol and progesterone prevent cuprizone provoked demyelination of corpus callosum in male mice

(2008) Peter Acs et al.   GLIA

Microglia: gatekeepers of central nervous system immunology

(2008) Bart R. Tambuyzer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Recovery from Chronic Demyelination by Thyroid Hormone Therapy: Myelinogenesis Induction and Assessment by Diffusion Tensor Magnetic Resonance Imaging

(2008) L.-A. Harsan et al.   JOURNAL OF NEUROSCIENCE

Monitoring demyelination and remyelination by magnetization transfer imaging in the mouse brain at 9.4 T

(2008) Wafaa Zaaraoui et al.   MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE

Magnetization Transfer MR Imaging in Multiple Sclerosis

(2008) Stefan Ropele et al.   NEUROIMAGING CLINICS OF NORTH AMERICA